scholarly journals Case Report: A Review of the Literature on Spinal Intradural Hemangiopericytoma With Spinal Cord Infiltration and a Case Report

2020 ◽  
Vol 7 ◽  
Author(s):  
Liu Chunyang ◽  
Zhu Huiqin ◽  
Sun Mo ◽  
Wang Yubo ◽  
Zhang Xianfeng
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Postoperative Radiotherapy ◽  
Relevant Literature ◽  
Tumor Resection ◽  
Primary Objective ◽  
Rank Test ◽  
Related Factors ◽  
Who Grade ◽  
Clinical Patient

Purpose: Primary spinal intradural hemangiopericytoma (HPC) with spinal cord infiltration is rare. The purposes of this study were to investigate the clinical features of intradural HPC with spinal cord infiltration and to explore the related factors affecting tumor recurrence.Methods: We report a case of intramedullary HPC with intramedullary infiltration of the thoracic spine. The relevant literature was searched for with PubMed, and clinical data were extracted from the included studies. Clinical patient data were described and statistically analyzed. Then, Kaplan-Meier (KM) curves were used to describe the relapse-free survival (RFS) of patients in different groups, and the log-rank test was used for evaluation.Results: A total of 11 cases of spinal intradural HPC with spinal cord infiltration were included (including the case described in this report). Further data analysis showed that sex (P = 0.249), age (P = 0.876), tumor location (P = 0.524), and postoperative radiotherapy (P = 0.12) had no significant influence on RFS. The range of tumor resection (P = 0.004) and the WHO grade (P = 0.014) significantly affect the patient RFS.Conclusion: RFS was higher in patients with total tumor resection than in patients with subtotal tumor resection. The patients with lower WHO grade have better RFS. Total tumor resection is the primary objective of surgical treatment of spinal intradural HPC with spinal infiltration. Long-term postoperative follow-up is considered necessary.

Intramedullary inclusion cysts of the cervicothoracic junction

2007 ◽  
Vol 7 (2) ◽  
pp. 236-242 ◽  
Author(s):  
Alfred T. Ogden ◽  
Alexander G. Khandji ◽  
Paul C. McCormick ◽  
Michael G. Kaiser
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Surgical Treatment ◽  
Dermoid Cyst ◽  
Clinical Features ◽  
Epidermoid Cyst ◽  
Relevant Literature ◽  
Literature Discussion ◽  
Cervicothoracic Junction

✓Intramedullary inclusion cysts are extremely rare within the rostral spinal cord. In this case report the authors outline the clinical features and surgical treatment of one dermoid cyst and one epidermoid cyst of the cervicothoracic junction. The authors also include a relevant literature discussion regarding the treatment and the embryological origin of these lesions.

scholarly journals Xanthomatous meningioma, a rare histological variant: Case report

2021 ◽  
Vol 6 (4) ◽  
pp. 305-310
Author(s):  
Sandeep Mohindra ◽  
Ninad R Patil ◽  
Manjul Tripathi ◽  
Sonikpreet Aulakh ◽  
Nirmalya Banerjee ◽  
...  
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Immunohistochemical Staining ◽  
Relevant Literature ◽  
Definitive Diagnosis ◽  
Who Grade ◽  
Radiographic Features ◽  
Histological Variant ◽  
Vacuolated Cytoplasm ◽  
Sphenoid Wing Meningioma

Xanthomatous meningioma is a WHO grade I metaplastic meningioma where neoplastic cells contain lipid-filled vacuolated cytoplasm. The origin of xanthomatous meningiomas is believed to be from meningothelial cells but diagnosis remains difficult because of their close resemblance with the histiocytes. Peculiar radiographic features may aid in diagnosis, however, definitive diagnosis requires immunohistochemical staining. We report a case of 43-year-old male with sphenoid wing meningioma revealing xanthomatous changes and received treatment as grade 1 meningioma. Though the exact pathophysiology remains unknown, we believe focal or gross metaplastic changes lead to transformation of tumor cells into the xanthomatous subtype. Authors discuss this interesting a rare histologic variant with discussion of the relevant literature.

Pediatric spinal cord diffuse midline glioma, H3 K27-altered with intracranial and spinal leptomeningeal spread: A case report

2022 ◽  
pp. 197140092110674
Author(s):  
Bettina L Serrallach ◽  
Brandon H Tran ◽  
David F Bauer ◽  
Carrie A Mohila ◽  
Adekunle M Adesina ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Female Adolescent ◽  
Rapid Progression ◽  
Imaging Features ◽  
High Grade ◽  
Who Grade ◽  
Leptomeningeal Seeding ◽  
High Grade Gliomas ◽  
Diffuse Midline Glioma

Primary spinal cord high-grade gliomas, including those histologically identified as glioblastoma (GBM), are a rare entity in the pediatric population but should be considered in the differential diagnosis of intramedullary lesions. Pediatric spinal cord high-grade gliomas have an aggressive course with poor prognosis. The aim of this case report is to present a 15-year-old female adolescent with histopathologically confirmed spinal cord GBM with H3F3A K27 M mutation consistent with a diffuse midline glioma (DMG), H3 K27-altered, CNS WHO grade 4 with leptomeningeal seeding on initial presentation. As imaging features of H3 K27-altered DMGs are non-specific and may mimic more frequently encountered neoplastic diseases as well as demyelinating disorders, severe neurological deficits at presentation with short duration, rapid progression, and early leptomeningeal seeding should however raise the suspicion for a pediatric-type diffuse high-grade glioma like DMG, H3 K27-altered.

Surgery for Spinal Cord Ependymomas

Neurosurgery ◽  
2011 ◽  
Vol 68 (2) ◽  
pp. 302-309 ◽  
Author(s):  
Azize Boström ◽  
Marec von Lehe ◽  
Wolfgang Hartmann ◽  
Torsten Pietsch ◽  
Mareike Feuss ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Independent Predictor ◽  
Postoperative Radiotherapy ◽  
Progression Free Survival ◽  
World Health ◽  
Incomplete Resection ◽  
Who Grade ◽  
Free Survival ◽  
Oncological Outcomes ◽  
Operative Notes

Abstract BACKGROUND: Spinal cord tumors account for 5% to 10% of all primary central nervous system tumors. The most common intramedullary neoplasms are ependymomas, composing 50% to 60% of spinal neuroepithelial tumors in adults. OBJECTIVE: To evaluate the clinical and oncological outcomes of patients with spinal ependymoma primarily treated with microsurgery. METHODS: Patient charts and operative notes were analyzed to evaluate the clinical and oncological outcomes of 57 patients (33 men, 24 women) undergoing surgery for spinal ependymal tumors between 1987 and 2007. Mean follow-up was 67 months (range, 1-195 months; median, 56 months). Histopathological findings were 1 subependymoma World Health Organization (WHO) grade I, 16 myxopapillary ependymomas WHO grade I, 39 ependymomas WHO grade II, and 1 anaplastic ependymoma WHO grade III. Histopathological diagnoses were reviewed in 52 cases (91%) using the 2007 WHO classification. RESULTS: There were 47 complete resections (83%). Only 4 patients (7%) underwent (postoperative) radiotherapy. Forty-nine of 57 patients (86%) had stable or improved McCormick grades directly after surgery. A permanent decrease in the McCormick grade was seen in 4 (7%) patients. Multivariate logistic regression revealed only the preoperative neurological status of the patient as an independent predictor of functional outcome (P = .007). Recurrent tumors were diagnosed 12 to 72 months after surgery in 5 of 57 patients (9%) including 3 of 16 myxopapillary ependymomas (19%). In 4 of 5 patients, the primary tumor was incompletely resected. The progression-free survival rate was 89% and 84% for all patients at 5 and 10 years, respectively. An incomplete resection proved the only independent predictor of progression-free survival (P = .05). CONCLUSION: These results support early surgery aiming at complete resection as the primary treatment for presumed spinal ependymomas. The prognosis after surgery for some myxopapillary ependymomas seems worse than generally believed.

scholarly journals Spinal Neurocytoma: A Case Report and Review of Literature

2017 ◽  
Vol 06 (03) ◽  
pp. 228-231
Author(s):  
Khalil Guedira ◽  
Nidhal Matar ◽  
Maher Salem ◽  
Ines Chelly ◽  
Ihsen Zemmel
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Relevant Literature ◽  
Review Of Literature ◽  
Pediatric Case ◽  
Sporadic Cases

AbstractExtraventricular locations of neurocytoma are extremely rare, especially in the spinal cord, which has been reported in only sporadic cases. In this article, we report a new pediatric case of a spinal neurocytoma in a 12-year-old girl and briefly review the relevant literature.

scholarly journals RONC-08. SURVIVAL IMPACT OF POSTOPERATIVE RADIOTHERAPY TIMING IN PEDIATRIC AND YOUNG ADULT EPENDYMOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii457-iii457
Author(s):  
Sunny Shah ◽  
Chase Mallory ◽  
Kevin Gates ◽  
Muni Rubens ◽  
Ossama Maher ◽  
...  
Keyword(s):  
Postoperative Radiotherapy ◽  
Postoperative Recovery ◽  
Rank Test ◽  
Optimal Timing ◽  
Subtotal Resection ◽  
Who Grade ◽  
Factors Associated ◽  
Intracranial Ependymoma ◽  
Radiotherapy Dose ◽  
Delayed Time

Abstract INTRODUCTION Postoperative radiotherapy is commonly given for WHO Grade 2–3 intracranial ependymoma. Clinicians generally aim to begin radiotherapy ≤5 weeks following surgery, but the optimal timing remains uncertain. METHODS The National Cancer Database was queried for patients (age ≤39 years) with localized WHO Grade 2–3 intracranial ependymoma treated with surgery and postoperative radiotherapy. Multivariable logistic regression was used to identify factors associated with delayed postoperative radiotherapy, defined as starting >8 weeks after surgery. Overall survival (OS) curves were plotted based on radiotherapy timing (≤5 weeks, 5–8 weeks, and >8 weeks after surgery) and compared by log-rank test. Multivariate analysis (MVA) was used to identify factors associated with OS. RESULTS In the final analytic set of 1,043 patients, age ≥21 years (OR 2.07, 95% CI 1.56–2.74) and WHO Grade 2 tumors (OR 1.41, 95% CI 1.08–1.85) were significantly associated with delayed time to adjuvant radiotherapy. No difference in 3-year OS was observed in patients who initiated radiotherapy ≤5 weeks, 5–8 weeks, and >8 weeks after surgery (89.8% vs. 89.1% vs. 88.4%; p= 0.796). On MVA, anaplastic histology (HR 2.414, 95% CI 1.784–3.268, p<0.001) and subtotal resection (HR 2.398, 95% CI 1.519–3.788, p<0.001) were significantly associated with reduced OS. Timing of radiotherapy, total radiotherapy dose, age, insurance status, and other factors were not significant. CONCLUSION Delayed postoperative radiotherapy was not associated with inferior survival in patients with intracranial ependymoma, suggesting delayed radiotherapy initiation may be considered in patients requiring longer postoperative recovery or referral to an appropriate radiotherapy center.

Poster 268: Mirror Therapy for Persistent Upper Limb Pain Following Spinal Cord Tumor Resection: A Case Report

PM&R ◽  
2009 ◽  
Vol 1 ◽  
pp. S220-S220 ◽  
Author(s):  
Gary P. Chimes ◽  
Cheryl D. Bernstein ◽  
Megan H. Cortazzo ◽  
Lynne M. Huber
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Upper Limb ◽  
Spinal Cord Tumor ◽  
Tumor Resection ◽  
Mirror Therapy ◽  
Limb Pain ◽  
Upper Limb Pain

Radiotherapy for atypical meningiomas

2011 ◽  
Vol 115 (4) ◽  
pp. 811-819 ◽  
Author(s):  
Richard Mair ◽  
Kevin Morris ◽  
Ian Scott ◽  
Thomas A. Carroll
Keyword(s):  
Cox Regression ◽  
Postoperative Radiotherapy ◽  
Tumor Resection ◽  
Subtotal Resection ◽  
Who Grade ◽  
Grade Ii ◽  
Atypical Meningiomas ◽  
Tumor Remnant ◽  
First Time

Object The role of postoperative radiotherapy in patients undergoing first-time resection of WHO Grade II meningioma remains unclear as reflected by varied practices in published clinical studies and national professional surveys. Much of the relevant literature is based on pre-2000 WHO grading criteria for atypical meningiomas. Authors in this study set out to explore the role of postoperative radiotherapy in patients undergoing first-time surgery for WHO Grade II meningiomas diagnosed using revised WHO 2000 criteria, against a background of otherwise limited published literature on this issue. Methods The authors retrospectively collected data on 114 consecutive patients who underwent first-time resection of WHO Grade II atypical meningiomas diagnosed using 2000 WHO criteria, and who variably underwent postoperative radiotherapy according to individual surgeon practices. Outcomes, including radiological recurrence, were submitted to Kaplan-Meier and Cox regression analyses. Results Postoperative radiotherapy demonstrated a significant benefit only when patients who had undergone gross-total tumor resection and those who had undergone subtotal resection along with postoperative radiosurgery to the tumor remnant were excluded from analysis. Conclusions The authors have performed the largest study in the literature to examine the use of radiotherapy for WHO Grade II, atypical, meningiomas following a first-time resection. They suggest that radiotherapy is not appropriate after first-time resection of those lesions in which a gross-total resection (Simpson Grade 1 or 2) has been achieved. They also advise that any tumor remnant radiologically demonstrated on postoperative imaging should be treated with radiosurgery and that postoperative radiotherapy after a first-time resection should be reserved for tumor remnants too large for radiosurgery and for which a second staged operation is not planned.

scholarly journals Case report of Pilomyxoid astrocytoma of the thoracic spinal cord: Literature review with presenting an extremely rare Case of over 70 year’s old patient

2021 ◽  
Author(s):  
Zeyad Abousabie ◽  
Mohamed Almzeogi ◽  
aleksandar janicijevic ◽  
Goran Tasic
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Literature Review ◽  
Rare Case ◽  
Postoperative Radiotherapy ◽  
Surgical Removal ◽  
Thoracic Spinal Cord ◽  
Pilomyxoid Astrocytoma ◽  
Case Summary ◽  
Thoracic Spinal

Case summary: The MRI of a 73 year old male patient with paraparesis, showed an intramedullary mass at the thoracic spinal cord extending from T6 to T8. Partial surgical removal was preformed and a biopsy was taken, followed by postoperative radiotherapy.

Sign in / Sign up

Export Citation Format

Share Document