scholarly journals Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats

2018 ◽  
Vol 12 ◽  
Author(s):  
Shenandoah Robinson ◽  
Fatu S. Conteh ◽  
Akosua Y. Oppong ◽  
Tracylyn R. Yellowhair ◽  
Jessie C. Newville ◽  
...  
Keyword(s):  
Posthemorrhagic Hydrocephalus ◽  
Neonatal Treatment

HEMMUNG VON TESTOSTERONABHÄNGIGEN DIFFERENZIERUNGSVORGÄNGEN DER MÄNNLICHEN RATTE NACH DER GEBURT

1967 ◽  
Vol 54 (2) ◽  
pp. 227-240 ◽  
Author(s):  
F. Neumann ◽  
J. D. Hahn ◽  
M. Kramer
Keyword(s):  
Sexual Behaviour ◽  
Cyproterone Acetate ◽  
Post Partum ◽  
Sexual Attitude ◽  
Normal Male ◽  
Corpora Lutea ◽  
List Type ◽  
Newborn Rats ◽  
Neonatal Treatment ◽  
Triangular Shape

ABSTRACT Male newborn rats were injected with 2 mg of an antiandrogen (1,2α-methylene-6-chloro-pregna-4,6-dien-17α-ol-3,20-dione-17α-acetate = cyproterone acetate) daily from their 1st to their 14th day of life. The following effects of this treatment were observed in these animals after onset of sexual maturity: 84% of the animals are unable to reproduce. Penis: the frenulum is broadened to a lamina of triangular shape, which almost completely prevents the preputium from being pushed back. These males show a rather insufficient male sexual behaviour towards females in oestrus. After castration and ovar implantation, some of the treated animals show true corpora lutea and at attempts of cohabitation partially female sexual behaviour towards normal male animals. From these results it can be concluded, that differentiation of the penis is not completed at the time of birth. The infertility of the animals may be caused by the penile changes (difficulties with intromission) as well as by the aimless sexual behaviour. This aimless sexual behaviour, the ability to produce true corpora lutea and finally their partially female sexual attitude under the influence of the hormones from the implanted ovaries led to the conclusion, that the above described neonatal treatment apparently inhibited testosterone-depending post partum developments of sexual differentiation in hypothalamic centers.

Technical Nuances in Neuroendoscopic Lavage for Germinal Matrix Hemorrhage in Preterm Infants: Twenty Tips and Pearls after More than One Hundred Procedures

2021 ◽  
pp. 1-9
Author(s):  
Jorge Tirado-Caballero ◽  
Jorge Herreria-Franco ◽  
Mónica Rivero-Garvía ◽  
Gloria Moreno-Madueño ◽  
Maria Jose Mayorga-Buiza ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Cerebrospinal Fluid Leak ◽  
Tips And Tricks ◽  
Germinal Matrix ◽  
Suitable Alternative ◽  
Posthemorrhagic Hydrocephalus ◽  
Mortality And Morbidity ◽  
Germinal Matrix Hemorrhage ◽  
Preoperative Stage ◽  
Fluid Leak

<b><i>Introduction:</i></b> Posthemorrhagic hydrocephalus in preterm infants is a serious entity related to high mortality and morbidity. Neuroendoscopic lavage (NEL) is a suitable alternative for the management of this pathology. However, as with every endoscopic technique, it requires some experience and several cases to master. <b><i>Methods:</i></b> We present a descriptive study of some technical nuances, tips, and tricks that have been learned in the last 8 years with over a hundred NELs performed in preterm infants. These variations are classified into 3 categories according to their temporal relationship with the surgical procedure: preoperative stage, intraoperative stage, and postoperative stage. We include a brief description of each one and the reasons why they are included in our current clinical practice. <b><i>Results:</i></b> Twenty tips and pearls were described in detail and are reported here. Preoperative, intraoperative, and postoperative variations were exposed and related to the most frequent complications of this procedure: infection, cerebrospinal fluid leak, and rebleeding. <b><i>Conclusions:</i></b> NEL is a useful technique for the management of germinal matrix hemorrhage in preterm infants. These technical nuances have improved the results of our technique and helped us to prevent complications related to the procedure.

Influence of neonatal treatment with the pyrethroid insecticide cypermethrin on the development of dopamine receptors in the rat kidney

1998 ◽  
Vol 103 (2) ◽  
pp. 165-178 ◽  
Author(s):  
Franco Cantalamessa ◽  
Paolo Barili ◽  
Roberto Cavagna ◽  
Maurizio Sabbatini ◽  
Gabriella Tenore ◽  
...  
Keyword(s):  
Dopamine Receptors ◽  
Rat Kidney ◽  
Pyrethroid Insecticide ◽  
Neonatal Treatment

scholarly journals Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine

2013 ◽  
Vol 35 (1) ◽  
Author(s):  
Valdemiro Amaro da Silva Junior ◽  
Waldo Oliveira Monteiro Filho ◽  
Catarina Ferreira Pinto ◽  
Sandra Maria de Torres ◽  
Bruno Mendes Tenorio
Keyword(s):  
Wistar Rats ◽  
Neonatal Treatment

Posterior fossa craniotomy for trapped fourth ventricle in shunt-treated hydrocephalic children: long-term outcome

2011 ◽  
Vol 7 (1) ◽  
pp. 52-63 ◽  
Author(s):  
Suhas Udayakumaran ◽  
Naresh Biyani ◽  
David P. Rosenbaum ◽  
Liat Ben-Sira ◽  
Shlomi Constantini ◽  
...  
Keyword(s):  
Posterior Fossa ◽  
Subarachnoid Space ◽  
Fourth Ventricle ◽  
Late Complication ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Posthemorrhagic Hydrocephalus ◽  
Spinal Subarachnoid Space ◽  
Trapped Fourth Ventricle

Object Trapped fourth ventricle (TFV) is a rare late complication of postinfectious or posthemorrhagic hydrocephalus. This entity is distinct from a large fourth ventricle because TFV entails pressure in the fourth ventricle and posterior fossa due to abnormal inflow and outflow of CSF, causing significant symptoms and signs. As TFV is mostly found in children who were born prematurely and have cerebral palsy, diagnosis and treatment options are a true challenge. Methods Between February 1998 and February 2007, 12 children were treated for TFV in Dana Children's Hospital by posterior fossa craniotomy/craniectomy and opening of the TFV into the spinal subarachnoid space. The authors performed a retrospective analysis of relevant data, including pre- and postoperative clinical characteristics, surgical management, and outcome. Results Thirteen fenestrations of trapped fourth ventricles (FTFVs) were performed in 12 patients. In 6 patients with prominent arachnoid thickening, a stent was left from the opened fourth ventricle into the spinal subarachnoid space. One patient underwent a second FTFV 21 months after the initial procedure. No perioperative complications were encountered. All 12 patients (100%) showed clinical improvement after FTFV. Radiological improvement was seen in only 9 (75%) of the 12 cases. The follow-up period ranged from 2 to 9.5 years (mean 6.11 ± 2.3 years) after FTFV. Conclusions Fenestration of a TFV via craniotomy is a safe and effective option with a very good long-term outcome and low rate of morbidity.

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