scholarly journals Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

2020 ◽  
Vol 11 ◽  
Author(s):  
Xinmin Yang ◽  
Linbo Yao ◽  
Xianghui Fu ◽  
Rajarshi Mukherjee ◽  
Qing Xia ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Animal Models ◽  
Translational Research ◽  
Specific Treatment ◽  
Current Status ◽  
Anatomical Site ◽  
Human Pancreas ◽  
The Past ◽  
Substantial Morbidity

Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its pathogenesis and development of new therapeutic strategies. Due to the unpredictable course of acute pancreatitis and relatively concealed anatomical site in the retro-peritoneum, research on the human pancreas remains challenging. As a result, for over the last 100 years studies on the pathogenesis of this disease have heavily relied on animal models. This review aims to summarize different animal models of acute pancreatitis from the past to present and discuss their main characteristics and applications. It identifies key studies that have enhanced our current understanding of the pathogenesis of acute pancreatitis and highlights the instrumental role of animal models in translational research for developing novel therapies.

Bioengineered in vitro Vascular Models for Applications in Interventional Radiology

2019 ◽  
Vol 24 (45) ◽  
pp. 5367-5374 ◽  
Author(s):  
Xiaoyun Li ◽  
Seyed M. Moosavi-Basri ◽  
Rahul Sheth ◽  
Xiaoying Wang ◽  
Yu S. Zhang
Keyword(s):  
Interventional Radiology ◽  
Animal Models ◽  
Blood Vessels ◽  
In Vitro Models ◽  
The Past ◽  
Endovascular Interventions ◽  
Conventional Animal ◽  
Vascular Structures

The role of endovascular interventions has progressed rapidly over the past several decades. While animal models have long-served as the mainstay for the advancement of this field, the use of in vitro models has become increasingly widely adopted with recent advances in engineering technologies. Here, we review the strategies, mainly including bioprinting and microfabrication, which allow for fabrication of biomimetic vascular models that will potentially serve to supplement the conventional animal models for convenient investigations of endovascular interventions. Besides normal blood vessels, those in diseased states, such as thrombosis, may also be modeled by integrating cues that simulate the microenvironment of vascular disorders. These novel engineering strategies for the development of biomimetic in vitro vascular structures will possibly enable unconventional means of studying complex endovascular intervention problems that are otherwise hard to address using existing models.

Virus Decline of Strawberry in California and the Role of Insect Vectors and Associated Viruses

2015 ◽  
Vol 16 (4) ◽  
pp. 211-215 ◽  
Author(s):  
Surendra K. Dara
Keyword(s):  
Frankliniella Occidentalis ◽  
Western Flower Thrips ◽  
Trialeurodes Vaporariorum ◽  
Current Status ◽  
Insect Vectors ◽  
The Past ◽  
Disease Vector ◽  
Flower Thrips ◽  
Purple Coloration

Greenhouse white fly, Trialeurodes vaporariorum (Westwood); western flower thrips, Frankliniella occidentalis (Pergande); and strawberry aphid, Chaetosiphon fragaefolii (Cockerell), are common pests of strawberries in California and are vectors of one or more viruses. Most of the viruses transmitted by these vectors do not cause symptoms on strawberry when the infection occurs individually. However, when one of the viruses (Beet pseudoyellows virus or Strawberry pallidosis-associated virus) transmitted by T. vaporariorum is present along with one of the viruses transmitted by F. occidentalis, C. fragaefolii, or other sources, it results in a virus decline of strawberry, which can cause significant crop losses. Stunted root and plant growth, purple coloration of foliage, and dieback of the plant are some of the symptoms associated with virus decline. Increases in T. vaporariorum infestations during the past few years significantly elevated the risk of whitefly as a crop pest and a disease vector. This article reviews virus decline of strawberry, symptoms of infection, and the current status of insect vectors in California strawberries. Accepted for publication 17 November 2015. Published 20 November 2015.

Learning from the Past: A Review of Clinical Trials Targeting Amyloid, Tau and Neuroinflammation in Alzheimer’s Disease

2020 ◽  
Vol 17 (2) ◽  
pp. 112-125 ◽  
Author(s):  
Kelly Ceyzériat ◽  
Thomas Zilli ◽  
Philippe Millet ◽  
Giovanni B. Frisoni ◽  
Valentina Garibotto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Animal Models ◽  
Phase Iii ◽  
Current Status ◽  
Central Feature ◽  
Phase Iii Trial ◽  
The Past ◽  
Positive Results

Alzheimer’s Disease (AD) is the most common neurodegenerative disease and cause of dementia. Characterized by amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau, AD pathology has been intensively studied during the last century. After a long series of failed trials of drugs targeting amyloid or Tau deposits, currently, hope lies in the positive results of one Phase III trial, highly debated, and on other ongoing trials. In parallel, some approaches target neuroinflammation, another central feature of AD. Therapeutic strategies are initially evaluated on animal models, in which the various drugs have shown effects on the target (decreasing amyloid, Tau and neuroinflammation) and sometimes on cognitive impairment. However, it is important to keep in mind that rodent models have a less complex brain than humans and that the pathology is generally not fully represented. Although they are indispensable tools in the drug discovery process, results obtained from animal models must be viewed with caution. In this review, we focus on the current status of disease-modifying therapies targeting amyloid, Tau and neuroinflammation with particular attention on the discrepancy between positive preclinical results on animal models and failures in clinical trials.

Insulin protects acinar cells during cellular and animal models of acute pancreatitis: Role of Akt-mediated phosphorylation of the glycolytic enzyme PFKFB2

Pancreatology ◽  
2019 ◽  
Vol 19 ◽  
pp. S101-S102
Author(s):  
Rosa Sanchez-Alvarez ◽  
Sarah Sudgen ◽  
M Dolors Sans ◽  
John A. Williams ◽  
Jason I.E. Bruce
Keyword(s):  
Acute Pancreatitis ◽  
Animal Models ◽  
Acinar Cells ◽  
Glycolytic Enzyme

scholarly journals Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Hannah C. Kinney ◽  
Joseph J. Volpe
Keyword(s):  
Brain Injury ◽  
White Matter ◽  
Animal Models ◽  
Translational Research ◽  
Developmental Trajectories ◽  
Axonal Injury ◽  
White Matter Lesions ◽  
Human Condition ◽  
Cerebral White Matter

Translational research in preterm brain injury depends upon the delineation of the human neuropathology in order that animal models faithfully reiterate it, thereby ensuring direct relevance to the human condition. The major substrate of human preterm brain injury is the encephalopathy of prematurity that is characterized by gray and white matter lesions reflecting combined acquired insults, altered developmental trajectories, and reparative phenomena. Here we highlight the key features of human preterm brain development and the encephalopathy of prematurity that are critical for modeling in animals. The complete mimicry of the complex human neuropathology is difficult in animal models. Many models focus upon mechanisms related to a specific feature, for example, loss of premyelinating oligodendrocytes in the cerebral white matter. Nevertheless, animal models that simultaneously address oligodendrocyte, neuronal, and axonal injury carry the potential to decipher shared mechanisms and synergistic treatments to ameliorate the global consequences of the encephalopathy of prematurity.

scholarly journals The Role of Ultrasound as a Diagnostic and Therapeutic Tool in Experimental Animal Models of Stroke: A Review

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1609
Author(s):  
Mari Carmen Gómez-de Frutos ◽  
Fernando Laso-García ◽  
Iván García-Suárez ◽  
Luke Diekhorst ◽  
Laura Otero-Ortega ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Current Status ◽  
Experimental Stroke ◽  
Full Potential ◽  
Therapeutic Tool ◽  
Noninvasive Technique ◽  
Experimental Animal Models ◽  
Ultrasound Application

Ultrasound is a noninvasive technique that provides real-time imaging with excellent resolution, and several studies demonstrated the potential of ultrasound in acute ischemic stroke monitoring. However, only a few studies were performed using animal models, of which many showed ultrasound to be a safe and effective tool also in therapeutic applications. The full potential of ultrasound application in experimental stroke is yet to be explored to further determine the limitations of this technique and to ensure the accuracy of translational research. This review covers the current status of ultrasound applied to monitoring and treatment in experimental animal models of stroke and examines the safety, limitations, and future perspectives.

Land use in the hills and uplands

1985 ◽  
Vol 10 ◽  
pp. 113-121 ◽  
Author(s):  
T. H. Thomas ◽  
D. Harding ◽  
R. Hattey ◽  
W. D. Martin
Keyword(s):  
Land Use ◽  
Resource Planning ◽  
Current Status ◽  
Landscape Conservation ◽  
The Past ◽  
Policy Objectives ◽  
Water Provision ◽  
Land Use Competition ◽  
Wild Life

AbstractThe paper summarises briefly the current status of the major land using activities in the hills and uplands. The dominant land use roles of agriculture and forestry arc explained, as are other uses of recreation, water provision and wild life and landscape conservation. Land use competition in the hills and uplands is seen as the end result of conflicting policy objectives pursued by the major rural resource planning agencies over the past 50 years. The role of these agencies is analysed, as is their ability to meet their objectives in competition with each other. Finally, an attempt is made to establish a quantitative framework within which the interests of the various groups are recognised and priorities in land use can be determined.

scholarly journals Screening and prevention of colorectal cancer

BMJ ◽  
2021 ◽  
pp. n1855
Author(s):  
Priyanka Kanth ◽  
John M Inadomi
Keyword(s):  
Colorectal Cancer ◽  
New Technologies ◽  
Current Status ◽  
Non Invasive ◽  
The Past ◽  
The Us ◽  
Screening And Prevention ◽  
Current Emphasis

Abstract Mortality from colorectal cancer is reduced through screening and early detection; moreover, removal of neoplastic lesions can reduce cancer incidence. While understanding of the risk factors, pathogenesis, and precursor lesions of colorectal cancer has advanced, the cause of the recent increase in cancer among young adults is largely unknown. Multiple invasive, semi- and non-invasive screening modalities have emerged over the past decade. The current emphasis on quality of colonoscopy has improved the effectiveness of screening and prevention, and the role of new technologies in detection of neoplasia, such as artificial intelligence, is rapidly emerging. The overall screening rates in the US, however, are suboptimal, and few interventions have been shown to increase screening uptake. This review provides an overview of colorectal cancer, the current status of screening efforts, and the tools available to reduce mortality from colorectal cancer.

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