scholarly journals Early Sensory and Temperament Features in Infants Born to Mothers With Asthma: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Carly A. Mallise ◽  
Vanessa E. Murphy ◽  
Linda E. Campbell ◽  
Alix J. Woolard ◽  
Olivia M. Whalen ◽  
...  
Keyword(s):  
Perinatal Outcomes ◽  
Developmental Outcomes ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Sensory Profile ◽  
Cross Sectional ◽  
Increased Risk ◽  
Sensory Features ◽  
Adverse Perinatal Outcomes ◽  
And Control

Maternal asthma in pregnancy is associated with an increased risk of adverse perinatal outcomes. Adverse perinatal outcomes may result in poorer infant developmental outcomes, such as temperament and sensory difficulties. This study aimed to (1) assess differences in temperament and sensory features between infants born to mothers with and without asthma and (2) investigate differences in these infant behaviours as a function of maternal asthma severity and asthma control. Mothers completed the Carey Temperament Scales and the Sensory Profile 2 at either 6 weeks, 6 months, or 12 months postpartum. Overall, we observed no significant differences between infants born to mothers with and without asthma in their temperament or sensory features; scores in both domains fell within the normative range. More infants in the asthma group, however, were reported to be highly distractible. When compared with normative data, infants in both groups were reported to have poor predictability of biological functions and fewer infants engaged in low levels of sensory behaviours. Some infants were observed to experience difficulties with hyper-reactivity within several domains. Maternal asthma severity and control during pregnancy were not linked to significant differences between infant temperament and sensory features. The present findings indicate that infants born to mothers with asthma are not at an increased risk overall for temperament or sensory difficulties, compared to control infants. However, a subset of infants across both groups may be at risk for attention or sensory hyper-reactivity difficulties. Further research into the developmental outcomes of infants born to mothers with asthma is warranted.

Pregnancy-Related and Perinatal Outcomes in Women With Multiple Sclerosis

2021 ◽  
Vol 11 (4) ◽  
pp. 280-290
Author(s):  
Johanna Balslev Andersen ◽  
Tine Iskov Kopp ◽  
Finn Sellebjerg ◽  
Melinda Magyari
Keyword(s):  
Multiple Sclerosis ◽  
General Population ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Study Cohort ◽  
Sectional Study ◽  
Cross Sectional ◽  
Comparison Cohort ◽  
Adverse Perinatal Outcomes ◽  
In Pregnancy

ObjectiveTo investigate differences in pregnancy-related and perinatal outcomes in women with multiple sclerosis (MS) compared with the general population.MethodsWe conducted a cross-sectional study including pregnancies from January 1, 1997, to December 31, 2016, to women registered in the Danish Multiple Sclerosis Registry (the study cohort). Pregnancy-related and perinatal outcomes were compared with a randomly selected subcohort of pregnancies from the general population (the comparison cohort) using logistic regression adjusted for possible confounders.ResultsIn total, 2,930 pregnancies were included in the study cohort and 56,958 pregnancies in the comparison cohort. No differences were found in pregnancy-related complications (preeclampsia/gestational diabetes or placenta complications), emergency caesarean section (c-section), instrumental delivery, low Apgar score, stillbirth, preterm birth, or congenital malformations. Elective c-section (odds ratio [OR] 1.89 [95% confidence interval (CI) 1.65–2.16]), induced delivery (OR 1.15 [95% CI 1.01–1.31]), and being born small for gestational age (SGA) (OR 1.29 [95 %CI 1.04–1.60]) had a higher prevalence in the study cohort, whereas the prevalence of signs indicating asphyxia was lower in the study cohort (OR 0.87 [95% CI 0.78–0.97]) relative to the comparison cohort.ConclusionWe found a higher prevalence of elective c-sections, induced delivery, and infants being SGA among newborns to women with MS, whereas the prevalence of asphyxia was lower in the study cohort. There were no significant differences in severe adverse perinatal outcomes when comparing women with MS and their newborns with those of the general population.

scholarly journals Effect of inter-pregnancy interval on maternal and fetal outcome

2020 ◽  
Vol 15 (1) ◽  
pp. 58-61
Author(s):  
Pravin Shrestha ◽  
Vibha Mahato ◽  
Smita Karmacharya
Keyword(s):  
Placenta Previa ◽  
Perinatal Outcomes ◽  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Chronic Hypertension ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Increased Risk ◽  
The Impact ◽  
Inter Pregnancy Interval

Aims: To explore the impact of inter-pregnancy interval on maternal and fetal health Methods: Descriptive cross sectional study conducted at Department of Obstetrics and Gynaecology, Manipal Teaching hospital, Pokhara, Nepal. Inter-pregnancy interval (IPI) was calculated as the time elapsed between the woman’s last delivery and the date of last menstrual period for the present second or higher order birth. Intervals were taken in weeks and then converted to months. IPI were categorized as <18months, 18-23, 24-59, >59 months. Results: Among the 550 pregnancies studied, the majority (57%) of them had an IPI of more than 59 months. Long IPI of >59 months had increased risk of maternal complications like preeclampsia (12.4%), postdate pregnancy (10.8%), PROM (4.4%), oligohydramnios (3.8%), placenta previa (2.5%), gestational diabetes mellitus (2.2%), chronic hypertension (1.5%), abruptio placenta (0.3%), IUFD (0.6%) and overt DM (0.3%). Increased preterm birth was seen in IPI <18 months (25%). Short IPI had also increased risk of IUGR (8.3%) and anaemia. Adverse maternal outcome was least when IPI was between 18-23 months. Conclusions: IPI shorter than 18 months and longer than 59 months were associated with increased risk of adverse maternal and perinatal outcomes. Keywords: fetal, inter-pregnancy, interval

scholarly journals Inadequate Prenatal Visit and Home Delivery as Determinants of Perinatal Outcomes: Does Parity Matter?

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Nigus Bililign Yimer ◽  
Zelalem Tenaw ◽  
Kalkidan Solomon ◽  
Tesfahun Mulatu
Keyword(s):  
Antenatal Care ◽  
Computer Software ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Home Delivery ◽  
Cross Sectional ◽  
Significant Difference ◽  
Multiparous Women ◽  
Adverse Perinatal Outcomes ◽  
Study Participants

Background. Adverse perinatal outcomes are still high in developing countries. Contradicting evidences were reported about the effect of parity on adverse perinatal outcomes. The aim of this study was to compare perinatal outcomes in grand multiparous and low multiparity women in Hawassa University Comprehensive Specialized Hospital and Adare General Hospital of Ethiopia. Methods. Comparative cross-sectional study design was employed to include 461 mothers from February to June 2018. Data were collected by structured questionnaire using interview and from patient charts. Data were entered using EPI-DATA version 4.4.2.0. Descriptive statistics and logistic regression analyses were computed using STATA version 14 computer software. Results. Of all study participants, 24.9% (95% Confidence interval: 21.1%-29.1%) had at least one adverse perinatal outcome. Stillbirth (38.9), low Apgar score (51.9%), and congenital malformation (3.70%) were frequently occurred complications in grand multiparas compared to low multiparous women. Nevertheless, meconium aspiration, need for resuscitation, and macrosomia were higher in low multiparous women (9.84%, 14.75%, and 57.38%, respectively). Less than four prenatal visits (AOR: 1.74; 95% CI: 1.04, 2.92) and previous home delivery (AOR: 1.87; 95% CI: 1.04, 3.33) were independent predictors of adverse perinatal outcomes. However, parity did not show statistically significant difference in perinatal outcomes. Conclusion. This finding underscores the fact that frequency of antenatal care and place of delivery are significant predictors of perinatal outcomes. However, parity did not show statistically significant difference in perinatal outcomes. Women empowerment, promoting health facility delivery, and early, comprehensive antenatal care are needed.

Association of LOXL1 Gene Polymorphisms in Exfoliation Glaucoma Patients

2020 ◽  
Author(s):  
Elham TAGHAVI ◽  
Ramin DANESHVAR ◽  
Zahra NOORMOHAMMADI ◽  
Seyed Mohammad-Hossein MODARRESI ◽  
Mohammad Reza SEDAGHAT
Keyword(s):  
Gene Polymorphisms ◽  
Direct Sequencing ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Control Subjects ◽  
Increased Risk ◽  
Anterior Lens Capsule ◽  
Gene Transcripts ◽  
Exfoliative Glaucoma ◽  
And Control

Background: Pseudoexfoliation syndrome (XFS) is pathogenetically related to exfoliative glaucoma (XFG), which is the most common type of secondary glaucoma. We aimed to investigate the relationship between LOXL1 SNPs (rs1048661, rs3825942) and XFS and/or XFG in a cohort of Iranian subjects. Methods: This cross-sectional study investigated possible association between LOXL1 gene polymorphisms and exfoliative glaucoma in Northeastern part of Iran between May 2014 and May 2015. Sixty unrelated XFS/XFG patients, as well as 40 control subjects, were studied by direct sequencing. In fifteen senile cataract patients without glaucoma and fifteen patients with coexisting XFG and cataract, capsulorhexis specimen of the anterior lens capsule was used to evaluate LOXL1 gene transcripts by Real-Time PCR technique. We analyzed the results for allele frequencies and haplotype association and investigated the relative gene expression. Results: Significant associations between the rs382594 SNP and XFG and between rs1048661 SNP and XFG were observed (P<0.05 for both). The frequency of the G allele in the exonic SNP (rs1048661) appeared to be higher in XFS or XFG patients compared to control subjects (P= 0.0497). Moreover, in the rs3825942 SNP, the G allele was more frequent in XFS/XFG patients compared to control subjects (P=0.0016). The highest cumulative frequency was for the GG haplotype. GG haplotype was associated with increased risk of XFG compared to the rs1048661 G/T and rs3825942 G/A haplotypes. LOXL1 mRNA expression was not statistically significantly different between XFS/XFG and control subjects. Conclusion: We reported the LOXL1 gene polymorphism in an Iranian XFS/XFG cohort. Similar to many other ethnic groups and geographic regions, our results confirmed an association between LOXL1 gene variants and XFG in Iran.

scholarly journals Maternal and perinatal outcomes in multiple versus singleton pregnancies in Dakar, Senegal: a cross sectional study over 10 years

2020 ◽  
Vol 9 (4) ◽  
pp. 1705
Author(s):  
Mame D. Ndiaye ◽  
Mamour Gueye ◽  
Ndèye Aissatou Diop ◽  
Simon B. Ndour ◽  
Ndama Niang ◽  
...  
Keyword(s):  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Multiple Gestation ◽  
Multiple Pregnancies ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neonatal Deaths ◽  
Increased Risk ◽  
Study Results ◽  
Perineal Injuries

Background: The birth of twins is a singular event in most societies, and even more when it comes to multiple births. The objective of this study was to investigate maternal and perinatal outcomes in multiple versus singleton pregnancies.Methods: Cross-sectional study carried out at Philippe Maguilen Senghor health center in Dakar, Senegal from January 1, 2011 to June 30, 2019. Data were extracted from this E-perinatal electronic database and then analyzed in statistical package for social science software (SPSS 24, Mac version).Results: A total 42,870 mothers delivered 44,149 newborns including 1250 twins (2.8%) and 29 triplets. The mean maternal age was 27 years. Mothers with multiple pregnancies had 3 times the odds of poor maternal outcome compared to mothers with single pregnancies (OR 2.42, 95% CI; 1.98-2.94, p <0.001, for high blood pressure; OR, 2.66; 95% CI, 2.11-3.32, p= <0.001, for severe pre-eclampsia; and OR, 3.04; 95% CI, 1.64-5.66, p <0.001, for postpartum hemorrhage). Likewise, women with multiple gestations had significantly higher rates of preterm birth (OR 5.62; 95% CI: 4.91-6.41, p <0.001), breech presentations (OR = 11.02; CI = 9.68-12.53, p <0.001) and neonatal deaths (OR = 2.94; CI = 9.6852-12.5328 p= 0.004) as compared to women with singleton gestations. Furthermore, women with multifetal gestations had increased risk for caesarean section (OR 2.14; 95% CI: 1.91-2.41, p <0.001) compared with their singleton counterparts. The risks for episiotomy and perineal injuries were higher for women with singleton gestations as compared to multiple gestation mothers.Conclusions: This study results are in line with previous findings and contradict others. Particular attention should always be paid to multiple pregnancies’ management. However, the pattern of certain complications traditionally correlated with multiple pregnancies is to be confirmed.

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