scholarly journals Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Shujing Liang ◽  
Jingxian Yang ◽  
Yun Lin ◽  
Tong Li ◽  
Wenrong Zhao ◽  
...  
Keyword(s):  
Case Report ◽  
Survival Rate ◽  
Side Effects ◽  
Literature Review ◽  
Best Practices ◽  
Adverse Events ◽  
Myasthenia Gravis ◽  
Effective Treatment ◽  
Malignant Tumor ◽  
Clinical Benefit

Immunotherapy begins to be widely used due to the increasing exploration and gratifying effects in multiple cancers. Chordoma, as a rare bone malignant tumor, often recurs and metastasizes after undergoing surgery and radiotherapy. Therefore, immunotherapy can be explored as an emerging, potentially effective treatment to improve the survival rate and clinical benefit of patients. However, a variety of immune-related adverse events (irAEs) cannot be avoided completely. And the immunotherapy-induced myocarditis, as a rare but fatal irAE, has been increasingly reported. Understanding the mechanism involved in irAEs can inform best practices for side effects management. Here, we firstly reported a case of immune myocarditis and subsequent myasthenia gravis (MG) following anti-PD-1 treatment for chordoma.

Management of Vipadika with Mahisha Gritha Padanimajjana – a case report

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sharanya Suseela ◽  
Anandaraman Puthanmadom Venkatraramana Sharma ◽  
Kesavan Parameswaran Namboothiri ◽  
Prathibha Changuli Krishna Bhat
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Effective Treatment ◽  
Skin Disorder ◽  
Severe Pain ◽  
Case Presentation ◽  
Treatment Methods ◽  
Treatment Line ◽  
Short Period ◽  
Ayurvedic Treatment

Abstract Objectives Vipadika (Palmo plantar Psoriasis) is a Kshudra Kushta (minor skin disorder) of Vatakapha origin (body humors like vata and kapha) characterized by Sphutana (cracks) and Teevra Vedana (severe pain) in Pani (palm) and Pada (sole). Based on the symptoms it can be correlated to Palmo Plantar Psoriasis which is a variant of psoriasis which affects the skin of the palms and soles with the features of hyperkeratotic, pustular, or mixed morphologies. The treatment methods for Palmo plantor psoriasis causes severe side effects due to which an evident shift from modern treatments to ayurvedic treatment line. Case presentation A 15 year old, female, with complaint of cracks and dryness over sole of both feet with pain for the last 12 and half years. The case was managed with Padanimajjana (immersion of foot). Padanimajjana is a modified form of Avagaha Sweda (switz bath) where the affected part of the foot is dipped in medicated liquid. Here Mahisha Gritha (Buffaloe ghee) is used for Padanimajjana. Conclusions Mahisha Gritha Padanimajjana shows significant improvement in number of cracks, dryness and pain within short period of time. This is a very simple, economical, and effective treatment for Vipadika.

Myasthenia Gravis Associated With Programmed Death-1 (PD-1) Receptor Inhibitor Pembrolizumab: A 40-day Case Report

2020 ◽  
pp. 089719002097075
Author(s):  
Aidan S. Ziobro ◽  
Reid L. LaPlante ◽  
Shayna R. DeMari ◽  
Larissa M. Clark ◽  
David J. Kingsley ◽  
...  
Keyword(s):  
Cell Death ◽  
Case Report ◽  
Programmed Cell Death ◽  
Adverse Events ◽  
Myasthenia Gravis ◽  
Cardiopulmonary Arrest ◽  
Palliative Therapy ◽  
Treatment Modalities ◽  
Duration Of Treatment ◽  
Serious Adverse Events

Purpose: This case report describes myasthenia gravis-like symptoms after treatment with a programmed cell death 1 inhibitor, pembrolizumab, the treatment modalities utilized, and associated patient outcomes. Summary: A 76-year old male treated with pembrolizumab for palliative therapy for metastatic melanoma presented with increasing weakness, neck pain, diplopia in the left eye, abducens palsy, periorbital edema, and decreased appetite. The patient was diagnosed with acetylcholine receptor antibody (AChR) negative myasthenia gravis. The patient was started on prednisone 1 mg/kg/day, followed by pyridostigmine 60 mg by mouth 3 times a day, and IVIg for 5 days. Due to minor improvements in myasthenia gravis symptoms, 5 cycles of plasmapheresis were ordered. The patient was successfully treated for aspiration pneumonia after cardiopulmonary arrest. On day 28, the patient was diagnosed with ventilator associated pneumonia and received appropriate therapy. Due to ICU agitation and delirium, VAP, and long duration of treatment, the patient requested withdrawal of care and passed. Conclusion: Programmed cell death inhibitors, such as pembrolizumab, can provide great benefit to patients but can also be associated with rare but serious adverse events. With new reports of MG after use, providers should continually weigh the benefits versus harm in using these products and monitor patients closely for such adverse events.

Myasthenia gravis induced by nivolumab in patients with non-small-cell lung cancer: a case report and literature review

Immunotherapy ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 701-707 ◽  
Author(s):  
Yoshikazu Hasegawa ◽  
Shigeru Kawai ◽  
Takayo Ota ◽  
Hiroshi Tsukuda ◽  
Masahiro Fukuoka
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Literature Review ◽  
Myasthenia Gravis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals EFFECT OF PANCHKARMA IN MYASTHENIA GRAVIS: A CASE REPORT

2020 ◽  
Vol 8 (7) ◽  
pp. 4003-4008
Author(s):  
Atul Joshi ◽  
Amit Awadhiya ◽  
Neha Keshari ◽  
Anup Thakar
Keyword(s):  
Skeletal Muscle ◽  
Case Report ◽  
Side Effects ◽  
Myasthenia Gravis ◽  
Neuromuscular Disease ◽  
Acetylcholine Receptors ◽  
Present Observation ◽  
Autoimmune Attack ◽  
Skeletal Muscle Weakness

Myasthenia Gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The condition is caused by breakdown in communication between nerves and muscles. The underlying defect is a decrease in the number of available acetylcholine receptors (AChRs) at neuro-muscular junctions due to an antibody mediated autoimmune attack.1 The most commonly affected mus-cles are those of the eyes, face and swallowing. The cause of this disease can be understood in view of Dhatavgnimaandhya, Vyana Vayu Vikriti. The present observation was conducted with an objective to find out the efficacy of Ayurvedic management in Myasthenia Gravis. Here is a case of 60 years old Hindu male who was diagnosed as Myasthenia Gravis (MG) reported with complaint of slurred speech, low pitch of voice, difficulty to open the mouth and to swallow food and difficulty in elevating right eyebrow since 6 months was registered in OPD of Panchakarma, IPGT & RA, Jamnagar. Considering the signs and symp-toms patient was treated on the line of Aavrita Vata Chikitsa, Sthanika Abhyanga with Bala Taila, Nasya with Anu Taila, Jihwa Pratisarana with Vacha Churna and Ghritapana before meal with Go Ghrita was administered. Treatment shows significant improvement in the symptoms without any side effects.

scholarly journals In Search of a Histopathological Pattern of Immune-Mediated Gastritis from Nivolumab Therapy: A Case Report with Literature Review

2021 ◽  
pp. 1-3
Author(s):  
Flor M Fernández-Gordón Sánchez ◽  
Flor M Fernández-Gordón Sánchez ◽  
Elena Gomez Dominguez ◽  
Cristina Garfia Castillo ◽  
Jorge Arroyo Andres ◽  
...  
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Literature Review ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
Gastrointestinal Symptoms ◽  
Specific Pattern ◽  
Immune Mediated ◽  
Upper Gastrointestinal Symptoms ◽  
Upper Gastrointestinal

Immunotherapy with checkpoint inhibitors is associated with termed inflammatory and immune-related side effects (irAE). Upper gastrointestinal symptoms are infrequent and appear mainly in patients on combination therapy with two checkpoint inhibitor drugs. We present the case of a patient with IIIB stage cutaneous melanoma treated with Nivolumab in monotherapy who developed an immune-mediated gastritis. Histopathologically, due to the paucity of published cases, no specific pattern of Nivolumab-immune-mediated gastritis has been described. We have reviewed the literature and compared the histopathology of the cases available in the literature.

scholarly journals Effective treatment of apatinib in desmoplastic small round cell tumor: a case report and literature review

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Chunyu Shi ◽  
Ye Feng ◽  
Lei Chao Zhang ◽  
Da Yong Ding ◽  
Ming Yu Yan ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Effective Treatment ◽  
Cell Tumor ◽  
Round Cell ◽  
Round Cell Tumor ◽  
Small Round Cell Tumor ◽  
Small Round Cell

scholarly journals Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1251
Author(s):  
Hui Min Tan ◽  
Susan Swee-Shan Hue ◽  
Aileen Wee ◽  
Kay Choong See
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Literature Review ◽  
Side Effect ◽  
Clinical Course ◽  
Rapid Development ◽  
Asian Population ◽  
Common Side Effect ◽  
Review Of Literature ◽  
Post Vaccination

With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi–Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.

scholarly journals Rare Side Effects of Propofol Administration—Case Report and a Brief Literature Review

2017 ◽  
Vol 5 (11) ◽  
Author(s):  
Ersin Ismail ◽  
Plamen Dimitrov ◽  
Dimana Mitsova ◽  
Svetoslav Dobrev ◽  
Snezhana Stancheva ◽  
...  
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Literature Review
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