scholarly journals Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1783
Author(s):  
María Dolores Rodríguez-Pérez ◽  
Juan Antonio López-Villodres ◽  
María Monsalud Arrebola ◽  
Esther Martín-Aurioles ◽  
África Fernández-Prior ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Model ◽  
Nitrosative Stress ◽  
Virgin Olive Oil ◽  
Diabetic Rats ◽  
Oxidative And Nitrosative Stress ◽  
Statistical Correlations ◽  
Calculated Creatinine Clearance ◽  
Nephroprotective Effect

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67–73%), calculated creatinine clearance was significantly increased (26–38%), and the glomerular volume and glomerulosclerosis index were decreased (20–30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.

scholarly journals Synergistic Effect of 3′,4′-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1983
Author(s):  
José Pedro De La Cruz Cortés ◽  
Leticia Vallejo-Carmona ◽  
María Monsalud Arrebola ◽  
Esther Martín-Aurioles ◽  
María Dolores Rodriguez-Pérez ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Platelet Aggregation ◽  
Synergistic Effect ◽  
Experimental Model ◽  
Nitrosative Stress ◽  
Oxidized Ldl ◽  
Virgin Olive Oil ◽  
Oxidative And Nitrosative Stress ◽  
Cardiovascular Biomarkers

The objective of this study was to assess a possible synergistic effect of two extra-virgin olive oil polyphenols, 3,4,-dyhydroxyphenylglycol (DHPG) and hydroxytyrosol (HT), in an experimental model of type 1 diabetes. Seven groups of animals were studied: (1) Nondiabetic rats (NDR), (2) 2-month-old diabetic rats (DR), (3) DR treated with 5 mg/kg/day p.o. HT, (4) DR treated with 0.5 mg/kg/day p.o. DHPG, (5) DR treated with 1 mg/kg/day p.o. DHPG, (6) DR treated with HT + DHPG (0.5), (7) DR treated with HT + DHPG (1). Oxidative stress variables (lipid peroxidation, glutathione, total antioxidant activity, 8-isoprostanes, 8-hydroxy-2-deoxyguanosine, and oxidized LDL), nitrosative stress (3-nitrotyrosine), and some cardiovascular biomarkers (platelet aggregation, thromboxane B2, prostacyclin, myeloperoxidase, and vascular cell adhesion protein 1 (VCAM-1)) were analyzed. The diabetic animals showed an imbalance in all of the analyzed variables. HT exerted an antioxidant and downregulatory effect on prothrombotic biomarkers while reducing the fall of prostacyclin. DHPG presented a similar, but quantitatively lower, profile. HT plus DHPG showed a synergistic effect in the reduction of oxidative and nitrosative stress, platelet aggregation, production of prostacyclin, myeloperoxidase, and VCAM-1. This synergism could be important for the development of functional oils enriched in these two polyphenols in the proportion used in this study.

scholarly journals Virgin olive oil administration improves the effect of aspirin on retinal vascular pattern in experimental diabetes mellitus

2010 ◽  
Vol 104 (4) ◽  
pp. 560-565 ◽  
Author(s):  
Jose Pedro De La Cruz ◽  
Sergio Del Río ◽  
Juan Antonio López-Villodres ◽  
Maria Auxiliadora Villalobos ◽  
Nuria Jebrouni ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Aggregation ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Platelet Inhibition ◽  
Diabetic Rats ◽  
No Production ◽  
Vascular Pattern ◽  
Pharmacodynamic Profile

The aim of the present study is to evaluate the possible influence of virgin olive oil (VOO) on the effect of acetylsalicylic acid (ASA) in platelet aggregation, prostanoid and NO production and retinal vascular pattern in rats with experimental type 1-like diabetes. We used 100 male Wistar rats that were distributed into five groups: (1) non-diabetic rats (NDR); (2) untreated diabetic rats (DR); (3) DR treated with ASA (2 mg/kg per d per os (p.o.)); (4) DR treated with VOO (0·5 ml/kg per d p.o.); (5) DR treated with ASA plus VOO. The duration of diabetes was 3 months, and each treatment was administered from the first day of diabetes. Variables that were quantified were platelet aggregation (Imax), thromboxane B2 (TxB2), aortic prostacyclin (6-keto-PGF1α) and NO, and the percentage of retina with horseradish peroxidase-permeable vessels (HRP-PV). Diabetic rats showed a higher Imax (35 %) and TxB2 (63 %) than NDR, and a lower 6-keto-PGF1α, NO and HRP-PV than NDR ( − 74·6 %). ASA and VOO administration reduced these differences and prevented the percentage of HRP-PV ( − 59·7 % with ASA and − 46·7 % with VOO). The administration of ASA plus VOO showed a strong platelet inhibition (80·2 v. 23·4 % for VOO and 50·6 % for ASA+VOO, P < 0·0001), and reduced HRP-PV differences to − 31·6 % (P < 0·001 with respect to DR and P < 0·0001 with respect to DR treated with ASA). In conclusion, the administration of VOO to rats with type 1-like diabetes mellitus improves the pharmacodynamic profile of ASA, and increases its retinal anti-ischaemic effect.

scholarly journals Nephroprotective effects of polyherbal extract via attenuation of the severity of kidney dysfunction and oxidative damage in the diabetic experimental model

2022 ◽  
Vol 67 (4) ◽  
pp. 42-55
Author(s):  
Mohd. Adnan Kausar ◽  
Kehkashan Parveen ◽  
Waseem A. Siddiqui ◽  
Sadaf Anwar ◽  
Aqeela Zahra ◽  
...  
Keyword(s):  
Experimental Model ◽  
Inflammatory Cytokines ◽  
Nitrosative Stress ◽  
Antioxidant Properties ◽  
Kidney Injury ◽  
Redox Status ◽  
Renal Tissue ◽  
Diabetic Rats ◽  
Oxidative And Nitrosative Stress ◽  
Long Term Study

In view of many complications of diabetes, kidney failure is considered as one of the main complications. The oxidative stress-induced due to persistent hyperglycemic conditions is the major cause of kidney disease. The present study was designed to explore the nephroprotective efficacy of polyherbal (PH) extract in a diabetic model induced by streptozotocin (STZ). STZ (55 mg/kg body weight, intraperitoneal) was injected in overnight fasting rats to develop the diabetic experimental model. Effect on kidney injury was evaluated by investigating biochemical and histological evidences in renal tissue after 56 days of treatment of PH extract. Results showed the high glucose level in STZ treated rats that suggested hyperglycemia persistence along with the successful establishment of nephropathy in diabetic rats with altered renal function, inflammatory cytokines level as well as oxidative and nitrosative stress. Administration of PH extract significantly improved the glycemic condition, glomerular function and proximal reabsorptive markers. Further, elevated pro-inflammatory cytokines levels and disturbed redox status were restored. Moreover, findings were fostered and substantiated by histopathological examinations. Our work strongly proposes that the nephroprotective effect of the PH extract on renal damage could be attributed due to its anti-inflammatory and antioxidant properties. Thus, PH extract could have potential as a pharmaceutical drug for diabetes mellitus (DM). Additional long-term study or clinical trial is required for further investigations.

Effect of virgin olive oil plus acetylsalicylic acid on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus

2010 ◽  
Vol 471 (2) ◽  
pp. 89-93 ◽  
Author(s):  
José Pedro De La Cruz ◽  
Sergio Del Río ◽  
María Monsalud Arrebola ◽  
Juan Antonio López-Villodres ◽  
Nuria Jebrouni ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Acetylsalicylic Acid ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Brain Slices ◽  
Hypoxia Reoxygenation

Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats

2018 ◽  
Vol 27 (3) ◽  
pp. 691-697 ◽  
Author(s):  
Habib Yaribeygi ◽  
Nastaran Faghihi ◽  
Mohammad Taghi Mohammadi ◽  
Amirhossein Sahebkar
Keyword(s):  
Nitrosative Stress ◽  
Diabetic Rats ◽  
Oxidative And Nitrosative Stress

scholarly journals Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Joel Ramírez-Emiliano ◽  
Martha E. Fajardo-Araujo ◽  
Ismael Zúñiga-Trujillo ◽  
Victoriano Pérez-Vázquez ◽  
Cuauhtémoc Sandoval-Salazar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Nitrosative Stress ◽  
Full Term ◽  
Mitochondrial Content ◽  
Oxidative And Nitrosative Stress

scholarly journals Effects of Extracts of Plathymenia Reticulata Benth and Azadirachta Indica (Neem) in Glycated Hemoglobin in Diabetic Rats

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A438-A439
Author(s):  
Ezio De Martino Neto ◽  
Joyce Satil Chaves da Silva ◽  
Eliane Cristina Lourenço ◽  
Arthur Cesário de Castro Neto ◽  
Isabella Cecilio Resende Ferreira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Azadirachta Indica ◽  
Insulin Treatment ◽  
Glycated Hemoglobin ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Male Adult ◽  
Significant Difference

Abstract Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.

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