scholarly journals Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections

2021 ◽  
Vol 9 ◽  
Author(s):  
Tejas P. Joshi ◽  
Sara Anvari ◽  
Meera R. Gupta ◽  
Carla M. Davis ◽  
Joud Hajjar
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Immunoglobulin E ◽  
Skin Infections ◽  
Severe Eczema ◽  
Bacterial Skin Infections

The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and recurrent bacterial skin infections.

Right frontotemporal craniotomy for ECA-to-MCA direct and indirect bypass and occipital artery indirect bypass to the posterior circulation: case report

2020 ◽  
pp. 1-5
Author(s):  
Mitchell W. Couldwell ◽  
Samuel Cheshier ◽  
Philipp Taussky ◽  
Vance Mortimer ◽  
William T. Couldwell
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Posterior Circulation ◽  
Occipital Artery ◽  
Transient Ischemic Attacks ◽  
Collateral Vessel ◽  
Suboccipital Craniotomy ◽  
Uncommon Disease ◽  
Indirect Revascularization ◽  
The Brain

Moyamoya is an uncommon disease that presents with stenoocclusion of the major vasculature at the base of the brain and associated collateral vessel formation. Many pediatric patients with moyamoya present with transient ischemic attacks or complete occlusions. The authors report the case of a 9-year-old girl who presented with posterior fossa hemorrhage and was treated with an emergency suboccipital craniotomy for evacuation. After emergency surgery, an angiogram was performed, and the patient was diagnosed with moyamoya disease. Six months later, the patient was treated for moyamoya using direct and indirect revascularization; after surgery there was excellent vascularization in both regions of the bypass and no further progression of moyamoya changes. This case illustrates a rare example of intracerebral hemorrhage associated with moyamoya changes in the posterior vascularization in a pediatric patient and subsequent use of direct and indirect revascularization to reduce the risk of future hemorrhage and moyamoya progression.

Candida spp. In linear gingival erythema lesions in HIV- infeceted children: reports of six cases

2013 ◽  
Author(s):  
Maristela Barbosa Portela,
Keyword(s):  
Case Report ◽  
Hiv Infection ◽  
Pediatric Patients ◽  
Predictive Marker ◽  
Etiologic Agent ◽  
Candida Spp ◽  
Oral Manifestation ◽  
Oral Candidosis ◽  
Positive Growth ◽  
Microbiological Analyses

Linear gingival erythema (LGE), formally referred as HIV-gingivitis, is the most common form of HIV-associated periodontal disease in HIV-infection. These lesions were recently evaluated as a possible form of erythematous oral candidosis, mainly caused by Candida albicans. Other species are also being associated such as C. tropicalis, C. stellatoidea, C. krusei, C. parapsilosis, C. glabrata and C. dubliniensis, that was identified in some HIV-infected subjects. This case report demonstrates the presence of typical LGE lesions in six HIV-infected children, also investigates the etiologic agent by microbiological exams and correlates this oral manifestation with patients’ systemic conditions. Microbiological analyses showed positive growth for Candida spp in all patients, all of whom had severe imunessupression. After antifungal medication, the regression of lesions could be note. The presence of LGE in pediatric patients with AIDS may indicate its feature as a predictive marker in progression of HIV-infection in children.

scholarly journals Antibacterial, antioxidant, and sun protection potential of selected ethno medicinal plants used for skin infections in Uganda

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Jane Namukobe ◽  
Peter Sekandi ◽  
Robert Byamukama ◽  
Moses Murungi ◽  
Jennifer Nambooze ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Inhibitory Concentration ◽  
Antioxidant Properties ◽  
Sun Protection ◽  
Albino Rats ◽  
Skin Infections ◽  
Double Beam ◽  
Protection Potential ◽  
Bacterial Skin Infections

Abstract Background Rural populations in Uganda rely heavily on medicinal plants for the treatment of bacterial skin infections. However, the efficacy of these medicinal plants for their pharmacological action is not known. The study aimed at evaluating the antibacterial, antioxidant, and sun protection potential of Spermacoce princeae, Psorospermum febrifugum, Plectranthus caespitosus, and Erlangea tomentosa extracts. Methods The plant samples were extracted by maceration sequentially using hexane, dichloromethane, ethyl acetate, methanol, and distilled water. Antibacterial activity of each extract was carried out using an agar well diffusion assay against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonie, Streptococcus pyogenes, and Salmonella typhi. Acute dermal toxicity of the aqueous extract of S. princeae and P. febrifugum, and E. tomentosa was assessed in young adult healthy Wistar albino rats at a dose of 8000 and 10,000 mg/kg body weight. The antioxidant activity of each extract was carried out using a 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The sun protection factor was determined using Shimadzu UltraViolet-Visible double beam spectrophotometer between 290 and 320 nm. Results The plant extracts showed good antibacterial activity against the tested bacterial strains with minimum inhibitory concentration (MIC) ranging between 3.12 and 12.5 mg/ml. There was no significant change in the levels of creatinine, alanine aminotransferase, and aspartate aminotransferase in the rats even at a higher dose of 10,000 mg/kg, which was related to the results of biochemical analysis of the blood samples from the treated and control groups. The aqueous and methanol extracts of S. princeae showed potential antioxidant properties, with half maximal inhibitory concentration (IC50) values of 59.82 and 61.20 μg/ml respectively. The organic and aqueous extracts of P. caespitosus showed high levels of protection against Ultraviolet light with sun protection potential values ranging between 30.67 and 37.84. Conclusions The study demonstrated that the selected medicinal plants possessed good antibacterial, antioxidant, and sun protection properties. Therefore, the plants are alternative sources of antibacterial, antioxidant, and sun protection agents in managing bacterial skin infections.

SKIN INFECTIONS IN PEDIATRIC PATIENTS

2001 ◽  
pp. 211-232
Author(s):  
Michelle R. Wanna ◽  
Jonathan A. Dyer
Keyword(s):  
Pediatric Patients ◽  
Skin Infections

Extensive Extraneural Metastases of Cerebral Glioblastoma in a Pediatric Patient: An Extreme Case Report and Comprehensive Review of the Literature

2021 ◽  
pp. 1-6
Author(s):  
Kadir Oktay ◽  
Dogu Cihan Yildirim ◽  
Arbil Acikalin ◽  
Kerem Mazhar Ozsoy ◽  
Nuri Eralp Cetinalp ◽  
...  
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Extreme Case ◽  
Rare Condition ◽  
Review Of The Literature ◽  
Pertinent Literature ◽  
Cervical Lymph Nodes ◽  
Case Presentation ◽  
Comprehensive Review ◽  
Extraneural Metastases

<b><i>Introduction:</i></b> Extraneural metastases of glioblastoma are very rare clinical entities, especially in pediatric patients. Because of their rarity, they can be confused with other pathological processes. <b><i>Case Presentation:</i></b> We report a case of 16-year-old boy with extensive extraneural metastases of glioblastoma. Lung, liver, cervical lymph nodes, skin, and bone metastases were detected in the patient. <b><i>Conclusion:</i></b> We describe the presentation, evaluation, and diagnosis of this rare condition with regard to pertinent literature.

A STUDY ON THE CLINICAL AND SUB-CLINICAL FEATURES OF BACTERIAL SKIN INFECTIONS

2020 ◽  
pp. 56-61
Author(s):  
Anh Mai Ba Hoang ◽  
Phuong Nguyen Thi Thanh ◽  
My Nguyen Thi Tra ◽  
Nguyen Le Thi Cao ◽  
Nam Tran Ngoc Khanh
Keyword(s):  
Systemic Effect ◽  
High Rate ◽  
Skin Infections ◽  
Age Group ◽  
Normal Number ◽  
Dermatology Clinic ◽  
Functional Symptoms ◽  
Common Skin ◽  
Keywords Infection ◽  
Bacterial Skin Infections

Background: Bacterial skin infections are common due to the bacteral invasion into the skin and cause a variety of clinical manifestation. In order to assess the characteristics of this group, we conducted this study to evaluate the clinical and main subclinical features. Methods: A total of 95 patients were diagnosed with bacterial skin infections at Dermatology Clinic of Hue University of Medicine and Pharmacy Hospital from June 2015 to May 2016, of which 34 patients had some tests and 19 patients had samples for culture. Results: The age group of 16 - 30 years old was the most popular: 50.5%; High rate of patients came for consultation in winter (49.5%), most patients had no fever. For functional symptoms, pain accounted for the highest proportion: 71.6%. The most common skin lesion was nodule: 38.8%, the lower extremities were the most common position: 38.9%. Furuncle had the highest incidence: 45.3%. For main laboratory tests, most patients had a normal number of leucocyte: 71.4%; ESR increased by two times accounting for a rate of 20.6%; culture results showed Staphylococcus aureus being a highest percentage: 57.9%. Conclusion: Most skin infections localized and were less systemic effect, the most common agent was S. aureus. Keywords: infection, bacteria, skin, fever, S. aureus

Pediatric Anastomosing Hemangioma: Case Report and Review of Renal Vascular Tumors in Children

2018 ◽  
Vol 22 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Alvin B Caballes ◽  
Agustina D Abelardo ◽  
Miguel J Farolan ◽  
Januario Antonio D Veloso
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Wilms Tumor ◽  
Vascular Lesion ◽  
Renal Tumors ◽  
Vascular Tumors ◽  
Malignant Neoplasms ◽  
Therapeutic Implications ◽  
Renal Vascular ◽  
Anastomosing Hemangioma

The case involves a 10-year-old child who underwent a left radical nephrectomy for what was believed to be a Wilms’ tumor. Histopath examination indicated a benign vascular lesion, subsequently determined to be an anastomosing hemangioma of the kidney. A comparison with the previously cited pediatric patients with renal vascular tumors is provided, and the inconsistent diagnostic terminologies for these conditions are highlighted. The therapeutic implications of these predominantly benign renal tumors, in the context of the much more frequently encountered malignant neoplasms in children, are additionally discussed.

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