scholarly journals Editorial: Iron Metabolism at the Crossroad of Innate Immune Response and Cancer Progression

2022 ◽  
Vol 12 ◽  
Author(s):  
Paola Zacchi ◽  
Stefania Recalcati
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Cancer Progression ◽  
Iron Metabolism ◽  
Innate Immune

scholarly journals The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Weiwei Fu ◽  
Hong Li ◽  
Haiyang Fu ◽  
Shuchao Zhao ◽  
Weiping Shi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Innate Immune Response ◽  
Cancer Progression ◽  
Nodal Metastasis ◽  
Innate Immune ◽  
Prostate Cancer Progression ◽  
Class Iii ◽  
Expression Levels ◽  
Mrna And Protein Expression

The sirtuins (SIRTs), including seven family members, belong to class III histone deacetylase (HDAC) enzymes, which have been intensively investigated in cancers. Although the function of SIRTs in the cancer immunology is explored, SIRT-specific mechanisms regulating necroptosis-related innate immune response are not clear. In our present study, we found that both the mRNA and protein expression levels of SIRT3 and SIRT6 are significantly increased in the PCa tissues (HR, CI P = 3.30 E − 03 ; HR, CI P = 2.35 E − 08 ; and HR, CI P = 9.20 E − 08 ) and were associated with patients’ Gleason score and nodal metastasis. Furthermore, multivariate analysis showed that the PCa patients with higher expression levels of SIRT3 and SIRT6 had shorter overall survival (OS). Mechanistically, we found that SIRT3 and SIRT6 promote prostate cancer progress by inhibiting RIPK3-mediated necroptosis and innate immune response. Knockdown of both SIRT3 and SIRT6 not only activates TNF-induced necroptosis but also refreshes the corresponding recruitment of macrophages and neutrophils. Overall, our study identified that SIRT3 and SIRT6 are key regulators of necroptosis during prostate cancer progression.

scholarly journals Metabolic Hormones Modulate Macrophage Inflammatory Responses

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4661
Author(s):  
Matthew J. Batty ◽  
Gwladys Chabrier ◽  
Alanah Sheridan ◽  
Matthew C. Gage
Keyword(s):  
Immune Response ◽  
Inflammatory Response ◽  
Innate Immune Response ◽  
Cancer Progression ◽  
Metabolic Diseases ◽  
Inflammatory Responses ◽  
Innate Immune ◽  
Metabolic Hormones ◽  
Cancer Types

Macrophages are phagocytotic leukocytes that play an important role in the innate immune response and have established roles in metabolic diseases and cancer progression. Increased adiposity in obese individuals leads to dysregulation of many hormones including those whose functions are to coordinate metabolism. Recent evidence suggests additional roles of these metabolic hormones in modulating macrophage inflammatory responses. In this review, we highlight key metabolic hormones and summarise their influence on the inflammatory response of macrophages and consider how, in turn, these hormones may influence the development of different cancer types through the modulation of macrophage functions.

scholarly journals Iron metabolism and the innate immune response to infection

2012 ◽  
Vol 14 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Erin E. Johnson ◽  
Marianne Wessling-Resnick
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Iron Metabolism ◽  
Innate Immune

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

IL-17C is a mediator of respiratory epithelial innate immune response

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Pfeifer ◽  
M Voss ◽  
B Wonnenberg ◽  
M Bischoff ◽  
F Langer ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Respiratory Epithelial

Macrophage-derived extracellular vesicles mediate a long-lasting innate immune response against hepatitis C virus

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
C Cai ◽  
B Koch ◽  
S Akhras ◽  
E Hildt ◽  
S Zeuzem ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Extracellular Vesicles ◽  
Innate Immune Response ◽  
Innate Immune

IKK2 hepatocyte specific deletion accelerates the liver regeneration and enhances the innate immune response in mice

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
Y Malato ◽  
N Beraza ◽  
LE Sander ◽  
L Sander ◽  
M Al-Masaoudi ◽  
...  
Keyword(s):  
Immune Response ◽  
Liver Regeneration ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Specific Deletion
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