scholarly journals Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women

2020 ◽  
Vol 8 ◽  
Author(s):  
Jessica De Loma ◽  
Anda R. Gliga ◽  
Michael Levi ◽  
Franz Ascui ◽  
Jacques Gardon ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Future Research ◽  
Linear Regression Models ◽  
Inductively Coupled ◽  
Lower Protein ◽  
Plasma Mass Spectrometry ◽  
Arsenic Metabolites ◽  
Related Proteins

Indigenous people living in the Bolivian Andes are exposed through their drinking water to inorganic arsenic, a potent carcinogen. However, the health consequences of arsenic exposure in this region are unknown. The aim of this study was to evaluate associations between arsenic exposure and changes in cancer-related proteins in indigenous women (n = 176) from communities around the Andean Lake Poopó, Bolivia. Arsenic exposure was assessed in whole blood (B-As) and urine (as the sum of arsenic metabolites, U-As) by inductively coupled plasma-mass spectrometry (ICP-MS). Cancer-related proteins (N = 92) were measured in urine using the proximity extension assay. The median B-As concentration was 2.1 (range 0.60–9.1) ng/g, and U-As concentration was 67 (12–399) μg/L. Using linear regression models adjusted for age, urinary osmolality, and urinary leukocytes, we identified associations between B-As and four putative cancer-related proteins: FASLG, SEZ6L, LYPD3, and TFPI2. Increasing B-As concentrations were associated with lower protein expression of SEZ6L, LYPD3, and TFPI2, and with higher expression of FASLG in urine (no association was statistically significant after correcting for multiple comparisons). The associations were similar across groups with different arsenic metabolism efficiency, a susceptibility factor for arsenic toxicity. In conclusion, arsenic exposure in this region was associated with changes in the expression of some cancer-related proteins in urine. Future research is warranted to understand if these proteins could serve as valid biomarkers for arsenic-related toxicity.

Arsenic speciation in rice and risk assessment of inorganic arsenic from Ghentugachhi village of Chakdaha block, Nadia, West Bengal, India

2020 ◽  
Vol 57 (2) ◽  
pp. 85-93
Author(s):  
B Sinha ◽  
K Bhattacharyya
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
West Bengal ◽  
Arsenic Speciation ◽  
Inorganic Arsenic ◽  
Rice Grain ◽  
Species Determination ◽  
Inductively Coupled ◽  
As Species ◽  
Plasma Mass Spectrometry

The purpose of the present study was to assess arsenic (As) speciation in rice from West Bengal, India, in order to improve understanding of the health risk posed by arsenic in Indian rice. Rice is a potentially important route of human exposure to arsenic, especially in populations with rice-based diets. However, arsenic toxicity varies greatly with species. Determination of arsenic (As) species in rice is necessary because inorganic As species are more toxic than organic As. Total arsenic was determined by inductively coupled plasma mass spectrometry; arsenite, arsenate, monomethylarsonic acid, and dimethyarsinic acid were quantified by high-performance liquid chromatography- inductively coupled plasma mass spectrometry. The analysis of a rice flour certified reference material (SRM-1568-a) were evaluated for quality assurance. The use of 2M TFA for extraction with an isocratic mobile phase was optimized for extraction and employed for arsenic speciation in rice. The extraction method showed a high recovery of arsenic. Most of the As species in rice were noticed to be inorganic [Arsenite (As-III), Arsenate As-V]. It appeared very clear from the present study that inorganic arsenic shared maximum arsenic load in rice straw while in grains it is considerably low. As species recovered from rice grain and straw are principally As-III and As-V with a little share of DMA and almost non-detectable MMA and As-B. The order of As species in rice grain revealed in this study were As-III (54.5-65.4 %)>As-V(21.2-28.3%)>DMA(5.2%).

Arsenic exposure and seafood intake in Korean adults

2016 ◽  
Vol 36 (5) ◽  
pp. 451-460 ◽  
Author(s):  
H-S Bae ◽  
I-G Kang ◽  
S-G Lee ◽  
S-Y Eom ◽  
Y-D Kim ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Geometric Mean ◽  
Arsenic Exposure ◽  
Geographic Location ◽  
Inductively Coupled ◽  
Individual Interviews ◽  
Korean Adults ◽  
Plasma Mass Spectrometry ◽  
Exposure Levels ◽  
Fish And Shellfish

Arsenic (As) is widely distributed in the environment, and humans can be exposed to As from various sources such as air, water, soil, and food. This study was performed to evaluate the As exposure levels in Korean adults by measuring total As in urine and its relation with the consumption of seafood, a favorite food in Korea. A total of 2077 adults were the study subjects; they ranged in age from 19 to 83, and they were recruited by probability sampling stratified by area, sex, and age. None of the subjects had been exposed to As occupationally. We collected information about the demographic characteristics, lifestyles, and food consumption of study subjects using a questionnaire and followed urine sampling. Diet was assessed in individual interviews using the 24-h recall method. Total As in urine was analyzed using inductively coupled plasma mass spectrometry (PerkinElmer NEXION 300S; Concord, Ontario, Canada). The geometric mean concentration of total As in urine was observed to be 97.6 µg/L and was higher in males (103.9 µg/L) than in females (93.0 µg/L). Total As levels in urine were affected by sex, age, seafood intake, and geographic location. In this study, total As in urine was positively correlated with fish and shellfish consumption, and was mainly determined by As intake through fish and shellfish/grains/flavors. These findings suggest that seafood consumption might be a major contributor to urinary As levels in Korean adults.

Application of μ-TLC for speciation of inorganic arsenic by laser ablation inductively coupled plasma mass spectrometry

2020 ◽  
Vol 159 ◽  
pp. 105443
Author(s):  
Amir Shafiee Kisomi ◽  
Taher Alizadeh ◽  
Alireza Shakeri ◽  
Arezoo Nouri ◽  
Majid Farsadrooh ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Inorganic Arsenic ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

A sequential solid phase microextraction system coupled with inductively coupled plasma mass spectrometry for speciation of inorganic arsenic

2014 ◽  
Vol 6 (12) ◽  
pp. 4205-4211 ◽  
Author(s):  
Peng Li ◽  
Xiao-qin Zhang ◽  
Yi-jun Chen ◽  
Hong-zhen Lian ◽  
Xin Hu
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Inorganic Arsenic ◽  
Inductively Coupled ◽  
Monolithic Capillary Columns ◽  
Icp Ms ◽  
Separation And Preconcentration ◽  
Plasma Mass Spectrometry

A sequential solid phase microextraction (SPME) system consisting of two monolithic capillary columns was developed for simultaneous separation and preconcentration of inorganic arsenic, followed by inductively coupled plasma mass spectrometry (ICP-MS) detection.

Determination of Arsenic (III) and Arsenic (V) Species by Preconcentration and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in Drinking Water Samples Analysis

2011 ◽  
Vol 264-265 ◽  
pp. 1684-1689 ◽  
Author(s):  
M.M. Rahman ◽  
Alias Mohd Yusof ◽  
A.K.H. Wood ◽  
A. Shamsiah
Keyword(s):  
Mass Spectrometry ◽  
Solvent Extraction ◽  
Water Samples ◽  
Inductively Coupled Plasma ◽  
Inorganic Arsenic ◽  
Arsenic Species ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Dissolved Inorganic Arsenic

A simple and less expensive solvent extraction method was used with inductively coupled plasma mass spectrometry (ICP-MS) in the speciation of two environmentally significant, toxic forms of arsenic: arsenite and arsenate. Dissolved inorganic arsenic species in drinking waters from reservoirs and treatment plants were determined by the inductively coupled plasma mass spectrometry analyses. Prior to the analysis the water samples were precocentrated by solvent extraction using APCDT to separate the arsenic species from elemental interferences. The detection limit of this method achieved was 0.059 gL-1. The suitability of the technique in this work is discussed in relation to risk assessment studies of public health.

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