scholarly journals Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury

2022 ◽  
Vol 12 ◽  
Author(s):  
Anastasiia O. Sosnovtseva ◽  
Olga V. Stepanova ◽  
Aleksei A. Stepanenko ◽  
Anastasia D. Voronova ◽  
Andrey V. Chadin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Spinal Cord Injury ◽  
Gene Transfer ◽  
Spinal Cord Injuries ◽  
Ex Vivo ◽  
Direct Injection ◽  
Nerve Tissue ◽  
Popular Approach ◽  
Cord Injury

The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy is a popular approach for the treatment of such patients. The delivery of therapeutic genes is carried out in a variety of ways, such as direct injection of therapeutic vectors at the site of injury, retrograde delivery of vectors, and ex vivo therapy using various cells. Recombinant adenoviruses are often used as vectors for gene transfer. This review discusses the advantages, limitations and prospects of adenovectors in spinal cord injury therapy.

scholarly journals Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury: a proof of principle study

2021 ◽  
Vol 16 (3) ◽  
pp. 550 ◽  
Author(s):  
HyunJoon Lee ◽  
RustemRobertovich Islamov ◽  
FilipOlegovich Fadeev ◽  
FaridVagizovich Bashirov ◽  
VaheArshaluysovich Markosyan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Ex Vivo ◽  
Cord Injury ◽  
Proof Of Principle

scholarly journals What to know in Managing Spinal Cord Injury for Anesthesiologists?

2020 ◽  
Vol 2 ◽  
pp. 89-93
Author(s):  
Charles Charles
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Disorders ◽  
Spinal Cord Injuries ◽  
Spinal Nerve ◽  
Cost Of Care ◽  
Nerve Tissue ◽  
Cord Injury ◽  
The Cost ◽  
Very High

Background: Spinal cord injury (SCI) is trauma to the area of the vertebrae resulting in spinal cord lesions resulting in neurological disorders, depending on the location of the spinal nerve damage and the injured nerve tissue. The symptoms of SCI can range from pain and paralysis to incontinence. SCI due to trauma is estimated to occur in 30–40 per million population per year, and about 8000–10,000 sufferers each year, generally, occurs in adolescents and young adults. Although the annual incidence of events is relatively low, the cost of care and rehabilitation for spinal cord injuries is very high, at around US $ 53,000/patient. Methods: This study aims to provide an overview of how to manage SCI. This study reviewed various sources then reviewed as a literature review. Conclusion: Treatment in the hospital includes all systems that may experience complications from SCI, starting from the respiratory, cardiovascular, urological, gastrointestinal, skin, to non-operative. and operative reduction measures.

scholarly journals Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury

2021 ◽  
Vol 16 (2) ◽  
pp. 357 ◽  
Author(s):  
RustemR Islamov ◽  
AlbertA Rizvanov ◽  
FaridV Bashirov ◽  
MikhailE Sokolov ◽  
AndreiA Izmailov ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Spinal Cord Injury ◽  
Ex Vivo ◽  
Pig Model ◽  
Cord Injury ◽  
Ex Vivo Gene Therapy

scholarly journals Exoskeletons, Rehabilitation and Bodily Capacities

2021 ◽  
pp. 1357034X2110256
Author(s):  
Denisa Butnaru
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Crucial Role ◽  
Spinal Cord Injuries ◽  
Main Task ◽  
Cerebrovascular Accidents ◽  
Complex Processes ◽  
Cord Injury ◽  
Neurological Conditions

Motility impairments resulting from spinal cord injuries and cerebrovascular accidents are increasingly prevalent in society, leading to the growing development of rehabilitative robotic technologies, among them exoskeletons. This article outlines how bodies with neurological conditions such as spinal cord injury and stroke engage in processes of re-appropriation while using exoskeletons and some of the challenges they face. The main task of exoskeletons in rehabilitative environments is either to rehabilitate or ameliorate anatomic functions of impaired bodies. In these complex processes, they also play a crucial role in recasting specific corporeal phenomenologies. For the accomplishment of these forms of corporeal re-appropriation, the role of experts is crucial. This article explores how categories such as bodily resistance, techno-inter-corporeal co-production of bodies and machines, as well as body work mark the landscape of these contemporary forms of impaired corporeality. While defending corporeal extension rather than incorporation, I argue against the figure of the ‘cyborg’ and posit the idea of ‘residual subjectivity’.

scholarly journals Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury

2001 ◽  
Vol 533 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Leonard L. Jones ◽  
Martin Oudega ◽  
Mary Bartlett Bunge ◽  
Mark H. Tuszynski
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Spinal Cord Injury ◽  
Neurotrophic Factors ◽  
Cord Injury

scholarly journals Planet of the AAVs: The Spinal Cord Injury Episode

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 613
Author(s):  
Katerina Stepankova ◽  
Pavla Jendelova ◽  
Lucia Machova Urdzikova
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Spinal Cord Injury ◽  
Cell Types ◽  
Specific Cell ◽  
Adeno Associated Virus ◽  
Adequate Treatment ◽  
Cord Injury ◽  
The Central Nervous System ◽  
Transgene Delivery

The spinal cord injury (SCI) is a medical and life-disrupting condition with devastating consequences for the physical, social, and professional welfare of patients, and there is no adequate treatment for it. At the same time, gene therapy has been studied as a promising approach for the treatment of neurological and neurodegenerative disorders by delivering remedial genes to the central nervous system (CNS), of which the spinal cord is a part. For gene therapy, multiple vectors have been introduced, including integrating lentiviral vectors and non-integrating adeno-associated virus (AAV) vectors. AAV vectors are a promising system for transgene delivery into the CNS due to their safety profile as well as long-term gene expression. Gene therapy mediated by AAV vectors shows potential for treating SCI by delivering certain genetic information to specific cell types. This review has focused on a potential treatment of SCI by gene therapy using AAV vectors.

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