scholarly journals The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease

2021 ◽  
Vol 18 (23) ◽  
pp. 12337
Author(s):  
Kai-Fan Tsai ◽  
Pai-Chin Hsu ◽  
Chia-Te Kung ◽  
Chien-Te Lee ◽  
Huey-Ling You ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Odds Ratio ◽  
Cross Sectional ◽  
Factors Associated ◽  
Female Sex ◽  
Ckd Stage ◽  
Blood Cadmium ◽  
Male Patients

Low-level cadmium exposure has adverse effects on chronic kidney disease (CKD); however, the risk factors for elevated blood cadmium levels (BCLs) have not been studied in CKD. We conducted a cross-sectional investigation in 200 CKD patients and stratified them by the tertiles of BCL to compare their demographic, environmental, and biochemical data. The factors associated with BCL were identified, and their effects were examined in subgroups. In the analyses, female sex, smoking, and CKD stage 5D were associated with high BCL, and statin was inversely correlated with BCL (odds ratio [95% confidence interval, CI], 6.858 [2.381–19.746], p < 0.001, 11.719 [2.843–48.296], p = 0.001, 30.333 [2.252–408.520], p = 0.010, and 0.326 [0.122–0.873], p = 0.026; deviations of BCL [nmol/L, 95% CI], 2.66 [1.33–4.00], p < 0.001, 3.68 [1.81–5.56], p < 0.001, 3.38 [0.95–5.82], p = 0.007, and −2.07 [−3.35–−0.78], p = 0.002). These factors were also independently correlated with BCL in subgroups, including non-dialysis CKD, hypertensive patients, non-smokers, and male patients. In conclusion, female sex, smoking, and CKD stage 5D were the major risk factors for elevated BCL; additionally, statins were negatively associated with BCL in CKD.

scholarly journals Metabolic Syndrome and Smoking Are Associated with Future Development of Advanced Chronic Kidney Disease in Older Adults

2015 ◽  
Vol 6 (2) ◽  
pp. 108-115 ◽  
Author(s):  
Andrea R. Zammit ◽  
Mindy J. Katz ◽  
Carol Derby ◽  
Markus Bitzer ◽  
Richard B. Lipton
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cox Proportional Hazards ◽  
Hazard Ratio ◽  
Care Practice ◽  
Cross Sectional ◽  
Ckd Stage

Introduction: Metabolic syndrome (MetS) and smoking have been identified as risk factors for chronic kidney disease (CKD) in cross-sectional studies in various age groups, but longitudinal data on progression of CKD in older adults are limited. Our objectives were to examine whether MetS and its components and smoking predict the onset of CKD stage 3b (CKD-3b) in older adults. Methods: A subset of participants of the Einstein Aging Study who were free of diabetes, dementia, and CKD-3b at enrollment were included in this analysis. CKD-3b was defined as an estimated glomerular filtration rate <45 ml/min/1.73 m2. Cox proportional hazards models were used in these analyses. Results: In total, 413 ≥70-year-old individuals were eligible for this study. 65.4% were female and 26.6% were black. 22.3% of the participants had MetS at baseline, 4.4% were active smokers, and 6.1% developed CKD-3b over a mean of 4 years of follow-up. MetS and smoking independently predicted incident CKD in our fully adjusted model (hazard ratio 3.65, 95% CI 1.20-10.60, p = 0.022; hazard ratio 29.69, 95% CI 4.47-197.23, p = 0.000). Conclusion: MetS and smoking are associated with an increased incidence of CKD-3b. These risk factors are modifiable, easily identified and prevented through better health care practice and early diagnosis.

scholarly journals The Relationship between Demographic Status and Comorbid Disease with the Risk of Chronic Kidney Disease in the Cut Meutia Hospital, Aceh Utara Regency

2020 ◽  
Vol 3 (3) ◽  
pp. 2090-2101
Author(s):  
Anita Marlina ◽  
Said Usman ◽  
Yusni Yusni ◽  
Maimun Syukri ◽  
Hanifa Yusuf
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Secondary Data ◽  
P Value ◽  
Cross Sectional ◽  
Factors Associated ◽  
The Status ◽  
The Republic ◽  
The Relationship

This research aims to analyze the risk factors associated of Chronic Kidney Disease (CKD). This research was conducted in Rumah Sakit Umum Cut Meutia (RSUCM) North Aceh. Based on the Law of the Republic of Indonesia No. 39 Year 2009 regarding the prevention and control of disease not contagious is an attempt to improve the health of the community through activities promotive and preventive. This research is a cross sectional analytic research with a retrospective approach, this research is by searching the previous data. The data used in this study are secondary data at Rumah Sakit Umum Cut Meutia (RSUCM), North Aceh Regency in 2019, which aims to analyze risk factors associated with Chronic Kidney Disease (CKD). This research was conducted at Rumah Sakit Umum Cut Meutia (RSUCM), North Aceh District from 8 to 9 June 2020. The population included in this study were all patients with chronic kidney disease who received treatment at the Cut Meutia General Hospital in North Aceh Regency for the period January - December 2019 as many as 640 people.There is a relationship between the status of the demographics on the gender with risk the occurrence of disease chronic kidney where p value 0,452. There is relationship between disease comorbid in hypertension with the risk of the occurrence of disease chronic kidney where p value by 0,000. The relationship between disease comorbid in diabetes risk the occurrence of disease chronic kidney where p value by 0,000.

scholarly journals Risk Factors for Progression of Chronic Kidney Disease With Glomerular Etiology in Hospitalized Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Guohua He ◽  
Chenglong Li ◽  
Xuhui Zhong ◽  
Fang Wang ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Migration Rate ◽  
Primary Outcome ◽  
Study Cohort ◽  
Glomerular Diseases ◽  
Medical Migration ◽  
Factors Associated ◽  
Ckd Stage

Aim: To Identify association between risk factors to Chronic kidney disease (CKD) stage 5 in children with glomerular diseases in children in China.Methods: The Hospital Quality Monitoring System database was used to extract data for the study cohort. The primary outcome included progression to CKD stage 5 or dialysis. Cox regression was used to assess potential risk factors. Patients with lower stages (CKD stage 1 and 2) and higher stages (CKD stage 3 and 4) at baseline were analyzed separately.Results: Of 819 patients (4,089 hospitalization records), 172 (21.0%) patients reached the primary outcome during a median followed-up of 11.4 months. In the lower stages group, factors associated with the primary outcome included older age [Hazard Ratio (HR), 1.21; 95% confidence interval (CI), 1.10–1.34] and out-of-pocket payment (HR, 4.14; 95% CI, 1.57–10.95). In the higher stages group, factors associated with the primary outcome included CKD stage 4 (HR, 2.31; 95% CI, 1.48–3.62) and hypertension (HR, 1.99; 95% CI, 1.29–3.07). The medical migration rate was 38.2% in this study population.Conclusion: There are different risk factors for progression to the primary outcome in different stages in CKD with glomerular etiology. Further prospective studies are needed to assess these risk factors. The high medical migration rate reflected the regional disparities in the accessibility of pediatric kidney care between regions.

scholarly journals Risk factors associated with mortality in COVID-19 patients in Nishtar Hospital Multan.

2021 ◽  
Vol 28 (12) ◽  
pp. 1696-1700
Author(s):  
Zahra Nazish ◽  
Fatima Tu Zahra ◽  
Haroon Aziz Khan Babar
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Heart Disease ◽  
Respiratory Failure ◽  
Kidney Disease ◽  
Urban Areas ◽  
Cross Sectional ◽  
X Ray ◽  
Factors Associated ◽  
Chest X Ray

Objective: To identify risk factors associated with mortality in COVID-19. Study Design: Retrospective Cross Sectional Study. Setting: Nishtar Hospital Multan. Period: April 2020 to September 2020. Material & Methods: Charts of all PCR confirmed COVID-19 cases expired during the study period. Results: Out of 96 cases, 62(64.6%) were male and 34(35.4%) were  female. 65(67.7%) were from urban areas. Niney two(95.8%) patients had a co-morbid condition. Fifty two(54.2%) had diabetes, 42(43.8%) had hypertension, 29(30.20%) had heart disease, 21(21.9%) had chronic kidney disease and 14(14.5%) had chronic lung disease and 5(5,2%) had chronic liver disease. Mean respiratory rate was 25.01±7.80, mean SaO2 was73.99±17.53 and 59.37% had bilateral infiltrates on chest X-ray. Mean CRP was 59.95±46.28, mean S/LDH was 765.92 ±266.61, mean S/Ferritin was 1446.00±1261.69 and mean D-Dimers were 1.26±0.45µg/ml. 35(36.45%) had sepsis, 26(27.08%) had cytokine storm, 17(17.7%) had respiratory failure and 13(13.5%) had hypotension. Conclusion: Male gender, old age, diabetes, hypertension, Ischemic heart disease and chronic kidney disease were associated with increased mortality in COVID 19. Tachypnea, hypoxia, bilateral infiltrates on chest X-ray and raised inflammatory markers also had poor prognosis. Sepsis, Cytokine release syndrome, shock, and respiratory failure were common complications. These high risk patients with COVID 19 should be timely admitted and managed aggressively to improve outcome.

scholarly journals Evaluation of carotid intima media thickness and associated risk factors in patients with chronic kidney disease: a cross sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 526
Author(s):  
Mote Srikanth ◽  
Jeyapalan Kuppusamy ◽  
Hemachandar Radhakrishnan ◽  
Arun Prasath Palamalai
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ckd Stage

Background: Chronic kidney disease is distinguished by progressive loss of kidney function over a period of years in the end leading to irreversible kidney failure. CKD is a significant prognosticator of cardiovascular disease. Atherosclerosis is common in patients with risk factors associated with chronic kidney disease.Methods: It was a cross sectional study on CKD patients in a tertiary care hospital. About 90 CKD stage 3-5 patients aged above 18 years were enrolled in the study. Serum lipid profile, RFT, serum calcium, phosphorous, and BP were estimated among all the patient. Patient risk factors were noted and CIMT levels were compared accordingly.Results: Out of 90 patients, males were predominant. There was a significant positive correlation between stage 5 and CIMT (P value <0.001). Mean CIMT was higher in patients with type 2 Diabetes. Patients with higher phosphorous the mean CIMT was significantly higher.Conclusions: The CIMT is early marker for atherosclerosis. Author observed it was significantly higher in patients with stage 3 and 5 CKD. CIMT is a non- invasive marker which should be done in all patients with CKD which is cost effective.

scholarly journals Heart Rate Variability and Long Chain n-3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2453
Author(s):  
Ana M Pinto ◽  
Helen L MacLaughlin ◽  
Wendy L Hall
Keyword(s):  
Chronic Kidney Disease ◽  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Kidney Disease ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Death ◽  
Cross Sectional ◽  
Ckd Stage ◽  
Long Chain

Low heart rate variability (HRV) is independently associated with increased risk of sudden cardiac death (SCD) and all cardiac death in haemodialysis patients. Long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) may exert anti-arrhythmic effects. This study aimed to investigate relationships between dialysis, sleep and 24 h HRV and LC n-3 PUFA status in patients who have recently commenced haemodialysis. A cross-sectional study was conducted in adults aged 40–80 with chronic kidney disease (CKD) stage 5 (n = 45, mean age 58, SD 9, 20 females and 25 males, 39% with type 2 diabetes). Pre-dialysis blood samples were taken to measure erythrocyte and plasma fatty acid composition (wt % fatty acids). Mean erythrocyte omega-3 index was not associated with HRV following adjustment for age, BMI and use of β-blocker medication. Higher ratios of erythrocyte eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) were associated with lower 24 h vagally-mediated beat-to-beat HRV parameters. Higher plasma EPA and docosapentaenoic acid (DPAn-3) were also associated with lower sleep-time and 24 h beat-to-beat variability. In contrast, higher plasma EPA was significantly related to higher overall and longer phase components of 24 h HRV. Further investigation is required to investigate whether patients commencing haemodialysis may have compromised conversion of EPA to DHA, which may impair vagally-mediated regulation of cardiac autonomic function, increasing risk of SCD.

scholarly journals FGF-23 and Phosphate in Children with Chronic Kidney Disease: A Cross-Sectional Study in Kazakhstan

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 15
Author(s):  
Altynay Balmukhanova ◽  
Kairat Kabulbayev ◽  
Harika Alpay ◽  
Assiya Kanatbayeva ◽  
Aigul Balmukhanova
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fibroblast Growth Factor 23 ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ckd Stage ◽  
Advanced Stages ◽  
Fgf 23 ◽  
Stage 1

Background and objectives: Chronic kidney disease (CKD) in children is a complex medical and social issue around the world. One of the serious complications is mineral-bone disorder (CKD-MBD) which might determine the prognosis of patients and their quality of life. Fibroblast growth factor 23 (FGF-23) is a phosphaturic hormone which is involved in the pathogenesis of CKD-MBD. The purpose of the study was to determine what comes first in children with CKD: FGF-23 or phosphate. Materials and Methods: This cross-sectional study included 73 children aged 2–18 years with CKD stages 1–5. We measured FGF-23 and other bone markers in blood samples and studied their associations. Results: Early elevations of FGF-23 were identified in children with CKD stage 2 compared with stage 1 (1.6 (1.5–1.8) pmol/L versus 0.65 (0.22–1.08), p = 0.029). There were significant differences between the advanced stages of the disease. FGF-23 correlated with PTH (r = 0.807, p = 0.000) and phosphate (r = 0.473, p = 0.000). Our study revealed that the elevated level of FGF-23 went ahead hyperphosphatemia and elevated PTH. Thus, more than 50% of children with CKD stage 2 had the elevating level of serum FGF-23, and that index became increasing with the disease progression and it achieved 100% at the dialysis stage. The serum phosphate increased more slowly and only 70.6% of children with CKD stage 5 had the increased values. The PTH increase was more dynamic. Conclusions: FGF-23 is an essential biomarker, elevates long before other markers of bone metabolism (phosphate), and might represent a clinical course of disease.

scholarly journals Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA study

2021 ◽  
Vol 41 (3) ◽  
pp. 337-346
Author(s):  
Lidia Martínez Fernández ◽  
J. Emilio Sánchez-Alvarez ◽  
César Morís de la Tassa ◽  
José Joaquín Bande Fernández ◽  
Virtudes María ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Factors Associated ◽  
Valvular Calcification ◽  
Disease Analysis

MO515CONSTIPATION IN CHRONIC KIDNEY DISEASE: PREVALENCE AND RISK FACTORS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Sourabh Sharma ◽  
Neha Sharma ◽  
Kailash Sharma
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Functional Constipation ◽  
Common Symptom ◽  
Psychological Burden ◽  
Ckd Stage ◽  
Stool Form ◽  
Rome Iv

Abstract Background and Aims Among various gastrointestinal disorders, constipation is one of the most common symptom in chronic kidney disease (CKD). However it is often neglected by nephrologists as self-limiting condition. Constipation impacts quality of life in multiple ways and increases socio-psychological burden. Constipation and associated risk factors have been poorly studied and most studies are retrospective. Method We enrolled CKD stage 3 to 5 patients on regular follow-up with nephrologist from June 2018 to June 2020, at a tertiary care centre in North India. Constipation was defined using Rome IV criteria (Functional constipation) which is composed of six constipation related symptoms, and diagnosis of constipation is established by presence of two or more symptoms for at least 3 months. Patients were also asked to maintain a 7 day prospective stool diary. It consisted of seven day written prospective chart of stool form and frequency. Patients were instructed to record when each bowel movement happened and to mark stool form type for each movement as described in words and pictures on Bristol Stool Form Scale (BSFS). Opioid induced constipation was defined as per Rome IV criteria. The diagnostic criteria is similar to functional constipation, but with requisite that new or worsening symptoms occurred when initiating, changing or increasing opioid therapy. Results Two hundred twenty five patients were studied out of which 59 (26.2%) patients were in CKD stage3, eighty one (36%) patients were in CKD stage4 and 85 (37.8%) patients were in stage5. Out of 85 CKD stage5 patients, 23 (27%) were on dialysis. Mean age of patients was 49.1 years. Out of 225 patients, 135 (60%) were male. Constipation symptoms and diagnosis reported in each stage has been depicted in Table 1. Clinical correlates of constipation has been depicted in Table 2. Conclusion Constipation measured using Rome IV criteria affects around two-third of CKD stage 3-5 patients. Diabetes, hypertension and opioid use has been found to be significantly associated with constipation.

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