scholarly journals Factors Influencing Vitamin D Levels in Neonatal Umbilical Cord Blood: A Two-Center Study From Tibet and Shenyang

2020 ◽  
Vol 8 ◽  
Author(s):  
Mingli Yu ◽  
Xiuxiu Liu ◽  
Jiujun Li
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cord Blood ◽  
Sea Level ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Calcium ◽  
Factors Influencing ◽  
Vitamin D Levels ◽  
Calcium Phosphorus

Objective: To investigate the factors influencing the levels of vitamin D (vitD) in the umbilical cord blood of neonates born in Naqu, Tibet (4,500 m above sea level), and Shenyang, Liaoning Province (500 m above sea level).Methods: This prospective study was conducted from June 2017 to October 2018 in Naqu (the plateau group) and Shenyang, (the non-plateau group). Healthy mothers that gave birth to healthy neonates of >2,000g after 38 weeks' gestation were enrolled in the study, as were their neonates. After separation of serum from the umbilical cord and mothers for routine biochemical tests, discarded samples were remained for analyses of vitD, calcium, phosphorus, alkaline phosphatase (ALP) and parathyroid hormone (PTH). Questionnaires were developed covering the demographic characteristics and possible risk factors for neonatal vitD deficiency of mothers. Statistical analysis was performed to identify associations between the calcium, phosphorus, ALP, PTH, maternal factors and neonatal vitD levels.Results: In total, 295 neonates and 225 mothers were enrolled in the study. VitD deficiency was common in neonates and mothers. The risk of vitD deficiency was higher in the plateau group than in the non-plateau group. The mean levels of 25-hydroxy vitD (25(OH)D) in mothers and neonates from the plateau group were 8.49 ± 4.12 ng/mL and 10.17 ± 5.07 ng/mL, respectively. Such levels were significantly lower than those in the non-plateau group (19.77 ± 9.57 ng/mL and 23.93 ± 11.01 ng/mL, respectively). The vitD levels of neonates and mothers were highest in the summer and lowest in the winter. Cord blood vitD was positively correlated with the vitD levels in mothers' serum (r = 0.75, P < 0.05). Increased PTH levels in mothers and decreased cord blood calcium levels were risk factors for neonatal vitD deficiency. A lack of vitD supplementation during pregnancy was associated with an 8.91-fold higher probability of neonatal vitD deficiency (OR = 8.91, 95% CI = 1.521–9.429, P < 0.001).Conclusions: The levels of neonatal and maternal vitD in the plateau group were generally lower than those in the non-plateau group. VitD supplementation during pregnancy could effectively reduce the risk of vitD deficiency in neonates.

scholarly journals Seasonal variation of serum 25(OH) vitamin D levels in maternal and umbilical cord blood in Japanese women

2019 ◽  
Vol 66 (1.2) ◽  
pp. 128-133 ◽  
Author(s):  
Eishi Sogawa ◽  
Takashi Kaji ◽  
Soichiro Nakayama ◽  
Atsuko Yoshida ◽  
Naoto Yonetani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Japanese Women ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Ethnic differences in umbilical cord blood vitamin D and parathyroid hormone – South Asians compared to Whites born in the UK

2010 ◽  
Vol 23 (11) ◽  
pp. 1315-1317 ◽  
Author(s):  
Raashda A. Sulaiman ◽  
Caroline L. Sharratt ◽  
Pek-wan Lee ◽  
Alyson Skinner ◽  
Melanie J. Griffiths ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Ethnic Differences ◽  
Umbilical Cord Blood ◽  
South Asians ◽  
The Uk

Incidence and risk factors of food allergy after umbilical cord blood transplantation in children

2017 ◽  
Vol 5 (6) ◽  
pp. 1789-1791 ◽  
Author(s):  
Alfonso Hernández-Ojeda ◽  
Nicolás Rojas ◽  
Francisco Barriga ◽  
María Angélica Wietstruck ◽  
Pamela S. Morales ◽  
...  
Keyword(s):  
Risk Factors ◽  
Food Allergy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Blood Transplantation

scholarly journals Increased Levels of Umbilical Cord Blood Interleukin-6 (IL-6) and Serum C-Reactive Protein (CRP) in Premature Infants of Vitamin D Deficient Mothers

2021 ◽  
pp. 21-25
Author(s):  
Lisnawati Yuyun ◽  
Marianna Yesy ◽  
Rinawati Rohsiswatmo
Keyword(s):  
Vitamin D ◽  
Umbilical Cord ◽  
Premature Infants ◽  
Umbilical Cord Blood ◽  
Serum Vitamin ◽  
C Reactive Protein ◽  
Serum Vitamin D ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Serum Crp

Objective: Increased levels of inflammatory factors in newborns are often associated with lower maternal vitamin D levels. This study aimed to find out the relationship between maternal and umbilical cord vitamin D serum levels on umbilical cord Interleukin-6 (IL-6) and serum C-Reactive Protein (CRP) levels in premature infants.Methods: The study was an observational analytic, cross-sectional design in mothers who underwent preterm birth at 28-34 weeks' gestation due to premature rupture of membranes (PROM) and their infants at Dr. Cipto Mangunkusumo General Hospital (RSCM), Jakarta and Persahabatan General Hospital, Jakarta, from January 2017 to August 2018. Levels of serum vitamin D of the maternal and umbilical cord, umbilical cord IL-6 and serum CRP in premature infants were recorded. Vitamin D level was divided into deficiency (<10 ng/mL), insufficiency (10–29 ng/mL), and normal (>30 ng/mL) groups. The relationship of vitamin D levels with IL-6 and CRP was carried out using Kruskal Wallis test.Results: A total of 70 subjects met the research criteria. Umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers were higher (20.31 pg/mL and 0.50 mg/L) compared to insufficient (3.34 pg/mL and 0.45 mg/L) and  normal  mothers (3.29 pg/mL and 0.30 mg/L), although  not  statistically  significant (IL-6 p = 0.665, CRP p = 0.89). Referring to the umbilical cord blood vitamin D levels, the results were different and not as expected, in which the umbilical cord IL-6 and serum CRP levels of preterm infants in the deficiency (3.76 pg/mL and 0.35 mg/L) and insufficiency (3.37 pg/mL and 0.40 mg/L) groups were lower (IL-6) and not different (CRP) than the normal group (9.41 pg/mL and 0.40 mg/L).Conclusion: There were an increasing tendency for umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers although these were not statistically significant. Based on the levels of vitamin D umbilical cord blood, the CRP levels in the serum of premature infants were not different, while the IL-6 levels in the deficiency and insufficiency group were lower than in the normal group.Keywords: CRP, IL-6, maternal vitamin D, umbilical cord vitamin D.   Abstrak Tujuan: Peningkatan kadar faktor inflamasi pada  bayi baru lahir sering dikaitkan dengan rendahnya kadar vitamin D ibu. Penelitian ini bertujuan untuk mengetahui hubungan kadar serum vitamin D ibu dan tali pusat, dengan kadar IL-6 tali pusat dan serum C-Reactive Protein (CRP) bayi prematur.Metode: Studi observasional analitik dengan desain potong lintang pada  subjek  ibu yang mengalami kelahiran prematur di usia 28–34 minggu kehamilan disebabkan ketuban pecah dan bayi yang dilahirkannya, di  Rumah   Sakit  Umum  Pusat  Nasional dr. Cipto Mangunkusumo (RSCM) dan Rumah Sakit Umum Pusat Persahabatan, Jakarta, pada bulan Januari 2017 sampai Agustus 2018.  Variabel data adalah kadar serum vitamin D ibu dan tali pusat, kadar serum IL-6 tali pusat dan  kadar  CRP  darah  bayi.  Kadar vitamin D (25(OH)D) dibagi menjadi defisiensi (<10 ng/mL), insufisiensi (10–29 ng/mL) dan normal (>30 ng/mL) dan dicari hubungannya dengan kadar IL-6 tali pusat dan serum CRP bayi prematur, menggunakan uji Kruskal Wallis. Hasil: Sebanyak  70  subjek  telah memenuhi kriteria penelitian.  Kadar IL-6 tali pusat dan serum CRP bayi prematur dari kelompok ibu defisiensi vitamin D (20,31 pg/ml dan 0,50 mg/L) lebih tinggi dibandingkan kelompok ibu insufisiensi vitamin D (3,34 pg/mL dan 0,45 mg/L) maupun kelompok ibu normal vitamin D (3,29 pg/mL dan 0,30 mg/L) tetapi perbedaan tersebut tidak bermakna (IL-6 p=0,665 dan CRP p = 0,899).   Mengacu pada kadar vitamin D darah tali pusat didapatkan hasil yang berbeda dan tidak sesuai harapan, dimana tali pusat IL-6 dan serum CRP bayi prematur mengalami defisiensi (3,76 pg / mL dan 0,35 mg / L) dan insufisiensi. (3,37 pg / mL dan 0,40 mg / L) kelompok lebih rendah (IL-6) dan tidak berbeda (CRP) dibandingkan kelompok normal (9,41 pg / mL dan 0,40 mg / L).Kesimpulan: Didapat kecenderungan peningkatan kadar IL-6 darah tali pusat dan serum CRP bayi prematur dari ibu dengan defisiensi kadar vitamin D walaupun secara statistik tidak signifikan. Berdasarkan kelompok vitamin D darah tali pusat, kadar CRP serum bayi prematur tidak berbeda, sedangkan kadar IL-6 pada kelompok defisiensi dan insufisiensi lebih rendah dibandingkan pada kelompok normal.Kata kunci: CRP, IL-6, vitamin D ibu, vitamin D tali pusat.  

scholarly journals Umbilical Cord Blood Culture in General in the Diagnosis of Sageis Newborns

2020 ◽  
pp. 126-131
Author(s):  
Naredra P. Porval ◽  
Kanvikar Reshmi ◽  
D. B. Potdar ◽  
S. B. Karanjkar
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
High Risk ◽  
Blood Culture ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Neonatal Sepsis ◽  
Venous Blood ◽  
Peripheral Venous Blood

Worldwide neonatal sepsis is among the most frequent causes of neonatal death. Various studies have tried to establish the relationship between prevalence of neonatal septicemia risk factors and bacteriological profiling, low birth weight, prematurity, etc. Current study was aimed to compare early onset of neonatal sepsis (EONS) among primigravida and multigravida mothers using umbilical cord blood (UCB) and peripheral venous blood (PVB) samples. It was also aimed to establish the utilization of umbilical cord blood culture (UCBC) in comparison to peripheral venous blood culture (PVBC) in identifying EONS. In present study the blood samples were collected from high risk neonates for the clinical blood culture and screening. Among the 75 neonates in the study, 24 (32.0%) were observed to have sepsis screen positive. Study of high risk neonates umbilical cord blood culture (UCBC) positivity was 17.3% while Peripheral Venous blood culture positivity was 5.3%. Moreover,  in this study all risk factors like Prematurity, Low birth weights, Premature rupture of membrane, and birth asphyxia were significantly (p<0.05) associated with UCBC growth/positivity. Low birth weight (86%) was mostly reported in the high risk neonates with other associated sepsis factors. Similarly maternal fever and prolonged rupture of membrane was highly significantly (p<0.01) associated with UCBC positivity. Gram negative bacterias  were  more  commonly found,  such as Pseudomonas (5.3%), followed by E. coli (4%), and Klebsiella (2.7%) and gram positive Streptococcus sp. (2.7%), etc. From our analysis it can be said that the UCBC has strong diagnostic outcomes as compared to the PVBC for etiological evaluation of bacterial sepsis in neonates at high risk.

Pre-Emptive Rituximab for the Prevention of EBV-Related PTLD in Umbilical Cord Blood Transplantion Patients

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3031-3031
Author(s):  
Sheila Mitsuma ◽  
Jose Licona ◽  
Robert Lynch ◽  
Amy Sievers ◽  
Corey Cutler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cumulative Probability ◽  
High Risk Population ◽  
Viral Loads ◽  
Ebv Dna ◽  
Ebv Viremia

Abstract Abstract 3031 Objective: We observed a high rate of Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) in our umbilical cord blood transplantation (UCBT) patients. We retrospectively analyzed all UBCTs performed at our institution in order to 1) define risk factors for the development of PTLD and 2) assess whether pre-emptive therapy with rituximab (RTX) altered the incidence and outcomes of PTLD in patients with EBV viremia. Patients and Methods: One hundred twenty-seven patients underwent UCBTs, with primarily double cord units, between March 2003 and April 2010. EBV viral loads were monitored by quantitative PCR. Viremia was defined as any detectable level of EBV DNA in peripheral blood. EBV events included all cases of isolated viremia, sustained viremia (≥ 2 positive viral loads on two separate dates), or biopsy/autopsy proven PTLD. One to four weekly doses of RTX (375mg/m2) were given pre-emptively to prevent PTLD in patients with sustained viremia. The frequency of monitoring, the decision to treat with RTX and the duration of treatment were at the clinician's discretion. Fisher's exact test and Cox modeling were used to evaluate the effect of clinical variables on the probability of developing PTLD. Results: Cohort Characteristics: Ninety-nine of 127 patients (77%) underwent reduced-intensity conditioning (RIC) transplantion. Eighty-five (86%) of those who received RIC transplants were conditioned with fludarabine, melphalan and anti-thymocyte globulin (ATG). Seventy-nine of the 99 patients (80%) who underwent RIC transplantation received ATG doses at 6mg/kg or greater. PTLD rate and risk factors: Thirty-three patients (26%) had an EBV event. 9 patients (7%) had isolated viremia. No patient with isolated viremia was treated with RTX and none developed PTLD. 11 patients developed sustained viremia but not PTLD. Thirteen patients (10%) had biopsy-proven PTLD, a one-year cumulative probability of 12% (95% CI, 0.08–0.15). All patients who developed PTLD underwent RIC transplant and received at least 6mg/kg of ATG. ATG use was found to be a statistically significant risk factor for PTLD (p = 0.02) yet ATG use was not associated with decreased survival. Age, primary disease, degree of HLA match, graft-versus-host disease (GVHD) and type of GVHD prophylaxis were not identified as PTLD risk factors. Effect of pre-emptive rituximab: 14 patients developed sustained viremia and did not have clinical evidence of PTLD at the time viremia was detected (12%). Twelve of these patients were treated pre-emptively with RTX. EBV DNA became undetectable in 9 of 12 (67%) of these patients, none of whom developed PTLD. EBV viremia resolved in 1 patient without RTX; this patient did not develop PTLD. One patient died of other causes before RTX could be given. Viremia initially cleared in one patient who later progressed to PTLD but achieved complete remission after treatment with virus-specific cytotoxic T-lymphocytes (CTL). Viremia did not resolve in 2 patients, both of whom developed PTLD. Despite treatment with virus-specific CTL both died of PTLD. The adjusted hazard ratio (HR) for the development of PTLD among patients with sustained viremia was 230 (95% CI, 29–1856); the adjusted HR of pre-emptive rituximab was 0.24 (95% CI, 0.07 – 0.9). Conclusions: ATG doses of 6mg/kg or greater were associated with PTLD in the UBCT population. Isolated EBV viremia was not a risk factor for the development of PTLD. Sustained EBV viremia conferred considerable risk. This risk of developing PTLD in patients with sustained viremia was reduced when RTX was given as pre-emptive therapy in this cohort. Further studies to better define the optimal duration of RTX therapy are needed. Prophylactic immune reconstitution with closely HLA-matched virus-specific CTL may also be an alternative option in this high-risk population. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document