scholarly journals Effect of Galvanic Corrosion on the Degradability of Biomedical Magnesium

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongzhou Peng ◽  
Wei Wang ◽  
Haomiao Jiang ◽  
Rui Zan ◽  
Yu Sun ◽  
...  
Keyword(s):  
Clinical Trials ◽  
High Purity ◽  
Galvanic Corrosion ◽  
Scale Up ◽  
Pure Titanium ◽  
Stainless Steel 316L ◽  
Metallic Implants ◽  
Corrosion Behaviors ◽  
Galvanic Couples ◽  
Biodegradable Magnesium

With recent progress in clinical trials and scale-up applications of biodegradable magnesium-based implants, the scenarios of transplanting biodegradable Mg with other non-degradable metals may occur inevitably. Galvanic corrosion appears between two metallic implants with different electrochemical potentials and leads to accelerated degradation. However, a quantitative measurement on the galvanic corrosion of Mg in contact with other metallic implants has not been conducted. Here we study the corrosion behaviors and mechanical attenuation of high purity magnesium (Mg)in contact with stainless steel (316L), pure titanium (TA2), and magnesium alloy (AZ91) respectively to form different galvanic couples in simulated body fluids. The results show that all of these three heterogeneous metal pairs accelerate the degradation of high purity Mg to different degrees, yielding declined tensile strength and mechanical failure after 4 days of immersion. Our observations alert the potential risk of co-implanting different metallic devices in clinical trials.

CORROSION BEHAVIORS OF ND: YAG LASER-GMA HYBRID WELDMENT OF AA5052-H32 Al ALLOYS

2009 ◽  
Vol 16 (01) ◽  
pp. 43-47
Author(s):  
DA-QUAN ZHANG ◽  
YOUNG WOO PARK ◽  
KANG YONG LEE
Keyword(s):  
Base Alloy ◽  
Galvanic Corrosion ◽  
Composition Analysis ◽  
Fusion Boundary ◽  
Yag Laser ◽  
Corrosion Behaviors ◽  
Acidic Chloride ◽  
Corrosion Susceptibility ◽  
Weld Fusion Zone ◽  
Galvanic Couples

This paper investigated the corrosion behaviors of the Nd: YAG laser-gas metal arc (GMA) AA5052-H32 weldments comparing with the base alloy. The corrosion susceptibility of weldments was higher than that of the base alloy. The weld fusion zone (WFZ) suffered the severe pitting in acidic chloride media. The zones adjacent to the weld fusion boundary showed less corrosion tendency. A corrosion cracking was associated with pitting in the weldments. The surface morphology observation and composition analysis were investigated by the scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) spectroscopy. At the WFZ/HAZ interface and the HAZ/base alloy interface, the galvanic corrosion coupling existed. From the comparison, the WFZ showed anodic behavior, the zone adjacent to the weld fusion boundary showed cathodic behavior. The corrosion of WFZ was progressed by the formation of the galvanic couples.

scholarly journals Effect of Laser Power on Microstructure and Micro-Galvanic Corrosion Behavior of a 6061-T6 Aluminum Alloy Welding Joints

Metals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 3
Author(s):  
Huiling Zhou ◽  
Fanglian Fu ◽  
Zhixin Dai ◽  
Yanxin Qiao ◽  
Jian Chen ◽  
...  
Keyword(s):  
Aluminum Alloy ◽  
Laser Power ◽  
Galvanic Corrosion ◽  
Gas Metal Arc Welding ◽  
Immersion Test ◽  
Intermetallic Particles ◽  
Metal Arc Welding ◽  
Corrosion Behaviors ◽  
Welding Joints ◽  
Corrosion Pits

The 6061-T6 aluminum alloy welding joints were fabricated using gas metal arc welding (GMAW) of various laser powers, and the effect of laser power on the microstructure evolution of the welding joints was investigated. The corrosion behaviors of 6061-T6 aluminum alloy welding joints were investigated in 3.5 wt% NaCl solution using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The results showed that the micro-galvanic corrosion initiation from Mg2Si or around the intermetallic particles (Al-Fe-Si) is observed after the immersion test due to the inhomogeneous nature of the microstructure. The preferential dissolution of the Mg2Si and Al-Fe-Si is believed to be the possible cause of pitting corrosion. When the laser power reached 5 kW, the microstructure of the welded joint mainly consisted of Al-Fe-Si rather than the Mg2Si at 2 kW. The relatively higher content of Al-Fe-Si with increasing in laser power would increase the volume of corrosion pits.

Corrosion Behavior of High Purity Vanadium

CORROSION ◽  
1960 ◽  
Vol 16 (2) ◽  
pp. 70t-72t ◽  
Author(s):  
DAVID SCHLAIN ◽  
CHARLES B. KENAHAN ◽  
WALTER L. ACHERMAN
Keyword(s):  
Stainless Steel ◽  
Nitric Acid ◽  
Corrosion Behavior ◽  
High Purity ◽  
Galvanic Corrosion ◽  
Acid Solutions ◽  
Ocean Water ◽  
Nitric Acid Solutions

Abstract Chemical and galvanic corrosion experiments at 35 C show that ductile vanadium is resistant to corrosion in substitute ocean water. It is also resistant in 60 percent sulfuric and 20 percent hydrochloric acids but corrodes rapidly in nitric acid solutions. Vanadium is less noble than stainless steel and copper and more noble than aluminum, magnesium and steel (SAE 4130) in substitute ocean water. 6.3.18

scholarly journals Optimization and scale up of microfluidic nanolipomer production method for preclinical and potential clinical trials

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrew Gdowski ◽  
Kaitlyn Johnson ◽  
Sunil Shah ◽  
Ignacy Gryczynski ◽  
Jamboor Vishwanatha ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Scale Up ◽  
Production Method

Chapter 14. Scale-up and Current Clinical Trials for Nanogels in Therapeutics

2017 ◽  
pp. 283-289 ◽  
Author(s):  
Ajeet Kaushik ◽  
Arti Vashist ◽  
Pratik Shah ◽  
Sneham Tiwari ◽  
Rahul Dev Jayant ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Scale Up

scholarly journals Crevice Corrosion Behaviors Between CFRP and Stainless Steel 316L for Automotive Applications

2019 ◽  
Vol 32 (10) ◽  
pp. 1219-1226
Author(s):  
Xia-Yu Wu ◽  
Jia-Kun Sun ◽  
Jia-Ming Wang ◽  
Yi-Ming Jiang ◽  
Jin Li
Keyword(s):  
Stainless Steel ◽  
Crevice Corrosion ◽  
Automotive Applications ◽  
Stainless Steel 316L ◽  
Corrosion Behaviors

scholarly journals Nanopharmaceutics: Part I—Clinical Trials Legislation and Good Manufacturing Practices (GMP) of Nanotherapeutics in the EU

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 146 ◽  
Author(s):  
Eliana B. Souto ◽  
Gabriela F. Silva ◽  
João Dias-Ferreira ◽  
Aleksandra Zielinska ◽  
Fátima Ventura ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Scale Up ◽  
Intravenous Iron ◽  
Matrix Composition ◽  
Clinical Settings ◽  
The European Union ◽  
Production Methods ◽  
Good Manufacturing Practices ◽  
Copolymer Micelle

The latest advances in pharmaceutical technology are leading to the development of cutting edged approaches to produce what is now known as the “Holy Grail” of medicine—nanopharmaceutics. Over the latest decade, the pharmaceutical industry has made important contributions to the scale up of these new products. To ensure their quality, efficacy, and safety for human use, clinical trials are mandatory. Yet, regulation regarding nanopharmaceuticals is still limited with a set of guidelines being recently released with respect to compliance with quality and safety. For the coming years, updates on regulatory issues about nanopharmaceuticals and their use in clinical settings are expected. The use of nanopharmaceuticals in clinical trials depends on the approval of the production methods and assurance of the quality of the final product by implementation and verification of the good manufacturing practices (GMP). This review addresses the available legislation on nanopharmaceuticals within the European Union (EU), the GMP that should be followed for their production, and the current challenges encountered in clinical trials of these new formulations. The singular properties of nanopharmaceuticals over their bulk counterparts are associated with their size, matrix composition, and surface properties. To understand their relevance, four main clinical trial guidelines, namely, for intravenous iron-based nanopharmaceuticals, liposomal-based nanopharmaceuticals, block copolymer micelle-based nanopharmaceuticals, and related to surface coating requirements, are described here.

RETRACTED: Fretting and galvanic corrosion behaviors and mechanisms of Co–Cr–Mo and Ti–6Al–4V alloys

Wear ◽  
2001 ◽  
Vol 249 (10-11) ◽  
pp. 883-891 ◽  
Author(s):  
Daxiong He ◽  
Tiancheng Zhang ◽  
Yinshun Wu
Keyword(s):  
Galvanic Corrosion ◽  
Corrosion Behaviors

Numerical Modeling of Galvanic Corrosion Behaviors on Uranium Surface

2013 ◽  
Vol 702 ◽  
pp. 140-144
Author(s):  
Ping An Shi ◽  
Hong Liang Zhou
Keyword(s):  
Numerical Simulation ◽  
Current Distribution ◽  
Galvanic Corrosion ◽  
Corrosion Current ◽  
Electrode Kinetics ◽  
Uniform Corrosion ◽  
Corrosion Rates ◽  
Ohmic Resistance ◽  
Circular Defect ◽  
Corrosion Behaviors

The Uranium and Titanium corrosion rates are described by a Tafel’s relationship, and the cathodic protection of Uranium is a function of a Wagner number. A numerical simulation of galvanic corrosion of Uranium surface under thin layer electrolyte is presented. The model considered that the effect of a circular defect and oxygen reduction and corrosion in the Uranium surface, the effect of electrolyte thickness and conductivity and defect radius on corrosion current distribution of Uranium with is investigated. The results shows that the corrosion rate at the center is non-uniform, and it could lead to the formation of a hemispherical-shaped pit. And the effect of radius is to increase the importance of the electrode kinetics relative to ohmic resistance, and to increase the potential difference between the center and edge of the Uranium surface, resulting in non-uniform corrosion current distribution.

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