Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability

The effects of transcranial electrical stimulation (tES) approaches have been widely studied for many decades in the motor field, and are well known to have a significant and consistent impact on the rehabilitation of people with motor deficits. Consequently, it can be asked whether tES could also be an effective tool for targeting and modulating plasticity in the sensory field for therapeutic purposes. Specifically, could potentiating sensitivity at the central level with tES help to compensate for sensory loss? The present review examines evidence of the impact of tES on cortical auditory excitability and its corresponding influence on auditory processing, and in particular on hearing rehabilitation. Overall, data strongly suggest that tES approaches can be an effective tool for modulating auditory plasticity. However, its specific impact on auditory processing requires further investigation before it can be considered for therapeutic purposes. Indeed, while it is clear that electrical stimulation has an effect on cortical excitability and overall auditory abilities, the directionality of these effects is puzzling. The knowledge gaps that will need to be filled are discussed.

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Transcranial Electrical and Magnetic Stimulation

10.1093/med/9780190228484.003.0028 ◽

2017 ◽

Author(s):

Alexander Rotenberg ◽

Alvaro Pascual-Leone ◽

Alan D. Legatt

Keyword(s):

Electrical Stimulation ◽

Direct Current ◽

Action Potentials ◽

Magnetic Stimulation ◽

Cortical Excitability ◽

Electrical Current ◽

Cortical Mapping ◽

Transcranial Electrical Stimulation ◽

Advanced Stages ◽

Low Amplitude

Noninvasive magnetic and electrical stimulation of cerebral cortex is an evolving field. The most widely used variant, transcranial electrical stimulation (TES), is routinely used for intraoperative monitoring. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are emerging as clinical and experimental tools. TMS has gained wide acceptance in extraoperative functional cortical mapping. TES and TMS rely on pulsatile stimulation with electrical current intensities sufficient to trigger action potentials within the stimulated cortical volume. tDCS, in contrast, is based on neuromodulatory effects of very-low-amplitude direct current conducted through the scalp. tDCS and TMS, particularly when applied in repetitive trains, can modulate cortical excitability for prolonged periods and thus are either in active clinical use or in advanced stages of clinical trials for common neurological and psychiatric disorders such as major depression and epilepsy. This chapter summarizes physiologic principles of transcranial stimulation and clinical applications of these techniques.

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Modern concepts of the pathogenesis of obesity and new approaches to its correction

Obesity and metabolism ◽

10.14341/omet9491 ◽

2018 ◽

Vol 15 (2) ◽

pp. 11-16

Author(s):

Oksana V. Logvinova ◽

Alexandra G. Poydasheva ◽

Ilya S. Bakulin ◽

Olga V. Lagoda ◽

Elena I. Kremneva ◽

...

Keyword(s):

Eating Disorders ◽

Electrical Stimulation ◽

Transcranial Magnetic Stimulation ◽

Brain Stimulation ◽

Magnetic Stimulation ◽

Cellular Level ◽

Transcranial Electrical Stimulation ◽

Food Behavior ◽

Physiological Mechanisms ◽

Non Invasive

The present review considers modern concepts of the physiological mechanisms of the formation of food behavior in a norm at several levels, beginning with the cellular level and ending with the level of functional systems. Neuroimaging methods used for both the study of the pathophysiological foundations of eating disorders and for determining the target for neurostimulation techniques are described. Methods of non-invasive brain stimulation such as transcranial magnetic stimulation and transcranial electrical stimulation, the mechanisms of their influence and aspects of safety of application are reviewed, the latest data on the results of studies on the use of the above methods in the therapy of obesity are summarized.

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fMRI and Transcranial Electrical Stimulation (tES): A systematic review of parameter space and outcomes

10.1101/2020.06.03.20121202 ◽

2020 ◽

Cited By ~ 1

Author(s):

Peyman Ghobadi-Azbari ◽

Asif Jamil ◽

Fatemeh Yavari ◽

Zeinab Esmaeilpour ◽

Nastaran Malmir ◽

...

Keyword(s):

Systematic Review ◽

Electrical Stimulation ◽

Parameter Space ◽

Brain Activity ◽

Random Noise ◽

Brain Regions ◽

Transcranial Electrical Stimulation ◽

Future Studies ◽

Non Invasive ◽

And Behavior

AbstractThe combination of non-invasive brain stimulation interventions with human brain mapping methods have supported research beyond correlational associations between brain activity and behavior. Functional MRI (fMRI) partnered with transcranial electrical stimulation (tES) methods, i.e., transcranial direct current (tDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation, explore the neuromodulatory effects of tES in the targeted brain regions and their interconnected networks and provide opportunities for individualized interventions. Advances in the field of tES-fMRI can be hampered by the methodological variability between studies that confounds comparability/replicability. In order to explore variability in the tES-fMRI methodological parameter space (MPS), we conducted a systematic review of 222 tES-fMRI experiments (181 tDCS, 39 tACS and 2 tRNS) published before February 1, 2019, and suggested a framework to systematically report main elements of MPS across studies. We have organized main findings in terms of fMRI modulation by tES. tES modulates activation and connectivity beyond the stimulated areas particularly with prefrontal stimulation. There were no two studies with the same MPS to replicate findings. We discuss how to harmonize the MPS to promote replication in future studies.

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One-shot tagging during wake and cueing during sleep with spatiotemporal patterns of transcranial electrical stimulation can boost long-term metamemory of individual episodes in humans

10.1101/672378 ◽

2019 ◽

Author(s):

Praveen K. Pilly ◽

Steven W. Skorheim ◽

Ryan J. Hubbard ◽

Nicholas A. Ketz ◽

Shane M. Roach ◽

...

Keyword(s):

Electrical Stimulation ◽

Real World ◽

Spectral Power ◽

Memory Performance ◽

Nrem Sleep ◽

Transcranial Electrical Stimulation ◽

Sensory Cues ◽

Non Invasive ◽

Episodic Memories ◽

The One

AbstractTargeted memory reactivation (TMR) during slow-wave oscillations (SWOs) in non-rapid eye movement (NREM) sleep has been demonstrated with sensory cues to achieve about 5-12% improvement in post-nap memory performance on simple laboratory tasks. But prior work has neither addressed the one-shot aspect of episodic memory acquisition, nor dealt with the presence of interference from ambient environmental cues in real-world settings for the sensory cues. Moreover, TMR with sensory cues may not be scalable to the multitude of experiences over one’s lifetime. We designed a novel non-invasive paradigm that tags one-shot experiences of minute-long naturalistic episodes within immersive virtual reality (VR) with unique spatiotemporal amplitude-modulated patterns (STAMPs) of transcranial electrical stimulation (tES) and cues them during SWOs. In particular, we demonstrate that these STAMPs can be re-applied as brief pulses to temporally coincide with UP states of SWOs (0.4167 – 1 s) on two consecutive nights to achieve about 20% improvement in the metamemory of targeted episodes at 48 hours after the one-shot viewing, compared to the control episodes. Post-sleep metamemory of the targeted episodes was driven by an interaction between their pre-sleep metamemory and the number of STAMP applications for those episodes during sleep. Overnight metamemory improvements were mediated by spectral power increases from 6.18 to 6.7 s following the offset of STAMPs in the slow-spindle band (9-12 Hz) for left temporal areas in the scalp electroencephalography (EEG) during sleep. These results prescribe an optimal strategy to leverage STAMPs for boosting metamemory and suggest that real-world episodic memories can be modulated in a targeted manner even with coarser, non-invasive spatiotemporal stimulation.

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Transcranial electrical stimulation (tES) mechanisms and its effects on cortical excitability and connectivity

Journal of Inherited Metabolic Disease ◽

10.1007/s10545-018-0181-4 ◽

2018 ◽

Vol 41 (6) ◽

pp. 1123-1130 ◽

Cited By ~ 25

Author(s):

Thomas Reed ◽

Roi Cohen Kadosh

Keyword(s):

Electrical Stimulation ◽

Cortical Excitability ◽

Transcranial Electrical Stimulation

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T188. THE CLINICAL SCIENCE OF TRANSCRANIAL DIRECT CURRENT STIMULATION STUDIES IN SCHIZOPHRENIA: SYSTEMATIC REVIEW AND META-ANALYSIS

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa029.748 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S303-S303

Author(s):

Joshua Mervis ◽

Angus MacDonald

Keyword(s):

Electrical Stimulation ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Meta Analysis ◽

Transcranial Electrical Stimulation ◽

Direct Current Stimulation ◽

Non Invasive ◽

Schizophrenia Spectrum ◽

Pubmed Database ◽

Study Characteristics

Abstract Background Transcranial direct current stimulation interventions have produced findings that inform clinical neuroscience, and may have potential as a treatment for the cognitive symptoms of schizophrenia-spectrum illnesses. The first recorded study of tDCS in this population was in 1994 and every year since then has seen growth in the number of studies conducted, with 15+ studies each year since 2013. This project is a meta-analysis of studies using transcranial direct current stimulation in people with schizophrenia-spectrum illnesses and any domain of cognition. Methods Search terms sought out articles in populations with schizophrenia, schizoaffective, schizotypal, schizoid, unspecified psychosis, and thought disorder illnesses. Within these populations, non-invasive electrical stimulation terms included transcranial direct current stimulation, tDCS, and transcranial electrical stimulation. Within those studies, cognitive terms included working memory, memory, cognitive control, executive function, attention, recall, recognition, perception, learning, cognition, inhibition, and executive control. PRISMA guidelines were followed. Results 177 Articles were located through a literature search using the PubMed database. 39 studies were screened out by title, 102 studies were screened out by abstract, 7 studies were screened out by text. Finally, 29 studies were subjected to meta-analysis. Discussion While the research on transcranial direct current stimulation continues to develop, the current study highlights methodological trends like studies with stimulation concurrent to task and those using training approaches. Overall effects are summarized by defining study characteristics and cognitive domains, where appropriate.

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Electrical neuromodulation biases brightness perception of flickering light

10.1101/2021.06.26.450021 ◽

2021 ◽

Author(s):

Marina Fiene ◽

Jan-Ole Radecke ◽

Jonas Misselhorn ◽

Malte Sengelmann ◽

Christoph S. Herrmann ◽

...

Keyword(s):

Electrical Stimulation ◽

Electric Fields ◽

Subjective Experience ◽

Phase Synchronization ◽

Temporal Dynamics ◽

Cortical Excitability ◽

Brightness Discrimination ◽

Transcranial Electrical Stimulation ◽

Subjective Perception ◽

Brightness Perception

Human brightness estimation often pronouncedly dissociates from objective viewing conditions. Yet, the physiological substrate underlying subjective perception is still poorly understood. Rather than physical illumination, the subjective experience of brightness has been shown to correlate with temporal dynamics in the amplitude of cortical neural responses. Here, we aimed to experimentally manipulate visual flicker-evoked steady-state responses and related perception via concurrent modulation of cortical excitability by transcranial alternating current stimulation. Participants performed a brightness discrimination task of two visual flicker stimuli, one of which was targeted by same-frequency electrical stimulation at varying phase shifts. Transcranial electrical stimulation was applied with an occipital and a periorbital active control montage, based on finite-element method simulations of electric fields. Experimental results reveal that flicker brightness perception is modulated dependent on the phase shift between sensory and electrical stimulation, solely under stable flicker entrainment and exclusively under occipital electrical stimulation. The degree of induced brightness modulation was positively correlated with the strength of neuronal phase locking to the flicker, recorded prior to electrical stimulation. This finding was corroborated by a neural network model, demonstrating a comparable dependency between flicker-evoked phase synchronization and amplitude modulations of entrained neural rhythms by phase shifted visual and electric inputs. Our data suggest a causal role of the amplitude of neural activity in visual cortex for brightness perception in humans. This finding provides an important step towards understanding the basis of visual perception and further confirms electrical stimulation as a tool for advancing controlled modulations of neural excitability and related behavior.

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