scholarly journals NCOA4-Mediated Ferritinophagy: A Vicious Culprit in COVID-19 Pathogenesis?

2021 ◽  
Vol 8 ◽  
Author(s):  
Fengju Jia ◽  
Hongxia Liu ◽  
Shan Kang
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Nuclear Receptor ◽  
Organ Damage ◽  
Cellular Damage ◽  
Nuclear Receptor Coactivator ◽  
Loss Of Life ◽  
Inflammatory Reactions ◽  
Excess Iron ◽  
Global Pandemic

Coronavirus disease 2019 (COVID-19) is a global pandemic that has caused widespread loss of life. Notably, in this disease, severe inflammatory reactions characterized by cytokine storms are caused by severe acute respiratory syndrome coronavirus 2. The cytokine storms may promote hyper-ferritinemia which can further intensify the inflammation. Moreover, elevated ferritin levels trigger nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, in which ferritin is degraded and iron is released. Excess iron released from ferritinophagy can promote ferroptosis and cellular damage. Therefore, we propose that NCOA4-mediated ferritinophagy can be targeted to limit the ferroptosis and prevent the multi-organ damage and severity in COVID-19 patients.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

The Unparalleled Growth of COVID-19 Publications (Preprint)

2020 ◽  
Author(s):  
Paul Fontelo ◽  
Mrigendra Bastola ◽  
Craig Locatis ◽  
Fang Liu
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Evidence Base ◽  
Research Papers ◽  
Global Pandemic ◽  
The Us ◽  
International Collaborative ◽  
Number Of Publications ◽  
Collaborative Publishing

UNSTRUCTURED The global pandemic of COVID-19 has generated an unprecedented number of research papers from clinicians and scientists worldwide. We searched PubMed for articles on coronaviruses from 1970 to June 2020. Surges of publications occurred in 2003 from SARS and, again in 2012 from MERS. Although the name COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was only announced by WHO in February 2020, the number of publications has already exceeded 16000 by June this year. China and the US lead in publications, but a significant number also come from countries hardest hit by the illness. International collaborative publishing is significant. Since these publications are generally free to access worldwide, it provides a rich evidence base for clinicians and scientists combatting the COVID-19 pandemic.

scholarly journals KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients

2021 ◽  
Vol 9 (6) ◽  
pp. 1259
Author(s):  
Carla Prezioso ◽  
Ugo Moens ◽  
Giuseppe Oliveto ◽  
Gabriele Brazzini ◽  
Francesca Piacentini ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthcare Workers ◽  
Respiratory Pathogens ◽  
Threshold Values ◽  
Cycle Threshold ◽  
Viral Interference ◽  
Disease Outcomes ◽  
Global Pandemic ◽  
Wu Polyomavirus ◽  
Washington University

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 healthcare workers not infected by SARS-CoV-2, were collected from March 2020 through May 2020 and tested for KIPyV and WUPyV DNA presence. Of the 112 SARS-CoV-2 positive patients, 27 (24.1%) were co-infected with KIPyV, 5 (4.5%) were positive for WUPyV, and 3 (2.7%) were infected simultaneously by KIPyV and WUPyV. Neither KIPyV nor WUPyV DNA was detected in samples of healthcare workers. Significant correlations were found in patients co-infected with SARS-CoV-2 and KIPyV (p < 0.05) and between SARS-CoV-2 cycle threshold values and KIPyV, WUPyV and KIPyV and WUPyV concurrently detected (p < 0.05). These results suggest that KIPyV and WUPyV may behave as opportunistic respiratory pathogens. Additional investigations are needed to understand the epidemiology and the prevalence of respiratory polyomavirus in COVID-19 patients and whether KIPyV and WUPyV could potentially drive viral interference or influence disease outcomes by upregulating SARS-CoV-2 replicative potential.

scholarly journals Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance

2012 ◽  
Vol 287 (45) ◽  
pp. 38295-38304 ◽  
Author(s):  
Zhaoting Wu ◽  
Meng Yang ◽  
Hongjie Liu ◽  
Hongchao Guo ◽  
Yuan Wang ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Nuclear Receptor Coactivator ◽  
Pluripotency Maintenance

scholarly journals A case of SLE with COVID-19 and multiple infections

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 1054-1060
Author(s):  
Ruoqi Ning ◽  
Silu Meng ◽  
Fangxu Tang ◽  
Chong Yu ◽  
Dong Xu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Severe Acute Respiratory Syndrome ◽  
Lupus Erythematosus ◽  
Influenza A ◽  
Immunosuppressive Drugs ◽  
Multiple Infections ◽  
Systemic Lupus ◽  
Suspected Infection ◽  
Global Pandemic ◽  
Chronic Use

AbstractThe coronavirus disease 2019 (COVID-19) has become a global pandemic, which is induced by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with systemic lupus erythematosus (SLE) are susceptible to infections due to the chronic use of immunosuppressive drugs and the autoimmune disorders. Now we report a case of SLE infected with SARS-CoV-2, influenza A virus and Mycoplasma pneumoniae concurrently. The patient used hydroxychloroquine and prednisone chronically to control the SLE. After infection of SARS-CoV-2, she was given higher dose of prednisone than before and the same dosage of hydroxychloroquine. Besides, some empirical treatments such as antiviral, antibiotic and immunity regulating therapies were also given. The patient finally recovered from COVID-19. This case indicated that hydroxychloroquine may not be able to fully protect SLE patient form SARS-CoV-2. Intravenous immunoglobulin therapies and increased dose of corticosteroids might be adoptable for patient with both COVID-19 and SLE. Physicians should consider SARS-CoV-2 virus test when SLE patient presented with suspected infection or SLE flare under the epidemic of COVID-19.

scholarly journals Inactivation of the Nuclear Receptor Coactivator RAP250 in Mice Results in Placental Vascular Dysfunction

2003 ◽  
Vol 23 (4) ◽  
pp. 1260-1268 ◽  
Author(s):  
Per Antonson ◽  
Gertrud U. Schuster ◽  
Ling Wang ◽  
Björn Rozell ◽  
Elin Holter ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Blood Circulation ◽  
Transcriptional Activity ◽  
Vascular Dysfunction ◽  
Diverse Group ◽  
Placental Development ◽  
Nuclear Receptor Coactivator ◽  
The Past ◽  
Placental Blood

ABSTRACT Coactivators constitute a diverse group of proteins that are essential for optimal transcriptional activity of nuclear receptors. In the past few years many coactivators have been identified but it is still unclear whether these proteins interact indiscriminately with all nuclear receptors and whether there is some redundancy in their functions. We have previously cloned and characterized RAP250 (ASC-2/PRIP/TRBP/NRC), an LXXLL-containing coactivator for nuclear receptors. In order to study its biological role, Rap250 null mice were generated by gene targeting. Here we show that genetic disruption of Rap250 results in embryonic lethality at embryonic day (E) 13.5. Histological examination of placentas revealed a dramatically reduced spongiotrophoblast layer, a collapse of blood vessels in the region bordering the spongiotrophoblast, and labyrinthine layers in placentas from Rap250−/− embryos. These findings suggest that the lethality of Rap250−/− embryos is the result of obstructed placental blood circulation. Moreover, the transcriptional activity of PPARγ is reduced in fibroblasts derived from Rap250−/− embryos, suggesting that RAP250 is an essential coactivator for this nuclear receptor in the placenta. Our results demonstrate that RAP250 is necessary for placental development and thus essential for embryonic development.

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