scholarly journals Vaccination Is a Suitable Tool in the Control of Aujeszky’s Disease Outbreaks in Pigs Using a Population Dynamics P Systems Model

Animals ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 909 ◽  
Author(s):  
Maria Angels Colomer ◽  
Antoni Margalida ◽  
Lorenzo Fraile
Keyword(s):  
Population Dynamics ◽  
Computational Models ◽  
Economic Cost ◽  
P Systems ◽  
Economic Losses ◽  
Stock Management ◽  
Systems Model ◽  
Aujeszky's Disease ◽  
Aujeszky’S Disease ◽  
The Impact

Aujeszky’s disease is one of the main pig viral diseases and results in considerable economic losses in the pork production industry. The disease can be controlled using preventive measures such as improved stock management and vaccination throughout the pig-rearing period. We developed a stochastic model based on Population Dynamics P systems (PDP) models for a standard pig production system to differentiate between the effects of pig farm management regimes and vaccination strategies on the control of Aujeszky’s disease under several different epidemiological scenarios. Our results suggest that after confirming the diagnosis, early vaccination of most of the population (>75%) is critical to decrease the spread of the virus and minimize its impact on pig productivity. The direct economic cost of an outbreak of Aujeszky’s disease can be extremely high on a previously uninfected farm (from 352–792 Euros/sow/year) and highlights the positive benefits of investing in vaccination measures to control infections. We demonstrate the usefulness of computational models as tools in the evaluation of preventive medicine programs aimed at limiting the impact of disease on animal production.

scholarly journals The Attenuated Pseudorabies Virus Vaccine Strain Bartha K61: A Brief Review on the Knowledge Gathered during 60 Years of Research

Pathogens ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 897
Author(s):  
Jonas L. Delva ◽  
Hans J. Nauwynck ◽  
Thomas C. Mettenleiter ◽  
Herman W. Favoreel
Keyword(s):  
Vaccine Strain ◽  
Pseudorabies Virus ◽  
Economic Losses ◽  
Vaccination Programs ◽  
Live Vaccines ◽  
Vector Vaccine ◽  
Short Summary ◽  
Aujeszky's Disease ◽  
Aujeszky’S Disease ◽  
Disease Epidemics

Pseudorabies virus (PRV) is a member of the alphaherpesvirus subfamily of the herpesviruses and is the causative agent of Aujeszky’s disease in pigs, causing respiratory, neurological, and reproductive symptoms. Given the heavy economic losses associated with Aujeszky’s disease epidemics, great efforts were made to develop efficacious vaccines. One of the best modified live vaccines to this day is the attenuated Bartha K61 strain. The use of this vaccine in extensive vaccination programs worldwide has assisted considerably in the eradication of PRV from the domesticated pig population in numerous countries. The Bartha K61 strain was described in 1961 by Adorján Bartha in Budapest and was obtained by serial passaging in different cell cultures. Ever since, it has been intensively studied by several research groups, for example, to explore its efficacy as a vaccine strain, to molecularly and mechanistically explain its attenuation, and to use it as a retrograde neuronal tracer and as a vector vaccine. Given that the Bartha K61 vaccine strain celebrates its 60th birthday in 2021 with no sign of retirement, this review provides a short summary of the knowledge on its origin, characteristics, and use as a molecular tool and as a vaccine.

Minimization of the Impact of Aujeszky’s Disease Outbreaks in The Netherlands: A Conceptual Framework

2012 ◽  
Vol 60 (4) ◽  
pp. 303-314 ◽  
Author(s):  
K. J. Bosman ◽  
M. C. M. Mourits ◽  
A. G. J. M. Oude Lansink ◽  
H. W. Saatkamp
Keyword(s):  
The Netherlands ◽  
Conceptual Framework ◽  
Disease Outbreaks ◽  
Aujeszky's Disease ◽  
Aujeszky’S Disease ◽  
The Impact

scholarly journals The Valproic Acid Derivative Valpromide Inhibits Pseudorabies Virus Infection in Swine Epithelial and Mouse Neuroblastoma Cell Lines

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2522
Author(s):  
Sabina Andreu ◽  
Inés Ripa ◽  
Beatriz Praena ◽  
José Antonio López-Guerrero ◽  
Raquel Bello-Morales
Keyword(s):  
Valproic Acid ◽  
Cell Line ◽  
Pseudorabies Virus ◽  
Neuroblastoma Cell ◽  
Antiviral Effect ◽  
Nucleoside Analogues ◽  
Economic Losses ◽  
Suitable Alternative ◽  
Aujeszky's Disease ◽  
Aujeszky’S Disease

Pseudorabies virus (PRV) infection of swine can produce Aujeszky’s disease, which causes neurological, respiratory, and reproductive symptoms, leading to significant economic losses in the swine industry. Although humans are not the natural hosts of PRV, cases of human encephalitis and endophthalmitis caused by PRV infection have been reported between animals and workers. Currently, a lack of specific treatments and the emergence of new PRV strains against which existing vaccines do not protect makes the search for effective antiviral drugs essential. As an alternative to traditional nucleoside analogues such as acyclovir (ACV), we studied the antiviral effect of valpromide (VPD), a compound derived from valproic acid, against PRV infection in the PK15 swine cell line and the neuroblastoma cell line Neuro-2a. First, the cytotoxicity of ACV and VPD in cells was compared, demonstrating that neither compound was cytotoxic at a specific concentration range after 24 h exposure. Furthermore, the lack of direct virucidal effect of VPD outside of an infected cell environment was demonstrated. Finally, VPD was shown to have an antiviral effect on the viral production of two strains of pseudorabies virus (wild type NIA-3 and recombinant PRV-XGF) at the concentrations ranging from 0.5 to 1.5 mM, suggesting that VPD could be a suitable alternative to nucleoside analogues as an antiherpetic drug against Aujeszky’s disease.

Mechanisms of protective immunity against Aujeszky's disease virus

2000 ◽  
Vol 31 (1) ◽  
pp. 132-132 ◽  
Author(s):  
F. A. Zuckermann ◽  
S. Martin ◽  
R. Husmann
Keyword(s):  
Disease Virus ◽  
Protective Immunity ◽  
Aujeszky's Disease ◽  
Aujeszky’S Disease ◽  
Aujeszky’S Disease Virus

No Aujeszky's disease or PRRS in Finland

2000 ◽  
Vol 31 (1) ◽  
pp. 153-154
Author(s):  
P.M.-L. Veijalainen ◽  
H. Tapiovaara
Keyword(s):  
Aujeszky's Disease ◽  
Aujeszky’S Disease

Long-term population dynamics of the red deer and European roe deer at the protected and not-protected areas in Mountain Crimea

2017 ◽  
Vol 7 (4) ◽  
pp. 65-72
Author(s):  
V. N. Shmagol' ◽  
V. L. Yarysh ◽  
S. P. Ivanov ◽  
V. I. Maltsev
Keyword(s):  
Population Dynamics ◽  
Protected Areas ◽  
Red Deer ◽  
Nature Reserve ◽  
Roe Deer ◽  
Precipitation Amount ◽  
Annual Precipitation ◽  
Population Number ◽  
The Impact

<p>The long-term population dynamics of the red deer (<em>Cervus elaphus</em> L.) and European roe deer (<em>Capreolus</em> <em>capreolus</em> L.) at the mountain and forest zone of Crimea during 1980-2017 is presented. Fluctuations in numbers of both species are cyclical and partly synchronous. Period of oscillations in the population of red deer is about 25 years, the average duration of the oscillation period of number of roe deer is 12.3 years. During the fluctuations in the number the increasing and fall in population number of the red deer had been as 26-47 %, and roe deer – as 22-34 %. Basing on the dada obtained we have assumed that together with large-scale cycles of fluctuations in population number of both red deer and roe deer the short cycles of fluctuations in the number of these species with period from 3.5 to 7.5 years take place. Significant differences of the parameters of cyclical fluctuations in the number of roe deer at some sites of the Mountainous Crimea: breaches of synchronicity, as well as significant differences in the duration of cycles are revealed. The greatest deviations from the average values of parameters of long-term dynamics of the number of roe deer in Crimea are noted for groups of this species at two protected areas. At the Crimean Nature Reserve the cycle time of fluctuations of the numbers of roe deer was 18 years. At the Karadag Nature Reserve since 1976 we can see an exponential growth in number of roe deer that is continued up to the present time. By 2016 the number of roe deer reached 750 individuals at a density of 437 animals per 1 thousand ha. Peculiarity of dynamics of number of roe deer at some sites proves the existence in the mountain forest of Crimea several relatively isolated groups of deer. We assumed that "island" location of the Crimean populations of red deer and European roe deer, their relatively little number and influence of permanent extreme factors of both natural and anthropogenic origination have contributed to a mechanism of survival of these populations. The elements of such a mechanism include the following features of long-term dynamics of the population: the reduction in the period of cyclic population fluctuations, while maintaining their amplitude and the appearance of additional small cycles, providing more flexible response of the population to the impact of both negative and positive environmental factors. From the totality of the weather conditions for the Crimean population of roe deer the recurring periods of increases and downs in the annual precipitation amount may have relevance. There was a trend of increase in the roe deer population during periods of increasing annual precipitation.</p>

THE MAIN DIRECTIONS OF ECONOMIC SUPPORT OF THE REGIONAL SECURITY SYSTEM OF THE POPULATION

2020 ◽  
Vol 1 (11) ◽  
pp. 133-140
Author(s):  
E. V. DMITRIEVA ◽  
Keyword(s):  
Crisis Management ◽  
Security System ◽  
Regional Security ◽  
Economic Losses ◽  
Economic Damage ◽  
Economic Activities ◽  
The Sustainable Development ◽  
Economic Support ◽  
The Impact ◽  
Crisis Situations

The article considers topical issues of economic support for the development of the regional security system of the population against various risks. The dependence of the impact of the scale of crisis situations on economic activities in the constituent entities of the Russian Federation, which become a serious barrier to the sustainable development of the regions of the country, was investigated. The increasing importance of risks of economic losses from accidents and disasters at potentially dangerous facilities as a result of the complex influence of natural, manmade and fire factors has been established. An analysis was carried out and proposals were developed to implement the key tasks of the state in the field of ensuring the protection of the population and territories of the country from disasters in order to ensure the stability of the economy. The organizational structure, division of tasks and functions between officials, crisis management structures and responding units were analyzed, taking into account the reduction in current financial costs. On the basis of a study of the peculiarities of the regions of the country, recommendations were formed to fulfill the necessary tasks by the anti-crisis management bodies in the field of reducing economic damage on the basis of preventing crisis situations and ensuring fire safety. It is proposed to organize the practical application of a complex automated security system based on modern developments with the application of improving the qualities and efficiency of anti-crisis management processes in order to increase economic efficiency. Initial data were formed to reduce potential threats of a natural, man-made, fire and other nature in the regions using financial and economic mechanisms. It is proposed to implement a set of priority measures to further improve and increase the potential of economic support for the anti-crisis management system. The materials of the article can be used in planning the main directions of the development of the regional population security system and the implementation of socio-economic development programs.

scholarly journals Evaluation of the impact of compliance of precast discs of overlapping on the work of the frame of a multi-storey building

2019 ◽  
Vol 97 ◽  
pp. 04022
Author(s):  
Nikolay Trekin ◽  
Emil Kodysh ◽  
Alexander Bybka ◽  
Alexander Yamalov ◽  
Nikita Konkov
Keyword(s):  
Economic Performance ◽  
Computational Models ◽  
Precast Concrete ◽  
Building Frames ◽  
Frame Building ◽  
Numerical Studies ◽  
Frame Buildings ◽  
The Impact ◽  
Structural Solutions ◽  
Storey Building

The article provides an analysis and justification of the need to take into account the compliance of discs of overlapping and coatings when calculating frames from precast concrete structures. Previously conducted full-scale experiments showed that the rigidity of the precast overlapping with full filling of the seams, in comparison with the monolithic overlapping, decreases by 3-15 times due to the ductility of the joints. The use of refined computational models of structural solutions for frames, which take into account the compliance of the conjugations of elements, makes it possible to trace possible redistribution of efforts. Such an approach when reconstructing, it is possible to optimally select and calculate the enforcement of structure, and on new designing, to increase reliability and / or improve the economic performance of frame buildings. According to the results of analytical studies, formulas were adopted for the parameters that allow one to take into account the overall compliance of overlapping disks and coatings in computational models of building frames. Numerical studies on the computational model of a frame building made it possible to evaluate the effect of accounting for compliance on the stress-strain state of a multi-storey frame.

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