Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study

Background: Lipids are known to accumulate abnormally in the alveoli and circulate during pulmonary alveolar proteinosis (PAP). However, the relationship between lipid ratios and PAP is not clear. In this study, we investigated the lipid ratios in PAP patients and explored the relationships between lipid ratios and the severity of PAP.Methods: A total of 122 PAP patients were diagnosed and divided the mild- moderate PAP group (n = 61) and the severe PAP group (n = 61) according to the value of disease severity score (DSS). One hundred thirty healthy volunteers were classified as the control group. Routine blood examination and pulmonary function tests were performed and lipid profile were measured.Results: Compared with the control group, patients with PAP had significantly higher TG, TC/HDL-C, TG/HDL-C, and non-HDL-C, while lower HDL-C (all P < 0.05). Patients with the severe PAP had higher TC, TG, LDL-C, TC/HDL-C, and non-HDL-C, while lower HDL-C than patients with the mild- moderate PAP (all P < 0.05). Binary logistic regression analysis indicated that TC/HDL-C (OR = 2.322, 95% CI 1.621–3.713, P = 0.024) and non-HDL-C (OR = 1.797, 95% CI 1.239–3.109, P = 0.036) were all significantly correlated with the severity of PAP after adjustment for other risk factors. The AUC value of TC/HDL-C for predicting the severity of PAP was larger than that of non-HDL-C. The AUROC for TC/HDL-C was 0.741 (0.654–0.828), and the optimal cut-off point for TC/HDL-C was 5.05 (sensitivity: 73.6%, specificity: 68.1%).Conclusions: Lipid ratios, including TC-HDL-C and non-HDL-C, were independent risk factors for the severity of PAP. TC/HDL-C is a promising biomarker for the severity of PAP.

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Spexin Levels are Associated with Painful Diabetic Peripheral Neuropathy

10.21203/rs.3.rs-660017/v1 ◽

2021 ◽

Author(s):

Lu Zhu ◽

Hangping Zheng ◽

Yaojing Jiang ◽

Qi Zhang ◽

Bin Lu ◽

...

Keyword(s):

Neuropathic Pain ◽

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Antinociceptive Effect ◽

Experimental Studies ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Control Group ◽

Binary Logistic Regression Analysis ◽

Cross Sectional

Abstract Background: Spexin is implicated in multiple functions of energy metabolism and glucose homeostasis regulation. Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and approximately half of the patients with DPN suffer from neuropathic pain. Recent experimental studies in mice have shown that Spexin has an antinociceptive effect, but there are no relevant reports in clinical studies. This study aimed to evaluate Spexin levels in people with painful DPN and controls and assess the correlation between serum Spexin levels and painful DPN.Methods: This is a cross-sectional study including 20 patients with diabetes but without DPN (non-DPN) as a control group, 24 patients with painless DPN, and 16 patients with painful DPN. Questionnaires and laboratory surveys were conducted to collect demographic and clinical data. The existence and severity of DPN were assessed using neurological symptom score, neurological examination, and electromyography. Serum Spexin levels were measured by ELISA. Results: Serum Spexin levels of patients with painful DPN were significantly lower than those of non-DPN patients (p<0.001) and painless DPN patients (p=0.035). Serum Spexin levels were negatively correlated with neuropathic pain score. Compared with individuals with higher levels of Spexin, the prevalence rate of painful DPN in those with lower levels of Spexin was signiﬁcantly higher. Binary logistic regression analysis showed that the odds ratios for painful DPN were significantly elevated along with decreasing Spexin levels even after adjusting for age, sex, BMI, diabetes duration, HbA1c, 2hPBG, hypertension and smoking or drinking status. serum Spexin levels have a sensitivity of 84.1% and a specificity of 56.2% for predicting painful DPN.Conclusions: Decreased serum Spexin levels were strongly associated with painful DPN, suggesting a possible role of this peptide in pain-related pathogenesis.

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Spexin is associated with Painful Diabetic Peripheral Neuropathy

10.21203/rs.3.rs-340396/v1 ◽

2021 ◽

Author(s):

Lu Zhu ◽

Ping hang Zheng ◽

jing yao Jiang ◽

Qi Zhang ◽

Bin Lu ◽

...

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Antinociceptive Effect ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Control Group ◽

Binary Logistic Regression Analysis ◽

Cross Sectional ◽

Lower Serum Level ◽

Patients With Diabetes

Abstract Background: Spexin exerts multiple functions in the regulation of energy metabolism and glucose homeostasis. Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and almost one-third of patients with DPN suffer from neuropathic pain. Recent studies have shown that Spexin has antinociceptive effect. This study aims to evaluate the correlation between circulating Spexin level with the painful DPN. Methods: This is a cross-sectional study including 20 patients with diabetes but without DPN (non-DPN) as the control group, 24 patients with painless DPN and 16 patients with painful DPN. A questionnaire and laboratory investigation were carried out to obtain information on demographic and clinical data. The existence and severity of DPN was assessed by electromyography (EMG) examination. Serum Spexin level was measured by ELISA. Results: The serum Spexin level of patients with painful DPN was significantly lower than that of non-DPN patients (p<0.001) and painless DPN patients (p=0.035). The binary logistic regression analysis showed that lower serum level of Spexin was independently associated with the presence of painful DPN after adjusting for age, sex, BMI, duration of diabetes, HbA1c, 2hPBG, hypertension and status of smoking or drinking. Compared to individuals with higher level of Spexin, the prevalence rate of painful DPN in those with lower level of Spexin was signiﬁcantly higher. Conclusion: Circulating Spexin level decreased in painful DPN, suggesting a possible role of this peptide in pain-related pathogenesis.

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Prevalence and Extrinsic Risk Factors for Dental Erosion in Adolescents

Journal of Clinical Pediatric Dentistry ◽

10.17796/1053-4628-41.2.102 ◽

2017 ◽

Vol 41 (2) ◽

pp. 102-111 ◽

Cited By ~ 11

Author(s):

Ana C Mafla ◽

Ximena A Cerón-Bastidas ◽

Maria E Munoz-Ceballos ◽

Diana C Vallejo-Bravo ◽

Maria C Fajardo-Santacruz

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Binary Logistic Regression ◽

Dental Erosion ◽

Cross Sectional Study ◽

Binary Logistic Regression Analysis ◽

Cross Sectional ◽

Risks Factors ◽

Middle Adolescence ◽

Extrinsic Risk

Objective: This manuscript examined the prevalence and extrinsic risk factors for dental erosion (DE) in early and middle adolescents in Pasto, Colombia. Study design: Dental erosion was evaluated in a random sample of 384 individuals aged 10–15 years attending three primary and high schools in this cross-sectional study. Clinical dental assessment for DE was done using O'Sullivan index. Data on general sociodemographic variables and extrinsic risks factors were obtained. Descriptive and univariate binary logistic regression analyses were performed. Results: Dental erosion was observed in 57.3% of individuals. The univariate binary logistic regression analysis showed that frequency of drinking natural fruit juices (OR 2.670, 95% CI 1.346 – 5.295, P=0.004) and their pH (OR 2.303, 95% CI 1.292 – 4.107, P=0.004) were more associated with the odd of DE in early adolescence. However, a high SES (OR 10.360, 95% CI 3.700 – 29.010, P<0.001) and frequency of snacks with artificial lemon taste (OR 3.659, 95% CI 1.506 – 8.891, P=0.003) were highly associated with the risk of DE in middle adolescence. Conclusions: The results suggest that DE is a prevalent condition in adolescents living in a city in southern Colombia. The transition from early to middle adolescence implies new bio-psychosocial changes, which increase the risk for DE.

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Prevalence and Risk Factors of Dance Injury During COVID-19: A Cross-Sectional Study From University Students in China

Frontiers in Psychology ◽

10.3389/fpsyg.2021.759413 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yanan Dang ◽

Yiannis Koutedakis ◽

Rouling Chen ◽

Matthew A. Wyon

Keyword(s):

Risk Factors ◽

Injury Severity ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Binary Logistic Regression Analysis ◽

Full Time ◽

Training Environment ◽

Severe Injuries ◽

Cross Sectional ◽

Dance Injury

Objectives: Although coronavirus disease 2019 (COVID-19) has transformed the training environment of dancers worldwide, little is known on how this has affected injury prevalence, causes, and risk factors.Methods: An online investigation involving Chinese full-time dance students was conducted (September–November 2020), which covered two 6-month periods just before and during the first COVID-19 lockdown.Results: 2086 students (19 ± 2.4 years) responded to the investigation. Injury prevalence dropped from 39.6% (before the lockdown) to 16.5% (during the lockdown) (p < 0.01). It was noted that a significant increase in injury severity during the lockdown was caused due to a 4.1% increase in moderate-to-severe injuries (p < 0.05). During the lockdown, the injuries on the lower back, feet, and shoulders decreased significantly (p < 0.01), but the knee, ankle, and groin/hip joint injuries remained the same. Fatigue and the recurrence of an old injury remained as the top two perceived causes of an injury between the two periods with the increase in an unsuitable floor (p < 0.01), a cold environment (p < 0.05), and set/props (p < 0.05). The fatigue degree of students decreased (p < 0.01) and their hours of sleep increased (p < 0.01) during the lockdown. Binary Logistic Regression analysis indicated that dance injury is associated with fatigue, the hours of sleep, and the actions taken if they suspect an injury during the lockdown (p < 0.05), but is only related to the time set aside for a cooldown and age before the lockdown period (p < 0.05).Conclusion: Although injury prevalence dropped significantly during the first COVID-19 lockdown in Chinese dance students, the main dance injury characteristics remained the same. Decreased fatigue and longer hours of sleep could explain the aforementioned drop in injury prevalence during the lockdown.

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Depression among predictors of intermittent claudication: A cross-sectional study

Physiology International ◽

10.1556/2060.2021.00186 ◽

2021 ◽

Author(s):

Gergely Tóth-Vajna ◽

Zsombor Tóth-Vajna ◽

Barna Konkoly Thege ◽

Piroska Balog

Keyword(s):

Risk Factors ◽

Intermittent Claudication ◽

Depressive Symptomatology ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Hazardous Drinking ◽

Binary Logistic Regression Analysis ◽

Sectional Study ◽

Cross Sectional ◽

Traditional Risk Factors

Abstract Purpose The aim of the present cross-sectional study was to investigate the relationship between depression and intermittent claudication (IC), independently of traditional risk factors. Main methods The sample consisted of 300 individuals (M age = 65.3 ± 8.7 years, 61.0% female) recruited from the offices of 33 general practitioners. Participants’ medical history and the presence of major cardiovascular risk factors were recorded. Participants completed the Edinburgh Claudication Questionnaire. The role of depression (assessed by a shortened version of the Beck Depression Inventory) in predicting IC was examined using a binary logistic regression analysis – controlled for sex, age, hypertonia, diabetes, smoking, hypercholesterinemia, hazardous drinking, and body mass index (BMI). Results The descriptive data indicated that the prevalence of depression was 57.9% in the IC subgroup and 16.1% in those free of IC. The bivariate analyses indicated that hypercholesterinemia, smoking, hazardous drinking, BMI, and depression were significantly associated with IC. Male sex and age showed a trend toward being a significant correlate of IC. Results of the multivariate analyses indicated that depressive symptomatology was significant in predicting IC (OR: 1.08 (1.05–1.11)), even after controlling for lifestyle and traditional risk factors such as smoking, hazardous drinking, and BMI. Among traditional risk factors, smoking (OR: 2.44 (1.26–4.74)), hazardous drinking (OR: 1.19 (1.02–1.40)), and hypercholesterinemia (OR: 2.17 (1.26–3.75)) showed a significant, positive relationship with IC. Conclusions These results underscore the importance of a multidisciplinary approach that focuses on supporting health-related behavioral changes and managing mental health symptoms when providing care for patients with IC.

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MO376CLINICAL OUTCOMES OF ACUTE KIDNEY INJURY FOLLOWING SNAKE BITE INJURIES

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab082.0030 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Weerakit Naweera ◽

Thapat Wannarong

Keyword(s):

Acute Kidney Injury ◽

Logistic Regression ◽

Kidney Injury ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Renal Recovery ◽

Binary Logistic Regression Analysis ◽

Cross Sectional ◽

Hospital Arrival ◽

Russell’S Viper

Abstract Background and Aims Snakebite is a common animal bite injury in tropical countries. Acute kidney injury (AKI) is an important complication in snakebite patients. This study aimed to comprehensively investigate the clinical profiles and outcomes of patients following hematotoxin-related snakebite associated with kidney impairment. Method We conducted a hospital-based, cross-sectional study of 238 patients with hematotoxin-related snakebite injuries. Data were retrieved from the King Narai Hospital Registry from October 2014 to August 2020. The prevalence of complications associated with snakebite injuries, including acute kidney injury (AKI) and its severity, was determined. Univariate and Multivariate predictors of AKI diagnosis were evaluated using binary logistic regression analysis Results A total of 238 patients, with 63.4% men, median (IQR) age 49.8 (39-61) years and median duration from injury to a hospital arrival of 1 hour (0.5-2) hours, were injured by Green pit viper (85.7%), Russell’s viper (12.6%) and Malayan pit viper (1.7%). AKI mostly occurred in Russell’s viper group 66.7%. An AKI was reported in thirty (12.6%, 95% CI: 8.7 % - 17.5%) patients, with the severity of 66.7% stage one, 6.7% stage two, 26.6% stage three by KDIGO classifications, and 13.3% requiring hemodialysis. Complete renal recovery was seen in twenty-two patients (73.3%), while partial renal recovery was 23.3%. Other complications included 84.4 % limb cellulitis, 4.6% significantly bleeding, 2.5% hypotension, 25.6% prolonged venous clotting time (VCT), 46.7% prolonged prothrombin time (PT), and 14.3% prolonged partial thromboplastin time (PTT). Of total patients, 60.1% were treated with anti-venom. Mortality was relatively low (0.4%). In multivariable logistic regression analyses, AKI was significantly associated with time to hospital arrival more than 3 hours (p = 0.04), Russell’s viper bitten (p = 0.01), clinical bleeding (p = 0.01), and prolonged PT (p < 0.01). Conclusion The prevalence of AKI in patients bitten by hematotoxin snakes was 12.6%, mostly from Russell’s viper. Factors associated with AKI outcomes were time to hospital arrival more than 3 hours, Russell’s viper bitten, clinical bleeding, and prolonged PT. Besides, one-fourth of AKI patients turned to chronic kidney disease.

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Prevalence of risk factors for stuttering among boys: analytical cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2014.1323617 ◽

2014 ◽

Vol 132 (3) ◽

pp. 152-157 ◽

Cited By ~ 2

Author(s):

Cristiane Moço Canhetti Oliveira ◽

Paula Roberta Nogueira

Keyword(s):

Risk Factors ◽

Cross Sectional Study ◽

Physical Stress ◽

Control Group ◽

Sectional Study ◽

Quality Factors ◽

Hearing Disorders ◽

Cross Sectional ◽

Family Attitudes ◽

Developmental Stuttering

CONTEXT AND OBJECTIVE:There have been few studies on the risk factors for subgroups of stuttering. The aim of this study was to characterize the risk factors for developmental familial stuttering among boys who stutter and who do not stutter, such as disfluency types, associated quality and communication factors, emotional and physical stress, familial attitudes and personal reactions.DESIGN AND SETTING:Analytical cross-sectional study with a control group, performed at the Fluency Studies Laboratory of the Department of Speech and Hearing Disorders of a public university.METHODS: The parents of 40 age-matched stuttering and non-stuttering boys took part in this study. The participants were divided into two groups: stuttering children (SC) and non-stuttering children (NSC), with ages between 6 years 0 months and 11 years 11 months. Initially, all of the participants underwent a fluency assessment and then data were gathered using the Protocol for the Risk of Developmental Stuttering.RESULTS:There were no differences in the physical stress distribution factors and personal reactions between the groups. Inappropriate familial attitudes were presented by 95% of the SC and 30% of the NSC. Four risk factors analyzed were not shown by the NSC, namely stuttering-like disfluency, quality factors, physical stress and emotional stresses.CONCLUSIONS:The findings suggest that the presence of stuttering-like disfluency, associated quality and communication factors, emotional stress and inappropriate family attitudes are important risk factors for familial developmental stuttering among boys.

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The Uptake and Vaccination Willingness of COVID-19 Vaccine among Chinese Residents: Web-Based Online Cross-Sectional Study

Vaccines ◽

10.3390/vaccines10010090 ◽

2022 ◽

Vol 10 (1) ◽

pp. 90

Author(s):

Yi Kong ◽

Hao Jiang ◽

Zhisheng Liu ◽

Yi Guo ◽

Dehua Hu

Keyword(s):

Health Status ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Personal Health ◽

Binary Logistic Regression Analysis ◽

Snowball Sampling ◽

Cross Sectional ◽

Web Based ◽

The Difference ◽

High Level

Objective: To investigate the uptake and vaccination willingness of the COVID-19 vaccine among Chinese residents and analyze the difference and factors that impact vaccination. Methods: The snowball sampling method was used to distribute online questionnaires. Relevant sociodemographic data along with the circumstances of COVID-19 vaccination were collected from the respondents. The χ2 test, independent samples t test and binary logistic regression analysis were used to analyze the data. Results: Among 786 respondents, 84.22% had been vaccinated. Over 80% of the vaccinated population have completed all the injections because of supporting the national vaccination policies of China, while the unvaccinated population (23.91%) is mainly due to personal health status. Meanwhile, statistical analysis revealed that the main predictors of not being vaccinated were younger age (3 to 18 years old), personal health status, and lower vaccinated proportion of family members and close friends (p < 0.05). Conclusions: There was a high level of uptake of the COVID-19 vaccine in China, and people who have not been vaccinated generally had a low willingness to vaccinate in the future. Based on our results, it suggested the next work to expand the coverage of the COVID-19 vaccination should be concentrated on targeted publicity and education for people who have not been vaccinated.

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Splenectomy and its relation to non-transfusion-transmitted infection in thalassemic patients

Paediatrica Indonesiana ◽

10.14238/pi46.3.2006.134-8 ◽

2016 ◽

Vol 46 (3) ◽

pp. 134

Author(s):

Mururul Aisyi ◽

Alan Roland Tumbelaka ◽

Bulan Ginting Munthe ◽

Bambang Madiyono

Keyword(s):

Risk Factors ◽

Common Cold ◽

Severe Infection ◽

Cross Sectional Study ◽

Control Group ◽

Transmitted Infection ◽

Cross Sectional ◽

Transfusion Transmitted Infection ◽

Common Group ◽

Level Of Significance

Background Splenectomy has been associated with an increasedsusceptibility to infection. Overwhelming postspelenectomy infec-tion (OPSI) can lead to high mortality. Decreased IgM and tuftsinconcentration on splenectomized patients seems to play a role ininfection’s susceptibility. Many studies have been performed todetermine the risk factors of infection in thalassemic patients.Objective To find out morbidity patterns and risk factors for pre-dicting the likelihood of infection in splenectomized thalassemicpatients.Methods A retrospective cross sectional study was conducted onconfirmed thalassemic children who came to Department of ChildHealth, Cipto Mangunkusumo Hospital within the period of 1973-2003. Splenectomized patients were categorized as cases groupand non-splenectomized patients as control group. Risk factors fordevelopment of common cold and diarrhea were analyzed usingchi-square test with level of significance <0.05.Results A total of 300 thalassemic patients, 100 of them were sple-nectomized, were enrolled in this study. The 15-year-age group orabove is the most common group underwent splenectomy (35%).Common cold is the most common mild infection in both splenec-tomized group (75%) and non-splenectomized (71%). A significantassociation was found between the risk of infection and splenec-tomy in thalassemic patients (OR=3.8;CI=2.2;6.62; P=0.000). As-sociation between time after splenectomy and frequency of com-mon cold in thalassemia was significant (OR=2.85;CI=1.16;7.14;P=0.011). Severe infection and acute diarrhea were considerednot significantly different between the two groups.Conclusion Splenectomy in thalassemia can increase the sus-ceptibility of non-transfusion-transmitted mild infection. Furtherstudy is needed to elaborate this finding

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Short-term residential care for dementia patients: predictors for utilization and expected quality from a family caregiver's point of view

International Psychogeriatrics ◽

10.1017/s1041610209009193 ◽

2009 ◽

Vol 21 (4) ◽

pp. 703-710 ◽

Cited By ~ 13

Author(s):

Carolin Donath ◽

Angelika Winkler ◽

Elmar Gräßel

Keyword(s):

Family Caregivers ◽

Residential Care ◽

Qualitative Content Analysis ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Point Of View ◽

Binary Logistic Regression Analysis ◽

Short Term ◽

Cross Sectional ◽

Dementia Patients

ABSTRACTBackground: Short-term residential care (SRC) has proved to be effective in reducing the burden on family caregivers of dementia patients. Nevertheless, little is known about the factors which influence its usage or the expectations of family caregivers regarding quality. In this paper we address the following questions: (i) which variables of the care situation, the caregivers and their attitudes act as predictors for the utilization of SRC facilities? (ii) What are the views of caregivers about the quality of SRC?Methods: The cross-sectional study was carried out as an anonymous written survey of family caregivers of dementia patients in four regions of Germany. With a 20% response it was possible to analyze the quantitative and qualitative data from 404 and 254 family caregivers respectively. Predictors for utilization were evaluated using binary logistic regression analysis. The answers to questions of quality were evaluated using qualitative content analysis.Results: Significant predictors for the utilization of SRC are the assessment of the helpfulness of SRC and the caregiver's knowledge of the accessibility of SRC facilities. Family caregivers who had already used SRC most frequently expressed the wish for “good care” in SRC facilities, followed by a program of suitable activities for dementia patients.Conclusions: In order to increase the rate of utilization, family caregivers must be convinced of the relevant advantages of using SRC facilities. The staff should be trained in caring for dementia patients and appropriate activities should be available.

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