scholarly journals Cardiovascular Risk, Obesity, and Sociodemographic Indicators in a Brazilian Population

2021 ◽  
Vol 9 ◽  
Author(s):  
Nayla Cristina do Vale Moreira ◽  
Ibrahimu Mdala ◽  
Akhtar Hussain ◽  
Bishwajit Bhowmik ◽  
Tasnima Siddiquee ◽  
...  
Keyword(s):  
Risk Score ◽  
Central Obesity ◽  
Framingham Risk Score ◽  
Population Based ◽  
Brazilian Population ◽  
Sociodemographic Characteristics ◽  
Cross Sectional Survey ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Framingham Risk

Background and Aims: Cardiovascular diseases (CVDs) are the leading cause of death globally and in Brazil. Evidence suggests that the risk of CVDs differs by race/ethnicity. Scarce information exists about the association between CVD risk, obesity indicators and sociodemographic characteristics in the Brazilian population.Objectives: We aimed to assess the CVD risk following the Framingham risk score in relation to the population's sociodemographic profile. Further, we examined the association between anthropometric markers and risk of CVDs.Methods: A total of 701 subjects aged ≥20 years from North-eastern Brazil were recruited randomly to participate in a population-based, cross-sectional survey. Age-adjusted data for CVD risk, sociodemographic characteristics, and anthropometric indices were assessed, and their relationships examined.Results: High CVD risk (Framingham risk score ≥10%) was observed in 18.9% of the population. Males (31.9 vs. 12.5%) and older subjects (age ≥45 years: 68.9% vs. age <45 years: 4.2%) had significantly higher risk of CVDs, whereas those employed in manual labor showed lower risk (7.6 vs. 21.7%). Central obesity measures like waist-to-hip ratio and waist-to-height ratio were more strongly associated with predicted CVD risk than body mass index.Conclusions: Our population had a high risk of CVDs using the Framingham risk score. Cost-effective strategies for screening, prevention and treatment of CVDs may likely reduce disease burden and health expenditure in Brazil. Central obesity measures were strongly associated with predicted CVD risk and might be useful in the clinical assessment of patients. Follow-up studies are warranted to validate our findings.

scholarly journals RISIKO PENYAKIT KARDIOVASKULER PADA PESERTA PROGRAM PENGELOLAAN PENYAKIT KRONIS (PROLANIS) DI PUSKESMAS KOTA BIMA: KORELASINYA DENGAN ANKLE BRACHIAL INDEX DAN OBESITAS

2019 ◽  
Author(s):  
Martiningsih Martiningsih ◽  
Abdul Haris
Keyword(s):  
Cardiovascular Disease ◽  
Community Health ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Ankle Brachial Index ◽  
High Risk Group ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Framingham Risk

Penyakit kardiovaskular (PKV) adalah penyakit yang disebabkan oleh gangguan fungsi jantung dan pembuluh darah. PKV dapat dicegah terutama pada kelompok berisiko, diantaranya dengan penilaian risiko menggunakan Framingham Risk Score (FRS). Tujuan penelitian ini adalah untuk menganalisis risiko PKV dan korelasinya dengan Ankle Brachial Index (ABI) dan obesitas pada peserta Prolanis di Kota Bima. Pengambilan data menggunakan instrumen Framingham Risk Score, pengukuran tekanan darah, indeks massa tubuh, lingkar lengan, dan lingkar perut. Jenis penelitian ini adalah penelitian deskriptif analitik dengan rancangan cross-sectional. Pemilihan sampel ditentukan secara consecutive sampling pada semua responden yang aktif mengikuti kegiatan Prolanis dan memenuhi kriteria inklusi di lima Puskesmas di Kota Bima tahun 2018. Analisis data dengan uji parametrik Spearman. Hasil penelitian menunjukkan kelompok risiko tinggi 33 orang (40,7%), risiko sedang 28 orang (34,6%), dan risiko rendah 20 orang (24,7%). Tidak terdapat korelasi antara risiko PKV dengan ABI dan obesitas. Temuan lain dalam penelitian ini mengindikasikan adanya korelasi antara risiko PKV dengan subvariabel obesitas sentral walaupun tidak ditemukan adanya signifikansi (p> 0,05). Pada penelitian selanjutnya, disarankan jumlah sampel yang lebih banyak di komunitas dengan proporsi laki-laki dan perempuan yang berimbang. Kata Kunci: ABI, Framingham, kardiovaskuler, obesitas Abstract Risk of Cardiovascular Disease at Chronic Disease Management Program Participants in The Community Health Centers of Bima Town: The Correlation with Ankle Brachial Index and Obesity. Cardiovascular disease (CVD) is a disease caused by impaired heart and blood vessel function, which can be prevented, especially in risk groups that can be risk assessed using the Framingham Risk Score (FRS). The purpose of this study was to analyze the risk of CVD and the correlation with ABI and obesity in Prolanis participants at Bima City. Data collection was done by using the instrument FRS and measuring systolic blood pressure, body mass index, arm circumference, and waist circumference. This study was a descriptive-analytic study with a cross-sectional design. The sample selection was determined by consecutive sampling for all respondents who actively participated in Prolanis activities and fulfilled the inclusion criteria in five community health center at Bima City in 2018. Data analyzed with Spearmen parametric test. The results of research showed high risk group was 33 peoples (40.7%), moderate risk was 28 peoples (34.6%), and low risk was 20 peoples (24.7%). There was no correlation between risk of CVD  with ABI and obesity. Other findings in this study indicate a correlation between CVD risk and subvariable central obesity, although no significance was found (p> 0.05). In further research, it is recommended that a larger number of samples in the general community with a balanced proportion of men and women. Keywords:  ABI, cardiovaskuler, Framingham, obesity

scholarly journals Cardiovascular Risk Factors in HIV-Infected Adults in North-Central Nigeria: Prevalence, Associated Factors and Assessment of Risk Using the Framingham Risk Score – Preliminary Results from a Survey

2021 ◽  
Vol 4 (1) ◽  
pp. 71-83
Author(s):  
GA Amusa ◽  
G Osaigbovo ◽  
L Imoh ◽  
B Awokola
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Local Environment ◽  
University Teaching ◽  
P Value ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Framingham Risk

HIV/AIDS is an increasingly important cause of cardiovascular (CVD) morbidity world-wide. We sought to evaluate the prevalence of CVD risk factors in HIV positive (HIV+) adults and assessment of these risks using the Framingham risk score (FRS). A cross-sectional study of adult clients of the HIV clinic at Jos University Teaching Hospital. One hundred and fifty HIV+ selected randomly with 50 (age and sex matched) HIV negative (HIV-) participants were enrolled. Relevant history, physical examination and biochemical investigations and 12-lead electrocardiography were performed. Data was analyzed using Epi-info 7.2 statistical software and P value < 0.05 was considered significant. The prevalent major CVD risk factors were dyslipidaemia (30.0% versus 6.0%), hypertension (34.0% versus 10.0%) and diabetes mellitus (10.0% versus 2.0%) among the HIV+ and HIV- participants respectively. The FRS of the HIV+, 3 (IQR 3-28) were statistically significantly higher than that of the HIV- participants, 2 (IQR 1-13); P=0.001. Furthermore, 32% of the HIV+ had moderate-high FRS compared to 2% of HIV- participants. CD4 count ≤ 200 cells/ml, use of anti-retroviral (ART), ART use ≥ 2 years and use of protease inhibitors (PI) emerged as predictors of moderate-high FRS among the HIV+ participants. In conclusion, a high prevalence of CVD risk factors exists among HIV+ population in our local environment. These risk factors can be identified early by baseline/periodic cardiovascular work-up which should include use of CVD risk tools. Early diagnosis and treatment will significantly reduce morbidity and mortality in these patients.

scholarly journals RISIKO PENYAKIT KARDIOVASKULER PADA PESERTA PROGRAM PENGELOLAAN PENYAKIT KRONIS (PROLANIS) DI PUSKESMAS KOTA BIMA: KORELASINYA DENGAN ANKLE BRACHIAL INDEX DAN OBESITAS

2019 ◽  
Vol 22 (3) ◽  
pp. 200-208
Author(s):  
Martiningsih Martiningsih ◽  
Abdul Haris
Keyword(s):  
Cardiovascular Disease ◽  
Community Health ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Ankle Brachial Index ◽  
High Risk Group ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Framingham Risk

Penyakit kardiovaskular (PKV) adalah penyakit yang disebabkan oleh gangguan fungsi jantung dan pembuluh darah. PKV dapat dicegah terutama pada kelompok berisiko, diantaranya dengan penilaian risiko menggunakan Framingham Risk Score (FRS). Tujuan penelitian ini adalah untuk menganalisis risiko PKV dan korelasinya dengan Ankle Brachial Index (ABI) dan obesitas pada peserta Prolanis di Kota Bima. Pengambilan data menggunakan instrumen Framingham Risk Score, pengukuran tekanan darah, indeks massa tubuh, lingkar lengan, dan lingkar perut. Jenis penelitian ini adalah penelitian deskriptif analitik dengan rancangan cross-sectional. Pemilihan sampel ditentukan secara consecutive sampling pada semua responden yang aktif mengikuti kegiatan Prolanis dan memenuhi kriteria inklusi di lima Puskesmas di Kota Bima tahun 2018. Analisis data dengan uji parametrik Spearman. Hasil penelitian menunjukkan kelompok risiko tinggi 33 orang (40,7%), risiko sedang 28 orang (34,6%), dan risiko rendah 20 orang (24,7%). Tidak terdapat korelasi antara risiko PKV dengan ABI dan obesitas. Temuan lain dalam penelitian ini mengindikasikan adanya korelasi antara risiko PKV dengan subvariabel obesitas sentral walaupun tidak ditemukan adanya signifikansi (p> 0,05). Pada penelitian selanjutnya, disarankan jumlah sampel yang lebih banyak di komunitas dengan proporsi laki-laki dan perempuan yang berimbang. Kata Kunci: ABI, Framingham, kardiovaskuler, obesitas Abstract Risk of Cardiovascular Disease at Chronic Disease Management Program Participants in The Community Health Centers of Bima Town: The Correlation with Ankle Brachial Index and Obesity. Cardiovascular disease (CVD) is a disease caused by impaired heart and blood vessel function, which can be prevented, especially in risk groups that can be risk assessed using the Framingham Risk Score (FRS). The purpose of this study was to analyze the risk of CVD and the correlation with ABI and obesity in Prolanis participants at Bima City. Data collection was done by using the instrument FRS and measuring systolic blood pressure, body mass index, arm circumference, and waist circumference. This study was a descriptive-analytic study with a cross-sectional design. The sample selection was determined by consecutive sampling for all respondents who actively participated in Prolanis activities and fulfilled the inclusion criteria in five community health center at Bima City in 2018. Data analyzed with Spearmen parametric test. The results of research showed high risk group was 33 peoples (40.7%), moderate risk was 28 peoples (34.6%), and low risk was 20 peoples (24.7%). There was no correlation between risk of CVD  with ABI and obesity. Other findings in this study indicate a correlation between CVD risk and subvariable central obesity, although no significance was found (p> 0.05). In further research, it is recommended that a larger number of samples in the general community with a balanced proportion of men and women. Keywords:  ABI, cardiovaskuler, Framingham, obesity

scholarly journals A comparative study of cardiovascular disease risk among bus drivers and bus conductors of a state transport corporation in North Goa

2021 ◽  
Vol 8 (6) ◽  
pp. 3023
Author(s):  
Shefalee Pai Vernekar ◽  
Hemangini Kishore Shah
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Bus Drivers ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Framingham Risk ◽  
The Difference ◽  
Bus Conductors

Background: Bus drivers and bus conductors are predisposed to increased cardiovascular disease (CVD) risks.Driving for long duration involves prolonged sitting, which enforces sedentary behavior among drivers in comparison to conductors who have the freedom to move aboutBackground: Bus drivers and bus conductors are predisposed to increased cardiovascular disease (CVD) risks.Driving for long duration involves prolonged sitting, which enforces sedentary behavior among drivers in comparison to conductors who have the freedom to move about in the bus. The aim and objectives of the study were to identify selected risk factors for CVDs among bus drivers and bus conductors; to estimate the CVDs risk among them using Framingham risk score and to study the difference of risk factors and CVDs risk between bus drivers and conductors.Methods: The present study was a comparative cross-sectional study among 105 bus drivers and 105 bus conductors at the Panaji bus depot of Goa. A pre-designed semi-structured questionnaire was used to collect data along with anthropometric, clinical examination and blood investigations. The Framingham risk score with BMI and lipids was used to compare the CVD risk.Results: Higher percentage of bus drivers had diabetes, hypertension, obesity and dyslipidemia. When the CVD risk was compared using the Framingham risk score, 63.8% bus drivers had intermediate-high CVD risk using FRS-BMI compared to 46.7% bus conductors and the difference is found to be significant. Using FRS- lipids, 65.7% bus drivers had intermediate-high risk compared to 53.3% bus conductors.Conclusions: The behavioral risk factors for CVD were higher among bus drivers compared to bus conductors. in the bus. Aims and objectives: 1) To identify selected risk factors for CVDs among bus drivers and bus conductors 2) To estimate the CVDs risk among them using Framingham risk score 3)To study the difference of risk factors and CVDs risk between bus drivers and conductors.Methods: The present study is a comparative cross sectional study among 105 bus drivers and 105 bus conductors at the Panaji bus depot of Goa.  A predesigned semi structured questionnaire was used to collect data along with anthropometric, clinical examination and blood investigations. The Framingham risk score with BMI and Lipids was used to compare the CVD riskResults:Higher percentage of bus drivers had diabetes, hypertension, obesity and dyslipidemia. When the CVD risk was compared using the Framingham risk score, 63.8 % bus drivers had intermediate-high CVD risk using FRS-BMI compared to 46.7 % bus conductors and the difference is found to be significant. Using FRS-Lipids, 65.7 % bus drivers had intermediate-high risk compared to 53.3 % bus conductors.Conclusion: The behavioural risk factors for CVD were higher among bus drivers compared to bus conductors.

scholarly journals Adding Estimated Cardiorespiratory Fitness to the Framingham Risk Score and Mortality Risk in a Korean Population-Based Cohort Study

2022 ◽  
Vol 19 (1) ◽  
pp. 510
Author(s):  
Inhwan Lee ◽  
Jeonghyeon Kim ◽  
Hyunsik Kang
Keyword(s):  
Cohort Study ◽  
Cardiorespiratory Fitness ◽  
Risk Score ◽  
Mortality Risk ◽  
Framingham Risk Score ◽  
Population Based ◽  
Added Value ◽  
Cvd Risk ◽  
Framingham Risk ◽  
Cvd Mortality

Background: The added value of non-exercise-based estimation of cardiorespiratory fitness (eCRF) to cardiovascular disease (CVD) risk factors for mortality risk has not been examined in Korean populations. Methods: This population-based prospective cohort study examined the relationship of the 10-year Framingham risk score (FRS) for CVD risk and eCRF with all-cause and CVD mortality in a representative sample of Korean adults aged 30 years and older. Data regarding a total of 38,350 participants (16,505 men/21,845 women) were obtained from the 2007–2015 Korea National Health and Nutrition Examination Survey (KNHANES). All-cause and CVD mortality were the main outcomes. The 10-year FRS point sum and eCRF level were the main exposures. Results: All-cause and CVD mortality was positively correlated with the 10-year FRS point summation and inversely correlated with eCRF level in this study population. The protective of high eCRF against all-cause and CVD mortality was more prominent in the middle and high FRS category than in the low FRS category. Notably, the FRS plus eCRF model has better predictor power for estimating mortality risk compared to the FRS only model. Conclusions: The current findings indicate that eCRF can be used as an alternative to objectively measured CRF for mortality risk prediction.

scholarly journals A 10-Years Risk of Cardiovascular Disease Among HIV-Positive Individuals Using BMI-Based Framingham Risk Score in Indonesia

2021 ◽  
Vol 7 ◽  
pp. 237796082198913
Author(s):  
Linlin Lindayani ◽  
Heni purnama ◽  
Nunung Nurhayati ◽  
Diwa Agus Sudrajat ◽  
Taryudi Taryudi
Keyword(s):  
Cardiovascular Disease ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Smoking History ◽  
Hiv Positive ◽  
Routine Practice ◽  
Cvd Risk ◽  
Hiv Patients ◽  
Cross Sectional ◽  
Framingham Risk

Introduction Cardiovascular disease (CVD) is the primary cause of death in HIV patients. The number of HIV patients suffering from cardiovascular disease is almost twice as high as that of patients who are not HIV-positive. Objective The purpose of this study was to evaluate risk of cardiovascular disease among HIV-positive persons. Methods We conducted a cross-sectional study with HIV positive individuals at public health center and non-AIDS govermental organization. We enrolled people diagnosed with HIV, age over 30 years old, and on CVD medications. We collected data of demographic, anthropometric and clinical information, smoking history, and non-fasting cholesterol and blood glucose. Estimation of 10-years CVD risk was calculated using the BMI-based Framingham Risk Score. Results Of 150 participants enrolled, 66.7% were male and mean age was 38.09 (SD = 7.99) years. The mean current CD4 counts was 493.3 (SD = 139.8) cells/mm3. Female were younger, had a shorter duration living with HIV and a shorted duration of receiving ART than males. About 8.7% of respondents had a high risk of developing a CVD event in the next 10 years, and higher among females than males. The most common CVD risk factors were smoking, high blood pressure, and hypercholestrolemia. Conclusion Our study demonstrates that HIV positive persons who are at risk for developing CVD in the next 10-years. There is an increasing need for educational programs on CVD prevention for the HIV-positive person and to further facilitate the identification of persons at elevated risk in routine practice.

scholarly journals Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Elijah Stone ◽  
Yuling Zhou ◽  
Herbert Jelinek ◽  
Craig S. Mclachlan
Keyword(s):  
Cardiovascular Risk ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Cross Sectional ◽  
Online Risk ◽  
Weak Association ◽  
Framingham Risk ◽  
Qrs Duration ◽  
Risk Parameters

Abstract Background Prolonged electrocardiogram (ECG) QRS duration has been associated with increased cardiovascular risk. It is unclear whether the main predictor of cardiovascular risk, the Framingham risk score also predicts short-term changes in ECG QRS duration. Our aim is to determine whether baseline Framingham risk score is associated with baseline or changes in QRS duration. Methods A retrospective cross-sectional analysis was performed using observational data obtained from two hundred two participants. Framingham risk score was calculated using an online risk calculator. QRS duration was obtained using a 10 s trace from a Welch Allyn PC-based 12-lead ECG system. Results Average follow-up duration was 3.3 ± 1.1 years. Mean QRS change was 1.8 ± 11.4 ms. Specifically, among two hundred two participants, there are 104 subjects with a greater QRS duration at follow-up, while 98 subjects had the same or a shorter follow-up QRS duration. Baseline Framingham risk score did not significantly predict an increase in QRSd with an odds ratio of 1.04 (P = 0.230). Regression analysis of QRS duration at baseline and Framingham risk at baseline had a weak association (R2 = 0.020; P = 0.043). The Framingham risk score at follow-up was likewise has a weak association with follow-up QRS duration (R2 = 0.045; P = 0.002). Conclusions Our results do not demonstrate a statistically significant association between Framingham risk parameters and future QRS duration changes over longitudinal time. QRS duration had variable changes between baseline and follow-up. This might suggest that a longer period of follow-up is required to document more stable increases in QRS duration associated with ventricular pathology. A larger population study is needed to confirm our observations.

scholarly journals Prediksi Tingkat Risiko Penyakit Kardiovaskuler Aterosklerotik pada Pasien yang Berobat di Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Engelin E. Emor ◽  
Agnes L. Panda ◽  
Janry Pangemanan
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Low Risk ◽  
Risk Level ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional ◽  
Framingham Risk

Abstract: Atherosclerotic cardiovascular disease is caused by the accumulation of plaque on the artery wall causing dysfunction of anatomical and hemodynamic system of the heart and blood flow. There are many risk factors that cause atherosclerotic cardiovascular disease which are divided into modifiable and unmodifiable risk factors. Prevention of this disease can be achieved with early detection, such as prediction the risk level of 10 years ahead of atherosclerotic cardiovascular disease by using the Framingham Risk Score (FRS). This study was aimed to obtain the risk level of atherosclerotic cardiovascular disease in patients at Internal Medicine Polyclinic of Prof. Dr. R. D. Kandou Hospital Manado by using their medical records from September to October 2017. This was a descriptive study with a cross sectional design. There were 100 samples obtained by using conclusive sampling technique. Of the 100 patients, 42 (42%) patients had low risk, 27 (27%) patients had moderate risk, and 31 (31%) patients had high risk of atherosclerotic cardiovascular disease in 10 years ahead. Conclusion: In this study, the highest percentage was in patients with low risk, followed by patients with high risk, and moderate risk.Keywords: ASCVD, Framingham Risk Score, Risk of atherosclerotic cardiovascular sisease. Abstrak: Penyakit kardiovaskuler aterosklerotik adalah penyakit yang disebabkan oleh adanya timbunan plak pada dinding arteri sehingga menyebabkan gangguan fungsional, anatomis serta sistem hemodinamis jantung dan pembuluh darah. Terdapat banyak faktor risiko yang menyebabkan terjadinya penyakit kardiovaskuler aterosklerotik yang dibagi menjadi faktor risiko yang dapat dimodifikasi dan yang tidak dapat dimodifikasi. Pencegahan penyakit ini dapat dilakukan dengan deteksi dini, salah satunya yaitu dengan memrediksi tingkat risiko 10 tahun kedepan terjadinya penyakit kardiovaskuler aterosklerotik dengan menggunakan Framingham Risk Score. Penelitian ini bertujuan untuk mengetahui tingkat risiko penyakit kardiovaskuler ateroskerotik pada pasien di Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang menggunakan data rekam medik pasien Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode September - Oktober 2017. Sampel penelitian berjumlah 100 orang dengan teknik pengambilan conclusive sampling. Terdapat 42 pasien (42%) dengan tingkat risiko rendah, 27 pasien (27%) dengan risiko sedang, dan 31 pasien (31%) dengan risiko tinggi terkena penyakit kardiovaskuler aterosklerotik 10 tahun kedepan. Simpulan: Pada studi ini, persentase tertinggi ialah pasien dengan tingkat risiko rendah terjadinya penyakit kardiovaskuler aterosklerotik, diikuti tingkat risiko tinggi dan risiko sedang.Kata kunci: ASCVD, Framingham Risk Score, tingkat risiko penyakit kardiovaskuler aterosklerotik

scholarly journals Does Adding Adverse Pregnancy Outcomes Improve the Framingham Cardiovascular Risk Score in Women? Data from the Tehran Lipid and Glucose Study

2022 ◽  
Author(s):  
Marzieh Saei Ghare Naz ◽  
Ali Sheidaei ◽  
Ali Aflatounian ◽  
Fereidoun Azizi ◽  
Fahimeh Ramezani Tehrani
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Pregnancy Outcomes ◽  
Framingham Risk Score ◽  
Adverse Pregnancy Outcomes ◽  
Proportional Hazard ◽  
Cvd Risk ◽  
C Statistic ◽  
Framingham Risk ◽  
Adverse Pregnancy

Background Limited and conflicting evidence is available regarding the predictive value of adding adverse pregnancy outcomes (APOs) to established cardiovascular disease (CVD) risk factors. Hence, the objective of this study was to determine whether adding APOs to the Framingham risk score improves the prediction of CVD events in women. Methods and Results Out of 5413 women who participated in the Tehran Lipid and Glucose Study, 4013 women met the eligibility criteria included for the present study. The exposure and the outcome variables were collected based on the standard protocol. Cox proportional hazard model was used to evaluate the association of APOs and CVDs. The variant of C‐statistic for survivals and reclassification of subjects into Framingham risk score categories after adding APOs was reported. Out of the 4013 eligible subjects, a total of 1484 (36.98%) women reported 1 APO, while 395 (9.84%) of the cases reported multiple APOs. Univariate proportional hazard Cox models showed the significant relations between CVD events and APOs. The enhanced model had a higher C‐statistic indicating more acceptable discrimination as well as a slight improvement in discrimination (C‐statistic differences: 0.0053). Moreover, we observed a greater risk of experiencing a CVD event in women with a history of multiple APOs compared with cases with only 1 APO (1 APO: hazard ratio [HR] = 1.22; 2 APOs: HR; 1.94; ≥3 APOs: HR = 2.48). Conclusions Beyond the established risk factors, re‐estimated CVDs risk by adding APOs to the Framingham risk score may improve the accurate risk estimation of CVD. Further observational studies are needed to confirm our findings.

scholarly journals 7500 steps per day is associated with lower cardiovascular risk in rural residents with a high prevalence of sedentary lifestyle

2021 ◽  
Vol 20 (Supplement_1) ◽  
Author(s):  
I Madujibeya ◽  
L Misook ◽  
T Lennie ◽  
G Mudd-Martin ◽  
M Biddle ◽  
...  
Keyword(s):  
Risk Score ◽  
Rural Areas ◽  
Framingham Risk Score ◽  
Step Count ◽  
Daily Step ◽  
Cvd Risk ◽  
Rural Residents ◽  
Physically Active ◽  
Framingham Risk ◽  
Daily Step Count

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Sedentary lifestyle is one of the modifiable risk factors that account for the high prevalence of cardiovascular diseases (CVD) in the rural areas.1,2 Daily step counting, using wearable devices, is increasingly used to monitor physical activity levels in interventions targeting CVD risk reduction in the rural areas.3,4 However, there is a lack of evidence to support a daily step count threshold that may reduce CVD risk among rural residents. The purpose of this study was to examine the relationship between daily step count cut-points and CVD risk. Methods This secondary analysis included 312 adults living in the rural areas in the southern United States. Daily step counts from pedometers were collected for 14 consecutive days. Established cut-points were used to categorize participants into groups based on mean daily step count as sedentary (≤ 5000 steps/day), less active (5000 -7499 steps/per), and physically active (≥7500 steps/day).5-7 CVD risk was measured with the Framingham risk score. Generalized additive models were used to examine differences among the 3 activity groups in Framingham risk score, controlling for educational level, perceived physical health status, depressive, marital status, and years of residence in a rural county. Results Among the participants (75% female, mean age 50.1 (±13.6) years), 40.7% were sedentary, 35.2% were less active, and 24.0% were physically active. The average Framingham risk score was 11.2% (±9.4%). Framingham risk scores were 1.7% lower in the less active compared to the sedentary group, but the effect was not significant (p &lt;  .11), and 2.6% lower in the physically active compared to the sedentary group (p &lt; .04). The model accounted for 22% of the variation in Framingham risk scores. Conclusion These findings indicate that rural residents who averaged 7500 steps or more per day had lower CVD risk, and the difference is clinically significant.

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