Risk Factors for Progression of Chronic Kidney Disease With Glomerular Etiology in Hospitalized Children

Low-level cadmium exposure has adverse effects on chronic kidney disease (CKD); however, the risk factors for elevated blood cadmium levels (BCLs) have not been studied in CKD. We conducted a cross-sectional investigation in 200 CKD patients and stratified them by the tertiles of BCL to compare their demographic, environmental, and biochemical data. The factors associated with BCL were identified, and their effects were examined in subgroups. In the analyses, female sex, smoking, and CKD stage 5D were associated with high BCL, and statin was inversely correlated with BCL (odds ratio [95% confidence interval, CI], 6.858 [2.381–19.746], p < 0.001, 11.719 [2.843–48.296], p = 0.001, 30.333 [2.252–408.520], p = 0.010, and 0.326 [0.122–0.873], p = 0.026; deviations of BCL [nmol/L, 95% CI], 2.66 [1.33–4.00], p < 0.001, 3.68 [1.81–5.56], p < 0.001, 3.38 [0.95–5.82], p = 0.007, and −2.07 [−3.35–−0.78], p = 0.002). These factors were also independently correlated with BCL in subgroups, including non-dialysis CKD, hypertensive patients, non-smokers, and male patients. In conclusion, female sex, smoking, and CKD stage 5D were the major risk factors for elevated BCL; additionally, statins were negatively associated with BCL in CKD.

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POS-495 RISK FACTORS ASSOCIATED WITH MORTALITY AMONG CHRONIC KIDNEY DISEASE PATIENTS ON REGULAR HEMODIALYSIS PRESENTING IN EMERGENCY SERVICES

Kidney International Reports ◽

10.1016/j.ekir.2021.03.522 ◽

2021 ◽

Vol 6 (4) ◽

pp. S214

Author(s):

T.M. SHRESTHA ◽

P.N. Prasad ◽

L. Bhusal ◽

R.P. Neupane ◽

R. Ghimire

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Emergency Services ◽

Factors Associated ◽

Regular Hemodialysis

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Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA study

Nefrología (English Edition) ◽

10.1016/j.nefroe.2021.08.002 ◽

2021 ◽

Vol 41 (3) ◽

pp. 337-346

Author(s):

Lidia Martínez Fernández ◽

J. Emilio Sánchez-Alvarez ◽

César Morís de la Tassa ◽

José Joaquín Bande Fernández ◽

Virtudes María ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Factors Associated ◽

Valvular Calcification ◽

Disease Analysis

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MO515CONSTIPATION IN CHRONIC KIDNEY DISEASE: PREVALENCE AND RISK FACTORS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab087.0035 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Sourabh Sharma ◽

Neha Sharma ◽

Kailash Sharma

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Tertiary Care ◽

Functional Constipation ◽

Common Symptom ◽

Psychological Burden ◽

Ckd Stage ◽

Stool Form ◽

Rome Iv

Abstract Background and Aims Among various gastrointestinal disorders, constipation is one of the most common symptom in chronic kidney disease (CKD). However it is often neglected by nephrologists as self-limiting condition. Constipation impacts quality of life in multiple ways and increases socio-psychological burden. Constipation and associated risk factors have been poorly studied and most studies are retrospective. Method We enrolled CKD stage 3 to 5 patients on regular follow-up with nephrologist from June 2018 to June 2020, at a tertiary care centre in North India. Constipation was defined using Rome IV criteria (Functional constipation) which is composed of six constipation related symptoms, and diagnosis of constipation is established by presence of two or more symptoms for at least 3 months. Patients were also asked to maintain a 7 day prospective stool diary. It consisted of seven day written prospective chart of stool form and frequency. Patients were instructed to record when each bowel movement happened and to mark stool form type for each movement as described in words and pictures on Bristol Stool Form Scale (BSFS). Opioid induced constipation was defined as per Rome IV criteria. The diagnostic criteria is similar to functional constipation, but with requisite that new or worsening symptoms occurred when initiating, changing or increasing opioid therapy. Results Two hundred twenty five patients were studied out of which 59 (26.2%) patients were in CKD stage3, eighty one (36%) patients were in CKD stage4 and 85 (37.8%) patients were in stage5. Out of 85 CKD stage5 patients, 23 (27%) were on dialysis. Mean age of patients was 49.1 years. Out of 225 patients, 135 (60%) were male. Constipation symptoms and diagnosis reported in each stage has been depicted in Table 1. Clinical correlates of constipation has been depicted in Table 2. Conclusion Constipation measured using Rome IV criteria affects around two-third of CKD stage 3-5 patients. Diabetes, hypertension and opioid use has been found to be significantly associated with constipation.

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Beberapa Faktor Risiko Kejadian Penyakit Ginjal Kronik (PGK) Stadium V pada Kelompok Usia Kurang dari 50 Tahun (Studi di RSUD dr.H.Soewondo Kendal dan RSUD dr.Adhyatma,MPH Semarang)

Jurnal Epidemiologi Kesehatan Komunitas ◽

10.14710/jekk.v3i1.3099 ◽

2018 ◽

Vol 3 (1) ◽

pp. 1

Author(s):

Ariyanto Ariyanto ◽

Suharyo Hadisaputro ◽

Lestariningsih Lestariningsih ◽

Mateus Sakundarno Adi

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Herbal Medicine ◽

Energy Drink ◽

Regression Result ◽

Age Group ◽

Case Control Studies ◽

Ckd Stage ◽

Energy Drink Consumption

Background: Chronic Kidney Disease (CKD) stage V is an end-stage chronic kidney disease characterized by glomerular filtration rate less than 15 mL /min /1.73 m2 and require dialysis therapy. The purpose of this study to prove risk factors the occurrence of CKD Vin the age group of less than 50 years. Method: This study was a mixed method, case-control studies design were inforced with indepht interview. Total respondents were 124 (62 cases and 62 controls) that taken by consecutive sampling. Research instrument was a questionnaire interview. Data analysis using univariate, bivariate (chi-square) and multivariate (logistic regression). Result: The variables that proved to be a risk factor for CKD V in the age group of less than 50 years were supplement energy drink consumption > 4 times/week (p=0.038; 95%CI = 1.063-7.944; OR=2.905), smoking ≥ 10 ciggarets/day (p=0.011; 95%CI=1.384-11.920; OR=4.061), and herbal medicine consumption > 4 times/week (p=0.007; 95%CI=1.431-9.949; OR=3.773). Variables that not proved were the consumption of coffee, supplements of vitamin C, soft drinks, alcohol, and NSAIDs. Qualitative results stated that the respondents consumed energy drink supplements to increase their stamina, smoke because it has become a habit, and consume herbal medicines because seen more natural and cure the sciatica fastly.Conclusion: Risk factors for the occurrence of CKD V in the age group of less than 50 years were the supplement energy drink consumption> 4 times/week, smoking ≥ 10 ciggarets/day, and the consumption of herbal medicine> 4 times/week.

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Beberapa Faktor Risiko Kejadian Penyakit Ginjal Kronik (PGK) Stadium V pada Kelompok Usia Kurang dari 50 Tahun (Studi di RSUD dr.H.Soewondo Kendal dan RSUD dr.Adhyatma,MPH Semarang)

Jurnal Epidemiologi Kesehatan Komunitas ◽

10.14710/j.e.k.k.v3i1.3099 ◽

2018 ◽

Vol 3 (1) ◽

pp. 1

Author(s):

Ariyanto Ariyanto ◽

Suharyo Hadisaputro ◽

Lestariningsih Lestariningsih ◽

Mateus Sakundarno Adi

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Herbal Medicine ◽

Energy Drink ◽

Regression Result ◽

Age Group ◽

Case Control Studies ◽

Ckd Stage ◽

Energy Drink Consumption

Background: Chronic Kidney Disease (CKD) stage V is an end-stage chronic kidney disease characterized by glomerular filtration rate less than 15 mL /min /1.73 m2 and require dialysis therapy. The purpose of this study to prove risk factors the occurrence of CKD Vin the age group of less than 50 years. Method: This study was a mixed method, case-control studies design were inforced with indepht interview. Total respondents were 124 (62 cases and 62 controls) that taken by consecutive sampling. Research instrument was a questionnaire interview. Data analysis using univariate, bivariate (chi-square) and multivariate (logistic regression). Result: The variables that proved to be a risk factor for CKD V in the age group of less than 50 years were supplement energy drink consumption > 4 times/week (p=0.038; 95%CI = 1.063-7.944; OR=2.905), smoking ≥ 10 ciggarets/day (p=0.011; 95%CI=1.384-11.920; OR=4.061), and herbal medicine consumption > 4 times/week (p=0.007; 95%CI=1.431-9.949; OR=3.773). Variables that not proved were the consumption of coffee, supplements of vitamin C, soft drinks, alcohol, and NSAIDs. Qualitative results stated that the respondents consumed energy drink supplements to increase their stamina, smoke because it has become a habit, and consume herbal medicines because seen more natural and cure the sciatica fastly.Conclusion: Risk factors for the occurrence of CKD V in the age group of less than 50 years were the supplement energy drink consumption> 4 times/week, smoking ≥ 10 ciggarets/day, and the consumption of herbal medicine> 4 times/week.

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Factors Associated with Functional Capacity in CKD Patients

Clinical Nursing Research ◽

10.1177/1054773820958540 ◽

2020 ◽

pp. 105477382095854

Author(s):

Emanuele Poliana Lawall Gravina ◽

Bruno Valle Pinheiro ◽

Luciana Angélica da Silva Jesus ◽

Fabrício Sciammarella Barros ◽

Leda Marília Fonseca Lucinda ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Functional Capacity ◽

Family Income ◽

Chronic Kidney Disease Stage ◽

Disease Stage ◽

Life Questionnaire ◽

Factors Associated ◽

Ckd Stage ◽

Related Quality

To evaluate the factors associated with functional capacity in patients with chronic kidney disease (CKD). All patients were submitted to six-minute walk test (6MWT), 10-repetition sit-to-stand test (STS-10) and SF-36 health-related quality of life questionnaire (HRQoL). Patients with functional capacity ≥80% exhibited higher education level, family income, body mass index, estimated glomerular filtration rate, and lower age and STS-10 time. Multiple linear regression showed that gender, age, family income, chronic kidney disease stage, STS-10 time, and physical component summary of HRQoL were significantly associated with the 6MWT distance. Functional capacity was significantly associated with gender, age, family income, CKD stage, STS-10 time, and physical component of HRQoL. The progression of CKD has an impact on the decrease in functional capacity in these patients.

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P0718HEALTH CARE COSTS IN CHRONIC KIDNEY DISEASE: A LONGITUDINAL STUDY FROM THE PIRP COHORT

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0718 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Paola Rucci ◽

Dino Gibertoni ◽

Claudio Voci ◽

Maria Pia Fantini ◽

Marcora Mandreoli ◽

...

Keyword(s):

Health Care ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Direct Costs ◽

Study Cohort ◽

Local Health Authority ◽

Progression Rate ◽

Ckd Stage ◽

Per Capita ◽

Care Costs

Abstract Background and Aims Health care costs in patients with chronic kidney disease (CKD) vary widely according to patients’ severity. In patients followed up in a community-based project, it is of interest to determine cost variations over time, as a result of treatment and CKD progression. The aim of the study was to estimate the costs incurred by the health care system for CKD patients in an Italian region. Method Patients recruited in the Emilia-Romagna (Italy) PIRP project in the years 2007-2014 with CKD stage 3a to 5 were included in the study. Patients were stratified at baseline into 7 groups at different risk of progression according to the CT-PIRP classification (Rucci et al., A clinical stratification tool for chronic kidney disease progression rate based on classification tree analysis, NDT 2014). To calculate the annual medical costs, we multiplied the number of services used by the respective unit cost. Per capita costs were obtained dividing overall costs by person-years. We used DRG tariffs as a proxy of costs for hospital admissions, the regional nomenclator for outpatient visits and lab tests, and cost unit for prescribed drugs. Mixed effects generalized linear models were used to estimate the annual direct costs of CT-PIRP groups, adjusted for calendar year of entry in PIRP and local health authority of residence. Results The study cohort includes 7737 CKD patients, aged 73.2±11.6 years, 64.5% males, mostly in CKD stage 4 (3136, 40.5%) and 3b (2799, 36.2%); 697 patients (9.0%) entered the study at stage 5. The CT-PIRP classification and frequency distribution is shown in Tab.1. After 4 years, 5017 (64.8%) were still alive, 1743 (22.5%) died, 546 (7.2%) were on ESKD and 422 (5.5%) were lost. The overall direct costs of patients while still enrolled in the PIRP project decreased from 36.89 million € in the first year to 32.22 in the fourth year, while the per capita annual median costs were stable around 2200 €. The cost breakdown showed a decrease of hospitalization and drugs costs and an increase in specialty visits costs (Fig.1). The model-estimated average annual costs were significantly higher for proteinuric, low GFR patients of CT-PIRP groups 2 and 3 (7239 € and 8825 € respectively), while non-diabetic, younger patients of group 5 determined a significantly lower burden (3350 €).

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