scholarly journals The Risk Threshold for Hemoglobin A1c Associated With Albuminuria: A Population-Based Study in China

2021 ◽  
Vol 12 ◽  
Author(s):  
Hong Lian ◽  
Hongshi Wu ◽  
Jie Ning ◽  
Diaozhu Lin ◽  
Chulin Huang ◽  
...  

BackgroundDiabetic kidney disease (DKD) is a kind of common microvascular complication of diabetes. This study aims to explore the possible links between blood sugar level and albuminuria, providing the exact cut point of the “risk threshold” for blood glucose with DKD.MethodsThe relationship between blood glucose and albuminuria was modeled using linear and logistic regression in the REACTION study cohorts (N= 8932). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression model. Two-slope linear regression was used to simulate associations between blood glucose and ACR.ResultsWe found that the increase in ACR was accompanied by increased HbA1c, with a turning point at 5.5%. The positive correlation remained highly significant (P<0.001) when adjusted for age, sex, marital status, education, smoking status, drinking status, BMI, waistline, SBP and DBP. In subgroup analyses including gender, obesity, hypertension, and smoking habits, the relationship was significant and stable.ConclusionsWe determined a risk threshold for HbA1c associated with albuminuria in a Chinese population over the age of 40. HbA1c ≥ 5.5% was positively and independently associated with ACR. These results suggest the necessity of early blood glucose control and renal function screening for DKD in at-risk populations.

2007 ◽  
Vol 33 (12) ◽  
pp. 2085-2092 ◽  
Author(s):  
Nam Nguyen ◽  
Katrina Ching ◽  
Robert Fraser ◽  
Marianne Chapman ◽  
Richard Holloway

2021 ◽  
Author(s):  
Yiyi Ding ◽  
Shuo Wang ◽  
Rui Guo ◽  
Aizhen Zhang ◽  
Yufang Zhu

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.


2017 ◽  
Vol 33 (6) ◽  
pp. 285
Author(s):  
Agus Heri Setiawan ◽  
Yayi Suryo Prabandari ◽  
Riris Andono Ahmad

Implementation of the smoke-free neighborhood program in YogyakartaPurposeThis study aimed to identify the successfulness of smoke-free neighborhood and to understand the relationship between the householders' knowledge and household smoking status. MethodsAn observational analytic study was conducted using cross-sectional surveys. Chi-square, Fisher exact and logistic regression tests were used to analyze the correlation between variables. ResultsFrom those numbers, qualified households which fulfill the program criteria were 76.1% and 75.9%, respectively. To be more specific, in smoke-free neighborhood, about 56.8% householders were under smoking status and 43.2% householders were identified as ex- or non-smoker. Bivariable analysis showed that there was a significant correlation between educational background, age, knowledge, and perception of householder with smoking status. The last model of multivariable analysis showed that knowledge, and age of householders was related to household smoking status. ConclusionThis study shows that smoke-free neighborhood program has not yet affected passive smoker protection significantly. A more specific controlling program to improve the knowledge especially for elderly (> 45 years old) has to be increased in smoke-free neighborhood of Yogyakarta.


Sign in / Sign up

Export Citation Format

Share Document