scholarly journals Sensor Micro and Nanoparticles for Microfluidic Application

2020 ◽  
Vol 10 (23) ◽  
pp. 8353
Author(s):  
Raminta Mazetyte-Stasinskiene ◽  
Johann Michael Köhler
Keyword(s):  
Direct Contact ◽  
Microfluidic Devices ◽  
Chemical Signals ◽  
Biological Applications ◽  
Microfluidic Systems ◽  
Valuable Component ◽  
Optical Readout ◽  
Sensing Systems ◽  
Functional Units ◽  
Physical And Chemical

Micro and nanoparticles are not only understood as components of materials but as small functional units too. Particles can be designed for the primary transduction of physical and chemical signals and, therefore, become a valuable component in sensing systems. Due to their small size, they are particularly interesting for sensing in microfluidic systems, in microarray arrangements and in miniaturized biotechnological systems and microreactors, in general. Here, an overview of the recent development in the preparation of micro and nanoparticles for sensing purposes in microfluidics and application of particles in various microfluidic devices is presented. The concept of sensor particles is particularly useful for combining a direct contact between cells, biomolecules and media with a contactless optical readout. In addition to the construction and synthesis of micro and nanoparticles with transducer functions, examples of chemical and biological applications are reported.

scholarly journals Split and flow: reconfigurable capillary connection for digital microfluidic devices

Lab on a Chip ◽  
2014 ◽  
Vol 14 (18) ◽  
pp. 3589-3593 ◽  
Author(s):  
Florian Lapierre ◽  
Maxime Harnois ◽  
Yannick Coffinier ◽  
Rabah Boukherroub ◽  
Vincent Thomy
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic Systems ◽  
Digital Microfluidic

How to take advantage of superhydrophobic microgrids to address the problem of coupling continuous to digital microfluidic systems? A reconfigurable capillary connection for digital microfluidic devices is presented.

Electrode interfaces switchable by physical and chemical signals for biosensing, biofuel, and biocomputing applications

2012 ◽  
Vol 405 (11) ◽  
pp. 3659-3672 ◽  
Author(s):  
Evgeny Katz ◽  
Segiy Minko ◽  
Jan Halámek ◽  
Kevin MacVittie ◽  
Kenneth Yancey
Keyword(s):  
Chemical Signals ◽  
Physical And Chemical

Rapid switching of chemical signals in microfluidic devices

Lab on a Chip ◽  
2009 ◽  
Vol 9 (21) ◽  
pp. 3059 ◽  
Author(s):  
Albert J. Bae ◽  
Carsten Beta ◽  
Eberhard Bodenschatz
Keyword(s):  
Microfluidic Devices ◽  
Chemical Signals ◽  
Rapid Switching

scholarly journals Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245206
Author(s):  
Harry Felton ◽  
Robert Hughes ◽  
Andrea Diaz-Gaxiola
Keyword(s):  
Rapid Prototyping ◽  
Point Of Care ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Appropriate Technology ◽  
Channel Cross Section ◽  
Microfluidic Systems ◽  
3D Printed

This paper reports a novel, negligible-cost and open-source process for the rapid prototyping of complex microfluidic devices in polydimethylsiloxane (PDMS) using 3D-printed interconnecting microchannel scaffolds. These single-extrusion scaffolds are designed with interconnecting ends and used to quickly configure complex microfluidic systems before being embedded in PDMS to produce an imprint of the microfluidic configuration. The scaffolds are printed using common Material Extrusion (MEX) 3D printers and the limits, cost & reliability of the process are evaluated. The limits of standard MEX 3D-printing with off-the-shelf printer modifications is shown to achieve a minimum channel cross-section of 100×100 μm. The paper also lays out a protocol for the rapid fabrication of low-cost microfluidic channel moulds from the thermoplastic 3D-printed scaffolds, allowing the manufacture of customisable microfluidic systems without specialist equipment. The morphology of the resulting PDMS microchannels fabricated with the method are characterised and, when applied directly to glass, without plasma surface treatment, are shown to efficiently operate within the typical working pressures of commercial microfluidic devices. The technique is further validated through the demonstration of 2 common microfluidic devices; a fluid-mixer demonstrating the effective interconnecting scaffold design, and a microsphere droplet generator. The minimal cost of manufacture means that a 5000-piece physical library of mix-and-match channel scaffolds (100 μm scale) can be printed for ~$0.50 and made available to researchers and educators who lack access to appropriate technology. This simple yet innovative approach dramatically lowers the threshold for research and education into microfluidics and will make possible the rapid prototyping of point-of-care lab-on-a-chip diagnostic technology that is truly affordable the world over.

scholarly journals The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2945 ◽  
Author(s):  
Grissel Trujillo-de Santiago ◽  
Brenda Giselle Flores-Garza ◽  
Jorge Alfonso Tavares-Negrete ◽  
Itzel Montserrat Lara-Mayorga ◽  
Ivonne González-Gamboa ◽  
...  
Keyword(s):  
Cancer Research ◽  
Solid Tumors ◽  
3D Culture ◽  
Microfluidic Devices ◽  
Pharmaceutical Compounds ◽  
Microfluidic Systems ◽  
Cancer Etiology ◽  
Culture Systems ◽  
On Chip

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better understanding of cancer etiology and development of better anticancer therapies—is highly challenging. Tumors are complex three-dimensional (3D) tissues that establish a dynamic cross-talk with the surrounding tissues through complex chemical signaling. An extensive body of experimental evidence has established that 3D culture systems more closely recapitulate the architecture and the physiology of human solid tumors when compared with traditional 2D systems. Moreover, conventional 3D culture systems fail to recreate the dynamics of the tumor niche. Tumor-on-chip systems, which are microfluidic devices that aim to recreate relevant features of the tumor physiology, have recently emerged as powerful tools in cancer research. In tumor-on-chip systems, the use of microfluidics adds another dimension of physiological mimicry by allowing a continuous feed of nutrients (and pharmaceutical compounds). Here, we discuss recently published literature related to the culture of solid tumor-like tissues in microfluidic systems (tumor-on-chip devices). Our aim is to provide the readers with an overview of the state of the art on this particular theme and to illustrate the toolbox available today for engineering tumor-like structures (and their environments) in microfluidic devices. The suitability of tumor-on-chip devices is increasing in many areas of cancer research, including the study of the physiology of solid tumors, the screening of novel anticancer pharmaceutical compounds before resourcing to animal models, and the development of personalized treatments. In the years to come, additive manufacturing (3D bioprinting and 3D printing), computational fluid dynamics, and medium- to high-throughput omics will become powerful enablers of a new wave of more sophisticated and effective tumor-on-chip devices.

Control of pressure-driven components in integrated microfluidic devices using an on-chip electrostatic microvalve

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51593-51602 ◽  
Author(s):  
Joshua D. Tice ◽  
Amit V. Desai ◽  
Thomas A. Bassett ◽  
Christopher A. Apblett ◽  
Paul J. A. Kenis
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic Systems ◽  
On Chip ◽  
Pressure Driven

We report an electrostatic microvalve and microfluidic “pressure-amplifier” circuits used to regulate pressure-driven components (e.g., microvalves) in microfluidic systems.

scholarly journals High-speed particle detection and tracking in microfluidic devices using event-based sensing

Lab on a Chip ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 3024-3035
Author(s):  
Jessie Howell ◽  
Tansy C. Hammarton ◽  
Yoann Altmann ◽  
Melanie Jimenez
Keyword(s):  
High Throughput ◽  
High Speed ◽  
Microfluidic Devices ◽  
Microfluidic Systems ◽  
Particle Detection ◽  
Detection And Tracking ◽  
Particle Imaging ◽  
Event Based ◽  
Cost Sensitivity

Event-based sensing offers unique advantages in terms of cost, sensitivity and compatibility with standard microscopes for high-throughput particle imaging in microfluidic systems.

scholarly journals Microfluidic devices manufacturing with a stereolithographic printer for biological applications

2021 ◽  
Vol 129 ◽  
pp. 112388
Author(s):  
Bastián Carnero ◽  
Carmen Bao-Varela ◽  
Ana Isabel Gómez-Varela ◽  
Ezequiel Álvarez ◽  
María Teresa Flores-Arias
Keyword(s):  
Microfluidic Devices ◽  
Biological Applications

scholarly journals Highly Sensitive and Selective H2S Chemical Sensor Based on ZnO Nanomaterial

2019 ◽  
Vol 9 (6) ◽  
pp. 1167 ◽  
Author(s):  
Vardan Galstyan ◽  
Nicola Poli ◽  
Elisabetta Comini
Keyword(s):  
Chemical Sensor ◽  
Gas Sensing ◽  
Chemical Properties ◽  
Device Fabrication ◽  
Sensing Systems ◽  
Highly Sensitive ◽  
Prepared Material ◽  
Significant Step ◽  
Reducing Gases ◽  
Physical And Chemical

ZnO is worth evaluating for chemical sensing due to its outstanding physical and chemical properties. We report the fabrication and study of the gas sensing properties of ZnO nanomaterial for the detection of hydrogen sulfide (H2S). This prepared material exhibited a 7400 gas sensing response when exposed to 30 ppm of H2S in air. In addition, the structure showed a high selectivity towards H2S against other reducing gases. The high sensing performance of the structure was attributed to its nanoscale size, morphology and the disparity in the sensing mechanism between the H2S and other reducing gases. We suggest that the work reported here including the simplicity of device fabrication is a significant step toward the application of ZnO nanomaterials in chemical gas sensing systems for the real-time detection of H2S.

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