scholarly journals Greater Dietary Inflammatory Potential Is Associated With Higher Likelihood of Abdominal Aortic Calcification

2021 ◽  
Vol 8 ◽  
Author(s):  
Zheng Qin ◽  
Kaixi Chang ◽  
Ruoxi Liao ◽  
Luojia Jiang ◽  
Qinbo Yang ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Positive Association ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Hypertension Status ◽  
Lateral Spine ◽  
Abdominal Aortic ◽  
Diabetes Status ◽  
Increased Risk ◽  
The Mean

Aims: We aimed to assess the association between dietary inflammation index (DII) and abdominal aortic calcification (AAC) in US adults aged ≥40 years.Methods: Data were obtained from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). Participants who were <40 years old and missing the data of DII and AAC were excluded. DII was calculated based on a 24-h dietary recall interview for each participant. AAC score was quantified by assessing lateral spine images and severe AAC was defined as AAC score >6. Weighted multivariable regression analysis and subgroup analysis were preformed to estimate the independent relationship between DII with AAC score and severe AAC.Results: A total of 2,897 participants were included with the mean DII of −0.17 ± 2.80 and the mean AAC score of 1.462 ± 3.290. The prevalence of severe AAC was 7.68% overall, and participants in higher DII quartile tended to have higher rates of severe AAC (Quartile 1: 5.03%, Quartile 2: 7.44%, Quartile 3: 8.38%, Quartile 4: 10.46%, p = 0.0016). A positive association between DII and AAC score was observed (β = 0.055, 95% CI: 0.010, 0.101, p = 0.01649), and higher DII was associated with an increased risk of severe AAC (OR = 1.067, 95% CI: 1.004, 1.134, p = 0.03746). Subgroup analysis indicated that this positive association between DII and AAC was similar in population with differences in gender, age, BMI, hypertension status, and diabetes status and could be appropriate for different population settings.Conclusion: Higher pro-inflammatory diet was associated with higher AAC score and increased risk of severe AAC. Anti-inflammatory dietary management maybe beneficial to reduce the risk of AAC.

scholarly journals Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

2021 ◽  
Vol 8 ◽  
Author(s):  
Zheng Qin ◽  
Hancong Li ◽  
Yingfei Xu ◽  
Jiameng Li ◽  
Baihai Su ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Inductively Coupled Plasma ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Inductively Coupled ◽  
Abdominal Aortic ◽  
Increased Risk

Aims: This study aimed to evaluate the association between blood lead level (BLL) and abdominal aortic calcification (AAC) in US adults aged ≥40 years.Methods: We obtained data from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES). Participants missing the data of BLL and AAC scores were excluded. BLL was measured using inductively coupled plasma mass spectrometry directly. AAC scores were quantified by Kauppila score system, and severe AAC was defined as AAC score >6. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between BLL with AAC score and severe AAC.Results: A total of 1,530 participants were included with the mean BLL of 1.45 ± 1.31 ng/dl and mean AAC score of 1.40 ± 3.13. The prevalence of severe AAC was 7.98% overall, and participants in higher BLL quartile showed higher prevalence of severe AAC (Quartile 1: 3.55%, Quartile 2: 7.28%, Quartile 3: 9.88%, Quartile 4: 12.58%, P < 0.0001). BLL was positively associated with higher AAC score (β = 0.15, 95% CI: 0.02, 0.27, P = 0.021) and increased risk of severe AAC (OR = 1.11; 95% CI: 1.00–1.22; P = 0.047). Subgroup analysis and interaction test indicated that the association between BLL and AAC was similar in different population settings.Conclusions: Higher BLL was associated with higher AAC score and increased risk of severe AAC. Lead burden should be considered for people with AAC in clinical settings.

scholarly journals Serum myostatin levels are negatively associated with abdominal aortic calcification in older men: the STRAMBO study

2012 ◽  
Vol 167 (6) ◽  
pp. 873-880 ◽  
Author(s):  
P Szulc ◽  
L C Hofbauer ◽  
M Rauner ◽  
C Goettsch ◽  
R Chapurlat ◽  
...  
Keyword(s):  
Serum Levels ◽  
Older Men ◽  
Aortic Calcification ◽  
Negative Regulator ◽  
Total Serum ◽  
Abdominal Aortic Calcification ◽  
Lateral Spine ◽  
Reactive Protein ◽  
Atherosclerotic Lesions ◽  
Abdominal Aortic

ObjectiveTo assess the association between abdominal aortic calcification (AAC) and serum levels of myostatin, a negative regulator of skeletal muscle mass, which has been implicated in the development of atherosclerotic lesions in mice.Design and patientsWe assessed AAC semiquantitatively from the lateral spine scans obtained using dual energy X-ray absorptiometry in 1071 men aged 20–87 years. Serum myostatin levels were measured by an immunoassay that detects all myostatin forms.ResultsTotal myostatin serum levels did not differ between men with or without self-reported ischemic heart disease, hypertension, or diabetes mellitus. Total serum myostatin levels were higher in men with higher serum calcium levels and lower in men with higher serum concentrations of highly sensitive C-reactive protein. Men with AAC had lower myostatin levels compared with men without AAC. Prevalence of AAC (AAC score >0) was lower in the highest myostatin quartile compared with the three lower quartiles (P<0.05). After adjustment for confounders, odds of AAC (AAC score >0) were lower (OR=0.62; 95% confidence interval (95% CI), 0.45–0.85; P<0.005) for the fourth myostatin quartile vs the three lower quartiles combined. In the sub-analysis of 745 men aged ≥60 years, the results were similar: AAC prevalence was lower in the highest myostatin quartile compared with the three lower quartiles combined (OR=0.54; 95% CI, 0.38–0.78; P<0.001).ConclusionsIn older men, total myostatin serum levels are inversely correlated with AAC. Further studies are needed to investigate mechanisms underlying this association and to assess utility of myostatin as a cardiovascular marker.

scholarly journals Cruciferous vegetable intake is inversely associated with extensive abdominal aortic calcification in elderly women: a cross-sectional study

2020 ◽  
pp. 1-9
Author(s):  
Lauren C. Blekkenhorst ◽  
Marc Sim ◽  
Simone Radavelli-Bagatini ◽  
Nicola P. Bondonno ◽  
Catherine P. Bondonno ◽  
...  
Keyword(s):  
Elderly Women ◽  
Vegetable Intake ◽  
Aortic Calcification ◽  
Cruciferous Vegetables ◽  
Abdominal Aortic Calcification ◽  
Lateral Spine ◽  
Cross Sectional ◽  
Brussels Sprouts ◽  
Cruciferous Vegetable ◽  
Abdominal Aortic

Abstract We have previously shown that higher intake of cruciferous vegetables is inversely associated with carotid artery intima-media thickness. To further test the hypothesis that an increased consumption of cruciferous vegetables is associated with reduced indicators of structural vascular disease in other areas of the vascular tree, we aimed to investigate the cross-sectional association between cruciferous vegetable intake and extensive calcification in the abdominal aorta. Dietary intake was assessed, using a FFQ, in 684 older women from the Calcium Intake Fracture Outcome Study. Cruciferous vegetables included cabbage, Brussels sprouts, cauliflower and broccoli. Abdominal aortic calcification (AAC) was scored using the Kauppila AAC24 scale on dual-energy X-ray absorptiometry lateral spine images and was categorised as ‘not extensive’ (0–5) or ‘extensive’ (≥6). Mean age was 74·9 (sd 2·6) years, median cruciferous vegetable intake was 28·2 (interquartile range 15·0–44·7) g/d and 128/684 (18·7 %) women had extensive AAC scores. Those with higher intakes of cruciferous vegetables (>44·6 g/d) were associated with a 46 % lower odds of having extensive AAC in comparison with those with lower intakes (<15·0 g/d) after adjustment for lifestyle, dietary and CVD risk factors (ORQ4 v. Q1 0·54, 95 % CI 0·30, 0·97, P = 0·036). Total vegetable intake and each of the other vegetable types were not related to extensive AAC (P > 0·05 for all). This study strengthens the hypothesis that higher intake of cruciferous vegetables may protect against vascular calcification.

scholarly journals Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men　― The Prospective MINOS Study ―

2018 ◽  
Vol 82 (12) ◽  
pp. 2954-2961 ◽  
Author(s):  
Pawel Szulc ◽  
Ez Zoubir Amri ◽  
Annie Varennes ◽  
Patricia Panaia-Ferrari ◽  
Eric Fontas ◽  
...  
Keyword(s):  
Positive Association ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

scholarly journals High prevalence of abdominal aortic calcification in patients with primary hyperparathyroidism as evaluated by Kauppila score

2016 ◽  
Vol 175 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Jessica Pepe ◽  
Daniele Diacinti ◽  
Emanuela Fratini ◽  
Italo Nofroni ◽  
Antonella D’Angelo ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Postmenopausal Women ◽  
Aortic Calcification ◽  
Mineral Density ◽  
Abdominal Aortic Calcification ◽  
Lateral Spine ◽  
Abdominal Aortic ◽  
Hormone Effect ◽  
Spine Radiograph

Objective The prevalence of abdominal aortic calcification (AAC) in primary hyperparathyroidism (PHPT) is unknown. We assessed both prevalence and severity of AAC in PHPT postmenopausal women. Methods In this study 70 PHPT postmenopausal women and 70 age- and sex-matched controls were enrolled. Each participant underwent biochemical evaluation, lateral spine radiograph, bone mineral density (BMD) measurement (lumbar, femoral, radial sites), and kidney ultrasound. Lateral lumbar films were analyzed in the region of L1–L4 vertebrae and the Kauppila score (a semi-quantitative grading system) was used to assess the severity of AAC. Results There were no differences regarding demographic and cardiovascular risk factors in the two groups. PHPT patients had higher prevalence of kidney stones (30% vs 7%, P=0.0008) and lower radial BMD values (0.558±0.071 vs 0.588±0.082 g/cm2, P<0.05) compared with controls. PHPT patients showed higher prevalence of AAC (31 vs 18, P=0.03), with more severe calcifications (Kauppila score 7.35±6.1 vs 5.05±3.5, P=0.007). PHPT patients with AAC were older and had been suffering from the disease for a longer period compared with those without ACC. Moreover, PHPT patients with severe AAC had mean higher serum parathyroid hormone levels compared with patients with moderate or mild calcifications. In PHPT patients with AAC, multiple regression analysis, adjusted for age and years since diagnosis, showed that only parathyroid hormone significantly correlated with Kauppila score. Conclusion We found a higher prevalence and severity of AAC in PHPT related to parathyroid hormone effect.

scholarly journals SUN-545 High Prevalence of Cardiometabolic Diseases and Abdominal Aortic Calcification in Psoriasis

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Sofia Ramos ◽  
Sheetal Daya ◽  
Mohammed Tikly ◽  
Nigel J Crowther ◽  
Nasrin Goolam Mahyoodeen
Keyword(s):  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Aortic Calcification ◽  
Aortic Bifurcation ◽  
Abdominal Aortic Calcification ◽  
The Metabolic Syndrome ◽  
Abdominal Aortic ◽  
Increased Risk ◽  
High Prevalence

Abstract Psoriasis has been shown to increase the risk of cardiovascular disease. Studies indicate that the presence of abdominal aortic calcification (AAC) is a strong predictor of future cardiovascular events and all-cause mortality. Multi-detector computed tomography provides a reliable and accurate method for the detection of abdominal aortic calcification. The aim of this study was to investigate the prevalence of AAC in patients with psoriasis. Adult psoriasis patients (n=69) and controls (n=80) were recruited from the Dermatology and Rheumatology clinics at 3 academic hospitals in Johannesburg, South Africa. Controls were matched for gender, ethnicity and body mass index (BMI). Non-contrast abdominal CT imaging was performed on patients and controls. The images were then assessed for presence and location (supra-coeliac, supramesenteric, supra-renal, proximal infra-renal, aortic bifurcation) of AAC. Patients had a mean age and disease duration of 53.3 ± 14.5 years and 18.9 ± 13.3 years, respectively. There was a significantly higher prevalence of smoking, hypertension and type 2 diabetes in patients compared to controls (56.5% vs 25.0%, P&lt;0.005; 72.5% vs 55.0%, P&lt;0.005; 24.6% vs 3.80%, P&lt;0.0005, respectively). Furthermore, there was a significantly higher prevalence of AAC at any site in psoriasis patients (47.8% vs 22.5%, P&lt;0.005). The aortic bifurcation was the commonest site for AAC in patients and controls, and the prevalence was significantly higher in the psoriasis group (42.0% vs 21.3%, p&lt;0.005). However, multivariable logistic regression analysis demonstrated that age, smoking and the metabolic syndrome were significantly associated with AAC (P&lt;0.0001, P=0.0002, P=0.027 respectively) and attenuated the relationship between psoriasis and AAC to non-significance (P=0.376). This suggests the increased risk of aortic calcification in psoriasis is mediated by the high prevalence of cardiometabolic disease in this population. These data highlight the increased cardiovascular disease risk within subjects with psoriasis and the need for lifestyle modification to decrease risk factor burden.

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