scholarly journals Corrigendum: Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

2022 ◽  
Vol 15 ◽  
Author(s):  
Huaqian Dong ◽  
Xiang Ye ◽  
Li Zhong ◽  
Jinhong Xu ◽  
Jinhua Qiu ◽  
...  
Keyword(s):  
Neuronal Apoptosis ◽  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

2019 ◽  
Vol 13 ◽  
Author(s):  
Huaqian Dong ◽  
Xiang Ye ◽  
Li Zhong ◽  
Jinhong Xu ◽  
Jinhua Qiu ◽  
...  
Keyword(s):  
Neuronal Apoptosis ◽  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder

2010 ◽  
Vol 3 ◽  
pp. IJTR.S4321 ◽  
Author(s):  
Nicholas W.S. Davies ◽  
Gilles Guillemin ◽  
Bruce J. Brew
Keyword(s):  
Neurodegenerative Disease ◽  
Differential Expression ◽  
Inflammatory Cells ◽  
Kynurenine Pathway ◽  
Motor Neurone ◽  
Neurocognitive Disorder ◽  
Pathogenetic Role ◽  
Hiv Associated Neurocognitive Disorder ◽  
The Brain

This review presents an up-to-date assessment of the role of the tryptophan metabolic and catabolic pathways in neurodegenerative disease and HIV-associated neurocognitive disorder. The kynurenine pathway and the effects of each of its enzymes and products are reviewed. The differential expression of the kynurenine pathway in cells within the brain, including inflammatory cells, is explored given the increasing recognition of the importance of inflammation in neurodegenerative disease. An overview of common mechanisms of neurodegeneration is presented before a review and discussion of the evidence for a pathogenetic role of the kynurenine pathway in Alzheimer's disease, HIV-associated neurocognitive disorder, Huntington's disease, motor neurone disease, and Parkinson's disease.

scholarly journals HIV-1 Tat increases BAG3 via NF-κB signaling to induce autophagy during HIV-associated neurocognitive disorder

Cell Cycle ◽  
2018 ◽  
Vol 17 (13) ◽  
pp. 1614-1623 ◽  
Author(s):  
Xiaoyan Wu ◽  
Huaqian Dong ◽  
Xiang Ye ◽  
Li Zhong ◽  
Tiantian Cao ◽  
...  
Keyword(s):  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics

2018 ◽  
Vol 19 (11) ◽  
pp. 3594 ◽  
Author(s):  
Ian Olivier ◽  
Ramón Cacabelos ◽  
Vinogran Naidoo
Keyword(s):  
Risk Factors ◽  
Immune Response ◽  
Human Genetics ◽  
Hiv Treatment ◽  
Specific Gene ◽  
People Living With Hiv ◽  
Neurocognitive Disorder ◽  
Host Genetics ◽  
Hiv Associated Neurocognitive Disorder

Neurocognitive impairments associated with human immunodeficiency virus (HIV) infection remain a considerable health issue for almost half the people living with HIV, despite progress in HIV treatment through combination antiretroviral therapy (cART). The pathogenesis and risk factors of HIV-associated neurocognitive disorder (HAND) are still incompletely understood. This is partly due to the complexity of HAND diagnostics, as phenotypes present with high variability and change over time. Our current understanding is that HIV enters the central nervous system (CNS) during infection, persisting and replicating in resident immune and supporting cells, with the subsequent host immune response and inflammation likely adding to the development of HAND. Differences in host (human) genetics determine, in part, the effectiveness of the immune response and other factors that increase the vulnerability to HAND. This review describes findings from studies investigating the role of human host genetics in the pathogenesis of HAND, including potential risk factors for developing HAND. The similarities and differences between HAND and Alzheimer’s disease are also discussed. While some specific variations in host genes regulating immune responses and neurotransmission have been associated with protection or risk of HAND development, the effects are generally small and findings poorly replicated. Nevertheless, a few specific gene variants appear to affect the risk for developing HAND and aid our understanding of HAND pathogenesis.

scholarly journals Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder

2013 ◽  
Vol 19 (6) ◽  
pp. 601-605 ◽  
Author(s):  
Beau K. Nakamoto ◽  
Cecilia M. Shikuma ◽  
Debra Ogata-Arakaki ◽  
Tracie Umaki ◽  
Edward A. Neuwelt ◽  
...  
Keyword(s):  
Potential Role ◽  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder

scholarly journals HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND)

2011 ◽  
Vol 58 (6) ◽  
pp. 656-664 ◽  
Author(s):  
Zainulabedin M. Saiyed ◽  
Nimisha Gandhi ◽  
Marisela Agudelo ◽  
Jessica Napuri ◽  
Thangavel Samikkannu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Neurocognitive Disorder ◽  
Histone Deacetylase 2 ◽  
Human Neurons ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

The Role of Viral Genetic Variability in HIV-Associated Neurocognitive Disorder

2014 ◽  
pp. 201-218
Author(s):  
Paul Shapshak ◽  
Alireza Minagar ◽  
Pandjassarame Kangueane ◽  
Simon Frost ◽  
Sergei L. Kosakovsky Pond ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder
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