scholarly journals Calcific Aortic Stenosis—A Review on Acquired Mechanisms of the Disease and Treatments

2021 ◽  
Vol 8 ◽  
Author(s):  
Banafsheh Zebhi ◽  
Mohamad Lazkani ◽  
David Bark
Keyword(s):  
Aortic Stenosis ◽  
Molecular Mechanisms ◽  
Progressive Disease ◽  
Diagnostic Methods ◽  
Calcific Aortic Stenosis ◽  
Treatment Practices ◽  
Prosthetic Valves

Calcific aortic stenosis is a progressive disease that has become more prevalent in recent decades. Despite advances in research to uncover underlying biomechanisms, and development of new generations of prosthetic valves and replacement techniques, management of calcific aortic stenosis still comes with unresolved complications. In this review, we highlight underlying molecular mechanisms of acquired aortic stenosis calcification in relation to hemodynamics, complications related to the disease, diagnostic methods, and evolving treatment practices for calcific aortic stenosis.

scholarly journals Towards Personalized Therapy of Aortic Stenosis

2021 ◽  
Vol 11 (12) ◽  
pp. 1292
Author(s):  
Piotr Mazur ◽  
Magdalena Kopytek ◽  
Michał Ząbczyk ◽  
Anetta Undas ◽  
Joanna Natorska
Keyword(s):  
Aortic Stenosis ◽  
Molecular Mechanisms ◽  
Randomized Trials ◽  
Current Knowledge ◽  
Lipid Lowering ◽  
Advanced Glycation ◽  
Calcific Aortic Stenosis ◽  
Treatment Pathways ◽  
Glycation End Products ◽  
Coagulation Proteins

Calcific aortic stenosis (CAS) is the most common cause of acquired valvular heart disease in adults with no available pharmacological treatment to inhibit the disease progression to date. This review provides an up-to-date overview of current knowledge of molecular mechanisms underlying CAS pathobiology and the related treatment pathways. Particular attention is paid to current randomized trials investigating medical treatment of CAS, including strategies based on lipid-lowering and antihypertensive therapies, phosphate and calcium metabolism, and novel therapeutic targets such as valvular oxidative stress, coagulation proteins, matrix metalloproteinases, and accumulation of advanced glycation end products.

scholarly journals Molecular aspects of the pathological activation and differentiation of valvular interstitial cells during the development of calcific aortic stenosis

2019 ◽  
Vol 34 (3) ◽  
pp. 66-72
Author(s):  
A. E. Kostyunin
Keyword(s):  
Aortic Stenosis ◽  
Cell Activation ◽  
Molecular Mechanisms ◽  
Interstitial Cells ◽  
Valvular Interstitial Cells ◽  
Calcific Aortic Stenosis ◽  
Valve Tissue ◽  
Pathological Differentiation ◽  
Molecular Aspects ◽  
Atherosclerotic Process

Calcific aortic stenosis is the most common valvular heart disease. The pathogenesis of this disease is complex and resembles the atherosclerotic process in the blood vessels. It is known that valvular interstitial cell activation and subsequent differentiation into osteoblast- and myofibroblast-like cells is the main driving force of fibrous and calcified aortic valve tissue. However, the molecular mechanisms behind these processes are still not fully understood. Current information on this issue is collected and analyzed in this article. The main molecular pathways mediating the pathological differentiation of the valvular interstitial cells and the reasons for their activation are considered.

Calcific Aortic Stenosis and Associated Lev’s Disease

Circulation ◽  
1995 ◽  
Vol 92 (10) ◽  
pp. 3138-3138
Author(s):  
Richard L. Mueller ◽  
Geoffrey Bergman
Keyword(s):  
Aortic Stenosis ◽  
Calcific Aortic Stenosis

scholarly journals THE SURGICAL CORRECTION OF CALCIFIC AORTIC STENOSIS IN ADULTS

1958 ◽  
Vol 36 (6) ◽  
pp. 759-776 ◽  
Author(s):  
Dwight E. Harken ◽  
Harrison Black ◽  
Warren J. Taylor ◽  
Wendell B. Thrower ◽  
Harry S. Soroff
Keyword(s):  
Aortic Stenosis ◽  
Surgical Correction ◽  
Calcific Aortic Stenosis

scholarly journals Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1236
Author(s):  
Jesús Burillo ◽  
Patricia Marqués ◽  
Beatriz Jiménez ◽  
Carlos González-Blanco ◽  
Manuel Benito ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Signaling ◽  
Molecular Mechanisms ◽  
Progressive Disease

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer’s disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.

Diabetes and hypercholesterolemia among patients with calcific aortic stenosis

1984 ◽  
Vol 37 (5) ◽  
pp. 407-415 ◽  
Author(s):  
Sigismond Deutscher ◽  
Howard E. Rockette ◽  
Venkatraman Krishnaswami
Keyword(s):  
Aortic Stenosis ◽  
Calcific Aortic Stenosis

scholarly journals Calcific Aortic Stenosis

2012 ◽  
Vol 60 (19) ◽  
pp. 1854-1863 ◽  
Author(s):  
Marc R. Dweck ◽  
Nicholas A. Boon ◽  
David E. Newby
Keyword(s):  
Aortic Stenosis ◽  
Calcific Aortic Stenosis
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