scholarly journals Biological Mechanisms of S-Nitrosothiol Formation and Degradation: How Is Specificity of S-Nitrosylation Achieved?

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1111
Author(s):  
Christopher M. Massa ◽  
Ziping Liu ◽  
Sheryse Taylor ◽  
Ashley P. Pettit ◽  
Marena N. Stakheyeva ◽  
...  
Keyword(s):  
Reaction Mechanisms ◽  
Chemical Nature ◽  
Biological Chemistry ◽  
Biological Functions ◽  
Post Translational Modification ◽  
Biological Mechanisms ◽  
Radical Intermediate ◽  
Biologically Relevant ◽  
The Impact

The modification of protein cysteine residues underlies some of the diverse biological functions of nitric oxide (NO) in physiology and disease. The formation of stable nitrosothiols occurs under biologically relevant conditions and time scales. However, the factors that determine the selective nature of this modification remain poorly understood, making it difficult to predict thiol targets and thus construct informatics networks. In this review, the biological chemistry of NO will be considered within the context of nitrosothiol formation and degradation whilst considering how specificity is achieved in this important post-translational modification. Since nitrosothiol formation requires a formal one-electron oxidation, a classification of reaction mechanisms is proposed regarding which species undergoes electron abstraction: NO, thiol or S-NO radical intermediate. Relevant kinetic, thermodynamic and mechanistic considerations will be examined and the impact of sources of NO and the chemical nature of potential reaction targets is also discussed.

scholarly journals The impact of O-glycan chemistry on the stability of intrinsically disordered proteins

2018 ◽  
Vol 9 (15) ◽  
pp. 3710-3715 ◽  
Author(s):  
Erica T. Prates ◽  
Xiaoyang Guan ◽  
Yaohao Li ◽  
Xinfeng Wang ◽  
Patrick K. Chaffey ◽  
...  
Keyword(s):  
Intrinsically Disordered Proteins ◽  
Protein Glycosylation ◽  
Disordered Proteins ◽  
Biological Functions ◽  
Post Translational Modification ◽  
Intrinsically Disordered ◽  
P Protein ◽  
The Stability ◽  
The Impact

Protein glycosylation is a diverse post-translational modification that serves myriad biological functions.

ON THE CLASSIFICATION OF DIGITAL TECHNOLOGIES IN CIVIL PROCESS

2019 ◽  
pp. 27-35
Author(s):  
Alexandr Neznamov
Keyword(s):  
Information Processing ◽  
Scientific Community ◽  
Digital Technologies ◽  
Significant Feature ◽  
Legal Proceedings ◽  
Civil Process ◽  
Civil Proceedings ◽  
Processing Information ◽  
The Impact

Digital technologies are no longer the future but are the present of civil proceedings. That is why any research in this direction seems to be relevant. At the same time, some of the fundamental problems remain unattended by the scientific community. One of these problems is the problem of classification of digital technologies in civil proceedings. On the basis of instrumental and genetic approaches to the understanding of digital technologies, it is concluded that their most significant feature is the ability to mediate the interaction of participants in legal proceedings with information; their differentiating feature is the function performed by a particular technology in the interaction with information. On this basis, it is proposed to distinguish the following groups of digital technologies in civil proceedings: a) technologies of recording, storing and displaying (reproducing) information, b) technologies of transferring information, c) technologies of processing information. A brief description is given to each of the groups. Presented classification could serve as a basis for a more systematic discussion of the impact of digital technologies on the essence of civil proceedings. Particularly, it is pointed out that issues of recording, storing, reproducing and transferring information are traditionally more «technological» for civil process, while issues of information processing are more conceptual.

Influence of internal and external risks on sustainability of financial system of Аltai krai

2018 ◽  
Vol 35 (4) ◽  
pp. 133-136
Author(s):  
R. N. Ibragimov
Keyword(s):  
Sustainable Development ◽  
Financial Stability ◽  
Management Strategy ◽  
Financial System ◽  
Risk Management Strategy ◽  
The Sustainable Development ◽  
The Stability ◽  
The Impact

The article examines the impact of internal and external risks on the stability of the financial system of the Altai Territory. Classification of internal and external risks of decline, affecting the sustainable development of the financial system, is presented. A risk management strategy is proposed that will allow monitoring of risks, thereby these measures will help reduce the loss of financial stability and ensure the long-term development of the economy of the region.

The Chemistry Of Antibiofilm Phytocompounds.

2020 ◽  
Vol 20 ◽  
Author(s):  
Dibyajit Lahiri ◽  
Moupriya Nag ◽  
Sayantani Garai ◽  
Rina Rani Ray
Keyword(s):  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Antibiotic Therapy ◽  
Antimicrobial Agents ◽  
Chemical Nature ◽  
Rapid Development ◽  
Wide Spread ◽  
Chronic Infections ◽  
Therapeutic Uses

: Phytocompounds are long known for their therapeutic uses due to their competence as antimicrobial agents. The antimicrobial activity of these bioactive compounds manifests their ability as an antibiofilm agent and is thereby proved to be competent to treat the wide spread of biofilm-associated chronic infections. Rapid development of antibiotic resistance in bacteria has made the treatment of these infections almost impossible by conventional antibiotic therapy, which forced in the switch over to the use of phytocompounds. The present overview deals with the classification of the huge array of phytocompounds according to their chemical nature, detection of their target pathogen, and elucidation of their mode of action.

Fish diversity

2017 ◽  
Author(s):  
Derek Burton ◽  
Margaret Burton
Keyword(s):  
Life Style ◽  
Fish Diversity ◽  
Additional Species ◽  
The Impact ◽  
Current Species

Fish diversity is considered in terms of variety of their morphological, taxonomic, habitat and population attributes. Fish, with over 30, 000 current species, represent the largest group of vertebrates. The complexity of classification of a group of this size and antiquity, together with recognition of additional species, demands continuous ongoing revision. The impact of the recent fundamental changes in fish classification in 2016 is discussed. Life in water involves adaptations to widely different habitats which can result in physiological morphological and life-style variations which are reviewed.

scholarly journals Formation of an Export-Oriented Agricultural Economy and Regional Open Innovations

2021 ◽  
Vol 7 (1) ◽  
pp. 32
Author(s):  
Victor L. Shabanov ◽  
Marianna Ya Vasilchenko ◽  
Elena A. Derunova ◽  
Andrey P. Potapov
Keyword(s):  
Agricultural Economy ◽  
Institutional Management ◽  
Agricultural Exports ◽  
Modeling Methodology ◽  
Fixed Assets ◽  
Analysis Application ◽  
The Impact ◽  
The Relationship

The aim of the work is to find relevant indicators for assessing the relationship between investments in fixed assets in agriculture, gross output of the industry, and agricultural exports using tools for modeling the impact of innovation and investment development on increasing production and export potential in the context of the formation of an export-oriented agricultural economy. The modeling methodology and the proposed estimating and forecasting tools for diagnosing and monitoring the state of sectoral and regional innovative agricultural systems are used to analyze the relationship between investments in fixed assets in agriculture, gross output of the industry, and agricultural exports based on the construction of the classification of Russian regions by factors that aggregate these features to diagnose incongruence problems and to improve institutional management in regional innovative export-oriented agrosystems. Based on the results of the factor analysis application, an underestimated role of indicators of investment in agriculture, the intensity and efficiency of agricultural production, were established. Based on the results of the cluster analysis, the established five groups of regions were identified, with significant differences in the level of investment in agriculture, the volume of production of the main types of agricultural products, and the export and exported food. The research results are of practical value for use in improving institutional management when planning reforms and transformations of regional innovative agrosystems.

scholarly journals Minimization of the Line Resistance Impact on Memdiode-Based Simulations of Multilayer Perceptron Arrays Applied to Pattern Recognition

2021 ◽  
Vol 11 (1) ◽  
pp. 9
Author(s):  
Fernando Leonel Aguirre ◽  
Nicolás M. Gomez ◽  
Sebastián Matías Pazos ◽  
Félix Palumbo ◽  
Jordi Suñé ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Ex Situ ◽  
Multilayer Perceptrons ◽  
Spice Simulation ◽  
Large Dataset ◽  
High Line ◽  
Calibration Algorithm ◽  
The Impact ◽  
Line Resistance

In this paper, we extend the application of the Quasi-Static Memdiode model to the realistic SPICE simulation of memristor-based single (SLPs) and multilayer perceptrons (MLPs) intended for large dataset pattern recognition. By considering ex-situ training and the classification of the hand-written characters of the MNIST database, we evaluate the degradation of the inference accuracy due to the interconnection resistances for MLPs involving up to three hidden neural layers. Two approaches to reduce the impact of the line resistance are considered and implemented in our simulations, they are the inclusion of an iterative calibration algorithm and the partitioning of the synaptic layers into smaller blocks. The obtained results indicate that MLPs are more sensitive to the line resistance effect than SLPs and that partitioning is the most effective way to minimize the impact of high line resistance values.

scholarly journals A Phantom Study to Investigate Robustness and Reproducibility of Grey Level Co-Occurrence Matrix (GLCM)-Based Radiomics Features for PET

2021 ◽  
Vol 11 (2) ◽  
pp. 535
Author(s):  
Mahbubunnabi Tamal
Keyword(s):  
Textural Features ◽  
Strongly Correlated ◽  
Segmentation Method ◽  
Diagnosis And Prognosis ◽  
Radiotracer Uptake ◽  
Positron Emission ◽  
Occurrence Matrix ◽  
The Impact ◽  
Robust To Noise

Quantification and classification of heterogeneous radiotracer uptake in Positron Emission Tomography (PET) using textural features (termed as radiomics) and artificial intelligence (AI) has the potential to be used as a biomarker of diagnosis and prognosis. However, textural features have been predicted to be strongly correlated with volume, segmentation and quantization, while the impact of image contrast and noise has not been assessed systematically. Further continuous investigations are required to update the existing standardization initiatives. This study aimed to investigate the relationships between textural features and these factors with 18F filled torso NEMA phantom to yield different contrasts and reconstructed with different durations to represent varying levels of noise. The phantom was also scanned with heterogeneous spherical inserts fabricated with 3D printing technology. All spheres were delineated using: (1) the exact boundaries based on their known diameters; (2) 40% fixed; and (3) adaptive threshold. Six textural features were derived from the gray level co-occurrence matrix (GLCM) using different quantization levels. The results indicate that homogeneity and dissimilarity are the most suitable for measuring PET tumor heterogeneity with quantization 64 provided that the segmentation method is robust to noise and contrast variations. To use these textural features as prognostic biomarkers, changes in textural features between baseline and treatment scans should always be reported along with the changes in volumes.

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