scholarly journals fMRI and Transcranial Electrical Stimulation (tES): A systematic review of parameter space and outcomes

2020 ◽  
Author(s):  
Peyman Ghobadi-Azbari ◽  
Asif Jamil ◽  
Fatemeh Yavari ◽  
Zeinab Esmaeilpour ◽  
Nastaran Malmir ◽  
...  
Keyword(s):  
Systematic Review ◽  
Electrical Stimulation ◽  
Parameter Space ◽  
Brain Activity ◽  
Random Noise ◽  
Brain Regions ◽  
Transcranial Electrical Stimulation ◽  
Future Studies ◽  
Non Invasive ◽  
And Behavior

AbstractThe combination of non-invasive brain stimulation interventions with human brain mapping methods have supported research beyond correlational associations between brain activity and behavior. Functional MRI (fMRI) partnered with transcranial electrical stimulation (tES) methods, i.e., transcranial direct current (tDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation, explore the neuromodulatory effects of tES in the targeted brain regions and their interconnected networks and provide opportunities for individualized interventions. Advances in the field of tES-fMRI can be hampered by the methodological variability between studies that confounds comparability/replicability. In order to explore variability in the tES-fMRI methodological parameter space (MPS), we conducted a systematic review of 222 tES-fMRI experiments (181 tDCS, 39 tACS and 2 tRNS) published before February 1, 2019, and suggested a framework to systematically report main elements of MPS across studies. We have organized main findings in terms of fMRI modulation by tES. tES modulates activation and connectivity beyond the stimulated areas particularly with prefrontal stimulation. There were no two studies with the same MPS to replicate findings. We discuss how to harmonize the MPS to promote replication in future studies.

Sham transcranial electrical stimulation and its effects on corticospinal excitability: a systematic review and meta-analysis

2018 ◽  
Vol 29 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Thusharika D. Dissanayaka ◽  
Maryam Zoghi ◽  
Michael Farrell ◽  
Gary F. Egan ◽  
Shapour Jaberzadeh
Keyword(s):  
Systematic Review ◽  
Electrical Stimulation ◽  
Meta Analysis ◽  
Random Noise ◽  
Corticospinal Excitability ◽  
Transcranial Electrical Stimulation ◽  
Placebo Effects ◽  
Randomized Controlled ◽  
Transcranial Random Noise Stimulation ◽  
Transcranial Alternating Current Stimulation

AbstractSham stimulation is used in randomized controlled trials (RCTs) to assess the efficacy of active stimulation and placebo effects. It should mimic the characteristics of active stimulation to achieve blinding integrity. The present study was a systematic review and meta-analysis of the published literature to identify the effects of sham transcranial electrical stimulation (tES) – including anodal and cathodal transcranial direct current stimulation (a-tDCS, c-tDCS), transcranial alternating current stimulation (tACS), transcranial random noise stimulation (tRNS) and transcranial pulsed current stimulation (tPCS) – on corticospinal excitability (CSE), compared to baseline in healthy individuals. Electronic databases – PubMed, CINAHL, Scopus, Science Direct and MEDLINE (Ovid) – were searched for RCTs of tES from 1990 to March 2017. Thirty RCTs were identified. Using a random-effects model, meta-analysis of a-tDCS, c-tDCS, tACS, tRNS and tPCS studies showed statistically non-significant pre-post effects of sham interventions on CSE. This review found evidence for statically non-significant effects of sham tES on CSE.

scholarly journals The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Clément Dondé ◽  
Jerome Brunelin ◽  
Jean-Arthur Micoulaud-Franchi ◽  
Julia Maruani ◽  
Michel Lejoyeux ◽  
...  
Keyword(s):  
Systematic Review ◽  
Electrical Stimulation ◽  
Clinical Samples ◽  
Transcranial Electrical Stimulation ◽  
Sleep Patterns ◽  
Non Invasive ◽  
Subjective Assessments ◽  
Registration Number ◽  
The Impact ◽  
The Brain

Transcranial Electrical Stimulation (tES) is a promising non-invasive brain modulation tool. Over the past years, there have been several attempts to modulate sleep with tES-based approaches in both the healthy and pathological brains. However, data about the impact on measurable aspects of sleep remain scattered between studies, which prevent us from drawing firm conclusions. We conducted a systematic review of studies that explored the impact of tES on neurophysiological sleep oscillations, sleep patterns measured objectively with polysomnography, and subjective psychometric assessments of sleep in both healthy and clinical samples. We searched four main electronic databases to identify studies until February 2020. Forty studies were selected including 511 healthy participants and 452 patients. tES can modify endogenous brain oscillations during sleep. Results concerning changes in sleep patterns are conflicting, whereas subjective assessments show clear improvements after tES. Possible stimulation-induced mechanisms within specific cortico-subcortical sleep structures and networks are discussed. Although these findings cannot be directly transferred to the clinical practice and sleep-enhancing devices development for healthy populations, they might help to pave the way for future researches in these areas. PROSPERO registration number 178910.

Transcranial Electrical Stimulation and Recording of Brain Activity using Freestanding Plant‐Based Conducting Polymer Hydrogel Composites

2019 ◽  
Vol 5 (3) ◽  
pp. 1900652 ◽  
Author(s):  
George D. Spyropoulos ◽  
Jeremy Savarin ◽  
Eliot F. Gomez ◽  
Daniel T. Simon ◽  
Magnus Berggren ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Conducting Polymer ◽  
Brain Activity ◽  
Transcranial Electrical Stimulation ◽  
Polymer Hydrogel ◽  
Hydrogel Composites

scholarly journals M70. THE EFFICACY OF COMBINING COGNITIVE REMEDIATION AND NON-INVASIVE BRAIN STIMULATION. A SYSTEMATIC REVIEW

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S162-S162
Author(s):  
Anika Poppe ◽  
Leonie Bais ◽  
Franziska Ritter ◽  
Branislava Curčić-Blake ◽  
Gerdina (Marieke) Pijnenborg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Functioning ◽  
Brain Stimulation ◽  
Cognitive Remediation ◽  
Strategy Use ◽  
Daily Functioning ◽  
Positive Trend ◽  
Future Studies ◽  
Non Invasive ◽  
Clinical Populations

Abstract Background Cognitive deficits are commonly observed in people diagnosed with schizophrenia and have been found to be more predictive of future daily and community functioning than the severity of clinical symptoms (e.g., hallucinations and delusions). Cognitive remediation (CR) is a psychological treatment developed to improve cognitive functioning and thereby daily functioning. Despite the effectivity of CR programs, reduced neuroplasticity in brain networks underlying the cognitive tasks may impede the effectiveness of these treatment programs. Increasing the neuroplasticity in these networks by the use of non-invasive brain stimulation (NIBS) like transcranial direct current stimulation or transcranial magnetic stimulation might boost the effect of CR. In a systematic review, we will address the question whether the combination of non-invasive brain stimulation and cognitive remediation may be a promising treatment strategy. We will apply a transdiagnostic perspective in order to determine the potential benefit of combining CR and NIBS in general, and not specific to a diagnostic category. Methods A systematic review of literature was conducted by searching PsycINFO, Pubmed, Web of Science, and Medline databases for combined treatments of CR and NIBS. Included studies were assessed for cognitive, clinical and functional outcomes. Results 64 studies were identified, with 40 studies including clinical populations (e.g., schizophrenia, Alzheimer’s disease, HIV, MS). The cognitive outcomes showed mixed results. Most effects were found on complex attention and executive functioning. In these domains about 38% of the studies found an added positive treatment effect for combining interventions, in comparison to single interventions (i.e. CR, NIBS, or CR+sham-stimulation). Functional outcome measures were included in ten of the 40 studies with clinical populations. Eight studies found a positive trend towards greater improvements in daily functioning when CR and NIBS were combined. Discussion So far, findings indicate promising effects of combining CR and NIBS on cognitive functioning and daily functioning in healthy and various clinical populations. There is a lot of variety between studies (e.g., duration of treatment, number of total sessions, number of weekly sessions, cognitive domains targeted) which may explain the mixed results. Especially, the design of the CR varied widely. Strategy-use and targeting meta-cognition, which were identified as effective elements of CR as a stand-alone treatment were not included in many combined CR+NIBS designs. Future studies have to elucidate whether the combining CR (including strategy-use and meta-cognition) and NIBS has an additive effect on cognitive and/or daily functioning compared to non-combined treatment. Moreover, future studies should evaluate whether beneficial effects from the experimental studies translate into long-term improvement in activities of daily life.

scholarly journals Brain Activity in Self- and Value-Related Regions in Response to Online Antismoking Messages Predicts Behavior Change

2015 ◽  
Vol 27 (3) ◽  
pp. 93-109 ◽  
Author(s):  
Nicole Cooper ◽  
Steve Tompson ◽  
Matthew Brook O’Donnell ◽  
B. Falk Emily
Keyword(s):  
Behavior Change ◽  
Risk Perceptions ◽  
Brain Activity ◽  
Smoking Behavior ◽  
Mechanistic Explanation ◽  
Health Behavior Change ◽  
Brain Regions ◽  
Self Report ◽  
Traditional Theory ◽  
And Behavior

Abstract. In this study, we combined approaches from media psychology and neuroscience to ask whether brain activity in response to online antismoking messages can predict smoking behavior change. In particular, we examined activity in subregions of the medial prefrontal cortex linked to self- and value-related processing, to test whether these neurocognitive processes play a role in message-consistent behavior change. We observed significant relationships between activity in both brain regions of interest and behavior change (such that higher activity predicted a larger reduction in smoking). Furthermore, activity in these brain regions predicted variance independent of traditional, theory-driven self-report metrics such as intention, self-efficacy, and risk perceptions. We propose that valuation is an additional cognitive process that should be investigated further as we search for a mechanistic explanation of the relationship between brain activity and media effects relevant to health behavior change.

Intravital Microscopy on a Closed Cranial Window in Mice: A Model to Study Trigeminovascular Mechanisms Involved in Migraine

Cephalalgia ◽  
2006 ◽  
Vol 26 (11) ◽  
pp. 1294-1303 ◽  
Author(s):  
S Gupta ◽  
S Akerman ◽  
AMJM van den Maagdenberg ◽  
PR Saxena ◽  
PJ Goadsby ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Intravital Microscopy ◽  
Control Group ◽  
Transcranial Electrical Stimulation ◽  
Trigeminovascular System ◽  
Future Studies ◽  
Cranial Window ◽  
Calcitonin Gene ◽  
Trigeminal Nerves ◽  
Baseline Diameter

The purpose of the study was to develop a mouse model to study trigeminovascular mechanisms using intravital microscopy on a closed cranial window. In addition, we studied exogenous and endogenous calcitonin gene-related peptide (CGRP)-mediated vasodilation in dural arteries. Arteries in C57BL/6Jico mice were constricted with endothelin-1, which reduced the baseline diameter by 65-75%. Subsequently, vasodilation was induced by α-CGRP, capsaicin or transcranial electrical stimulation of perivascular trigeminal nerves in the absence or presence of different concentrations of BIBN4096BS or sumatriptan. Both α-CGRP and capsaicin induced vasodilation in preconstricted arteries. Transcranial electrical stimulation also induced current-dependent relaxation of dural arteries with 100 μA producing maximal dilation in the control group. BIBN4096BS blocked the responses evoked by ä-CGRP and capsaicin, as well as electrical stimulation, whereas sumatriptan attenuated only vasodilation induced by electrical stimulation. This model is likely to prove useful in dissecting elements of the trigeminovascular system and for exploring pathophysiological aspects of migraine, especially in future studies using transgenic mice with mutations relevant to those observed in patients with migraine.

scholarly journals A Future of Current Flow Modelling for Transcranial Electrical Stimulation?

2021 ◽  
Author(s):  
J. S. A. Lee ◽  
S. Bestmann ◽  
C. Evans
Keyword(s):  
Electrical Stimulation ◽  
Current Flow ◽  
Brain Activity ◽  
Cost Effective ◽  
Electrical Current ◽  
Transcranial Electrical Stimulation ◽  
Concentric Spheres ◽  
Mri Scans ◽  
Dose Control ◽  
Health And Disease

Abstract Purpose of Review Transcranial electrical stimulation (tES) is used to non-invasively modulate brain activity in health and disease. Current flow modeling (CFM) provides estimates of where and how much electrical current is delivered to in the brain during tES. It therefore holds promise as a method to reduce commonplace variability in tES delivery and, in turn, the outcomes of stimulation. However, the adoption of CFM has not yet been widespread and its impact on tES outcome variability is unclear. Here, we discuss the potential barriers to effective, practical CFM-informed tES use. Recent Findings CFM has progressed from models based on concentric spheres to gyri-precise head models derived from individual MRI scans. Users can now estimate the intensity of electrical fields (E-fields), their spatial extent, and the direction of current flow in a target brain region during tES. Here. we consider the multi-dimensional challenge of implementing CFM to optimise stimulation dose: this requires informed decisions to prioritise E-field characteristics most likely to result in desired stimulation outcomes, though the physiological consequences of the modelled current flow are often unknown. Second, we address the issue of a disconnect between predictions of E-field characteristics provided by CFMs and predictions of the physiological consequences of stimulation which CFMs are not designed to address. Third, we discuss how ongoing development of CFM in conjunction with other modelling approaches could overcome these challenges while maintaining accessibility for widespread use. Summary The increasing complexity and sophistication of CFM is a mandatory step towards dose control and precise, individualised delivery of tES. However, it also risks counteracting the appeal of tES as a straightforward, cost-effective tool for neuromodulation, particularly in clinical settings.

scholarly journals Dataset of concurrent EEG, ECG, and behavior with multiple doses of transcranial electrical stimulation

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Nigel Gebodh ◽  
Zeinab Esmaeilpour ◽  
Abhishek Datta ◽  
Marom Bikson
Keyword(s):  
Electrical Stimulation ◽  
Demographic Data ◽  
Transcranial Electrical Stimulation ◽  
Brain State ◽  
High Definition ◽  
Before And After ◽  
Human Participant ◽  
Cortical Regions ◽  
And Behavior ◽  
Unique Dataset

AbstractWe present a dataset combining human-participant high-density electroencephalography (EEG) with physiological and continuous behavioral metrics during transcranial electrical stimulation (tES). Data include within participant application of nine High-Definition tES (HD-tES) types, targeting three cortical regions (frontal, motor, parietal) with three stimulation waveforms (DC, 5 Hz, 30 Hz); more than 783 total stimulation trials over 62 sessions with EEG, physiological (ECG, EOG), and continuous behavioral vigilance/alertness metrics. Experiment 1 and 2 consisted of participants performing a continuous vigilance/alertness task over three 70-minute and two 70.5-minute sessions, respectively. Demographic data were collected, as well as self-reported wellness questionnaires before and after each session. Participants received all 9 stimulation types in Experiment 1, with each session including three stimulation types, with 4 trials per type. Participants received two stimulation types in Experiment 2, with 20 trials of a given stimulation type per session. Within-participant reliability was tested by repeating select sessions. This unique dataset supports a range of hypothesis testing including interactions of tDCS/tACS location and frequency, brain-state, physiology, fatigue, and cognitive performance.

Sign in / Sign up

Export Citation Format

Share Document