scholarly journals Virgin olive oil administration improves the effect of aspirin on retinal vascular pattern in experimental diabetes mellitus

2010 ◽  
Vol 104 (4) ◽  
pp. 560-565 ◽  
Author(s):  
Jose Pedro De La Cruz ◽  
Sergio Del Río ◽  
Juan Antonio López-Villodres ◽  
Maria Auxiliadora Villalobos ◽  
Nuria Jebrouni ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Aggregation ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Platelet Inhibition ◽  
Diabetic Rats ◽  
No Production ◽  
Vascular Pattern ◽  
Pharmacodynamic Profile

The aim of the present study is to evaluate the possible influence of virgin olive oil (VOO) on the effect of acetylsalicylic acid (ASA) in platelet aggregation, prostanoid and NO production and retinal vascular pattern in rats with experimental type 1-like diabetes. We used 100 male Wistar rats that were distributed into five groups: (1) non-diabetic rats (NDR); (2) untreated diabetic rats (DR); (3) DR treated with ASA (2 mg/kg per d per os (p.o.)); (4) DR treated with VOO (0·5 ml/kg per d p.o.); (5) DR treated with ASA plus VOO. The duration of diabetes was 3 months, and each treatment was administered from the first day of diabetes. Variables that were quantified were platelet aggregation (Imax), thromboxane B2 (TxB2), aortic prostacyclin (6-keto-PGF1α) and NO, and the percentage of retina with horseradish peroxidase-permeable vessels (HRP-PV). Diabetic rats showed a higher Imax (35 %) and TxB2 (63 %) than NDR, and a lower 6-keto-PGF1α, NO and HRP-PV than NDR ( − 74·6 %). ASA and VOO administration reduced these differences and prevented the percentage of HRP-PV ( − 59·7 % with ASA and − 46·7 % with VOO). The administration of ASA plus VOO showed a strong platelet inhibition (80·2 v. 23·4 % for VOO and 50·6 % for ASA+VOO, P < 0·0001), and reduced HRP-PV differences to − 31·6 % (P < 0·001 with respect to DR and P < 0·0001 with respect to DR treated with ASA). In conclusion, the administration of VOO to rats with type 1-like diabetes mellitus improves the pharmacodynamic profile of ASA, and increases its retinal anti-ischaemic effect.

Effect of virgin olive oil plus acetylsalicylic acid on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus

2010 ◽  
Vol 471 (2) ◽  
pp. 89-93 ◽  
Author(s):  
José Pedro De La Cruz ◽  
Sergio Del Río ◽  
María Monsalud Arrebola ◽  
Juan Antonio López-Villodres ◽  
Nuria Jebrouni ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Acetylsalicylic Acid ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Brain Slices ◽  
Hypoxia Reoxygenation

scholarly journals Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1783
Author(s):  
María Dolores Rodríguez-Pérez ◽  
Juan Antonio López-Villodres ◽  
María Monsalud Arrebola ◽  
Esther Martín-Aurioles ◽  
África Fernández-Prior ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Model ◽  
Nitrosative Stress ◽  
Virgin Olive Oil ◽  
Diabetic Rats ◽  
Oxidative And Nitrosative Stress ◽  
Statistical Correlations ◽  
Calculated Creatinine Clearance ◽  
Nephroprotective Effect

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67–73%), calculated creatinine clearance was significantly increased (26–38%), and the glomerular volume and glomerulosclerosis index were decreased (20–30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.

Inflammatory process and virgin olive oil phenols: modulation of platelet aggregation and metalloprotease-9 expression in monocytes

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Dell'Agli ◽  
R Fagnani ◽  
G Galli ◽  
O Maschi ◽  
E de Fabiani ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Olive Oil ◽  
Inflammatory Process ◽  
Virgin Olive Oil

scholarly journals Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus

2012 ◽  
Vol 15 (2) ◽  
pp. 49-53
Author(s):  
Boris Il'ich Kuznik ◽  
Yury Antonovich Vitkovskiy ◽  
Marina Yur'evna Zakharova ◽  
Natalya Nikolaevna Klyuchereva ◽  
Olga Sergeevna Rodnina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Aggregation ◽  
Blood Samples ◽  
Significant Difference ◽  
Erythrocyte Adhesion ◽  
T1 And T2 ◽  
Aggregation Activity ◽  
Spontaneous Platelet Aggregation

Aims. To assess differences in blood formed elements aggregation activity in patients with type 1 (T1) and type 2 (T2) diabetes mellitus(DM). Materials and methods. We studied blood samples from 88 patients with T1 and T2 DM. Platelet aggregation activity was assessed bymeans of ?Biola? aggregometer; we also determined platelet-lymphocyte and leucocyte-erythrocyte adhesion intensity. Results. We show that spontaneous platelet aggregation is markedly increased in patients with T1DM but remains normal or slightlyelevated in case of T2DM. In blood from patients with T2DM platelet aggregation in response to ADP, epinephrine, ristomycineand contact with collagen was generally increased, whereas in T1DM we often observed its secondary reduction. Data on plateletlymphocyteadhesion in T1DM is controversial, but in T2DM this process seems to be significantly suppressed. Quantity of leucocyteerythrocyteaggregates was sharply increased in both T1DM and T2DM. Conclusion. We've determined significant difference in blood formed elements aggregation activity between patients with T1 and T2 DM.

scholarly journals Effects of Extracts of Plathymenia Reticulata Benth and Azadirachta Indica (Neem) in Glycated Hemoglobin in Diabetic Rats

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A438-A439
Author(s):  
Ezio De Martino Neto ◽  
Joyce Satil Chaves da Silva ◽  
Eliane Cristina Lourenço ◽  
Arthur Cesário de Castro Neto ◽  
Isabella Cecilio Resende Ferreira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Azadirachta Indica ◽  
Insulin Treatment ◽  
Glycated Hemoglobin ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Male Adult ◽  
Significant Difference

Abstract Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.

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