scholarly journals Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Peptides: When Is the Assessment of Cer-Tain Factors Warranted?

Antibodies ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Iftekhar Mahmood ◽  
Mark Pettinato
Keyword(s):  
Small Molecules ◽  
Inflammatory Diseases ◽  
The Body ◽  
Extrinsic Factors ◽  
Peptide Bonds ◽  
Substantial Impact ◽  
Disease States ◽  
Low Toxicity ◽  
The Impact ◽  
Intrinsic And Extrinsic Factors

Peptides are short chains of 2 to 50 amino acids (molecular weight of less than 10 kDa) linked together by peptide bonds. As therapeutic agents, peptides are of interest because the body naturally produces many different peptides. Short-chain peptides have many advantages as compared with long-chain peptides (e.g., low toxicity). The first peptide corticotropin was approved in 1952 for multiple inflammatory diseases and West syndrome. Since then, more than 60 peptides have been approved by the FDA. Pharmacokinetics (PK) is widely used in modern-day drug development for designing a safe and efficacious dose to treat a wide variety of diseases. There are, however, several factors termed as “intrinsic” or “extrinsic” which can influence the PK of a drug, and as a result, one has to adjust the dose in a patient population. These intrinsic and extrinsic factors can be described as age, gender, disease states such as renal and hepatic impairment, drug–drug interaction, food, smoking, and alcohol consumption. It is well known that these intrinsic and extrinsic factors can have a substantial impact on the PK of small molecules, but for macromolecules, the impact of these factors is not well established. This review summarizes the impact of intrinsic and extrinsic factors on the PK of peptides.

Anemia of Inflammation

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 276-280 ◽  
Author(s):  
Cindy N. Roy
Keyword(s):  
Inflammatory Diseases ◽  
Underlying Disease ◽  
Comorbid Condition ◽  
Regulatory Pathways ◽  
Hepcidin Expression ◽  
Disease States ◽  
Poor Outcomes ◽  
The Impact ◽  
Inflammatory Insult ◽  
Anemia Of Inflammation

Abstract Inflammation arising from various etiologies, including infection, autoimmune disorders, chronic diseases, and aging, can promote anemia. The anemia of inflammation (AI) is most often normocytic and normochromic and is usually mild. Characteristic changes in systemic iron handling, erythrocyte production, and erythrocyte life span all contribute to AI. The preferred treatment is directed at the underlying disease. However, when the inflammatory insult is intractable, or the cause has not been diagnosed, there are limited options for treatment of AI. Because anemia is a comorbid condition that is associated with poor outcomes in various chronic disease states, understanding its pathogenesis and developing new tools for its treatment should remain a priority. Hepcidin antimicrobial peptide has taken center stage in recent years as a potent modulator of iron availability. As the technology for quantitative hepcidin analysis improves, hepcidin's role in various disease states is also being revealed. Recent insights concerning the regulatory pathways that modify hepcidin expression have identified novel targets for drug development. As the field advances with such therapeutics, the analysis of the impact of normalized hemoglobin on disease outcomes will confirm whether anemia is a reversible independent contributor to the morbidity and mortality associated with inflammatory diseases.

The impact of intrinsic and extrinsic factors on the job satisfaction of dentists

2012 ◽  
Vol 40 (5) ◽  
pp. 474-480 ◽  
Author(s):  
K. Goetz ◽  
S.M. Campbell ◽  
B. Broge ◽  
C.E. Dörfer ◽  
M. Brodowski ◽  
...  
Keyword(s):  
Job Satisfaction ◽  
Extrinsic Factors ◽  
The Impact ◽  
Intrinsic And Extrinsic Factors

scholarly journals Epidemiology, etiology, and pathogenesis of tendinopathy among athletes

2021 ◽  
Vol 9 (1) ◽  
pp. 437
Author(s):  
Syed Asif Hasan ◽  
Ahmed Abdulrahman Othman ◽  
Yousuf Kamal Shagdar ◽  
Abdulrahman Anis Khan ◽  
Amal Baalqasim Sulaimani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Literature Review ◽  
Nerve Fibers ◽  
Systemic Diseases ◽  
Extrinsic Factors ◽  
Serious Adverse Events ◽  
Professional Careers ◽  
The Impact ◽  
Intrinsic And Extrinsic Factors

The treatment of tendinopathy can be challenging for clinicians and might be associated with serious adverse events. However, evidence shows that tendinopathy can significantly impact the professional careers of the affected athletes. The main clinical features of the condition include decreased performance and strength of the affected tendons, swelling, and localized pain.  Although tendinopathy might seem a non-critical condition, estimates show that it might be career-ending for many professional athletes, and therefore, reducing their quality of life. In the present literature review, we have discussed the epidemiology, etiology, and pathogenesis of tendinopathy among athletes. Different intrinsic and extrinsic factors were found to contribute to the development of the condition and the impact of various systemic diseases. Evidence also shows that the prevalence of the condition is high among athletes. However, these rates were variable across the different studies in the literature. This is probably owing to various factors, like demographics and the process of detection. The pathogenesis of the condition is also very complicated, and the development of pain has been attributed to the process of angiogenesis and associated ingrowth of nerve fibers.

Improving Replicability, Reproducibility, And Reliability In Preclinical Research: A Shared Responsibility

ILAR Journal ◽  
2019 ◽  
Vol 60 (2) ◽  
pp. 113-119
Author(s):  
Christopher Cheleuitte-Nieves ◽  
Neil S Lipman
Keyword(s):  
Biological Response ◽  
Animal Research ◽  
Shared Responsibility ◽  
Housing System ◽  
Preclinical Research ◽  
Extrinsic Factors ◽  
Study Planning ◽  
The Impact ◽  
Intrinsic And Extrinsic Factors

Abstract Reproducible and reliable scientific investigation depends on the identification and consideration of various intrinsic and extrinsic factors that may affect the model system used. The impact of these factors must be managed during all phases of a study: planning, execution, and reporting. The value of in vivo (animal) research has come under increasing scrutiny over the past decade because of multiple reports documenting poor translatability to human studies. These failures have been attributed to various causes, including poor study design and execution as well as deficiencies in reporting. It is important to recognize that achieving reproducible and reliable preclinical research results is a joint responsibility that requires a partnership between the investigative team and the animal care and use program staff. The myriad of intrinsic factors, such as species, strain/substrain, age, sex, physiologic and health status, and extrinsic factors, including temperature, humidity, lighting, housing system, and diet, need to be recognized and managed during study planning and execution, as they can influence animal physiology and biological response. Of equal importance is the need to document and report these details. The ARRIVE and PREPARE guidelines were developed by concerned scientists, veterinarians, statisticians, journal editors, and funding agencies to assist investigative teams and scientific journals manage and report on intrinsic and extrinsic factors to improve reproducibility and reliability. This issue of the ILAR Journal will focus on the various extrinsic factors that have been recognized to confound animal research.

Impacts of Nursing Unit Design on Visibility and Proximity and Its Influences on Communication, Privacy, and Efficiency

2019 ◽  
Vol 13 (2) ◽  
pp. 200-217
Author(s):  
Xiaodong Xuan ◽  
Xixi Chen ◽  
Zongfei Li
Keyword(s):  
Quality Of Healthcare ◽  
Medication Administration ◽  
Communication Patterns ◽  
The Body ◽  
Substantial Impact ◽  
Delivery Of Care ◽  
Nursing Unit ◽  
Questionnaire Surveys ◽  
Doctor's Office ◽  
The Impact

Objectives: This study examines the role of visibility and proximity on nurse communication patterns, perception of privacy, and efficiency in double-corridor nursing units. Background: Nurses are extremely important for the quality of healthcare. The literature suggests that visibility and proximity have a substantial impact on the delivery of care and staff experience. However, few studies have empirically examined nursing units in China. Method: Questionnaire surveys, observations, and simulations of medication administration tasks were employed. Results: Visibility and proximity influenced communication patterns, perceptions of privacy, and efficiency. The type of wall in the medication room could impact nurses’ perception of privacy and efficiency. A partial glass wall in the medication room could achieve balance between privacy and visibility. A medication room that is adjacent to and is easily accessed from the nurse station (NS) could provide efficient communication and efficient work. The partition type between the NS and the doctor’s office and the layout of the medication room could impact communication patterns. The relative position of the NS, medication room, and disposal room could influence the flow of medication administration tasks, and a geographically contiguous spatial layout could enhance work efficiency. Conclusions: The findings contribute to the body of knowledge on the impact of visibility and proximity on nurses’ communication patterns, perception of privacy, and efficiency. Recommendations to improve the design of double-corridor nursing units are also provided.

scholarly journals Assessment of Quality of Life among outpatients Visiting Dermatology Department at a Hospital in Pokhara, Nepal

2020 ◽  
Vol 10 (2) ◽  
pp. 6-10
Author(s):  
Sujata Bhandari ◽  
Gulam Muhammad Khan
Keyword(s):  
Quality Of Life ◽  
Quality Index ◽  
Skin Diseases ◽  
Life Quality ◽  
The Body ◽  
Extrinsic Factors ◽  
Dermatology Department ◽  
Life Quality Index ◽  
The Impact

Introduction: Skin is the outer covering of the body and thus it is exposed to injury by various extrinsic factors such as environmental, chemical, infectious agents as well as intrinsic factors such as metabolic, genetic and immunological. Considering the fact that these are the major contributors of disease burden in society, this study was conducted to assess the impact of dermatological conditions on quality of life by using dermatological life quality index (DLQI). Methods: A prospective observational study was conducted in the outpatient department of Green Pastures Hospital of Pokhara, Nepal. The validated dermatology Life Quality Index questionnaires were assessed to analyze the result. Results: A total of 246 patients (135 females and 111 males) were enrolled. The skin diseases were seen mostly in the age group of 19-29 (39.4%). The major skin disease seen in the study were Tinea skin infections (21.1%), Urticaria (11.8%), Eczema (11.1%), Dermatitis (10.6%) followed by Acne (8.1%) and so on.The quality of life of patients had improved after taking the medication. Conclusion: Demographic variants did not have significanteffect on quality of life. However, the study showed that there was a notable improvement in quality of life of patients after follow-up visit in comparison to the first visit. Therefore, the proper use of medication showed the positive impact on quality of life among the patient of skin diseases. 

scholarly journals Adolescent BMI: The Importance of Intrinsic and Extrinsic Factors

2018 ◽  
Vol 11 (1) ◽  
pp. 147-161
Author(s):  
Molly Jacobs
Keyword(s):  
Linear Models ◽  
Relative Importance ◽  
Sexual Encounter ◽  
Extrinsic Factors ◽  
Intrinsic Factors ◽  
Multinomial Logit Models ◽  
Adolescents And Adults ◽  
The Impact ◽  
Intrinsic And Extrinsic Factors ◽  
Weight Classification

Objectives:Research shows that weight trends in adolescence persist into adulthood, but do the same factors contribute to weight in adolescence as in adulthood? Are extrinsic factors presumably more important than intrinsic characteristics? This study identifies the correlation between BMI and various intrinsic and extrinsic factors and evaluates their relative importance in BMI development. It compares the primary determinants for adolescents (12-20 years old) and adults (21+ years old).Methods:Using 15 years of panel data, generalized linear models, we assessed the impact of extrinsic-environmental, biological, geographic and household-and intrinsic-sexual activity, substance use, desire to lose weight,etc.-characteristics on adolescent and adult BMI. Multinomial logit models tested the contribution of these characteristics to weight categories.Results:Race and age were the most significant BMI correlates at all ages. This remains true for weight classification as well. For young adolescents, intrinsic factors are highly deterministic, while extrinsic factors play no role. As adolescents age into adults, intrinsic factors continue to be deterministic, while extrinsic covariates also emerge as deterministic. Intrinsic determinates of significance include age of first sexual encounter, tobacco experimentation, perspective on general health, and desire to lose weight (or stay the same weight).Conclusion:While biological/genetic attributes are the largest determinants of BMI at every age, intrinsic factors play a larger role in adolescent BMI development than adults. As individuals age, intrinsic determinants remain important, but extrinsic characteristics contribute significantly to weight classification. Thus, the weight determinants differ between adolescents and adults suggesting different methods of policy intervention be used for adolescents and adults.

scholarly journals Peranan Ekosistem Hutan Mangrove Pada Imunitas Terhadap Malaria: Studi Di Kecamatan Labuhan Maringgai Kabupaten Lampung Timur

2015 ◽  
Vol 3 (2) ◽  
pp. 67 ◽  
Author(s):  
Agung Kartika Putra ◽  
Samsul Bakri ◽  
Betta Kurniawan
Keyword(s):  
Mangrove Forest ◽  
Regression Models ◽  
Forest Ecosystems ◽  
Binary Logistic Regression ◽  
Mangrove Forests ◽  
Extrinsic Factors ◽  
Logistic Regression Models ◽  
The Impact ◽  
Intrinsic And Extrinsic Factors ◽  
Better Than

One of the ecological function of mangrove forests is a habitat for mosquitoes that cause malaria (Anopheles sp.). Epidemic of malaria could increased as a result of mangrove degradation. The damage of mangrove forests stimulate Anopheles sp. migrate to other habitats such as settlements, that become malaria vector.  The purpose of this research was to determine the effect of mangrove forest ecosystems both intrinsic and extrinsic factors in immunity to malaria. This research was conducted on June 2014 in the Muara Gading Mas Village, Bandar Negeri, Sriminosari, and Margasari, Sub-district Labuhan Maringgai, District East Lampung.  The data were collected through interviews and survey/observations method. The impact of each variable used binary logistic regression models. Parameter optimization used software Minitab 16.  The result of research have been demonstrated that there is influence both intrinsic and extrinsic factors in immunity to malaria in mangrove forest. Factors that increase resistance to malaria: (a) gender, male37.42 fold of female, (b) age, getting older every 1 year doubled to 1.17 times of originally, (c) education, the higher it isreduced to 0.001 times the originally, (d) livelihood, besides fisher 0,001 fold of fisherman, (e) the distance settlements to the health facility, each reduced to 1 meter doubled to 0.09 times the originally, (f) the distance home to mangroves, each increase of 1 meter doubled to 1,001 times the originally, (g) the dustbin, there are bins 239.71 better than none, (h) the malaria program, multiply 3,71E+05 originally than none, (i) extensive mangrove, increasing 1 m2 become 1,001 fold of originally, and (j) mangrove density, increasing 1 population/ha multiply 1.18 fold originally.Keywords: Mangrove forest, immunity to malaria, Anopheles sp.

scholarly journals THE APPLICATION OF PLACENTA CRYOEXTRACT IN COMPLEX TREATMENT OF PATIENTS WITH PHLEGMONS OF MAXILLOFACIAL LOCALIZATION

2020 ◽  
pp. 58-62
Author(s):  
V.O. Lichman ◽  
K.P. Lokes ◽  
D.S. Avetikov ◽  
M.G. Skikevich ◽  
V.V. Bondarenko ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Evidence Base ◽  
The Body ◽  
Biologically Active ◽  
Comprehensive Treatment ◽  
Complex Treatment ◽  
Number Of Patients ◽  
Inflammatory Processes ◽  
The Individual ◽  
The Impact

Today the problem of pathogenesis and rational treatment of purulent-inflammatory odontogenic diseases of the maxillofacial area is quite relevant in the field of medical and SOCIAL problems. In recent years, the number of patients with odontogenic inflammatory does not catch an illness, while the number of complications increases. In case of the development of purulent inflammation the complex of interrelated morphological, biochemical, immunological and other changes is observded. The basis in the complex treatment of phlegmon of the maxillofacial area and neck of any localization is active surgical treatment. General therapy for odontogenic inflammatory diseases of the maxillofacial area primarily provides control of infection and intoxication, aimed at normalization of the impaired functions of organs and systems. The purpose of this research was to increase the effectiveness of comprehensive treatment of patients with odontogenic phlegmon of the maxillofacial localization by the use of cryopreserved placental cells. In most cases, the cause of inflammatory processes of maxillofacial localization was untreated periodontal teeth, retained teeth and negligent behavior of patients. That is why the majority of authors believe that the "cause" tooth should be urgently removed, but the solution depends on the individual features of the patient and in some cases may be postponed until the relief of the inflammatory process [3,4]. The combination of local and general factors is necessary to avoid further development of abscesses and phlegmons of the maxillofacial area and neck. The local factors are aerobic and anaerobic infection (staphylococcus, streptococcus, enterococcus, diplococcus, intestinal, gram-positive and gram-negative rods, but less often - mycoplasmas, the simplest of the family Trichomonas, spirochetes, and fungi of the genus Candida). The concentration of causal microflora, general and local nonspecific and specific protective factors of the body, the state of various organs and systems of the body, as well as anatomical and topographic features of the tissues of the maxillofacial area play a significant role in the development and course of purulent-inflammatory processes of the head and neck. All of the above determines the nature of the inflammatory reaction: normergic, hyperergic, hypoergic, anergic. Currently, placental cryoextract preparations are widely used in various fields of medicine, in particular, in urology, gynecology and general surgery. So, maxillofacial surgeons can be interested in their use in the treatment of patients with inflammatory purulent diseases of the maxillofacial localization. That is why carrying out a detailed analysis of native and foreign literature, we have concluded that it is necessary to continue study and scientifically substantiate the issue of optimizing conservative treatment of patients with odontogenic phlegmons with the use of biologically active substances. In further studies it is planned to investigate the impact on the mechanism of purulent wound healing by cryopreserved placenta and to create a morphological and biochemical evidence base for the effectiveness of the proposed treatment.

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