scholarly journals Periodontal Inflammation and Systemic Diseases: An Overview

2021 ◽  
Vol 12 ◽  
Author(s):  
Mireya Martínez-García ◽  
Enrique Hernández-Lemus
Keyword(s):  
Chronic Condition ◽  
Large Body ◽  
Adaptive Immune System ◽  
Systemic Diseases ◽  
Health Issues ◽  
Sources Of Information ◽  
Therapeutic Goals ◽  
Adaptive Immune ◽  
Periodontal Inflammation ◽  
Systemic Condition

Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

Evolution and age characteristics of the innate and adaptive immune system

2016 ◽  
Vol 75 (3) ◽  
pp. 74-84 ◽  
Author(s):  
A.E. Abaturov ◽  
◽  
E.A. Agafonova ◽  
N.I. Abaturova ◽  
V.L. Babich ◽  
...  
Keyword(s):  
Immune System ◽  
Adaptive Immune System ◽  
Adaptive Immune

scholarly journals Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System

2021 ◽  
Vol 8 (8) ◽  
pp. 2004979
Author(s):  
Jun‐Young Park ◽  
Sung Jean Park ◽  
Jun Young Park ◽  
Sang‐Hyun Kim ◽  
Song Kwon ◽  
...  
Keyword(s):  
Immune System ◽  
Adaptive Immune System ◽  
Protein Corona ◽  
Unfolded Protein ◽  
Adaptive Immune

scholarly journals Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mauro Di Pilato ◽  
Miguel Palomino-Segura ◽  
Ernesto Mejías-Pérez ◽  
Carmen E. Gómez ◽  
Andrea Rubio-Ponce ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Vaccinia Virus ◽  
Adaptive Immune System ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Adaptive Immune

AbstractNeutrophils are innate immune cells involved in the elimination of pathogens and can also induce adaptive immune responses. Nα and Nβ neutrophils have been described with distinct in vitro capacity to generate antigen-specific CD8 T-cell responses. However, how these cell types exert their role in vivo and how manipulation of Nβ/Nα ratio influences vaccine-mediated immune responses are not known. In this study, we find that these neutrophil subtypes show distinct migratory and motility patterns and different ability to interact with CD8 T cells in the spleen following vaccinia virus (VACV) infection. Moreover, after analysis of adhesion, inflammatory, and migration markers, we observe that Nβ neutrophils overexpress the α4β1 integrin compared to Nα. Finally, by inhibiting α4β1 integrin, we increase the Nβ/Nα ratio and enhance CD8 T-cell responses to HIV VACV-delivered antigens. These findings provide significant advancements in the comprehension of neutrophil-based control of adaptive immune system and their relevance in vaccine design.

scholarly journals Nurses’ Knowledge and Anxiety Levels toward COVID-19 in Saudi Arabia

2021 ◽  
Vol 11 (2) ◽  
pp. 356-363
Author(s):  
Fatmah Alsharif
Keyword(s):  
Saudi Arabia ◽  
Psychological Health ◽  
Care Staff ◽  
World Health ◽  
Health Issues ◽  
Sources Of Information ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
As Stress ◽  
Health Organization

Background: In the battle against the Coronavirus Disease 2019 (COVID-19) pandemic, medical care staff, especially nurses, are at a higher risk of encountering psychological health issues and distress, such as stress, tension, burdensome indications, and, most importantly, fear. They are also at higher risk of becoming infected and transmitting this virus. In Saudi Arabia, it was noticed that the healthcare workforce suffered from anxiety, and that this more evident in women than men. Objective: This study aimed to assess the knowledge of nurses regarding COVID-19 and the level of anxiety toward the COVID-19 outbreak in the current pandemic situation. Design: A cross-sectional design was used and a validated self-administered online questionnaire with a set of questions related to COVID-19 was distributed to 87 participating nurses. Results: The results showed that more than half of the nurses (71.90%) had an adequate and good knowledge about the causes, transmission, symptoms, treatment, and death rate of COVID-19. The main sources of information for the nurses were social media (51.7%) and the World Health Organization and the Ministry of Health (36.8%). Conclusions: The results allowed the conclusion that, though the nurses had satisfactory knowledge about COVID-19, more than 50% of them experienced mental health issues such as anxiety. To address this, along with providing more knowledge about COVID-19, nurses should be supported in managing their anxiety.

scholarly journals T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils

2021 ◽  
pp. 1-19
Author(s):  
Sonia George ◽  
Trevor Tyson ◽  
Nolwen L. Rey ◽  
Rachael Sheridan ◽  
Wouter Peelaerts ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
B Cells ◽  
Substantia Nigra ◽  
Adaptive Immune System ◽  
Proteinase K ◽  
T And B Cells ◽  
Adaptive Immune ◽  
Immunocompromised Mice ◽  
The Impact

Background: α-Synuclein (α-syn) is the predominant protein in Lewy-body inclusions, which are pathological hallmarks of α- synucleinopathies, such as Parkinson’s disease (PD) and multiple system atrophy (MSA). Other hallmarks include activation of microglia, elevation of pro-inflammatory cytokines, as well as the activation of T and B cells. These immune changes point towards a dysregulation of both the innate and the adaptive immune system. T cells have been shown to recognize epitopes derived from α-syn and altered populations of T cells have been found in PD and MSA patients, providing evidence that these cells can be key to the pathogenesis of the disease. Objective To study the role of the adaptive immune system with respect to α-syn pathology. Methods: We injected human α-syn preformed fibrils (PFFs) into the striatum of immunocompromised mice (NSG) and assessed accumulation of phosphorylated α-syn pathology, proteinase K-resistant α-syn pathology and microgliosis in the striatum, substantia nigra and frontal cortex. We also assessed the impact of adoptive transfer of naïve T and B cells into PFF-injected immunocompromised mice. Results: Compared to wildtype mice, NSG mice had an 8-fold increase in phosphorylated α-syn pathology in the substantia nigra. Reconstituting the T cell population decreased the accumulation of phosphorylated α-syn pathology and resulted in persistent microgliosis in the striatum when compared to non-transplanted mice. Conclusion: Our work provides evidence that T cells play a role in the pathogenesis of experimental α-synucleinopathy.

scholarly journals Immune Control of Herpesvirus Infection in Molluscs

Pathogens ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 618
Author(s):  
Jacinta R Agius ◽  
Serge Corbeil ◽  
Karla J Helbig
Keyword(s):  
Immune Response ◽  
Adaptive Immune System ◽  
Herpesvirus Infection ◽  
Viable Option ◽  
Important Species ◽  
Immune Priming ◽  
Adaptive Immune ◽  
Preventative Strategy ◽  
Herpesvirus 1 ◽  
Ostreid Herpesvirus 1

Molluscan herpesviruses that are capable of infecting economically important species of abalone and oysters have caused significant losses in production due to the high mortality rate of infected animals. Current methods in preventing and controlling herpesviruses in the aquacultural industry are based around biosecurity measures which are impractical and do not contain the virus as farms source their water from oceans. Due to the lack of an adaptive immune system in molluscs, vaccine related therapies are not a viable option; therefore, a novel preventative strategy known as immune priming was recently explored. Immune priming has been shown to provide direct protection in oysters from Ostreid herpesvirus-1, as well as to their progeny through trans-generational immune priming. The mechanisms of these processes are not completely understood, however advancements in the characterisation of the oyster immune response has assisted in formulating potential hypotheses. Limited literature has explored the immune response of abalone infected with Haliotid herpesvirus as well as the potential for immune priming in these species, therefore, more research is required in this area to determine whether this is a practical solution for control of molluscan herpesviruses in an aquaculture setting.

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