scholarly journals Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring

2021 ◽  
Vol 12 ◽  
Author(s):  
Alexander Hartmann ◽  
Christiane Hartmann ◽  
Riccardo Secci ◽  
Andreas Hermann ◽  
Georg Fuellen ◽  
...  
Keyword(s):  
Scoring Systems ◽  
Evidence Based ◽  
Biological Feature ◽  
Biomarkers Of Aging ◽  
Potential Biomarker ◽  
Living Organisms ◽  
Study Designs ◽  
Based Medicine ◽  
Measurement Effort ◽  
Biomarker Of Aging

Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of commonly mentioned and frequently used potential aging-related biomarkers. We were interested in biomarkers of aging in general and in biomarkers related to cellular senescence in particular. To answer the question whether a biological feature is relevant as a potential biomarker of aging or senescence in the scientific community we used the PICO strategy known from evidence-based medicine. We introduced two scoring systems, aimed at reflecting biomarker relevance and measurement effort, which can be used to support study designs in both clinical and research settings.

An overview of study designs

2020 ◽  
Vol 81 (5) ◽  
pp. 1-6
Author(s):  
Julian Aquilina ◽  
Joana B Neves ◽  
Maxine GB Tran
Keyword(s):  
Clinical Trials ◽  
Study Design ◽  
Evidence Based Medicine ◽  
Evidence Based ◽  
Advantages And Disadvantages ◽  
Valid Evidence ◽  
Study Designs ◽  
Based Medicine

The numbers of clinical trials have increased exponentially over the last decade, amplifying the pressure to select an appropriate study design to obtain reliable and valid evidence. The ability to find, critically appraise and use evidence to develop new interventions is fundamental to evidence-based medicine. Different study designs have their own advantages and disadvantages, and provide different evidentiary value. This article provides an overview of clinical trials, illustrating that, ultimately, the study design chosen needs to meet experimental and funding limitations, while minimising error.

Epidemiology 2: Study Design

2010 ◽  
pp. 47-58
Author(s):  
Muktar H. Aliyu
Keyword(s):  
Study Design ◽  
Scientific Evidence ◽  
Epidemiologic Study ◽  
Scientific Research ◽  
Time Frame ◽  
Epidemiologic Studies ◽  
Evidence Based ◽  
Study Designs ◽  
Based Medicine

The usefulness of evidence arising from scientific research is influenced by several factors, and foremost among these factors is the design of the epidemiologic study from which the findings are drawn. In evidence-based medicine, the quality of scientific evidence is often graded on the base of the type of study design and includes appraisal of methods by which studies of exposure and outcomes are planned and implemented. Several factors must be considered when designing a scientific study, including the hypothesis being tested, study cost, time frame, subject characteristics, choice of variables or measurements, and ethical concerns. In this chapter, the different types of study designs commonly encountered in clinical research, common measures of morbidity and mortality in epidemiology, and errors (random and systematic) that may threaten conclusions derived from inferences arising from epidemiologic studies are discussed.

What historiography can tell us about evidence-based medicine and policy: A response to Pawson’s ‘The Realist Foundations of Evidence-based Medicine’

Evaluation ◽  
2018 ◽  
Vol 24 (3) ◽  
pp. 318-324
Author(s):  
Axel Kaehne
Keyword(s):  
Experimental Study ◽  
Medical Research ◽  
Evidence Based Medicine ◽  
Policy Impact ◽  
Evidence Based ◽  
Different Types ◽  
History Of ◽  
Study Designs ◽  
Based Medicine ◽  
History Of Cancer

In the battle between experimental study designs and realist approaches, Ray Pawson has fired the next shot. This time evidence based medicine is in his aim. He argues that evidence based medicine is becoming more appreciative of specific circumstances of interventions and hence medical research may be approximating realist evaluation’s approach. He illustrates his argument with the history of cancer where the disease increasingly looks like it is playing ‘cat and mouse’ with researchers. In the paper I try to disentangle the epistemological and methodological dimensions of Pawson’s claim. I argue that, what may look similar on a narrative level, may not be consequential for the different types of epistemologies that sustain medical and policy impact research.

Hinchey Classification of Acute Diverticulitis

2017 ◽  
Author(s):  
Michael P. Catanzaro ◽  
Rachel J. Kwon
Keyword(s):  
Evidence Based Medicine ◽  
Paradigm Shift ◽  
Acute Diverticulitis ◽  
Scoring Systems ◽  
Historical Study ◽  
Evidence Based ◽  
Hinchey Classification ◽  
History Of ◽  
Based Medicine

This chapter provides a summary of a landmark historical study in surgery: the Hinchey classification of acute diverticulitis. It describes the history of the disease, gives a summary of the study including study design and results, and relates the study to a modern-day principle of evidence-based medicine: validation of scoring systems. Hinchey’s classification of diverticulitis has become the most widespread system and while the Hinchey score may currently have less clinical relevance as it did in his time, its publication and eventual adoption marked a practice-changing paradigm shift in the way diverticulitis is viewed and managed today.

scholarly journals Evidence-based Medicine and Clinical Study Designs: Examples of Applications for Allergy Research

2014 ◽  
Vol 7 (1) ◽  
pp. 1-9
Author(s):  
Simon F. Thomsen
Keyword(s):  
Clinical Study ◽  
Evidence Based Medicine ◽  
Randomised Controlled Trials ◽  
Case Control ◽  
Controlled Trials ◽  
Evidence Based ◽  
Case Control Studies ◽  
Randomised Controlled ◽  
Study Designs ◽  
Based Medicine

Evidence of the effect of clinical interventions in allergology, and in medicine as a whole, can be hierarchically grouped based on the research design producing the evidence. The most weight is given to systematic reviews and metaanalyses, and to randomised controlled trials. These trial designs are superior to non-randomised controlled trials and cohort studies, which in turn are superior to case-control studies. The least weight is given to case-studies and anecdotal evidence. Herein, the principles of evidence-based medicine and clinical study designs are reviewed in the context of examples from the allergology literature.

Cholangiokarzinome

Praxis ◽  
2002 ◽  
Vol 91 (34) ◽  
pp. 1352-1356
Author(s):  
Harder ◽  
Blum
Keyword(s):  
Supportive Care ◽  
Evidence Based Medicine ◽  
Best Supportive Care ◽  
Evidence Based ◽  
Systemische Chemotherapie ◽  
Chirurgische Resektion ◽  
Multimodale Therapiekonzepte ◽  
Based Medicine

Cholangiokarzinome oder cholangiozelluläre Karzinome (CCC) sind seltene Tumoren des biliären Systems mit einer Inzidenz von 2–4/100000 pro Jahr. Zu ihnen zählen die perihilären Gallengangskarzinome (Klatskin-Tumore), mit ca. 60% das häufigste CCC, die peripheren (intrahepatischen) Cholangiokarzinome, das Gallenblasenkarzinom, die Karzinome der extrahepatischen Gallengänge und das periampulläre Karzinom. Zum Zeitpunkt der Diagnose ist nur bei etwa 20% eine chirurgische Resektion als einzige kurative Therapieoption möglich. Die Lebertransplantation ist wegen der hohen Rezidivrate derzeit nicht indiziert. Die Prognose von nicht resektablen Cholangiokarzinomen ist mit einer mittleren Überlebenszeit von sechs bis acht Monaten schlecht. Eine wirksame Therapie zur Verlängerung der Überlebenszeit existiert aktuell nicht. Die wichtigste Massnahme im Rahmen der «best supportive care» ist die Beseitigung der Cholestase (endoskopisch, perkutan oder chirurgisch), um einer Cholangitis oder Cholangiosepsis vorzubeugen. Durch eine systemische Chemotherapie lassen sich Ansprechraten von ca. 20% erreichen. 5-FU und Gemcitabine sind die derzeit am häufigsten eingesetzten Substanzen, die mit einer perkutanen oder endoluminalen Bestrahlung kombiniert werden können. Multimodale Therapiekonzepte können im Einzellfall erfolgreich sein, müssen jedoch erst in Evidence-Based-Medicine-gerechten Studien evaluiert werden, bevor Therapieempfehlungen für die Praxis formuliert werden können.

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