Acute Necrotizing Pancreatitis following Long-Term Antipsychotic Use

Introduction. Psychiatrists commonly use antipsychotic medications in the treatment of psychotic and mood disorders. A rare but known side effect of atypical antipsychotics is acute pancreatitis. Most cases of antipsychotic-induced pancreatitis occur within six months of initiation. The mechanism believed to cause this reaction is hypertriglyceridemia. Here, we present a unique case of antipsychotic-induced pancreatitis that deviates from previous cases in the time to onset of the pancreatitis and the mechanism of presentation. Case Presentation. We present a case of a patient with treatment-resistant schizophrenia managed for over a decade on olanzapine and haloperidol. Twelve years after stabilization on this medication regimen, the patient developed acute pancreatitis, which after extensive medical workup was attributed to his psychotropic medications. We review his medical and psychiatric history, his medical course and workup during the episode of pancreatitis, and review recommendations for patients at risk for antipsychotic-induced pancreatitis based on this case and the current literature. Discussion. This case illustrates that acute pancreatitis can occur long after the initiation of antipsychotic medications and may be mediated by mechanisms other than hypertriglyceridemia. While there are reports of antipsychotic-induced psychosis occurring within months, and in a limited set of cases, years, after medication initiation, the twelve-year time interval in the present case is by far the longest duration of an antipsychotic precipitating this adverse event recorded in the literature. This case highlights that although exceedingly rare, prescribers should be aware of the risk for drug-induced pancreatitis in patients stable on antipsychotic medications.

Can digital transformation be measured from a strategic perspective? Some evidence based on content analysis in the banking and clothing industries.

Digital transformation is widely recognized to be a key issue in contemporary management studies. The area is attracting increasing attention because of both the general trend of the growing importance which digital technologies play in the present society, as well as the ways companies are using digital technologies to improve their competitive advantage. As a result, digital transformation is a subject of a growing number of papers, research, and managerial publications. The main aim of this work is to propose and validate a method to measure the phenomenon and its role in companies’ strategies, and to gather information on strategic directions for digital transformation in enterprises. This paper presents an overview of the literature discussion on digital transformation. A method to study directions of digital transformation in enterprises is demonstrated. It is based on the content analysis methodology and is used to study a choice-based sample of companies listed on the Warsaw Stock Exchange. The research carried out offers preliminary evidence supporting the conclusion that digital transformation is a phenomenon which can be measured with the content analysis framework. The findings also outline strategic directions for digital transformation and shed light on possible variables influencing the process.

Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion

We present a rare case of KRAS keratinocytic epidermal nevus syndrome with lymphatic malformation, responsive to treatment with sirolimus, an mTOR inhibitor. A brief review of the current literature regarding sirolimus use in vascular malformations, lymphatic malformations, regional overgrowth syndromes, and RASopathies is discussed.

Reconstruction of Islamic Institution Education the 21st Hopes, Challenges, Paradigms, and Roles of Arabic

This research aims to describe the problems are how the position, condition, standardization, accusation, and protection of Islamic institutions higher education to services customer’s or student in Indonesia and how is learning system and developing science in this age and challenges facing Islamic institution of higher education and the expectations and strategies to deal accretion. The method uses library research, observation to document, literature, discussion, and interview with experts about LPTI. The research finding is the 21st century is the age globalization. It takes to impact on interdependencies, competition, and advances in science, information and communication technology on institution of Islamic higher education. Interdependention describe the something happened in a country correlated with other country. This condition has to change of paradigm at management of institution higher education that the society make it is corporate has to protects and the best accusation and quickly services to customers. The conclusion are (1) the expectation that Islamic higher education must remain firm lying to the main foundations, the Qur'an and Hadith, and pay attention to and strengthen the teaching of Arabic and must be able to prove the truth of the foundation in human/community life and in addition to (2) Islamic higher educational must enter the official level of quality standards, and in the end (3) Islamic higher education make themselves as higher education research that aims to change the real (research to cange of emancipartory). It can be done from simple ways

A STUDY ON THE BENEFITS OF SPORTS TOURISM ON CITY MARKETING

The purpose of this study is to explore the benefits of sports tourism on city marketing. In recent years, Taiwan has been actively striving for the marketing of large-scale sports events in the development of international sports. The host city uses the resources invested before the holding of the sports event to develop sports tourism attractions, develop sports tourism policies, and make good use of marketing and promotion strategies to shape the city’s image; and uses media marketing as a tourism promotion tool to expand Taiwan’s sports tourism facets which would bring huge tourism effects. This study organizes the research of past scholars by way of literature discussion, and then collects, organizes and analyzes the data. It is concluded that Taiwan has opened up its international reputation through international large-scale sports events and city marketing. From the experience of hosting international large-scale events, Taiwan not only attracts countless domestic and foreign tourists, but also promotes its city’s culture, tourism, and economy. The vigorous development of related industries, the enhancement of sports tourism quality and the improvement of sports tourism image in Taiwan are also achieved. Finally, international large-scale events revitalize the city to bring business opportunities and make such events the pride of the city. Therefore, this study serves as a reference for future exploration of sports tourism development and city marketing issues, integrating relevant resources, and providing reference for relevant organizations to jointly build Taiwan as a sports tourism island. JEL: L10; L80; L83 <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0791/a.php" alt="Hit counter" /></p>

Queering K-12 Classrooms Through Literature Discussion and Dialogue

Schools are heteronormative and gendernormative spaces that reinforce a narrow range of experiences and identities. Creating classroom spaces that empower LGBTQ+ identities is critical in supporting K-12 learners to become thoughtful and empathetic learners. LGBTQ+ students continue to experience bullying, stereotyping, discrimination, and marginalization. This chapter focuses on supporting pre-service teachers' understanding of how to queer classroom spaces through the integration of intersectional children's and YA literature that affirms LGBTQ+ identities and experiences. Bishop's framework of mirrors, windows, and sliding glass doors is used with the addition of prisms. The prism provides a critical action to expand the notion and expectation of normal through intersectional representation.