scholarly journals Hemophagocytic Lymphohistiocytosis Associated to Klebsiella pneumoniae Infection: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhiyu Zhang ◽  
Junqian Liu ◽  
Jinggyue Wang ◽  
Yushi Wang
Keyword(s):  
Case Report ◽  
Klebsiella Pneumoniae ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Klebsiella Pneumonia ◽  
Initial Condition ◽  
Organ Function ◽  
Cardiac Intensive Care Unit ◽  
Function Impairment ◽  
Cardiac Intensive Care

This is a case analysis of a 73-year-old Chinese man admitted to the cardiac intensive care unit (ICU) with fever and general pain. Based on the patient’s initial condition of multi-organ function impairment and increased serum ferritin, and after a series of examinations, the patient was diagnosed with Klebsiella pneumonia-induced hemophagocytic lymphohistiocytosis (HLH). Meropenem and dexamethasone were used in combination to treat the patient, and the results were very successful. In this case report, it is further suggested that Klebsiella pneumoniae is a possible trigger of HLH, and a combination of antibiotics and corticosteroids can be effective in treating HLH. It is also recommended that doctors in the ICU of each department should pay attention to the role of hyperferritinemia in the diagnosis of HLH, and ICU admission teams should include ferritin in their monitoring.

Role of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of Newborn (PPHN) - Should it Be Withdrawn from Market of Bangladesh due to Threat of being Misuses

2020 ◽  
Vol 35 (2) ◽  
pp. 100-104
Author(s):  
Maksudur Rahman ◽  
Mohammad Abdullah Al Mamun ◽  
MAK Azad Chowdhury ◽  
Abu Sayeed Munsi
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cardiac Intensive Care Unit ◽  
Cross Sectional ◽  
Cardiac Intensive Care ◽  
Hospital Protocol

Background: Recently it has been apprehended that sildenafil, a drug which has been successfully using in the treatment of PPHN and erectile dysfunction in adult, is going to be withdrawn from the market of Bangladesh due to threat of its misuses. Objective: The aim of this study was to see the extent of uses of sildenafil in the treatment of PPHN and importance of availability of this drugs in the market inspite of its probable misuses. Methods: This cross sectional study was conducted in neonatal intensive care unit (NICU), special baby care unit (SCABU) and cardiac intensive care unit (CICU) of Dhaka Shishu (Children) Hospital from June, 2017 to May 2018. Neonates with PPHN were enrolled in the study. All cases were treated with oral sildenefil for PPHN along with others management according to hospital protocol. Data along with other parameters were collected and analyzed. Results: Total 320 patients with suspected PPHN were admitted during the study period. Among them 92 (29%) cases had PPHN. Male were 49(53 %) cases and female were 43(47%) cases. Mean age at hospital admission was 29.7±13.4 hours. Based on echocardiography,13(14%) cases had mild, 38 (41%) cases moderate and 41(45%) cases severe PPHN. Mean duration of sildenafil therapy was 11.9±7.1 days. Improved from PPHN were 83 (90%) cases. Mortality was 10% (9). Conclusion: In this study it was found that the incidence of PPHN is 29% among the suspected newborns. Sildenafil is successfull in improving the oxygenation of PPHN and to decrease the mortality of neonates. DS (Child) H J 2019; 35(2) : 100-104

scholarly journals The efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: a case report

2021 ◽  
Author(s):  
Qian Gao ◽  
Xiaowei Xin ◽  
Chun Zhao ◽  
Yujuan Wang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Multiple Organ ◽  
Clinical Experiences ◽  
Organ Function ◽  
Barr Virus ◽  
Ifn Γ ◽  
Epstein Barr

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially deadly condition associated with extensive inflammation and immune activation. Cytokine adsorption may serve as a supportive treatment that can stabilize organ function in affected patients by reducing their circulating cytokines levels. To date, no descriptions of clinical experiences associated with the use of HA330-II column hemoadsorption for the treatment of HLH children have been published. CASE SUMMARY We describe a 11-year-old children with Epstein-Barr virus (EBV)-associated HLH combined with liver failure. She underwent HA330-II column hemoadsorption and chemotherapy, and developed a decreased inflammatory cytokines including interleukin (IL)-6, IL-8, IL-10, and interferon (IFN)-γ. The patient’ condition and laboratory parameters gradually improved. CONCLUSION Hemoadsorption may play an important role in eliminating cytokines storm in children with Hemophagocytic lymphohistiocytosis combined with liver failure and consequent multiple organ failure. Keywords: hemoadsorption; HA330-II column; Hemophagocytic lymphohistiocytosis; Pediatric; Liver failure; Case report

Role of Early Postoperative Surface Echocardiography in the Pediatric Cardiac Intensive Care Unit

CHEST Journal ◽  
1994 ◽  
Vol 105 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Alvin J. Chin ◽  
Jane M. Vetter ◽  
Mohamed Seliem ◽  
Audrey A. Jones ◽  
Beth Ann A. Andrews
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Cardiac Intensive Care Unit ◽  
Cardiac Intensive Care

scholarly journals The Role of Pili Protein 38,6 kDa Klebsiella pneumoniae as a Hemagglutinin and Adhesin Protein which Serves as a Virulence Factor

2019 ◽  
Vol 5 (2) ◽  
pp. 9
Author(s):  
Regina Finka ◽  
Dini Agustina ◽  
Dwita Aryadina Rachmawati ◽  
Enny Suswati ◽  
Diana Chusna Mufida ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Virulence Factor ◽  
The Body ◽  
Influential Factor ◽  
Klebsiella Pneumonia ◽  
Adhesion Protein ◽  
Surface Receptors ◽  
Adhesin Protein ◽  
Adhesin Proteins

Klebsiella pneumoniae is an infectious bacteria in various parts of the body. The presence of proteins in pili that will bind to cell surface receptors (adhesin proteins) and cell membrane sugar molecules (hemagglutinin proteins) is a very influential factor in the ability of K. pneumoniae to enter the human body. The purpose of this study was to determine the role of pili 38.6 kDa K. pneumoniae protein as a hemagglutinin and adhesin protein which functions as a virulence factor. This type of research is pure experimental research using the electrophoresis method (SDS-PAGE) to obtain protein. The protein obtained was then tested for hemagglutination and adhesion test using erythrocyte cells and enterocytes of BALB / C mice to determine their role as hemagglutinin and adhesin proteins. Conclusion of this study pili protein 38.6 kDa Klebsiella pneumoniae acts as a hemagglutinin and adhesion protein which functions as a virulence factor. Keywords: Klebsiella pneumonia, 38,6 kDa Protein, Hemagglutinin, Adhesin

scholarly journals Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Ryan K. Shields ◽  
M. Hong Nguyen ◽  
Ellen G. Press ◽  
Liang Chen ◽  
Barry N. Kreiswirth ◽  
...  
Keyword(s):  
Case Report ◽  
Klebsiella Pneumoniae ◽  
Review Of Literature ◽  
Klebsiella Pneumoniae Carbapenemase

Abstract We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenem- susceptible Klebsiella pneumoniae that carried mutant blaKPC-3. Meropenem was bactericidal against ceftazidime-avibactam- resistant K pneumoniae isolates in vitro. Nevertheless, the role of carbapenems in treating such infections remains uncertain, because meropenem resistance is selected readily during passage experiments.

scholarly journals Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates

2014 ◽  
Vol 58 (11) ◽  
pp. 6982-6985 ◽  
Author(s):  
Zi-Ke Sheng ◽  
Fupin Hu ◽  
Weixia Wang ◽  
Qinglan Guo ◽  
Zhijun Chen ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Resistance Mechanisms ◽  
Clinical Isolates ◽  
Klebsiella Pneumonia ◽  
Content Type

ABSTRACTOf 26 tigecycline-nonsusceptibleKlebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations inramRand/oracrR(23 inramRand 10 inacrR). Eight TNSKP isolates possessed overexpression oframA,acrB,rarA, andoqxBsimultaneously, while 8 and 1 TNSKP strains had upregulation oframAandacrBand ofrarAandoqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolates cannot be explained by the present pathways. This study underscores the role of RamA in TNSKP and suggests the presence of novel tigecycline resistance mechanisms.

scholarly journals The Role of Genetic Testing in the Evaluation of Dilated Cardiomyopathies

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Kolade M. Agboola ◽  
Trevon McGill ◽  
Barry A. Boilson ◽  
Naveen L. Pereira ◽  
Jacob C. Jentzer
Keyword(s):  
Intensive Care Unit ◽  
African American ◽  
Intensive Care ◽  
Genetic Testing ◽  
Respiratory Failure ◽  
Clinical Utility ◽  
African American Male ◽  
Cardiac Intensive Care Unit ◽  
Cardiac Intensive Care

We present an adolescent African American male admitted to the cardiac intensive care unit with cardiogenic shock and acute respiratory failure. Through an overview of his presentation, diagnostic workup, and treatment, we demonstrate the clinical utility of genetic testing in the evaluation of unexplained dilated cardiomyopathies.

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