scholarly journals Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients

2021 ◽  
Vol 15 ◽  
Author(s):  
Nienke Wolthuis ◽  
Djaina Satoer ◽  
Wencke Veenstra ◽  
Marion Smits ◽  
Michiel Wagemakers ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Functional Connectivity ◽  
Resting State ◽  
Spanning Trees ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Global Integration ◽  
Healthy Individuals ◽  
Language Performance ◽  
Language Functioning

Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity (FC), the extent to which brain areas functionally interact. We studied FC networks in relation to language functioning in glioma and meningioma patients.Method: Patients with a low-grade glioma (N = 15) or meningioma (N = 10) infiltrating into/pressing on the language-dominant hemisphere underwent extensive language testing before and 1 year after surgery. Resting-state EEG was registered preoperatively, postoperatively (glioma patients only), and once in healthy individuals. After analyzing FC in theta and alpha frequency bands, weighted networks and Minimum Spanning Trees were quantified by various network measures.Results: Pre-operative FC network characteristics did not differ between glioma patients and healthy individuals. However, hub presence and higher local and global FC are associated with poorer language functioning before surgery in glioma patients and predict worse language performance at 1 year after surgery. For meningioma patients, a greater small worldness was related to worse language performance and hub presence; better average clustering and global integration were predictive of worse outcome on language function 1 year after surgery. The average eccentricity, diameter and tree hierarchy seem to be the network metrics with the more pronounced relation to language performance.Discussion: In this exploratory study, we demonstrated that preoperative FC networks are informative for pre- and postoperative language functioning in glioma patients and to a lesser extent in meningioma patients.

fMRI Resting-State Connectivity between Language and Nonlanguage Areas as Defined by Intraoperative Electrocortical Stimulation in Low-Grade Glioma Patients

2021 ◽  
Author(s):  
Jasper van Lieshout ◽  
Wouter Debaene ◽  
Marion Rapp ◽  
Herke Jan Noordmans ◽  
Geert-Jan Rutten
Keyword(s):  
Functional Connectivity ◽  
Spatial Resolution ◽  
Resting State ◽  
Imaging Techniques ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Operating Characteristics ◽  
Language Mapping ◽  
Current Form ◽  
Resting State Connectivity

Abstract Background and Objectives It remains to be determined whether noninvasive functional imaging techniques can rival the clinical potential of direct electrocortical stimulation (DES). In this study, we compared the results of resting-state functional magnetic resonance imaging (rs-fMRI) to those of DES for language mapping. Our goals were twofold: (1) to replicate a previous study that demonstrated that resting-state connectivity (RSC) was significantly larger between positive DES language sites than between negative DES language sites and (2) to compare the spatial resolution of rs-fMRI to that of DES. Methods We conducted a retrospective study of nine low-grade glioma patients. Language sites were identified by intraoperative DES. We compared RSC values between and within groups of DES-positive and DES-negative regions of interest (ROIs). Both close-negative sites (i.e., DES-negative sites <1 cm apart from and on the same gyrus as DES-positive sites) and far-negative sites (i.e., purely randomly chosen sites not in the vicinity of the tumor or of the DES-positive sites but on the same lobe) were included. Receiver operating characteristics were used to quantify comparisons. Results Functional connectivity between all positive language sites was on average significantly higher than between all close-negative sites and between all far-negative sites. The functional connectivity between the positive language ROIs and their respective close-negative control sites was not smaller than between all positive language sites. Conclusion rs-fMRI likely reflects similar neural information as detected with DES, but in its current form does not reach the spatial resolution of DES.

scholarly journals Glioma with Leptomeningeal Spread Mimics Chronic Meningoencephalitis in a Young Adult

2021 ◽  
pp. 179-183
Author(s):  
Ann-Kristin Becker ◽  
Marta Leonora Frank ◽  
Michael Friese ◽  
Joachim Röther
Keyword(s):  
Brain Tumor ◽  
Back Pain ◽  
Young Adult ◽  
Lower Back Pain ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Who Grade ◽  
Leptomeningeal Spread ◽  
Lower Back ◽  
Uncommon Case

The most malignant type of intrinsic brain tumor is glioblastoma (WHO grade IV). Primary leptomeningeal spread is rare and leads to a variety of differential considerations, as there is no typical clinical or imaging pattern. Here we present a rare and uncommon case of a primary leptomeningeal glioblastoma in combination with a low-grade glioma in a 21-year-old male, initially presenting with only headache and lower back pain. The presented case illustrates the challenging differential considerations and the severe course of leptomeningeal glioblastomas.

scholarly journals Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients

2020 ◽  
Vol 22 (9) ◽  
pp. 1388-1398 ◽  
Author(s):  
Veit M Stoecklein ◽  
Sophia Stoecklein ◽  
Franziska Galiè ◽  
Jianxun Ren ◽  
Michael Schmutzer ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Brain Area ◽  
Tumor Biology ◽  
Resting State Fmri ◽  
World Health ◽  
Low Grade ◽  
Clinical Value ◽  
Isocitrate Dehydrogenase 1 ◽  
Who Grade

Abstract Background Systemic infiltration of the brain by tumor cells is a hallmark of glioma pathogenesis which may cause disturbances in functional connectivity. We hypothesized that aggressive high-grade tumors cause more damage to functional connectivity than low-grade tumors. Methods We designed an imaging tool based on resting-state functional (f)MRI to individually quantify abnormality of functional connectivity and tested it in a prospective cohort of patients with newly diagnosed glioma. Results Thirty-four patients were analyzed (World Health Organization [WHO] grade II, n = 13; grade III, n = 6; grade IV, n = 15; mean age, 48.7 y). Connectivity abnormality could be observed not only in the lesioned brain area but also in the contralateral hemisphere with a close correlation between connectivity abnormality and aggressiveness of the tumor as indicated by WHO grade. Isocitrate dehydrogenase 1 (IDH1) mutation status was also associated with abnormal connectivity, with more alterations in IDH1 wildtype tumors independent of tumor size. Finally, deficits in neuropsychological performance were correlated with connectivity abnormality. Conclusion Here, we suggested an individually applicable resting-state fMRI marker in glioma patients. Analysis of the functional connectome using this marker revealed that abnormalities of functional connectivity could be detected not only adjacent to the visible lesion but also in distant brain tissue, even in the contralesional hemisphere. These changes were associated with tumor biology and cognitive function. The ability of our novel method to capture tumor effects in nonlesional brain suggests a potential clinical value for both individualizing and monitoring glioma therapy.

Symmetry of the arcuate fasciculus and its impact on language performance of patients with brain tumors in the language-dominant hemisphere

2017 ◽  
Vol 127 (6) ◽  
pp. 1407-1416 ◽  
Author(s):  
Margit Jehna ◽  
Juliane Becker ◽  
Karla Zaar ◽  
Gord von Campe ◽  
Kariem Mahdy Ali ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Fiber Tracking ◽  
Low Grade ◽  
High Grade ◽  
Arcuate Fasciculus ◽  
Language Performance ◽  
Language Deficits ◽  
Tumor Patients ◽  
Eloquent Areas ◽  
The Right

OBJECTIVECerebral damage in frontal, parietal, and temporal brain areas and, probably more importantly, their interconnections can lead to deficits in language. However, neural plasticity and repair allow the brain to partly compensate for neural injury, mediated by both functional and structural changes. In this study, the authors sought to systematically investigate the relationship between language performance in brain tumor patients and structural perisylvian pathways (i.e., the arcuate fasciculus [AF]) using probabilistic fiber tracking on diffusion tensor imaging. The authors used a previously proposed model in which the AF is divided into anterior, long, and posterior segments. The authors hypothesized that right-handed patients with gliomas in the language-dominant (left) hemisphere would benefit from a more symmetrical or right-lateralized language pathway in terms of better preservation of language abilities. Furthermore, they investigated to what extent specific tumor characteristics, including proximity to the AF, affect language outcome in such patients.METHODSTwenty-seven right-handed patients (12 males and 15 females; mean age 52 ± 16 years) with 11 low-grade and 16 high-grade gliomas of the left hemisphere underwent 3-T diffusion-weighted MRI (30 directions) and language assessment as part of presurgical planning. For a systematic quantitative evaluation of the AF, probabilistic fiber tracking with a 2 regions of interest approach was carried out. Volumes of the 3 segments of both hemispheric AFs were evaluated by quantifying normalized and thresholded pathways. Resulting values served to generate the laterality index of the AFs.RESULTSPatients without language deficits tended to have an AF that was symmetric or lateralized to the right, whereas patients with deficits in language significantly more often demonstrated a left-lateralized posterior segment of the AF. Patients with high-grade gliomas had more severe language deficits than those with low-grade gliomas. Backward logistic regression revealed the laterality index of the posterior AF segment and tumor grade as the only independent statistically significant predictors for language deficits in this cohort.CONCLUSIONSIn addition to the well-known fact that tumor entity influences behavioral outcome, the authors' findings suggest that the right homologs of structural language-associated pathways could be supportive for language function and facilitate compensation mechanisms after brain damage in functionally eloquent areas. This further indicates that knowledge about preoperative functional redistribution (identified by neurofunctional imaging) increases the chance for total or near-total resections of tumors in eloquent areas. In the future, longitudinal studies with larger groups are mandatory to overcome the methodological limitations of this cross-sectional study and to map neuroplastic changes associated with language performance and rehabilitation in brain tumor patients.

scholarly journals Psilocybin modulation of dynamic functional connectivity is associated with plasma psilocin and subjective effects

2021 ◽  
Author(s):  
Anders S Olsen ◽  
Anders Lykkebo-Valloee ◽  
Brice Ozenne ◽  
Martin K Madsen ◽  
Dea Siggaard Stenbaek ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Dwell Time ◽  
Brain State ◽  
Healthy Individuals ◽  
Acute Effects ◽  
Dynamic Functional Connectivity ◽  
Negatively Associated ◽  
State Dynamic ◽  
Brain States

Background: Psilocin, the neuroactive metabolite of psilocybin, is a serotonergic psychedelic that induces an acute altered state of consciousness, evokes lasting changes in mood and personality in healthy individuals, and has potential as an antidepressant treatment. Examining the acute effects of psilocin on resting-state dynamic functional connectivity implicates network-level connectivity motifs that may underlie acute and lasting behavioral and clinical effects. Aim: Evaluate the association between resting-state dynamic functional connectivity (dFC) characteristics and plasma psilocin level (PPL) and subjective drug intensity (SDI) before and right after intake of a psychedelic dose of psilocybin in healthy humans. Methods: Fifteen healthy individuals completed the study. Before and at multiple time points after psilocybin intake, we acquired 10-minute resting-state blood-oxygen-level-dependent functional magnetic resonance imaging scans. Leading Eigenvector Dynamics Analysis (LEiDA) and diametrical clustering were applied to estimate discrete, sequentially active brain states. We evaluated associations between the fractional occurrence of brain states during a scan session and PPL and SDI using linear mixed-effects models. We examined associations between brain state dwell time and PPL and SDI using frailty Cox proportional hazards survival analysis. Results: Fractional occurrences for two brain states characterized by lateral frontoparietal and medial fronto-parietal-cingulate coherence were statistically significantly negatively associated with PPL and SDI. Dwell time for these brain states was negatively associated with SDI and, to a lesser extent, PPL. Conversely, fractional occurrence and dwell time of a fully connected brain state was positively associated with PPL and SDI. Conclusion: Our findings suggest that the acute perceptual psychedelic effects induced by psilocybin may stem from drug-level associated decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs in exchange for increases in a uniform connectivity structure. We apply and argue for a modified approach to modeling eigenvectors produced by LEiDA that more fully acknowledges their underlying structure. Together these findings contribute to a more comprehensive neurobiological framework underlying acute effects of serotonergic psychedelics.

P.0593 Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals

2021 ◽  
Vol 53 ◽  
pp. S433-S434
Author(s):  
D. Mcculloch ◽  
M.K. Madsen ◽  
D.S. Stenbæk ◽  
S. Kristiansen ◽  
B. Ozenne ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Healthy Individuals ◽  
Resting State Functional Connectivity

scholarly journals LGG-08. A PHASE II PROSPECTIVE STUDY OF SELUMETINIB IN CHILDREN WITH RECURRENT OR REFRACTORY LOW-GRADE GLIOMA (LGG): A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) STUDY

2017 ◽  
Vol 19 (suppl_4) ◽  
pp. iv34-iv35 ◽  
Author(s):  
Jason Fangusaro ◽  
Arzu Onar-Thomas ◽  
Tina Y Poussaint ◽  
Shengjie Wu ◽  
Azra H Ligon ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Prospective Study ◽  
Phase Ii ◽  
Pediatric Brain Tumor ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Pediatric Brain

scholarly journals Individual pain sensitivity is associated with resting-state cortical activities in healthy individuals but not in patients with migraine: a magnetoencephalography study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Fu-Jung Hsiao ◽  
Wei-Ta Chen ◽  
Hung-Yu Liu ◽  
Yen-Feng Wang ◽  
Shih-Pin Chen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Pain Sensitivity ◽  
Large Population ◽  
Cingulate Cortex ◽  
Gamma Oscillation ◽  
Anterior Cingulate ◽  
Healthy Individuals ◽  
Clinical Pain ◽  
Cortical Regions

Abstract Background Pain sensitivity may determine the risk, severity, prognosis, and efficacy of treatment of clinical pain. Magnetic resonance imaging studies have linked thermal pain sensitivity to changes in brain structure. However, the neural correlates of mechanical pain sensitivity remain to be clarified through investigation of direct neural activities on the resting-state cortical oscillation and synchrony. Methods We recorded the resting-state magnetoencephalographic (MEG) activities of 27 healthy individuals and 30 patients with episodic migraine (EM) and analyzed the source-based oscillatory powers and functional connectivity at 2 to 59 Hz in pain-related cortical regions, which are the bilateral anterior cingulate cortex (ACC), medial orbitofrontal (MOF) cortex, lateral orbitofrontal (LOF) cortex, insula cortex, primary somatosensory cortex (SI), primary motor cortex (MI), and posterior cingulate cortex (PCC). The mechanical punctate pain threshold (MPPT) was obtained at the supraorbital area (the first branch of the trigeminal nerve dermatome, V1) and the forearm (the first thoracic nerve dermatome, T1) and further correlated with MEG measures. Results The MPPT is inversely correlated with the resting-state relative powers of gamma oscillation in healthy individuals (all corrected P < 0.05). Specifically, inverse correlation was noted between the MPPT at V1 and gamma powers in the bilateral insula (r = − 0.592 [left] and − 0.529 [right]), PCC (r = − 0.619 and − 0.541) and MI (r = − 0.497 and − 0.549) and between the MPPT at T1 and powers in the left PCC (r = − 0.561) and bilateral MI (r = − 0.509 and − 0.520). Furthermore, resting-state functional connectivity at the delta to beta bands, especially between frontal (MOF, ACC, LOF, and MI), parietal (PCC), and sensorimotor (bilateral SI and MI) regions, showed a positive correlation with the MPPT at V1 and T1 (all corrected P < 0.05). By contrast, in patients with EM, the MPPT was not associated with resting-state cortical activities. Conclusions Pain sensitivity in healthy individuals is associated with the resting-state gamma oscillation and functional connectivity in pain-related cortical regions. Further studies must be conducted in a large population to confirm whether resting-state cortical activities can be an objective measurement of pain sensitivity in individuals without clinical pain.

scholarly journals A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study

2017 ◽  
Vol 19 (8) ◽  
pp. 1135-1144 ◽  
Author(s):  
Anuradha Banerjee ◽  
Regina I. Jakacki ◽  
Arzu Onar-Thomas ◽  
Shengjie Wu ◽  
Theodore Nicolaides ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Phase I ◽  
Phase I Trial ◽  
Pediatric Patients ◽  
Pediatric Brain Tumor ◽  
Mek Inhibitor ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Pediatric Brain

scholarly journals The management of lomustine overdose in malignant glioma patients

2014 ◽  
Vol 1 (4) ◽  
pp. 178-183 ◽  
Author(s):  
Hans-Georg Wirsching ◽  
Isabel Tritschler ◽  
Antonella Palla ◽  
Christoph Renner ◽  
Michael Weller ◽  
...  
Keyword(s):  
Brain Tumor ◽  
High Risk ◽  
Malignant Glioma ◽  
Standard Of Care ◽  
Low Grade Glioma ◽  
Anaplastic Oligodendroglioma ◽  
Low Grade ◽  
Potential Complication ◽  
Tumor Patients

Abstract Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of lomustine overdose, highlight complications by exemplifying a case of inadvertent lomustine overdose, and outline the management of this potential complication of outpatient PCV therapy.

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