scholarly journals Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog

2021 ◽  
Vol 8 ◽  
Author(s):  
Tae-Yoon Eom ◽  
Ju-Won Choi ◽  
Kyong-Ah Yoon ◽  
Soon-Wuk Jeong ◽  
Jung-Hyun Kim
Keyword(s):  
Arterial Thrombosis ◽  
Clinical Symptoms ◽  
Blood Glucose Concentration ◽  
Weight Bearing ◽  
Recombinant Tissue Plasminogen Activator ◽  
Acute Onset ◽  
Tissue Plasminogen ◽  
Body Surface Temperature ◽  
The Right ◽  
Underlying Diseases

A 16-year-old spayed female Pomeranian dog was presented to the hospital with an acute onset of pain and non-weight-bearing lameness in the right forelimb. On physical examination, knuckling, coolness, pain, and cyanosis were observed in the affected forelimb. Peripheral blood glucose concentration and body surface temperature differed between the right and left forelimbs. Hypercoagulable thromboelastographic results and increased D-dimer levels were suggestive of thrombus. Accordingly, recombinant tissue plasminogen activator (rtPA) was administered intravenously. Prompt clinical improvements (including restored warmth of the affected limb) occurred, and rtPA was discontinued after two shots administered 2 h apart owing to concerns of bleeding side effects. The dog was discharged 6 days after admission, and outpatient treatment with clopidogrel was continued for the prevention of re-thrombosis. Following patient stabilization, further examinations for underlying diseases of hypercoagulability were conducted; hyperadrenocorticism (HAC) was diagnosed, and oral trilostane therapy was thus administered. Eight weeks later, the patient regained normal mobility. Finally, in the present canine patient with arterial thrombosis, thrombolysis with rtPA successfully improved clinical symptoms and the following administration of clopidogrel inhibited the formation of additional thrombus.

Recombinant Tissue Plasminogen Activator Treatment in Two Infants With Fulminant Meningococcemia

PEDIATRICS ◽  
1995 ◽  
Vol 96 (1) ◽  
pp. 144-148
Author(s):  
Werner Zenz ◽  
Wolfgang Muntean ◽  
Siegfried Gallistl ◽  
Gerfried Zobel ◽  
Hans M. Grubbauer
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Prognostic Significance ◽  
Case Fatality ◽  
Plasminogen Activator Inhibitor ◽  
Recombinant Tissue Plasminogen Activator ◽  
Acute Onset ◽  
Plasminogen Activator Inhibitor 1 ◽  
Tissue Plasminogen ◽  
Pai 1

Fulminant meningococcemia defines a life-threatening disease with acute onset, severe septic shock, and progressive hemorrhagic necrosis of the skin. Despite advances in intensive care, the case fatality rate of this disease is still between 30% and 50%.1-5 Disseminated intravascular coagulation (DIC) with deposition of fibrin and histologically demonstrable widespread microvascular thromboses contributes significantly to the pathogenesis.6-9 Impairment of fibrinolysis caused by elevation of plasminogen activator inhibitor 1 (PAI-1), the physiologic inhibitor of tissue plasminogen activator, is part of these clotting abnormalities and has prognostic significance; the extent of elevation of PAI-1 is correlated to the development of shock, renal impairment, and mortality.10,11

Displacement of an Ununited Medial Humeral Condylar Ossification Centre in the Cat

2018 ◽  
Vol 31 (02) ◽  
pp. 153-157
Author(s):  
Kerstin Erles ◽  
Thomas Maddox ◽  
Andy Morris
Keyword(s):  
Weight Bearing ◽  
Distal Humerus ◽  
Acute Onset ◽  
Outcome Evaluation ◽  
Ossification Centre ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Similar Appearance ◽  
The Right

AbstractA 2-year-old cat was presented with the complaint of acute-onset non–weight-bearing lameness of the right forelimb. When examined, the cat was of short stature and had multiple joint and cartilaginous abnormalities suggestive of chondrodysplasia. The cause of the acute lameness was radiographically identified as a displaced osseous fragment from the medial portion of the right humeral condyle. The features of the osseous fragment were consistent with an ununited medial condylar ossification centre of the distal humerus. Furthermore, a nondisplaced ununited ossified fragment of similar appearance and size was present in the contralateral elbow. Surgical treatment by excision of the displaced fragment resulted in a preinjury level of limb function in the long-term outcome evaluation.

scholarly journals Double Bolus Thrombolysis for Suspected Massive Pulmonary Embolism during Cardiac Arrest

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Gerard O’Connor ◽  
Gareth Fitzpatrick ◽  
Ayman El-Gammal ◽  
Peadar Gilligan
Keyword(s):  
Pulmonary Embolism ◽  
Cardiac Arrest ◽  
Recombinant Tissue Plasminogen Activator ◽  
Massive Pulmonary Embolism ◽  
Spontaneous Circulation ◽  
Right Heart ◽  
Tissue Plasminogen ◽  
End Tidal ◽  
The Right ◽  
High Level

More than 70% of cardiac arrest cases are caused by acute myocardial infarction (AMI) or pulmonary embolism (PE). Although thrombolytic therapy is a recognised therapy for both AMI and PE, its indiscriminate use is not routinely recommended during cardiopulmonary resuscitation (CPR). We present a case describing the successful use of double dose thrombolysis during cardiac arrest caused by pulmonary embolism. Notwithstanding the relative lack of high-level evidence, this case suggests a scenario in which recombinant tissue Plasminogen Activator (rtPA) may be beneficial in cardiac arrest. In addition to the strong clinical suspicion of pulmonary embolism as the causative agent of the patient’s cardiac arrest, the extremely low end-tidal CO2suggested a massive PE. The absence of dilatation of the right heart on subxiphoid ultrasound argued against the diagnosis of PE, but not conclusively so. In the context of the circulatory collapse induced by cardiac arrest, this aspect was relegated in terms of importance. The second dose of rtPA utilised in this case resulted in return of spontaneous circulation (ROSC) and did not result in haemorrhage or an adverse effect.

Displacement of a Functional Femoral Pseudoarthrosis in a Dog

1992 ◽  
Vol 05 (04) ◽  
pp. 176-178
Author(s):  
Gretchen Flo ◽  
R. L. Stickle ◽  
D. J. Jevens
Keyword(s):  
Bone Graft ◽  
Cancellous Bone ◽  
Hind Limb ◽  
Dynamic Compression ◽  
Weight Bearing ◽  
Acute Onset ◽  
Bone Plate ◽  
Cancellous Bone Graft ◽  
Mixed Breed ◽  
The Right

A mature mixed breed dog was evaluated for acute onset of non-weight-bearing lameness involving the right hind limb. The dog had, reportedly, walked normally for the previous three years. A diagnosis of acute displacement of a functional femoral pseudoarthrosis was made. The pseudoarthrosis was stabilized using a dynamic compression bone plate and an autogenous cancellous bone graft. The dog was walking normally five months after the operation.

scholarly journals Treatment of Middle Cerebral Artery Occlusion with Concomitant Partially Thrombosed Aneurysm: a Case Report

2020 ◽  
Vol 2 (12) ◽  
pp. 2907-2910
Author(s):  
Michel Klapp Oliger ◽  
Till-Karsten Hauser ◽  
Franz-Josef Strauss ◽  
Ulrike Ernemann
Keyword(s):  
Ischemic Stroke ◽  
Case Report ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Clinical Symptoms ◽  
Recombinant Tissue Plasminogen Activator ◽  
Artery Occlusion ◽  
Clinical Approach ◽  
Thrombosed Aneurysm ◽  
The Right

AbstractA 68-year-old female with an acute ischemic stroke demanding emergency thrombectomy which was complicated by the presence of an intracranial aneurysm. Computer tomography revealed the occlusion of the right middle cerebral artery with a distal non-ruptured partially thrombosed aneurysm. The treatment consisted in the administration of intravenous recombinant tissue plasminogen activator and the removal of the proximal thrombus via direct aspiration in order to prevent perforation of the distal aneurysm. After the procedure, the clinical symptoms improved significantly indicated by the National Institutes of Health Stroke Scale (NIHSS). The aim of the present case report is, therefore, to suggest a clinical approach to help physicians in the decision-making process for early and safe revascularization in patients with ischemic stroke and intracranial aneurysms.

scholarly journals Intravenous tPA in the treatment of acute stroke related to aortic dissection

2019 ◽  
Vol 12 (6) ◽  
pp. e229982
Author(s):  
Vikram Shivkumar ◽  
Dipali Nemade
Keyword(s):  
Aortic Dissection ◽  
Cerebral Hemisphere ◽  
Acute Onset ◽  
Medical Illness ◽  
Not Given ◽  
Ct Angiogram ◽  
Right Cerebral Hemisphere ◽  
Tissue Plasminogen ◽  
The Right ◽  
Time Of Presentation

A 61-year-old woman with no prior medical illness presented with acute onset stroke symptoms. She had no chest pain at the time of presentation. However, CT angiogram showed an extensive aortic dissection, resulting in hypoperfusion of the right cerebral hemisphere and thus causing stroke symptoms. Due to this finding, tissue plasminogen activator was not given and a negative outcome was avoided.

Disseminated Intravascular Coagulation: Clinical Spectrum and Established as well as New Diagnostic Approaches

1999 ◽  
Vol 82 (08) ◽  
pp. 706-712 ◽  
Author(s):  
Hugo ten Cate ◽  
Marcel Levi ◽  
Gert Müller-Berghaus
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Clinical Symptoms ◽  
Clinical Problem ◽  
Effective Management ◽  
Therapeutic Approaches ◽  
Intravascular Coagulation ◽  
Diagnostic Approaches ◽  
Definition Of ◽  
The Right ◽  
Underlying Diseases

IntroductionAlthough disseminated intravascular coagulation (DIC) is an “intermediary mechanism of disease”1 that has been intensively studied during the last three decades,2-4 several aspects relating to the clinical problem of DIC are still under debate. For example, a standardized definition of disseminated intravascular coagulation has not yet been agreed upon. A diagnosis can be accurately made using the facilities of a specialized laboratory, but time constraints make the diagnosis of DIC by the general laboratory difficult. Since DIC can be prevented if the right therapy is initiated early, the ability to quickly and accurately diagnose DIC and to monitor the involved dynamic processes are essential prerequisites for the effective management patients with DIC.Due to the problems associated with defining DIC, making an early diagnosis, and effectively treating the condition following diagnosis, the clinical management of DIC can be difficult. The transition from an activated hemostatic system to a well-defined state of DIC is indistinct, and the borderlines cannot easily be distinguished. In addition, different underlying diseases mediating DIC induce different clinical symptoms associated with DIC and demand different therapeutic approaches.

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