scholarly journals Alexithymia, Emotional Distress, and Perceived Quality of Life in Patients With Hashimoto’s Thyroiditis

2021 ◽  
Vol 12 ◽  
Author(s):  
Gabriella Martino ◽  
Andrea Caputo ◽  
Carmelo M. Vicario ◽  
Ulla Feldt-Rasmussen ◽  
Torquil Watt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Somatic Anxiety ◽  
Somatic Illness ◽  
Significant Difference ◽  
Toxic Goiter

Emotion-processing impairment represents a risk factor for the development of somatic illness, affecting negatively both health-related quality of life (HRQoL) and disease management in several chronic diseases. The present pilot study aims at (i) investigating the associations between alexithymia and depression, anxiety, and HRQoL in patients with Hashimoto’s thyroiditis (HT); (ii) examining the association between these three psychological conditions together with HRQoL, and thyroid autoantibodies status as well as thyroid echotexture in patients with HT; and (iii) comparing the intensity of all these clinical psychological features in patients with HT versus controls. Twenty-one patients with serologically or ultrasonographically verified HT and 16 controls with non-toxic goiter or postsurgical hypothyroidism were recruited for this study. Serum thyrotropin (TSH) and free thyroxine, as well as thyroid autoantibodies (thyroglobulin antibodies and thyroid peroxidase antibodies), were assayed. Alexithymia, depression, anxiety, and HRQoL were assessed with Toronto Alexithymia Scale; Beck Depression Inventory, second edition; Hamilton Anxiety Rating Scale; and Health Survey Short-Form 36, respectively. A negative relationship between the difficulty to describe feelings and the cognitive component of depression was found (r = -0.46, p = 0.04). Besides, patients with seronegative HT had lower somatic anxiety than patients with HT who tested positive (r = -0.68, p = 0.01 and r = -0.59, p = 0.04, respectively). Besides, no statistically significant difference was found between patients with HT and controls with regard to somatic anxiety. The present study suggests the relevance of alexithymia in patients suffering from HT, which may be intertwined with a possible state of underreported depression that is mainly expressed through physical complaints. Promoting the capability to describe and communicate feelings could contribute to psychological elaboration and coping with the disease and, consequently, to the improvement of self-management and perceived HRQoL.

scholarly journals A Clinical Trial for the Identification of Metabolic Biomarkers in Hashimoto’s Thyroiditis and in Psoriasis: Study Protocol

2021 ◽  
Vol 28 (2) ◽  
pp. 291-306
Author(s):  
Evangelia Sarandi ◽  
Sabine Kruger Kruger Krasagakis ◽  
Dimitris Tsoukalas ◽  
Gottfried Rudofsky ◽  
Aristides Tsatsakis
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Mediterranean Diet ◽  
Hashimoto’S Thyroiditis ◽  
Dietary Factors ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
The Mediterranean ◽  
Metabolic Biomarkers

Hashimoto’s thyroiditis and psoriasis are inflammatory disorders that significantly impact patients’ quality of life, stressing the need for novel biomarkers of early diagnosis. This randomized clinical trial (NCT04693936) aims to identify Hashimoto’s thyroiditis’ and psoriasis’ metabolic biomarkers and to investigate the effect of environmental factors on the disease-related metabolic imprint and quality of life. Patients with Hashimoto’s thyroiditis, patients with psoriasis, and healthy individuals aged 18–60 will be recruited, enrolled according to eligibility criteria (medical history, clinical thyroid markers and the PASI score) and randomized to two groups. The intervention group will receive a combination of nutraceuticals for 6 months as part of a Mediterranean diet, and the control group will follow their usual diet. Data will be collected at baseline and the end of the study, including metabolite levels, lifestyle and anthropometric measurements, adherence to the Mediterranean diet (through the Mediterranean Diet Score) and disease-specific quality of life (through the Thyroid Patient Report Outcome for Hashimoto’s group, and the Dermatology Life Quality Index for the psoriasis group). This study will investigate metabolic biomarkers and related changes in Hashimoto’s thyroiditis and psoriasis and evaluate the association of metabolic changes with dietary factors and quality of life.

scholarly journals SAT-430 Quality of Life After Thyroidectomy for Patients with Hashimoto’s Disease and Persistent Symptoms

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Priyanka Thatipamala ◽  
Julia Noel ◽  
Lisa Orloff
Keyword(s):  
Quality Of Life ◽  
Hashimoto’S Thyroiditis ◽  
General Health ◽  
Hashimoto's Thyroiditis ◽  
Health Score ◽  
Persistent Symptoms ◽  
Sf 36 ◽  
Hashimoto's Disease ◽  
General Health Score

Abstract Objective: To determine whether thyroidectomy improves quality of life in patients with Hashimoto’s thyroiditis with persistent symptoms despite biochemical euthyroidism. Study Design: A retrospective cohort study of patients undergoing thyroidectomy for Hashimoto’s thyroiditis. Setting: Tertiary referral center. Subjects and Methods: Included patients underwent thyroidectomy for Hashimoto’s thyroiditis at our institution between 2014 and 2018. The following variables were collected: age, race, body mass index (BMI), pre-operative symptoms, pre-operative thyroid peroxidase antibody (TPO Ab), thyroglobulin antibody (Tg Ab) thyroid stimulating hormone (TSH), free T4, specimen weight, and presence of thyroiditis or malignancy on the pathology report. The primary outcome was general health score on the Short Form-36 Health Survey (SF-36) ranging from 3–35 months postoperatively. Secondary outcomes included an additional questionnaire specifically addressing disease management after surgery as well as any adverse outcomes. Results: 19 patients were included in the study. 18 of the 19 patients were female with a mean age of 48 years (SD 13.6 years). The majority of patients were Caucasian. There was no significant difference between the general health score of the Hashimoto’s thyroiditis patients post-operatively compared to a healthy control population. (66.9 vs. 74.1; 95% CI [-16.9 + 2.5], p = 0.16). There were also no significant differences between groups within the 7 SF-36 subscores. Elevation in pre-operative TPO Ab correlated with lower reported post-operative energy levels (r = -0.63, p = 0.016) and emotional well-being (r = -.55, p = 0.041). 87.5% (14/16) of respondents reported to be moderately or extremely happy with their decision to proceed with surgery. Conclusions: Quality of life in patients with Hashimoto’s thyroiditis who undergo thyroidectomy is equivalent to the general population, and the majority of patients are satisfied with the decision to have undergone surgery. Thyroidectomy is a consideration for patients with Hashimoto’s disease and persistent symptoms despite optimization on medical therapy.

scholarly journals Comparison of immunoglobulin E anti-thyroid peroxidase antibodies in patients with Hashimoto thyroiditis and chronic spontaneous urticaria

2021 ◽  
Author(s):  
Songül Çildağ ◽  
Çiğdem Yenisey ◽  
Mustafa Ünübol ◽  
Taşkın Şentürk
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Immunoglobulin E ◽  
Chronic Spontaneous Urticaria ◽  
Hashimoto's Thyroiditis ◽  
Unknown Etiology ◽  
Enzyme Linked Immunosorbent Assay ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies ◽  
Significant Difference ◽  
History Of

Background and aim. Chronic spontaneous urticaria (CSU) is a disease of unknown etiology and autoimmunity has been thought to be an etiological factor. Immunoglobulin E (IgE)-anti-thyroid peroxidase antibodies (anti-TPO) may play a role in the pathogenesis of certain cases of urticaria. The aim of this study is to investigate IgE-anti-TPO in patients with chronic spontaneous urticaria and in patients with Hashimoto’s thyroiditis. Methods. A total of 175 -subjects were included in this study. 59 patients had chronic spontaneous urticaria without history of Hashimoto’s thyroiditis, while 58 patients had Hashimoto’s thyroiditis without history of urticaria. The control group consisted of 58 participants without history of Hashimoto’s thyroiditis and urticaria. Serum IgE-anti-TPO levels were analyzed by site-directed IgE capture Enzyme-Linked Immunosorbent Assay technique. We used this technique by modifying it. Results. IgE-anti-TPO antibodies were detected in all three groups and in all subjects. There was no significant difference between the three groups in terms of IgE-anti-TPO levels. Although total IgE and IgE-anti-TPO levels were higher in the IgG-anti-TPO positive chronic spontaneous urticaria, there was no significant difference. Conclusions. IgE-anti-TPO antibodies do not play a pathogenic role in the majority of patients with chronic spontaneous urticaria.

scholarly journals Surgical Treatment of Hashimoto’s Thyroiditis – Pros and Cons from the Perspective of Clinical Results

2020 ◽  
Vol 9 (3) ◽  
pp. 1208-1216 ◽  
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Hashimoto’S Thyroiditis ◽  
Clinical Results ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Quality Of Life Indicators ◽  
Sf 36 ◽  
Pros And Cons

Patients with Hashimoto’s thyroiditis have hypothyroidism, goiter, and extrathyroidal lesions. Substitution therapy with thyroxine drugs in some cases is not effective. The work studies the feasibility of using surgical treatment – removal of the active site of autoimmune aggression. To study the effect of thyroidectomy on the quality of life of patients with Hashimoto’s thyroiditis with extrathyroidal manifestations. Sixty-one patients with Hashimoto’s thyroiditis were examined. Among them 29 patients were treated with drugs (control group) and 32 with surgery (main group). The quality of life was studied using the SF-36 questionnaire. TSH levels within euthyroidism were controlled and the level of antibodies to thyroperoxidase was determined. Two years after the surgical treatment, the studied quality of life indicators was improved significantly. The growth in individual indicators ranged from 34 (role-functioning, conditioned by emotional state) to 57 % (vital activity), and the overall health indicator increased by 52 %. The level of antibodies to peroxidase decreased almost to the norm. In the group of patients receiving drug treatment, overall quality of life indicators did not change significantly, but there was a tendency to worsen. The level of antibodies to peroxidase remained at high rates without significant changes. Surgical treatment of patients with Hashimoto’s thyroiditis improves the quality of life. The level of antibodies to thyroperoxidase after thyroidectomy is reduced to almost physiologically significant indicators.

Quality of life after thyroid surgery in women with benign euthyroid goiter: influencing factors including Hashimoto's thyroiditis

2014 ◽  
Vol 207 (6) ◽  
pp. 974-979 ◽  
Author(s):  
Regina Promberger ◽  
Michael Hermann ◽  
Shanon Joan Pallikunnel ◽  
Rudolf Seemann ◽  
Moritz Meusel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Influencing Factors ◽  
Thyroid Surgery ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis

scholarly journals Coexistence of Thyroid Hormone Resistance and Autoimmune Thyroid Disease: Not a Mere Coincidence

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A924-A925
Author(s):  
Helen Prathiba Gnanapragasam ◽  
Amrutha Idupuganti ◽  
Salman Zahoor Bhat
Keyword(s):  
Thyroid Hormone ◽  
Autoimmune Thyroiditis ◽  
Hashimoto’S Thyroiditis ◽  
Alpha Subunit ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Hormone Resistance ◽  
Free T4 ◽  
Thyroid Hormone Resistance

Abstract Introduction: The coexistence of thyroid hormone resistance and autoimmune thyroiditis was initially thought to be a chance event. In a large cohort study, Barcoff et al. demonstrated an increased likelihood of thyroid autoantibodies in patients with thyroid hormone resistance (RTH). We report a unique case to epitomize the coexistence of these two conditions and discuss the postulated mechanisms. Clinical Case: A 22-year-old woman with a history of Hashimoto’s thyroiditis, attention deficit hyperactivity disorder, and migraine presented to the endocrinology clinic with symptoms of weight loss, fatigue, decreased appetite, and heat intolerance for 4 months. She was diagnosed with Hashimoto’s thyroiditis at age 12 with elevated TSH only and had been on levothyroxine 25 mcg since diagnosis. Physical exam demonstrated a body mass index of 34.14 kg/m2, blood pressure of 138/91 mmHg, pulse of 77 bpm, and an enlarged palpable thyroid gland. Laboratory investigations revealed elevated thyroid peroxidase (TPO) antibody at 234 IU/mL (<9) and thyroglobulin Antibody at 3 IU/mL (<1) with elevated free T4 of 3.76 ng/dL (0.61-1.36), elevated total T4 of 21.58 mcg/dL (6.09-12.23), increased T3 uptake of 51.2% uptake (32-48.4), and upper normal TSH of 3.99 uIU/mL (0.44-5.33). Elevated free T4 was confirmed by the equilibrium dialysis method at 6.2 ng/dL (0.9-2.2) with upper normal TSH at 3.77 uIU/mL. Thyroid ultrasound demonstrated thyromegaly and hypervascularity of the gland. TSH secreting pituitary adenoma was ruled out with a normal alpha subunit of 0.2 ng/ml (0.1-0.6) and molar ratio of the alpha subunit to TSH ratio <1 along with a normal pituitary MRI. She was not taking other medications or supplements. She was diagnosed with thyroid hormone resistance and is undergoing genetic testing to differentiate the THRB genetic mutations from Non-TR-RTH. Her symptoms improved after discontinuing her levothyroxine. Clinical Lesson: Our case highlights the importance of evaluating thyroid disorders properly before starting treatment and illustrates the coexistence of autoimmune thyroiditis with thyroid hormone resistance. Barcoff et al. demonstrated that there was an increased likelihood of thyroid autoantibodies with odds ratio = 2.36 (p = 0.002) in a large patient cohort with RTH, compared to their unaffected first-degree relatives. However, since there was no correlation in increased antibody with increased age and the duration of the disease, the proposed hypothesis did not substantiate chronic TSH stimulation inducing autoimmune response. The proposed mechanism is that the elevated TSH in RTH stimulates the immune system at the TRα level which was demonstrated in murine models with increased activation of thymic function in correlation with TSH level. More research is needed to understand the underlying mechanism of their coexistence.

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