High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease

Objective: To test the hypothesis that high glycemic diet is related to 1-year change in brain amyloid based on our prior cross-sectional evidence that high glycemic diet is associated with brain amyloid.Methods: This longitudinal, observational study assessed the relationship between reported habitual consumption of a high glycemic diet (HGDiet) pattern and 1-year brain amyloid change measured by Florbetapir F18 PET scans in 102 cognitively normal older adults with elevated or sub-threshold amyloid status that participated in a 1-year randomized, controlled exercise trial at the University of Kansas Medical Center in Kansas City.Results: Among all participants (n = 102), higher daily intake of the HGDiet pattern (β = 0.06, p = 0.04), sugar (β = 0.07, p = 0.01), and total carbohydrate (β = 0.06, p = 0.04) were related to more precuneal amyloid accumulation. These relationships in the precuneus were accentuated in participants with elevated amyloid at enrollment (n = 70) where higher intake of the HGDiet pattern, sugar, and carbohydrate were related to more precuneal amyloid accumulation (β = 0.11, p = 0.01 for all measures). In individuals with elevated amyloid, higher intake of the HGDiet pattern was also related to more amyloid accumulation in the lateral temporal lobe (β = 0.09, p < 0.05) and posterior cingulate gyrus (β = 0.09, p < 0.05) and higher sugar and carbohydrate intake were also related to more amyloid accumulation in the posterior cingulate gyrus (β = 0.10, p < 0.05 for both measures).Conclusion: This longitudinal observational analysis suggests that a high glycemic diet relates to higher brain amyloid accumulation over 1 year in regions of the temporoparietal cortex in cognitively normal adults, particularly in those with elevated amyloid status. Further studies are required to assess whether there is causal link between a high glycemic diet and brain amyloid.Clinical Trial Registration:ClinicalTrials.gov, Identifier (NCT02000583).

Download Full-text

Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer’s Disease Continuum

Journal of Alzheimer s Disease ◽

10.3233/jad-215024 ◽

2021 ◽

pp. 1-12

Author(s):

Takashi Nihashi ◽

Keita Sakurai ◽

Takashi Kato ◽

Kaori Iwata ◽

Yasuyuki Kimura ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Neuropsychological Assessment ◽

Visual Analysis ◽

Amyloid Pet ◽

Cingulate Gyrus ◽

Cognitively Normal ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus ◽

Stage Progression ◽

Normal Individuals

Background: Alzheimer’s disease (AD) is conceptualized as a biological continuum encompassing the preclinical (clinically asymptomatic but with evidence of AD pathology) and clinical (symptomatic) phases. Objective: Using 18F-THK5351 as a tracer that binds to both tau and MAO-B, we investigated the changes in 18F-THK5351 accumulation patterns in AD continuum individuals with positive amyloid PET consisting of cognitively normal individuals (CNp), amnestic mild cognitive impairment (aMCI), and AD and cognitively normal individuals (CNn) with negative amyloid PET. Methods: We studied 69 individuals (32 CNn, 11 CNp, 9 aMCI, and 17 AD) with structural magnetic resonance imaging, 11C-Pittsburgh compound-B (PIB) and 18F-THK5351 PET, and neuropsychological assessment. 18F-THK5351 accumulation was evaluated with visual analysis, voxel-based analysis and combined region of interest (ROI)-based analysis corresponding to Braak neurofibrillary tangle stage. Results: On visual analysis, 18F-THK5351 accumulation was increased with stage progression in the AD continuum. On voxel-based analysis, there was no statistical difference in 18F-THK5351 accumulation between CNp and CNn. However, a slight increase of the bilateral posterior cingulate gyrus in aMCI and definite increase of the bilateral parietal temporal association area and posterior cingulate gyrus/precuneus in AD were detected compared with CNn. On ROI-based analyses, 18F-THK5351 accumulation correlated positively with supratentorial 11C-PIB accumulation and negatively with the hippocampal volume and neuropsychological assessment. Conclusion: The AD continuum showed an increase in 18F-THK5351 with stage progression, suggesting that 18F-THK5351 has the potential to visualize the severity of tau deposition and neurodegeneration in accordance with the AD continuum.

Download Full-text

Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video

Operative Neurosurgery ◽

10.1093/ons/opy347 ◽

2018 ◽

Vol 17 (1) ◽

pp. E19-E20 ◽

Cited By ~ 1

Author(s):

N U Farrukh Hameed ◽

Bin Wu ◽

Fangyuan Gong ◽

Jie Zhang ◽

Hong Chen ◽

...

Keyword(s):

Cingulate Gyrus ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus ◽

Transcortical Approach

Download Full-text

Neural Correlates of Gender Face Perception in Transgender People

Journal of Clinical Medicine ◽

10.3390/jcm9061731 ◽

2020 ◽

Vol 9 (6) ◽

pp. 1731

Author(s):

Alessandra Daphne Fisher ◽

Jiska Ristori ◽

Giovanni Castellini ◽

Carlotta Cocchetti ◽

Emanuele Cassioli ◽

...

Keyword(s):

Neural Development ◽

Gender Discrimination ◽

Group Analysis ◽

Blood Oxygenation ◽

Angular Gyrus ◽

Cingulate Gyrus ◽

Transgender People ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus ◽

Oxygenation Level

To date, MRI studies focused on brain sexual dimorphism have not explored the presence of specific neural patterns in gender dysphoria (GD) using gender discrimination tasks. Considering the central role of body image in GD, the present study aims to evaluate brain activation patterns with 3T-scanner functional MRI (fMRI) during gender face discrimination task in a sample of 20 hormone-naïve transgender and 20 cisgender individuals. Additionally, participants were asked to complete psychometric measures. The between-group analysis of average blood oxygenation level dependent (BOLD) activations of female vs. male face contrast showed a significant positive cluster in the bilateral precuneus in transmen when compared to the ciswomen. In addition, the transwomen group compared to the cismen showed higher activations also in the precuneus, as well as in the posterior cingulate gyrus, the angular gyrus and the lateral occipital cortices. Moreover, the activation of precuneus, angular gyrus, lateral occipital cortices and posterior cingulate gyrus was significantly associated with higher levels of body uneasiness. These results show for the first time the existence of a possible specific GD-neural pattern. However, it remains unclear if the differences in brain phenotype of transgender people may be the result of a sex-atypical neural development or of a lifelong experience of gender non-conformity.

Download Full-text

Do metabolic parameters of posterior cingulate gyrus in multiple sclerosis correlate with the duration of the disease?

European Neuropsychopharmacology ◽

10.1016/s0924-977x(17)31317-2 ◽

2017 ◽

Vol 27 ◽

pp. S713-S714

Author(s):

A. Zacharzewska-Gondek ◽

T.M. Gondek ◽

A. Pokryszko-Dragan ◽

M. Sąsiadek ◽

J. Bladowska

Keyword(s):

Multiple Sclerosis ◽

Metabolic Parameters ◽

Cingulate Gyrus ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus

Download Full-text

P4-161: Incidence and Severity of Deposition of Amyloid beta Protein in the Precuneus and the Posterior Cingulate Gyrus in An Aging Cohort

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.08.220 ◽

2010 ◽

Vol 6 ◽

pp. e71-e71

Author(s):

Hiroyuki Hatsuta ◽

Yuko Saito ◽

Tadashi Adachi ◽

Tomio Arai ◽

Motoji Sawabe ◽

...

Keyword(s):

Amyloid Beta ◽

Amyloid Beta Protein ◽

Cingulate Gyrus ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus

Download Full-text

Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.64.4.552 ◽

1998 ◽

Vol 64 (4) ◽

pp. 552-554 ◽

Cited By ~ 51

Author(s):

N. Hirono ◽

E. Mori ◽

K. Ishii ◽

Y. Ikejiri ◽

T. Imamura ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cingulate Gyrus ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus

Download Full-text

Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer’s Disease

PLoS ONE ◽

10.1371/journal.pone.0105784 ◽

2014 ◽

Vol 9 (8) ◽

pp. e105784 ◽

Cited By ~ 11

Author(s):

Chera L. Maarouf ◽

Tyler A. Kokjohn ◽

Douglas G. Walker ◽

Charisse M. Whiteside ◽

Walter M. Kalback ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Brain Aging ◽

Cingulate Gyrus ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus ◽

Biochemical Assessment

Download Full-text

Magnetic resonance spectroscopy of anoxic brain injury after cardiac arrest

10.1101/2021.05.13.21257029 ◽

2021 ◽

Author(s):

Jong Woo Lee ◽

Lasya Sreepada ◽

Matthew B Bevers ◽

Karen Li ◽

Benjamin M Scirica ◽

...

Keyword(s):

Cardiac Arrest ◽

Brain Injury ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Cingulate Gyrus ◽

Posterior Cingulate ◽

Posterior Cingulate Gyrus ◽

Anoxic Injury ◽

Clinical Mri

Objective: We describe magnetic resonance spectroscopy (MRS) changes in comatose patients undergoing targeted temperature management (TTM) after cardiac arrest, and their relationships to relevant clinical, MRI, and EEG variables. Methods A prospective cohort of 50 patients was studied. The primary outcome was coma recovery to follow commands. Comparison of MRS measures in the posterior cingulate gyrus, parietal white matter, basal ganglia, and brainstem were also made to 25 normative control subjects. Results: Fourteen of 50 achieved coma recovery. Compared to patients who recovered, there was a significant decrease in total N-acetyl-aspartate (NAA/Cr) and glutamate; and an increase in lactate (Lac/Cr) and glutamine in patients who did not recover, with changes most prominent in the posterior cingulate gyrus. Patients who recovered had a decrease in NAA/Cr as compared to control subjects. Coma recovery was seen in patients with a moderate decrease in NAA/Cr, but the appearance of lactate resulted in a poor outcome. NAA/Cr had a linear relationship with MRI cortical apparent diffusion coefficient (ADC); lactate level exponentially increased with decreasing ADC. EEG suppression/burst suppression was universally associated with lactate elevation. Conclusions NAA and lactate changes are associated with clinical/MRI/EEG changes consistent with anoxic brain injury and are most prominent in the posterior cingulate gyrus. NAA/Cr decrease observed in patients with good outcomes suggests mild anoxic injury in patients asymptomatic at hospital discharge. The appearance of cortical lactate represents a deterioration of aerobic energy metabolism and is associated with EEG background suppression, synaptic transmission failure, and severe, potentially irreversible anoxic injury.

Download Full-text