scholarly journals Progress of MRI Radiomics in Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Xue-Qin Gong ◽  
Yun-Yun Tao ◽  
Yao–Kun Wu ◽  
Ning Liu ◽  
Xi Yu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Histological Grade ◽  
Microvascular Invasion ◽  
Diagnosis And Treatment ◽  
Research Progress ◽  
Imaging Method ◽  
Imaging Data ◽  
Magnetic Resonance Imaging Mri ◽  
High Throughput Imaging

BackgroundHepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third leading cause of cancer-related death. Although the diagnostic scheme of HCC is currently undergoing refinement, the prognosis of HCC is still not satisfactory. In addition to certain factors, such as tumor size and number and vascular invasion displayed on traditional imaging, some histopathological features and gene expression parameters are also important for the prognosis of HCC patients. However, most parameters are based on postoperative pathological examinations, which cannot help with preoperative decision-making. As a new field, radiomics extracts high-throughput imaging data from different types of images to build models and predict clinical outcomes noninvasively before surgery, rendering it a powerful aid for making personalized treatment decisions preoperatively.ObjectiveThis study reviewed the workflow of radiomics and the research progress on magnetic resonance imaging (MRI) radiomics in the diagnosis and treatment of HCC.MethodsA literature review was conducted by searching PubMed for search of relevant peer-reviewed articles published from May 2017 to June 2021.The search keywords included HCC, MRI, radiomics, deep learning, artificial intelligence, machine learning, neural network, texture analysis, diagnosis, histopathology, microvascular invasion, surgical resection, radiofrequency, recurrence, relapse, transarterial chemoembolization, targeted therapy, immunotherapy, therapeutic response, and prognosis.ResultsRadiomics features on MRI can be used as biomarkers to determine the differential diagnosis, histological grade, microvascular invasion status, gene expression status, local and systemic therapeutic responses, and prognosis of HCC patients.ConclusionRadiomics is a promising new imaging method. MRI radiomics has high application value in the diagnosis and treatment of HCC.

Diagnosis and treatment of microvascular invasion in hepatocellular carcinoma

2019 ◽  
Vol 52 (2) ◽  
pp. 55-68
Author(s):  
Rui-Sheng Ke ◽  
Qiu-cheng Cai ◽  
Yong-tai Chen ◽  
Li-Zhi Lv ◽  
Yi Jiang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion ◽  
Diagnosis And Treatment

scholarly journals The clinical significance of microvascular invasion in the surgical planning and postoperative sequential treatment in hepatocellular carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wentao Wang ◽  
Yaxun Guo ◽  
Jingtao Zhong ◽  
Qi Wang ◽  
Xin Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Tumors ◽  
Treatment Plan ◽  
Microvascular Invasion ◽  
Sequential Treatment ◽  
Postoperative Treatment ◽  
Research Progress ◽  
Comprehensive Treatment ◽  
Term Survival ◽  
Preoperative Prediction

AbstractHepatocellular carcinoma (HCC) is one of the most common and most lethal malignant tumors in the world. Microvascular invasion (MVI) is a major risk factor for survival outcomes and intrahepatic metastasis after resection in patients with HCC. Relevant English literatures retrieved using PubMed on the research progress of MVI in patients with HCC were reviewed. For HCC patients, especially those with MVI, it is very important to develop a comprehensive and sequential treatment plan to support the long-term survival of patients. This manuscript reviewed and analyzed the risk factors for MVI; the preoperative prediction of MVI, which informs the selection of surgical strategies; and the current situation and future direction of comprehensive postoperative treatment strategies; to provide a basis for the comprehensive treatment of HCC patients with MVI. For HCC patients with MVI, the preoperative prediction of MVI may play a certain guiding role in planning procedures, and the comprehensive sequential postoperative pathological detection of HCC MVI may provide a basis for treatment decisions.

scholarly journals Research Progress on Circular RNA in Glioma

2021 ◽  
Vol 11 ◽  
Author(s):  
Mengyu Chen ◽  
Chunyan Yan ◽  
Xihe Zhao
Keyword(s):  
Gene Expression ◽  
Early Diagnosis ◽  
Tumor Development ◽  
Circular Rna ◽  
Diagnosis And Treatment ◽  
Research Progress ◽  
Cyclic Structure ◽  
Original Function ◽  
Non Coding Rna ◽  
Potential Biomarker

The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure. They are highly expressed, spatiotemporal-specific and conservative across species. Importantly, circRNA participates in the occurrence of many kinds of tumors and regulates the tumor development. Glioma is featured by limited therapy and grim prognosis. Cancer-associated circRNA compromises original function or creates new effects in glioma, thus contributing to oncogenesis. Therefore, this article reviews the biogenesis, metabolism, functions and properties of circRNA as a novel potential biomarker for gliomas. We elaborate the expression characteristics, interaction between circRNA and other molecules, aiming to identify new targets for early diagnosis and treatment of gliomas.

scholarly journals Applications of Contemporary Imaging Modalities in Orthodontics

2021 ◽  
Vol 38 (SI-2) ◽  
pp. 104-112
Author(s):  
Emre CESUR ◽  
Kaan ORHAN
Keyword(s):  
Magnetic Resonance Imaging ◽  
Treatment Planning ◽  
Diagnosis And Treatment ◽  
Cone Beam ◽  
Imaging Method ◽  
Resonance Imaging ◽  
Panoramic Radiographs ◽  
Advantages And Disadvantages ◽  
Cone Beam Computerized Tomography ◽  
Magnetic Resonance Imaging Mri

The validity of orthodontic diagnosis and treatment planning depends on the accuracy of the photos, models and radiograps to be obtained from the patient. One of the most important parts of diagnosis and treatment planning is the use of appropriate imaging method. Although lateral cephalometric radiographs are still the most preferred imaging method, other methods such as hand-wrist radiographs, panoramic radiographs, cone beam computerized tomography (CBCT), magnetic resonance imaging (MRI), and ultrasound are also frequently used. For this reason, it is important to know the advantages and disadvantages of all imaging methods for orthodontists in order to select the most suitable method for the patient.

Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplanation

2001 ◽  
Vol 120 (5) ◽  
pp. A90-A90
Author(s):  
N ESNAOLA ◽  
G LAUWERS ◽  
N MIRZA ◽  
D NAGORNEY ◽  
D DOHERTY ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion

Expression of β-Catenin in Hepatocellular Carcinoma

2001 ◽  
Vol 71 (3) ◽  
pp. 116-125
Author(s):  
Norina Basa ◽  
Daniela Lazar ◽  
Remus Cornea ◽  
Sorina Taban ◽  
Melania Ardelean ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Mitotic Index ◽  
Histological Grade ◽  
Proliferation Index ◽  
Tumor Cell Proliferation ◽  
Ki 67 ◽  
B Virus ◽  
Development And Evolution

Alteration of β-catenin expression is involved in the development and evolution of hepatocellular carcinoma (HCC); β-catenin is able to influence tumor cell proliferation. We analyzed the immunohistochemical (IHC) expression of β-catenin on a group of 32 patients diagnosed with HCC using the anti-β-catenin monoclonal antibody (clone E247). We correlated the expression of β-catenin with the proliferation index of Ki-67 (PI Ki-67), the mitotic index (MI) and other clinical and pathological features. We observed an altered β-catenin expression in 58.38% of all HCC cases. This expression was insignificantly correlated with tumor size (]5 cm) (p = 0.683), histological grade G1-G2 (p = 0.307), vascular invasion (p = 0.299) and advanced pT stage (p = 0.453); we obtained a significantly higher MI in HCC with altered β-catenin expression (p = 0.018), as compared to HCC without overexpression (1.66 � 1.37) (p = 0.038) and a PI Ki-67 of 22.49 � 20.1 and 28.24 � 18.2, respectively in tumors with altered β-catenin expression with insignificant differences compared to HCC without overexpression (25.95 � 15.2) (p = 0.682 and p = 0.731, respectively). According to the results we obtained, aberrant β-catenin expression in HCC was correlated with a high mitotic index, therefore playing an important role in tumor progression by stimulating tumor cell proliferation; non-nuclear β-catenin overexpression can have a pathological significance in HCC, especially in cases of HCC associated with hepatitis B virus (HBV) infection.

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