scholarly journals Low-Frequency Intravesical Electrical Stimulation for the Treatment of Acute Urinary Retention: A Promising Therapeutic Approach

2021 ◽  
Vol 8 ◽  
Author(s):  
Tingting Cao ◽  
Bing Xie ◽  
Siyuan Yang ◽  
Jiaqi Wang ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Urinary Retention ◽  
Therapeutic Approach ◽  
Acute Urinary Retention ◽  
Low Frequency ◽  
Female Rats ◽  
Control Group ◽  
Detrusor Muscle ◽  
Submucosal Layer ◽  
Promising Therapeutic Approach

Acute urinary retention (AUR) is a troublesome urological disease, which causes various lower urinary tract symptoms. However, only few studies explored and evaluated the effective treatments to improve AUR. We aimed to find an effective approach to cure AUR through comparing the efficacy of existing classical low-frequency transcutaneous electrical nerve stimulation (TENS) and novel intravesical electrical stimulation (IVES). A total of 24 AUR female rats were divided into 3 groups as follows: control, TENS, and IVES groups. Rats in the control group had no fake stimulation. Rats in the TENS and IVES groups underwent transcutaneous or intravesical stimulation of a symmetrical biphasic rectangular current pulse with a frequency of 35 Hz, 30 min per day, for seven consecutive days. IVES significantly reduced the actin expression in the submucosal layer but increased its expression in the detrusor layer (p= 0.035,p= 0.001). The neovascularization in the submucosal layer in the IVES group was significantly increased than in the other 2 groups (p= 0.006). Low-frequency IVES performed better than TENS in terms of simultaneously relieving bladder hyperactivity, accelerating epithelial recovery, and strengthening detrusor muscle. IVES may be a promising therapeutic approach for bladder dysfunction, specifically for AUR and overactive bladder in clinical practice.

SIGNIFICANCE OF NON-INVASIVE SONO-MORPHOLOGICAL MARKERS IN THE EVALUATION OF BLADDER OUTLET OBSTRUCTION AND ACUTE URINARY RETENTION SECONDARY TO BENIGN PROSTATIC HYPERPLASIA

2021 ◽  
pp. 5-9
Author(s):  
Prasenjit Bhowmik ◽  
Soumendranath Mandal ◽  
Gaurav Sharma ◽  
Bandhan Bahal ◽  
Prashant Gupta ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Diagnostic Accuracy ◽  
Urinary Retention ◽  
Bladder Outlet Obstruction ◽  
Acute Urinary Retention ◽  
Bladder Wall ◽  
Outlet Obstruction ◽  
Threshold Value ◽  
Prostatic Hyperplasia ◽  
Control Group

Objectives: To dene the diagnostic accuracy of intravesical protrusion of prostate (IPP), bladder wall thickness (BWT) and prostate volume (PV) in diagnosis of bladder outlet obstruction (BOO) and prediction of future acute urinary retention (AUR). A prospective Materials and methods: study of 127 patients, presenting with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH) were enrolled with 50 patients among them manifesting AUR. 35 normal persons were selected as control group. After inclusion, all patients underwent transabdominal ultrasound and pressure ow urodynamic study (UDS). UDS parameter, BOO index (BOOI) were used as a reference standard for stratifying the patients into two groups, BOO and non-BOO. The sono-morphological parameters, IPP, BWT and PV were used to compare between these two groups with calculating the diagnostic accuracy for each individual index. IPP, BWT Results: and PV had statistically signicant difference between group 1 (BOOI < 40) and 2 ( BOOI > 40) with strong correlation with BOOI. The Pearson's correlation coefcient (r) for IPP, BWT and PV were 0.762, 0.702 and 0.660 respectively. The AUC for IPP, BWT and PV were 0.824, 0.786 and 0.650 with highest accuracy for IPP (79.2%) at cutoff value of 7 mm. Using the same threshold value, IPP had higher statistical difference than BWT in predicting AUR with similar diagnostic accuracy of IPP and BWT together. IPP and BWT in conjunction with PV in place Conclusions: of UDS had good clinical utility in diagnosis of BOO due to BPH and future AUR prediction.

A NOVEL ELECTRICAL STIMULATION PARADIGM FOR THE SUPPRESSION OF EPILEPTIFORM ACTIVITY IN ANIN VIVOMODEL OF MESIAL TEMPORAL LOBE STATUS EPILEPTICUS

2012 ◽  
Vol 22 (03) ◽  
pp. 1250006 ◽  
Author(s):  
YUANG TANG ◽  
DOMINIQUE M. DURAND
Keyword(s):  
Electrical Stimulation ◽  
Temporal Lobe ◽  
Epileptiform Activity ◽  
Low Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
Control Group ◽  
Hippocampal Commissure ◽  
Hippocampal Network ◽  
Mesial Temporal Lobe ◽  
Stimulation Paradigm

In this study, we present a novel low-frequency electrical stimulation paradigm for mesial temporal lobe epilepsy (MTLE). The paradigm utilizes the hippocampal commissure as a unique stimulation target to simultaneously influence large portions of the bilateral hippocampal network. When applied to an acute rat model of MTLE, animals that received stimulation exhibited an 88% reduction in the signal power of the bilateral epileptiform activity relative to the control group. In addition, the stimulation entrained the hippocampal network's spontaneous epileptiform activity and disrupted its bilateral synchrony.

Use of Low-Frequency Electrical Stimulation for the Treatment of Plantar Fasciitis

2009 ◽  
Vol 99 (6) ◽  
pp. 481-488 ◽  
Author(s):  
Michael Stratton ◽  
Thomas G. McPoil ◽  
Mark W. Cornwall ◽  
Kyle Patrick
Keyword(s):  
Electrical Stimulation ◽  
Functional Activity ◽  
Plantar Fasciitis ◽  
Soft Tissues ◽  
Low Frequency ◽  
Plantar Fascia ◽  
Muscular Contraction ◽  
Control Group ◽  
Foot Orthoses ◽  
Activity Levels

Background: Recent research has discussed the use of low-frequency electrical stimulation to increase blood flow by eliciting muscular contraction in soft tissues. This randomized clinical trial examined the efficacy of low-frequency electrical stimulation combined with stretching exercises and foot orthoses in individuals diagnosed as having plantar fasciitis for less than 6 months. Methods: Twenty-six participants aged 18 to 65 years diagnosed as having plantar fasciitis were randomly assigned to two treatment groups: a control group receiving only stretching and orthoses and a treatment group receiving low-frequency electrical stimulation in addition to stretching and orthoses. To assess treatment response, a visual analog scale was used to determine first-step morning pain, and changes in daily activity levels were monitored by using a validated outcome measure. All of the participants were assessed before starting treatment, after 4 weeks of treatment, and 3 months after the conclusion of treatment. Results: Participants in the control and experimental groups demonstrated pain reduction and improvements in functional activity levels after 4 weeks and 3 months. Conclusions: Regardless of whether low-frequency electrical stimulation was used as an intervention, the use of plantar fascia–specific stretching and prefabricated foot orthoses provided short-term (3-month) pain relief and improvement in functional activity levels. (J Am Podiatr Med Assoc 99(6): 481–488, 2009)

scholarly journals PO-147 Effect of Exercise-induced Fatigue on the Electrical Activity of the External Globus Pallidus Neurons in rats

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Hao Yu ◽  
Lijuan Hou ◽  
Jing Ma ◽  
Zhifeng Wang ◽  
Gang Zhao ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Globus Pallidus ◽  
Low Frequency ◽  
Extracellular Recording ◽  
Central Fatigue ◽  
Control Group ◽  
Indirect Pathway ◽  
Exercise Induced ◽  
Exercise Fatigue

Objective The motor cortex (MC) stimulation-induced unitary responses of globus pallidus external segment (GPe) neurons in control and exercise induced-fatigue rats were recorded in vivo to examine the role of cortical-striatum-external globus pallidal pathway in the mechanism of central fatigue. Methods 32 Clean healthy male Wistar rats (260~300g), were randomly divided into 4 groups: control group (Control), 1-day fatigue group (1FG), 3-day fatigue group (3FG) and 7-day fatigue group (7FG). Rats were subjected to a 5-day adaptive treadmill training. Modified Bedford treadmill exercise with progressively increasing load was used to creat the exercise fatigue model. （3 levels:8.2 m/min, 15 min; 15m/min, 15 min; 20 m/min, lasting till exhaustion） The spontaneous unit activity and responses to MC stimulation of GPe neurons were recorded by the electrophysiological technique of extracellular recording of glass microelectrodes. Results The results showed that the firing frequency of high-frequency firing with pause (HFP) and low frequency firing with burst (LFB) in the GPe of 1FG was comparable with that of control group (P>0.05). However in 3FG and 7FG , the percentage of HFP neuron was significantly decreased (P<0.05), while the proportion of LFB was significantly increased (P<0.05), and the average firing rate of LFB was higher and inter spike intervals (ISI) was significantly lower than that of the control group. With 200μA electrical stimulation, the explosive discharge of GPe neurons was attenuated after fatigue in rats. The response of GPe neurons to variable frequency stimulation in exhausted model groups was stronger than that of the control group.MC-stimulation typically induced a triphasic response composed of early excitation, inhibition, and late excitation in GPe neurons. The population of neurons showing a short inhibition slightly increased in 3FG and 7FG. Conclusions 1. The results confirmed that GPe is an important nucleus of basal ganglia involved in the regulation of exercise-induced fatigue by the change of spontaneous activity. Electrical stimulation on the cortex can alter response patterns of GPe neurons in exercise-induced fatigue rats, the results confirmed that the Ctx-Str-GPe neural pathway is involved in the regulation of exercise fatigue, and the indirect pathway is over-activated.

Moxibustion Treatment of Breech Presentation

2001 ◽  
Vol 29 (01) ◽  
pp. 37-45 ◽  
Author(s):  
Yoichi Kanajura ◽  
Kunio Kometani ◽  
Tetsurou Nagata ◽  
Kuniaki Niwa ◽  
Hiroshi Kamatsuki ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Treatment Group ◽  
Clinical Setting ◽  
Low Frequency ◽  
Breech Presentation ◽  
Electrical Current ◽  
Control Group ◽  
Acupuncture Points ◽  
Correction Rate ◽  
Spontaneous Correction

Breech presentation was successfully corrected by stimulating acupuncture points with moxibustion or low-frequency electrical current. Only patients with breech pregnancies at the 28th week or later were entered into the study. With moxibustion treatment, the control group had a spontaneous correction rate of 165/224 (73.66%), and the treatment group had a correction rate of 123/133 (92.48%) (P < 0.0001, x2 test). With low-frequency percutaneous electrical stimulation, the correction rate was 20/941 (83.87%) in the control group and 171/191 (89.52%) in the treatment group (P = 0.094, x2 test). The control is the moxibustion study did no exercises and received no external manipulation to correct breech presentation whereas those in the electrical stimulation study experienced both. Acupuncture stimulation, especially with moxibustion, is expected to serve as a safe and effective modality in the management of breech presentation in a clinical setting.

scholarly journals Thermographic and anthropometric assessment of electrical stimulation on localized body fat

2017 ◽  
Vol 30 (1) ◽  
pp. 29-37
Author(s):  
Graciele Guimarães Pitelli Aroca ◽  
Larissa Granato Viana ◽  
Rafaela Ferreira de Araújo Costa ◽  
Dalilia Schmildt ◽  
Ligia de Sousa
Keyword(s):  
Electrical Stimulation ◽  
Body Fat ◽  
Subcutaneous Tissue ◽  
Intervention Group ◽  
Low Frequency ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Significance Level ◽  
Before And After ◽  
And Control

Abstract Introduction: Adiposity is defined as the accumulation of energy reserves within the adipose tissue at specific body sites. Low-frequency electrical stimulation elicits lipolysis. When applied by insertion of needles into the dermis-hypodermis junction, it leads to a modification of the interstitial space, favoring metabolic changes and lipolysis. Objective: To investigate the effects of electrical stimulation on body fat localized to the abdomen and flanks. Methods: Randomized, controlled clinical trial consisted of two groups of women with body fat localized to the abdomen and flanks. The intervention group (IG) was made up of 9 women (± 24,77 years) who received ten sessions of electrical stimulation, whereas the control group (CG) was made up of 7 women (± 21,8 years) who did not receive electrical stimulation. Perimetric, adipometric and thermographic data were collected before and after the intervention. Data were analyzed using the Shapiro-Wilk test, t test, one-way ANOVA. The significance level was set at p < 0,05. Results: There were statistically significant differences between the intervention and control groups in the assessment immediately following intervention (IG: 33.08 ± 1.00; CG: 30.83 ± 1.5; p = 0.002), 15 minutes following intervention (IG: 33.05 ± 0.48; CG: 30.40± 1.24; p < 0.0001) and at the endpoint (IG: 32.22 ± 14.20; CG: 30.53 ± 1.34; p=0.005) for the thermographic data. For the anthropometric variables, there were no statistically significant differences before and after treatment. Conclusion: Electrical stimulation evokes a significant increase in the temperature of the subcutaneous tissue.

Features of the course of regeneration processes in myometry under the influence of general magnetotherapy and selective pulsed electrical stimulation with low frequency currents in patients after myomectomy

2020 ◽  
pp. 53-60
Author(s):  
K. V. Lyadov ◽  
E. S. Koneva ◽  
A. I. Muravlev
Keyword(s):  
Electrical Stimulation ◽  
Low Frequency ◽  
Early Postoperative Period ◽  
Control Group ◽  
Regenerative Processes ◽  
Low Frequencies ◽  
Magnetic Therapy ◽  
Suture Failure ◽  
Postoperative Scar ◽  
Regeneration Processes

The aim of the study was to identify the features of the course of repair processes in myometry under the influence of selective pulsed electrostimulation as a monomethod and in combination with system-wide magnetotherapy according to ultrasound data in patients after myomectomy. The study included 105 patients aged 28 to 59 years after myomectomy. All patients were divided into 3 groups of 35 people: the control group did not receive physical therapy. Patients of the main group with 2 days after surgery was carried out, the total magnetic therapy with the duration of 15 minutes, at the rate of 10 daily procedures in combination with the selective pulsed electrical stimulation currents of low frequency with a duration of 25 minutes, at the rate of 10 daily procedures; patients in the comparison group from the 2nd day after surgery was conducted by selective pulsed electrical stimulation currents of low frequency, duration 25 minutes, at the rate of 10 daily procedures. In the study it was found that the most pronounced stimulation of regenerative processes and proper formation of postoperative scar in patients in the early postoperative period after myomectomy was noted under the influence of complex application of General magnetic therapy in combination with selective pulsed electrical stimulation currents of low frequencies through tristimulous and regenerative eff ects are somewhat less significant results were obtained when monophospate selective pulsed electrical stimulation currents of low frequency. The obtained results indicate the prospects of including the developed complex in the programs of early rehabilitation of patients after myomectomy to improve the flow of regeneration processes in the myometrium and prevent the development of suture failure.

The effect of bromocriptine on mammary-gland ultrastructure of hyperprolactinemic rats

1984 ◽  
Vol 42 ◽  
pp. 204-205
Author(s):  
I.C. Murray
Keyword(s):  
Mammary Gland ◽  
Dopamine Agonist ◽  
Alveolar Epithelium ◽  
Mammary Glands ◽  
Female Rats ◽  
Control Group ◽  
Cell Hyperplasia ◽  
Once Daily ◽  
Long Evans

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.

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