scholarly journals Ferroptosis-Related Long Non-Coding RNA Signature Contributes to the Prediction of Prognosis Outcomes in Head and Neck Squamous Cell Carcinomas

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenru Jiang ◽  
Yingtao Song ◽  
Zhaowei Zhong ◽  
Jili Gao ◽  
Xiaofei Meng
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Head And Neck ◽  
Squamous Cell ◽  
Risk Group ◽  
External Validation ◽  
Low Risk ◽  
Survival Prediction ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Background: Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor, which makes the prognosis prediction challenging. Ferroptosis is an iron-dependent form of non-apoptotic regulated cell death, which could affect cancer development. However, the prognostic value of ferroptosis-related long non-coding RNA (lncRNA) in HNSCC is still limited.Methods: In the current study, we employed the DESeq2 method to characterize the differentially expressed ferroptosis-related genes (FEGs) between cancer and normal samples. Next, the FEG-related lncRNAs (FElncRNAs) were identified using Spearman’s correlation analysis and multiple permutation hypotheses. Subsequently, LASSO and stepwise multivariate Cox regression analyses were undertaken to recognize the prognosis-related FElncRNA signature (PFLS) and risk scores.Results: Herein, we first identified 60 dysregulated FEGs and their co-expressed FElncRNAs in HNSCC. Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients’ prognostic risks and survival outcomes. We also assessed the efficiency of PFLS in the test set and an external validation cohort. Further parsing of the tumor immune microenvironment showed the PFLS was closely associated with immune cell infiltration abundances. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability. In addition, we observed that the expression levels of two immune checkpoints (ICPs), i.e., programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1), showed significant associations with patients’ risk score, prompting the role of the PFLS in ICP blockade therapy. Finally, we also constructed a drug–PFLS network to reinforce the clinical utilities of the PFLS.Conclusion: In summary, our study indicated that FElncRNAs played an important role in HNSCC survival prediction. Identification of PFLS will contribute to the development of novel anticancer therapeutic strategies.

scholarly journals A Ferroptosis-Related Gene Signature for Predicting the Prognosis and Drug Sensitivity of Head and Neck Squamous Cell Carcinoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Lu ◽  
Yihua Wu ◽  
Shengyun Huang ◽  
Dongsheng Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Drug Sensitivity ◽  
Risk Group ◽  
Low Risk ◽  
Neck Squamous Cell Carcinoma ◽  
Survival Prediction ◽  
Prognostic Signature

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide and has a high mortality. Ferroptosis, an iron-dependent form of programmed cell death, plays a crucial role in tumor suppression and chemotherapy resistance in cancer. However, the prognostic and clinical values of ferroptosis-related genes (FRGs) in HNSCC remain to be further explored. In the current study, we constructed a ferroptosis-related prognostic model based on the Cancer Genome Atlas database and then explored its prognostic and clinical values in HNSCC via a series of bioinformatics analyses. As a result, we built a four-gene prognostic signature, including FTH1, BNIP3, TRIB3, and SLC2A3. Survival analysis showed that the high-risk group presented significantly poorer overall survival than the low-risk group. Moreover, the ferroptosis-related signature was found to be an independent prognostic predictor with high accuracy in survival prediction for HNSCC. According to immunity analyses, we found that the low-risk group had higher anti-tumor immune infiltration cells and higher expression of immune checkpoint molecules and meanwhile corelated more closely with some anti-tumor immune functions. Meanwhile, all the above results were validated in the independent HSNCC cohort GSE65858. Besides, the signature was found to be remarkably correlated with sensitivity of common chemotherapy drugs for HNSCC patients and the expression levels of signature genes were also significantly associated with drug sensitivity to cancer cells. Overall, we built an effective ferroptosis-related prognostic signature, which could predict the prognosis and help clinicians to perform individualized treatment strategy for HNSCC patients.

scholarly journals Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma

Head & Neck ◽  
2018 ◽  
Vol 40 (7) ◽  
pp. 1555-1564 ◽  
Author(s):  
Sulsal-Ul Haque ◽  
Liang Niu ◽  
Damaris Kuhnell ◽  
Jacob Hendershot ◽  
Jacek Biesiada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Differential Expression ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Neck Squamous Cell Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Programmed cell death ligand‐1 and cytotoxic T cell infiltrates in metastatic cutaneous squamous cell carcinoma of the head and neck

Head & Neck ◽  
2020 ◽  
Vol 42 (11) ◽  
pp. 3226-3234
Author(s):  
Stefan Kraft ◽  
Shekhar K. Gadkaree ◽  
Daniel G. Deschler ◽  
Derrick T. Lin ◽  
Mai P. Hoang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
T Cell ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cytotoxic T Cell

scholarly journals Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 73029-73036 ◽  
Author(s):  
Giuseppe Troiano ◽  
Vito Carlo Alberto Caponio ◽  
Linda Boldrup ◽  
Xiaolian Gu ◽  
Lorenzo Lo Muzio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

An Autophagy-related Long Non-coding RNA Signature for Breast Cancer

2021 ◽  
Vol 24 ◽  
Author(s):  
Feng Jiang ◽  
Chuyan Wu ◽  
Ming Wang ◽  
Ke Wei ◽  
Jimei Wang
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cox Regression ◽  
Risk Group ◽  
Expression Profiles ◽  
Risk Groups ◽  
Low Risk ◽  
Optimal Cutoff ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Background: The most prevalent malignant tumor in women is breast cancer (BC). Autophagic therapies have been identified for their contribution in BC cell death. Therefore, the potential prognostic role of long non-coding RNA (lncRNA) related to autophagy in patients with BC was examined. Methods: The lncRNAs expression profiles were derived from The Cancer Genome Atlas (TCGA) database. Throughout univariate Cox regression and multivariate Cox regression test, lncRNA with BC prognosis have been differentially presented. We then defined the optimal cutoff point between high and low-risk groups. The receiver operating characteristic (ROC) curves were drawn to test this signature. In order to examine possible signaling mechanisms linked to these lncRNAs, the Gene Set Enrichment Analysis (GSEA) has been carried out. Results: Based on the lncRNA expression profiles for BC, a 9 lncRNA signature associated with autophagy was developed. The optimal cutoff value for high-risk and low-risk groups was used. The high-risk group had less survival time than the low-risk group. The result of this lncRNA signature was highly sensitive and precise. GSEA study found that the gene sets have been greatly enriched in many cancer pathways. Conclusions: Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and these lncRNAs related to autophagy may play an important role in BC biology.

Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck

2017 ◽  
Vol 77 (3) ◽  
pp. 527-533 ◽  
Author(s):  
Juana María García-Pedrero ◽  
Pablo Martínez-Camblor ◽  
Susana Diaz-Coto ◽  
Pablo Munguia-Calzada ◽  
Aitana Vallina-Alvarez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Nodal Metastasis ◽  
Cutaneous Squamous Cell Carcinoma
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