scholarly journals Platelet Deposition Onto Vascular Wall Regulated by Electrical Signal

2021 ◽  
Vol 12 ◽  
Author(s):  
Mingyan Wang ◽  
Wei Zhang ◽  
Zhi Qi

Platelets deposition at the site of vascular injury is a key event for the arrest of bleeding and for subsequent vascular repair. Therefore, the regulation of platelet deposition onto the injured site during the process of platelet plug formation is an important event. Herein, we showed that electrical signal could regulate the deposition of platelets onto the injured site. On the one hand, the area of platelet deposition was reduced when the cathode of the applied electric field was placed at the injured site beforehand, while it was increased when the anode was at the site. On the other hand, if a cathode was placed at the injured site after the injury, the electrical signal could remove the outer layer of the deposited platelets. Furthermore, an electric field could drive rapid platelet deposition onto the blood vessel wall at the site beneath the anode even in uninjured blood vessels. Platelet deposition could thus be manipulated by externally applied electric field, which might provide a mechanism to drive platelet deposition onto the wall of blood vessels.

1972 ◽  
Vol 33 (C1) ◽  
pp. C1-63-C1-67 ◽  
Author(s):  
M. BERTOLOTTI ◽  
B. DAINO ◽  
P. Di PORTO ◽  
F. SCUDIERI ◽  
D. SETTE

2012 ◽  
Vol 15 (2-3) ◽  
pp. 127-139
Author(s):  
Tung Tran Anh ◽  
Laurent Berquez ◽  
Laurent Boudou ◽  
Juan Martinez-Vega ◽  
Alain Lacarnoy

2018 ◽  
Vol 23 (46) ◽  
pp. 7069-7085 ◽  
Author(s):  
Maria Drakopoulou ◽  
Konstantinos Toutouzas ◽  
Archontoula Michelongona ◽  
Dimitrios Tousoulis

Background: Atherosclerosis is a systemic, progressive lipid-driven inflammatory disease of the arterial vascular wall leading progressively to plaque development. The vulnerable plaque, the one considered to be the leading cause of cardiovascular events seems to exhibit a large and soft lipid-rich necrotic core covered by a thin and inflamed fibrous cap. Statin treatment is considered as one of the most effective methods for vulnerable plaque stabilization, currently being the principal drug in primary and secondary prevention of cardiovascular disease. </P><P> Objective: We sought to evaluate the beneficial effect of statins on biological processes involved in the evolution of vulnerable plaques </P><P> Method: We performed a systematic review of the literature searching MEDLINE via Pubmed for all experimental and human studies implementing statins in vulnerable plaque. </P><P> Results: Statins seem to have a beneficial role in plaque stabilization and patient outcome. It seems that this effect is mediated by improving endothelial function, decreasing oxidative stress and inflammation, reducing inflammatory activation and inhibiting thrombogenic response. Although these data are quite promising, it remains to be determined the extent of a potent benefit of the pleiotropic effects of statin therapy in clinical setting. </P><P> Conclusion: Prospective randomized trials should be conducted in order to further elucidate differences among type and dose of statin therapy, duration of treatment and association with LDL levels and clinical outcome.


2008 ◽  
Vol 75 (1) ◽  
Author(s):  
Q. Li ◽  
Y. H. Chen

A semi-permeable interface crack in infinite elastic dielectric/piezoelectric bimaterials under combined electric and mechanical loading is studied by using the Stroh complex variable theory. Attention is focused on the influence induced from the permittivity of the medium inside the crack gap on the near-tip singularity and on the energy release rate (ERR). Thirty five kinds of such bimaterials are considered, which are constructed by five kinds of elastic dielectrics and seven kinds of piezoelectrics, respectively. Numerical results for the interface crack tip singularities are calculated. We demonstrate that, whatever the dielectric phase is much softer or much harder than the piezoelectric phase, the structure of the singular field near the semi-permeable interface crack tip in such bimaterials always consists of the singularity r−1∕2 and a pair of oscillatory singularities r−1∕2±iε. Calculated values of the oscillatory index ε for the 35 kinds of bimaterials are presented in tables, which are always within the range between 0.046 and 0.088. Energy analyses for five kinds of such bimaterials constructed by PZT-4 and the five kinds of elastic dielectrics are studied in more detail under four different cases: (i) the crack is electrically conducting, (ii) the crack gap is filled with air/vacuum, (iii) the crack gap is filled with silicon oil, and (iv) the crack is electrically impermeable. Detailed comparisons on the variable tendencies of the crack tip ERR against the applied electric field are given under some practical electromechanical loading levels. We conclude that the different values of the permittivity have no influence on the crack tip singularity but have significant influences on the crack tip ERR. We also conclude that the previous investigations under the impermeable crack model are incorrect since the results of the ERR for the impermeable crack show significant discrepancies from those for the semi-permeable crack, whereas the previous investigations under the conducting crack model may be accepted in a tolerant way since the results of the ERR show very small discrepancies from those for the semi-permeable crack, especially when the crack gap is filled with silicon oil. In all cases under consideration the curves of the ERR for silicon oil are more likely tending to those for the conducting crack rather than to those for air or vacuum. Finally, we conclude that the variable tendencies of the ERR against the applied electric field have an interesting load-dependent feature when the applied mechanical loading increases. This feature is due to the nonlinear relation between the normal electric displacement component and the applied electromechanical loadings from a quadratic equation.


The Analyst ◽  
2020 ◽  
Vol 145 (6) ◽  
pp. 2412-2419 ◽  
Author(s):  
Rachel N. Deraney ◽  
Lindsay Schneider ◽  
Anubhav Tripathi

NA extraction and purification utilitzing a microfluidic chip with applied electric field to induce electroosmotic flow opposite the magnetic NA-bound bead mix.


2020 ◽  
Vol 10 (6) ◽  
pp. 780-787
Author(s):  
Hongyue Gao ◽  
Suna Li ◽  
Jicheng Liu ◽  
Wen Zhou ◽  
Fan Xu ◽  
...  

In this paper, we studied the holographic properties of liquid crystal (LC) thin film doped with carbon dots (CDs) which can be used as real-time holographic display screen. The maximum value of diffraction efficiency can reach up to 30% by using a low applied electric field 0.2 V/μm. Holograms in the LC film can be dynamically formed and self-erased. The hologram build-up time and the hologram self-erasure time in the material is fast enough to realize video refresh rate. In addition, the forming process of hologram was studied. The holographic diffraction efficiency was measured depending on the intensity of recording light, applied electric field, the intensity of readout light, and readout light polarization direction. Triple enhancement of the diffraction efficiency value by the modulation of voltage under the condition of low recording energy is presented. Therefore, we develop an easy way to obtain real-time dynamic holographic red, green and blue displays with high diffraction efficiency, which allow the LC film doped with CDs to be used as a holographic 3D display screen.


2013 ◽  
Vol 28 (03) ◽  
pp. 1340015 ◽  
Author(s):  
LANCE LABUN ◽  
JOHANN RAFELSKI

The electron vacuum fluctuations measured by [Formula: see text] do not vanish in an externally applied electric field ℰ. For an exactly constant field, that is for vacuum fluctuations in presence of a constant accelerating force, we show that [Formula: see text] has a Boson-like structure with spectral state density tanh -1(E/m) and temperature T M = eℰ/mπ = av/π. Considering the vacuum fluctuations of 'classical' gyromagnetic ratio g = 1 particles we find Fermi-like structure with the same spectral state density at a smaller temperature T1 = av/2π which corresponds to the Unruh temperature of an accelerated observer.


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