scholarly journals New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Minghai Shao ◽  
Chaoyang Ye ◽  
George Bayliss ◽  
Shougang Zhuang
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Efficacy ◽  
Chronic Renal Disease ◽  
Salvia Miltiorrhiza ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Clinical Effects ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.

scholarly journals Prescribed Renoprotective Chinese Herbal Medicines Were Associated with a Lower Risk of All-Cause and Disease-Specific Mortality among Patients with Chronic Kidney Disease: A Population-Based Follow-Up Study in Taiwan

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Chuan-Fa Hsieh ◽  
Huan-Cheng Chang ◽  
Song-Lih Huang ◽  
Chien-Lung Chen ◽  
Wei-Ta Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lower Risk ◽  
Salvia Miltiorrhiza ◽  
Herbal Medicines ◽  
Population Based ◽  
Cordyceps Sinensis ◽  
Angelica Sinensis ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Chinese herbal medicines (CHMs) containing aristolochic acid (AA) are associated with chronic kidney disease (CKD), but some prescribed CHMs have been shown to possess renoprotective effects. We conducted a nationwide retrospective cohort study to delineate the role of prescribed CHMs on the CKD progression. Renoprotective CHM (RPCHM) was defined if a CHM contained dong chong xia cao (Cordyceps sinensis (Berk.) Sacc.), da huang (Rheum palmatum L), huang qi (Astragalus membranaceus), dan shen (Salvia miltiorrhiza Bge.), and dong quai (Angelica sinensis (Oliv.) Diels) or belonged to specific mixture herbal formulations (Yishen capsule, Saireito, or Wen Pi Tang). Subjects who had ever used AA-containing CHMs, had cancer or HIV prior to CKD diagnosis, or died within the first month of CKD diagnosis were excluded. A total of 11,625 patients were eligible subjects. The adjusted hazard ratio (aHR) for all-cause mortality was 0.6 (p < 0.001) and 0.6 (p = 0.013) among subjects receiving RPCHMs containing Angelica sinensis and those receiving other RPCHMs, respectively. For CKD-related mortality, the aHR among subjects receiving RPCHMs containing Angelica sinensis was 0.6 (p = 0.025). The use of specific RPCHMs, especially those that contained Angelica sinensis, was associated with a lower risk of mortality among CKD patients.

scholarly journals Mechanisms and Efficacy of Chinese Herbal Medicines in Chronic Kidney Disease

2021 ◽  
Vol 11 ◽  
Author(s):  
Mingming Zhao ◽  
Yi Yu ◽  
Rumeng Wang ◽  
Meiying Chang ◽  
Sijia Ma ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Clinical Trials ◽  
Kidney Disease ◽  
Molecular Mechanisms ◽  
Herbal Medicines ◽  
Small Sample ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Anti Inflammatory ◽  
Meta Analyses

As the current treatment of chronic kidney disease (CKD) is limited, it is necessary to seek more effective and safer treatment methods, such as Chinese herbal medicines (CHMs). In order to clarify the modern theoretical basis and molecular mechanisms of CHMs, we reviewed the knowledge based on publications in peer-reviewed English-language journals, focusing on the anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated and antifibrotic effects of CHMs commonly used in kidney disease. We also discussed recently published clinical trials and meta-analyses in this field. Based on recent studies regarding the mechanisms of kidney disease in vivo and in vitro, CHMs have anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic effects. Several well-designed randomized controlled trials (RCTs) and meta-analyses demonstrated that the use of CHMs as an adjuvant to conventional medicines may benefit patients with CKD. Unknown active ingredients, low quality and small sample sizes of some clinical trials, and the safety of CHMs have restricted the development of CHMs. CHMs is a potential method in the treatment of CKD. Further study on the mechanism and well-conducted RCTs are urgently needed to evaluate the efficacy and safety of CHMs.

scholarly journals Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaolei Zhao ◽  
Jingxiang Pang ◽  
Jialei Fu ◽  
Meina Yang ◽  
Eduard Van Wijk ◽  
...  
Keyword(s):  
Photon Emission ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Bioactive Constituents ◽  
Curative Effect ◽  
Active Compounds ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Living Organisms ◽  
Natural Medicines

Ultraweak photon emission emitted by all living organisms has been confirmed to be a noninvasive indicator for their physiological and pathological characteristics. In this study, we investigated the characteristics of spontaneous photon emission (SPE) and the contents of specific active compounds of roots and flowers buds of several fresh Chinese herbal medicines (natural medicines) with different growth ages and varieties. The results revealed that the contents of specific active compounds from same species herbs with different growth ages and varieties were significantly different, and this difference could be reflected by their SPE. Because the contents of specific bioactive constituents in Chinese herbs are closely related to their quality and curative effect, the SPE measurement technique may contribute to the quality control of Chinese herbal medicine in the future.

scholarly journals Chinese herbal medicines with beneficial effects

2021 ◽  
Vol 1 (2) ◽  
pp. 79-83
Author(s):  
De-an Guo ◽  
Wenlong Wei ◽  
Changliang Yao ◽  
Jianqing Zhang ◽  
Qirui Bi
Keyword(s):  
Herbal Medicines ◽  
Extreme Environment ◽  
Chinese Herbs ◽  
Exploration And Exploitation ◽  
Chinese Herbal Medicines ◽  
Beneficial Effects ◽  
Medical Needs ◽  
Chinese Herbal ◽  
Potential Applications ◽  
Herbal Species

Abstract Among the vast resources of traditional Chinese medicine (TCM) herbal species, only a handful of Chinese herbs are growing in frigid regions or extreme environment but they have a unique property. The most recognizable TCM herb falling in this category is Panax ginseng, which is widely considered the representative tonic herb with oceans of beneficial effects on human health. In this article, we will introduce several typical Chinese herbal medicines with beneficial effects aiming to arouse broader attention from the scientific community to expand the exploration and exploitation on this for their potential applications to meet the increasingly demanding medical needs.

scholarly journals Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2303 ◽  
Author(s):  
Ke Han ◽  
Lei Zhang ◽  
Miao Wang ◽  
Rui Zhang ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Virtual Screening ◽  
Chinese Herbal Medicine ◽  
Screening Method ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Prediction Methods ◽  
Chinese Herbal Medicines ◽  
Advantages And Disadvantages ◽  
Chinese Herbal

Chinese herbal medicine has recently gained worldwide attention. The curative mechanism of Chinese herbal medicine is compared with that of western medicine at the molecular level. The treatment mechanism of most Chinese herbal medicines is still not clear. How do we integrate Chinese herbal medicine compounds with modern medicine? Chinese herbal medicine drug-like prediction method is particularly important. A growing number of Chinese herbal source compounds are now widely used as drug-like compound candidates. An important way for pharmaceutical companies to develop drugs is to discover potentially active compounds from related herbs in Chinese herbs. The methods for predicting the drug-like properties of Chinese herbal compounds include the virtual screening method, pharmacophore model method and machine learning method. In this paper, we focus on the prediction methods for the medicinal properties of Chinese herbal medicines. We analyze the advantages and disadvantages of the above three methods, and then introduce the specific steps of the virtual screening method. Finally, we present the prospect of the joint application of various methods.

Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases

2021 ◽  
pp. 1-20
Author(s):  
Jun-Yuan Zhang ◽  
Qian-Qian Chen ◽  
Jia Li ◽  
Lei Zhang ◽  
Lian-Wen Qi
Keyword(s):  
Sialic Acid ◽  
Cardiovascular Diseases ◽  
Chinese Herb ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Scutellariae Radix ◽  
Cytoplasmic Vesicles

Neuraminidase, also known as sialidase, is ubiquitous in animals and microorganisms. It is predominantly distributed in the cell membrane, cytoplasmic vesicles, and lysosomes. Neuraminidase generally recognizes the sialic acid glycosidic bonds at the ends of glycoproteins or glycolipids and enzymatically removes sialic acid. There are four types of neuraminidases, named as Neu1, Neu2, Neu3, and Neu4. Among them, Neu1 is the most abundant in mammals. Recent studies have revealed the involvement of Neu1 in several diseases, including cardiovascular diseases, diabetes, cancers, and neurological disorders. In this review, we center the attention to the role of Neu1 in cardiovascular diseases, including atherosclerosis, ischemic myocardial injury, cerebrovascular disease, congenital heart disease, and pulmonary embolism. We also summarize inhibitors from Chinese herbal medicines (CHMs) in inhibiting virus neuraminidase or human Neu1. Many Chinese herbs and Chinese herb preparations, such as Lonicerae Japonicae Flos, Scutellariae Radix, Yupingfeng San, and Huanglian Jiedu Decoction, have neuraminidase inhibitory activity. We hope to highlight the emerging role of Neu1 in humans and potentially titillate interest for further studies in this area.

scholarly journals Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Chen Wang ◽  
Shuang Ling ◽  
Jin-Wen Xu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Stem Cell Differentiation ◽  
Chinese Herbs ◽  
Active Ingredients ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Stem cells (SCs) are special types of cells with the ability of self-renewal and multidirectional differentiation. As the organism ages, the ability to maintain homeostasis and regeneration deteriorates and the number and activity of stem cells decline. Theoretically, the restoration of stem cells might reverse aging. However, due to their own aging, donor-derived immune rejection, and difficulties in stem cell differentiation control, a series of problems need to be solved to realize the potential for clinical application of stem cells. Chinese herbal medicine is a nature drug library which is suitable for the long-term treatment of aging-related diseases. Modern pharmacological studies have revealed that many active ingredients of Chinese herbal medicines with the effect of promoting stem cells growth and differentiation mainly belong to “reinforcing herbs.” In recent years, exploration of natural active ingredients from Chinese herbal medicines for delaying aging, improving the stem cell microenvironment, and promoting the proliferation and differentiation of endogenous stem cells has attracted substantial attention. This article will focus on active ingredients from Chinese herbs-mediated differentiation of stem cells into particular cell type, like neural cells, endothelial cells, cardiomyocytes, and osteoblasts. We will also discuss the effects of these small molecules on Wnt, Sonic Hedgehog, Notch, eNOS-cGMP, and MAP kinase signal transduction pathways, as well as reveal the role of estrogen receptor α and PPAR γ on selectively promoting or inhibiting stem cells differentiation. This review will provide new insights into the health aging strategies of active ingredients in Chinese herbal medicine in regenerative medicine.

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