Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus

We determined whether alterations in the mechanism of relaxation to H2O2potentially contribute to the enhanced prostaglandin-mediated contractile response to H2O2and posthypoxic reoxygenation seen in human placental vessels of pregnancies with gestational diabetes mellitus (GDM). Isolated placental arteries and veins from GDM and uncomplicated full-term pregnancies were precontracted with prostaglandin F2α([Formula: see text] 35–38 Torr) and then exposed to lactate (1–10 mM), arachidonic acid (0.01–10 μM), nitroglycerin (1 nM–1 μM), forskolin (0.01–10 μM), or H2O2(1 μM–1 mM + 10 μM indomethacin). The rates of tissue H2O2metabolism by catalase and nitrite production were measured. The relaxation to lactate was reduced in GDM placental arteries and veins by 54–85 and 66–80%, and the relaxation to H2O2was inhibited by 80–94% in GDM placental veins compared with vessels from uncomplicated full-term pregnancies. H2O2caused only minimal relaxation of placental arteries. Responses to other relaxing agents were not altered in the GDM placental vessels. Diabetic vessels showed rates of nitrite production that were increased by 113–195% and rates of H2O2metabolism by catalase that were decreased by 44–61%. The loss of relaxation to H2O2and lactate (mediated via H2O2), perhaps as a result of the inhibition of catalase by nitric oxide, may explain the previously reported enhancement of prostaglandin-mediated contractile responses to H2O2and posthypoxic reoxygenation seen in GDM placental vessels.

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Modulation of Cholesterol Transport by Insulin-Treated Gestational Diabetes Mellitus in Human Full-Term Placenta1

Biology of Reproduction ◽

10.1095/biolreprod.112.105619 ◽

2013 ◽

Vol 88 (1) ◽

Cited By ~ 33

Author(s):

Evemie Dubé ◽

Maude Ethier-Chiasson ◽

Julie Lafond

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Full Term ◽

Cholesterol Transport

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Clinical, metabolic and neurological disorders in full-term newborns from mothers with gestational diabetes mellitus

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2021-66-3-46-51 ◽

2021 ◽

Vol 66 (3) ◽

pp. 46-51

Author(s):

O. V. Remneva ◽

O. V. Rozhkova ◽

T. M. Cherkasova ◽

Yu. V. Korenovskiy ◽

N. V. Trukhacheva ◽

...

Keyword(s):

Diabetes Mellitus ◽

Central Nervous System ◽

Nervous System ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Full Term ◽

Electrolyte Balance ◽

Maternal Hyperglycemia ◽

The Central Nervous System ◽

Postnatal Adaptation

Objective. To determine the clinical and metabolic changes in children born from mothers with gestational diabetes mellitus and to predict perinatal injury of the central nervous system (CNS), taking into account the level of maternal hyperglycemia.Material and methods. The period of early postnatal adaptation was analyzed in 258 full-term infants, who were divided into two groups, depending on the glucose level in the mother’s venous blood during pregnancy: Group 1: 5,1–5,6 mmol/L, Group 2: 5,7–7,0 mmol/L.Results. Based on clinical, functional and laboratory markers (electrolyte balance and carbohydrate metabolism in the blood of a newborn) there was established a correlation between the severity of maternal hyperglycemia and the severity of neonatal disorders. In Group II infants born from mothers with more severe hyperglycemia are more likely to have a respiratory distress syndrome and ischemic-hypoxic injury of the central nervous system in combination with excess birth weight which significantly complicates postnatal adaptation.Conclusion. The concentration of neuron-specific enolase of 4,9 ng/ml in the fetal amniotic fluid is an antenatal marker of perinatal damage to the central nervous system in a newborn.

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Influences of Maternal Prepregnancy Obesity and Gestational Diabetes Mellitus on the Infant Gut Microbiome in Full-Term Infants

The Journal of Perinatal & Neonatal Nursing ◽

10.1097/jpn.0000000000000512 ◽

2020 ◽

Vol 34 (3) ◽

pp. E20-E20

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gut Microbiome ◽

Full Term ◽

Term Infants ◽

Prepregnancy Obesity ◽

Infant Gut Microbiome ◽

Maternal Prepregnancy Obesity

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Nutritional status of children born to mothers with gestational diabetes mellitus

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-185-1-67-74 ◽

2021 ◽

Vol 1 (1) ◽

pp. 67-74

Author(s):

D. S. Bogomaz ◽

O. V. Papysheva ◽

D. A. Shurygina ◽

L. V. Bogomaz

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Nutritional Status ◽

Gestational Diabetes Mellitus ◽

Maternity Hospital ◽

Physical Development ◽

Overweight And Obesity ◽

Full Term ◽

Student’S T ◽

Nutritional Status Of Children

Objective: to optimize the diagnosis of nutritional status disorders in children born at different gestational periods from mothers with diabetes mellitus by assessing their nutritional status to predict the development of morphofunctional changes in different periods of childhoodMaterials and methods: 84 children from mothers with gestational diabetes mellitus, born in the maternity hospital of the Bauman State Clinical Hospital. The assessment of children’s physical development was carried out in accordance with WHO Anthro standards (2006). A comparative analysis of the variables of children in different groups was carried out using the Student’s T-test. “Statistica 10 programm” was used.Results: preterm children by the age of 3 are not only aligned with full-term children in terms of nutritional status, but also begin to exceed the latter in terms of body weight and length. In further age periods, their indicators do not go beyond the population. In full-term children from 4 years of age, there is a tendency to overweight and obesity.Conclusion: the nutritional status and physical development of children born to mothers with gestational diabetes mellitus depends on the gestational age and undergoes dramatic changes in different age periods of childhood.

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