Evolution of Globus Pallidus Targeting for Parkinson's and Dystonia Deep Brain Stimulation: A 15-Year Experience

Objective: The aim of this study is to evaluate the evolution of GPi DBS targeting.Methods: This retrospective, single-center study included patients implanted with GPi DBS leads for dystonia or PD during the years 2004 to 2018 at the University of Florida Fixel Institute for Neurological Diseases. Each patient underwent a high-resolution targeting study on the day prior to the surgery, which was fused with a high resolution CT scan that was acquired on the day of the procedure. Intraoperative target location was selected using a digitized 3D Schaltenbrand-Bailey atlas. All patients underwent a high-resolution head CT scan without contrast approximately one month after lead implantation and accurate measurement of neuroanatomical lead position was acquired after fusion of pre-operative and post-operative image studies.Results: We analyzed 253 PD patients with 352 leads and 80 dystonia patients with 141 leads. During 15 years of follow-up, lead locations in the PD group migrated more laterally (β = 0.09, p < 0.0001), posteriorly [slope (β) = 0.04, p < 0.05], and dorsally (β = 0.07, p < 0.001), whereas leads in the dystonia group did not significantly change position aside from a trend in the dorsal direction (β = 0.06, p = 0.053).Conclusion: The evolving target likely results from multiple factors including improvements in targeting techniques and clinical feedback intraoperatively and post-operatively. Our demonstrates the potential importance of a systematic post-operative DBS lead measurement protocol to ensure quality control and to inform and optimize DBS programming.

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Socioeconomic patient benefits of a pediatric neurosurgery telemedicine clinic

Journal of Neurosurgery Pediatrics ◽

10.3171/2019.8.peds1925 ◽

2020 ◽

Vol 25 (2) ◽

pp. 204-208 ◽

Cited By ~ 2

Author(s):

Kelsey Hayward ◽

Sabrina H. Han ◽

Alexander Simko ◽

Hector E. James ◽

Philipp R. Aldana

Keyword(s):

Travel Time ◽

Cost Savings ◽

Transportation Cost ◽

Pediatric Neurosurgery ◽

University Of Florida ◽

Remote Location ◽

Socioeconomic Data ◽

The University ◽

Time Away

OBJECTIVEThe objective of this study was to examine the socioeconomic benefits to the patients and families attending a regional pediatric neurosurgery telemedicine clinic (PNTMC).METHODSA PNTMC was organized by the Division of Pediatric Neurosurgery of the University of Florida College of Medicine–Jacksonville based at Wolfson Children’s Hospital and by the Children’s Medical Services (CMS) to service the Southeast Georgia Health District. Monthly clinics are held with the CMS nursing personnel at the remote location. A retrospective review of the clinic population was performed, socioeconomic data were extracted, and cost savings were calculated.RESULTSClinic visits from August 2011 through January 2017 were reviewed. Fifty-five patients were seen in a total of 268 initial and follow-up PNTMC appointments. The average round-trip distance for a family from home to the University of Florida Pediatric Neurosurgery (Jacksonville) clinic location versus the PNTMC remote location was 190 versus 56 miles, respectively. The families saved an average of 2.5 hours of travel time and 134 miles of travel distance per visit. The average transportation cost savings for all visits per family and for all families was $180 and $9711, respectively. The average lost work cost savings for all visits per family and for all families was $43 and $2337, respectively. The combined transportation and work cost savings for all visits totaled $223 per family and $12,048 for all families. Average savings of $0.68/mile and $48.50/visit in utilizing the PNTMC were calculated.CONCLUSIONSManaging pediatric neurosurgery patients and their families via telemedicine is feasible and saves families substantial travel time, travel cost, and time away from work.

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Implant Treatment in an Urban General Dentistry Residency Program: A 4-Year Retrospective Study

Journal of Oral Implantology ◽

10.1563/0.725.1 ◽

2004 ◽

Vol 30 (6) ◽

pp. 364-368 ◽

Cited By ~ 5

Author(s):

Mohamed A. Maksoud ◽

Clifford B. Starr

Keyword(s):

Dental Implants ◽

Survival Rates ◽

First Year ◽

University Of Florida ◽

Residency Programs ◽

Implant Therapy ◽

The University ◽

Implant Treatment ◽

Florida College

Abstract Little data have been published on the survival rates of implants placed in dental residency programs. This study reports on the outcome of dental implants placed by first-year general dentistry residents in the University of Florida College of Dentistry–Jacksonville Clinic. The patients for this study received both surgical and restorative implant therapy from 1998 to 2002. A total of 108 patients (62 women, 46 men) were treated with dental implants. On average, a patient was 52.9 years old and received 2.6 implants. A variety of simple and complex restorative procedures were performed. Advanced general dentistry residents in conjunction with supervisory faculty treated all cases. The cumulative implant survival was 98.2%. Follow-up varied from 6 months to 4 years after placement. Cases included implants not yet loaded as well as implants loaded for 3 years or more. The findings of this study compare favorably with published studies and were unexpected in light of the residents' limited clinical experience.

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Five Years with the Rassias Method in German: a Follow-Up Report from the University of Florida

Foreign Language Annals ◽

10.1111/j.1944-9720.1983.tb01674.x ◽

1983 ◽

Vol 16 (5) ◽

pp. 343-354

Author(s):

Otto W. Johnston

Keyword(s):

University Of Florida ◽

The University

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Repeat Radiosurgery for Intracranial Arteriovenous Malformations

Neurosurgery ◽

10.1227/neu.0b013e31822c5740 ◽

2011 ◽

Vol 70 (1) ◽

pp. 150-154 ◽

Cited By ~ 11

Author(s):

John M. Stahl ◽

Yueh-Yun Chi ◽

William A. Friedman

Keyword(s):

Initial Treatment ◽

Arteriovenous Malformations ◽

Intracranial Arteriovenous Malformations ◽

University Of Florida ◽

The Status ◽

Median Volume ◽

Radiation Induced ◽

Prescription Dose ◽

The University

Abstract BACKGROUND Despite a high success rate in the stereotactic radiosurgical treatment of intracranial arteriovenous malformations (AVMs) that cannot be safely resected with microsurgery, some patients must be managed after treatment failure. OBJECTIVE To provide an update on the use of repeat linear accelerator radiosurgery as a treatment for failed AVM radiosurgery at the University of Florida. METHODS We reviewed 103 patients who underwent repeat radiosurgical treatment for residual AVM at the University of Florida between December 1991 and December 2007. Each of these patients had at least 2 radiosurgical treatments for the same AVM. Patient information, including AVM nidus volume, prescription dose, age, and sex, was collected at the time of initial treatment and again at the time of retreatment. Patients were followed up after treatment with magnetic resonance, computed tomography, and angiographic imaging at standard intervals to determine the status of their AVM. The median follow-up after retreatment was 31 months. RESULTS Between the first and second treatments, the median AVM nidus volume was decreased by 69% (from a median volume of 12.7 to 4.0 cm3), allowing the median prescribed dose to be increased from 1500 cGy on initial treatment to 1750 cGy on retreatment. The final obliteration rate on retreatment was 65.3%. After salvage retreatment, 5 patients (4.9%) experienced radiation-induced complications, and 6 patients (5.8%) experienced posttreatment hemorrhage. CONCLUSION Repeat radiosurgery is a safe and effective salvage treatment for AVMs.

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Implant Treatment in an Urban General Dentistry Residency Program: A 7-year Retrospective Study

Journal of Oral Implantology ◽

10.1563/807.1 ◽

2006 ◽

Vol 32 (3) ◽

pp. 142-147 ◽

Cited By ~ 15

Author(s):

Clifford B. Starr ◽

Mohamed A. Maksoud

Keyword(s):

Dental Implants ◽

Survival Rates ◽

First Year ◽

University Of Florida ◽

Residency Programs ◽

Implant Therapy ◽

The University ◽

Implant Treatment ◽

Florida College

Abstract Survival rates of multiple implant designs placed in various clinical situations average more than 90%. However, little data have been published on the survival rates of implants placed in dental residency programs. This study reports on the outcome of dental implants placed by first-year general dentistry residents in the University of Florida College of Dentistry–Jacksonville Clinic. The patients for this study received both surgical and restorative implant therapy from 1998 to 2005. A total of 263 patients (147 women, 116 men) were treated with dental implants. On average, a patient was 55.5 years old and received 3 implants. A variety of simple and complex restorative procedures were performed. Advanced general dentistry residents in conjunction with supervisory faculty treated all cases. The cumulative implant survival was 96.6%. Follow-up varied from 6 months to 7 years after placement. Cases included implants not yet loaded as well as implants loaded for 6 years or more. The findings of this study compare favorably with published studies and were unexpected in light of the residents' limited clinical experience.

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Silent science: a mixed-methods analysis of faculty engagement in science communication

Journal of Science Communication ◽

10.22323/2.20040209 ◽

2021 ◽

Vol 20 (04) ◽

pp. A09

Author(s):

Taylor T. Ruth ◽

Joy N. Rumble ◽

Lisa K. Lundy ◽

Sebastian Galindo ◽

Hannah S. Carter ◽

...

Keyword(s):

Mixed Methods ◽

Science Communication ◽

Spiral Of Silence ◽

Tenure Track ◽

University Of Florida ◽

The Public ◽

Effective Science ◽

The Spiral Of Silence ◽

The University

To address science literacy issues, university faculty have to engage in effective science communication. However, social pressures from peers, administration, or the public may silence their efforts. The purpose of this study was to understand the effect of the spiral of silence on faculty's engagement with science communication. A survey was distributed to a census of tenure-track faculty at the University of Florida [UF], and the findings did not support the spiral of silence was occurring. However, follow-up interviews revealed faculty did not perceive their peers to value science communication and were more concerned about how the public felt about their research and communication.

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Efficacy of Extended Valganciclovir Prophylaxis in Preventing Cytomegalovirus Infection in Pediatric Kidney Transplantation

The Open Urology & Nephrology Journal ◽

10.2174/1874303x014070100152 ◽

2014 ◽

Vol 7 (1) ◽

pp. 152-157

Author(s):

Hashim Faris ◽

A. Gregg Jon ◽

R. Dharnidharka Vikas

Keyword(s):

Late Onset ◽

Cmv Infection ◽

University Of Florida ◽

Pediatric Kidney Transplantation ◽

Final Study ◽

Significant Difference ◽

Infection Resistance ◽

The University ◽

Cmv Disease

Cytomegalovirus (CMV) is one of the most frequent opportunistic infection in renal transplant (RTx) recipients. Valganciclovir (VGC) has been showed to be safe and highly effective in prophylaxis of CMV infection in RTx recipients. Recently, an increase in delayed onset CMV disease has been noted with some arguing that longer prophylaxis may decrease the late-onset disease. We retrospectively tested the hypothesis that extended term prophylaxis (ETP) of VGC for 12 months is more effective than short term prophylaxis (STP) of 6 months in preventing CMV infection and disease in pediatric RTx performed at the University of Florida from July 2003 to December 2010. In this period, all recipients underwent prospective CMV PCR (Polymerase Chain Reaction) monitoring and were maintained on similar immunosuppression. Eighty six patients received RTx during that period. All eligible subjects had to have at least 12 months of graft survival and 18 months of follow up, leaving 73 eligible subjects in final study group. CMV infection or disease occurred in 6/29 (20%) in the STP group vs 6/44 (14%) in the ETP group with no statistical significant difference (P= 0.42). Donor positive/recipients negative CMV serology status (D+/R-) were associated with a higher risk of CMV infection in both univariate and multivariate analysis (P=0.01). Anemia and Leucopenia directly associated with VGC were similar in both groups (P=0.58 and P=0.2 respectively). Biopsy-proven acute rejection was also non-significant in both groups (P=0.39). Although ETP for CMV from 6 months to 12 months is safe and has minimal adverse effect, it did not reduce CMV infection or disease. Further controlled studies in pediatrics age group are considered to compare longer versus shorter periods of prophylaxis and their impact on prevention of CMV infection, resistance, cost, and toxicity.

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