scholarly journals Highly Sensitive Non-Enzymatic Detection of Glucose at MWCNT-CuBTC Composite Electrode

2020 ◽  
Vol 10 (23) ◽  
pp. 8419
Author(s):  
Adriana Remes ◽  
Florica Manea ◽  
Sorina Motoc (m. Ilies) ◽  
Anamaria Baciu ◽  
Elisabeta I. Szerb ◽  
...  
Keyword(s):  
Composite Electrode ◽  
Glucose Sensor ◽  
Low Cost ◽  
Multiwall Carbon Nanotubes ◽  
Linear Sweep Voltammetry ◽  
High Sensitivity ◽  
Differential Pulse ◽  
Roll Mill ◽  
Highly Sensitive ◽  
Enzymatic Detection

A novel electrochemical glucose sensor was developed, based on a multiwall carbon nanotubes (MWCNTs)-copper-1,3,5-benzenetricarboxylic acid (CuBTC)-epoxy composite electrode, named MWCNT-CuBTC. The electrode nanocomposite was prepared by a two-roll mill procedure and characterized morphostructurally by scanning electron microscopy (SEM). The CuBTC formed defined crystals with a wide size distribution, which were well dispersed and embedded in the MWCNTs. Its electrical conductivity was determined by four-point probe contact (DC) conductivity measurements. The electroactive surface area, determined using cyclic voltammetry (CV), was found to be 6.9 times higher than the geometrical one. The results of the electrochemical measurements using CV, linear sweep voltammetry (LSV), differential pulse voltammetry (DPV), chronoamperometry (CA) and multiple pulse amperometry (MPA) showed that the MWCNT-CuBTC composite electrode displayed high electrocatalytic activity toward the oxidation of glucose and, as a consequence, very high sensitivity. The best sensitivity of 14,949 µAmM−1cm−1 was reached using MPA at the potential value of 0.6 V/SCE, which was much higher in comparison with other copper-based electrodes reported in the literature. The good analytical performance, low cost and simple preparation method make this novel electrode material promising for the development of an effective glucose sensor.

Recent Electrochemical Assays on Cephalosporins

2020 ◽  
Vol 16 (4) ◽  
pp. 337-349
Author(s):  
Leyla Karadurmus ◽  
Kaan Eşme ◽  
Nurgul K. Bakirhan ◽  
Sibel A. Ozkan
Keyword(s):  
Low Cost ◽  
Linear Sweep Voltammetry ◽  
High Sensitivity ◽  
Differential Pulse ◽  
Electroanalytical Methods ◽  
Antibiotic Drugs ◽  
Short Time ◽  
Advanced Generation ◽  
Antibacterial Spectrum

: Antibiotics are an important class among drugs because they are a significant agent to deal with infections. Cephalosporins are a very important group of antibiotics in the β-lactam class. The cephalosporins are semisynthetic antibiotics derived from products of the fungus Cephalosporium. Cephalosporins are classified as first, second, third, fourth, and advanced generation, based largely on their antibacterial spectrum and stability to β-lactamases. Electrochemical methods have been used for the determination of cephalosporin just as used in the determination of many antibiotic drugs. Electroanalytical methods present generally high sensitivity, low cost, low requirements, ease of preparation of the samples in a very short time, and a short analysis time. The most commonly used types are cyclic voltammetry, differential pulse voltammetry, square wave voltammetry and linear sweep voltammetry. The aim of this review is to evaluate the advantages and uses of electroanalytical methods used in the determination of cephalosporins. In addition, current applications of the methods to the pharmaceutical analysis of cephalosporins will also be summarized in a table.

Highly sensitive detection of Cr(vi) in groundwater by bimetallic NiFe nanoparticles

2017 ◽  
Vol 9 (6) ◽  
pp. 1031-1037 ◽  
Author(s):  
Jingtao Liu ◽  
Yu Ding ◽  
Lifei Ji ◽  
Xin Zhang ◽  
Fengchun Yang ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Hexavalent Chromium ◽  
Low Cost ◽  
High Sensitivity ◽  
Sensitive Detection ◽  
Toxic Heavy Metal ◽  
Metal Pollutants ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Heavy Metal Pollutants

Hexavalent chromium (Cr(vi)) is one of the most toxic heavy metal pollutants in groundwater, and thus the detection of Cr(vi) with high sensitivity, accuracy, and simplicity and low cost is of great importance.

Highly sensitive, stable, and precise detection of dopamine with carbon dots/tyrosinase hybrid as fluorescent probe

RSC Advances ◽  
2014 ◽  
Vol 4 (87) ◽  
pp. 46437-46443 ◽  
Author(s):  
Hao Li ◽  
Juan Liu ◽  
Manman Yang ◽  
Weiqian Kong ◽  
Hui Huang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Carbon Dots ◽  
Low Cost ◽  
High Sensitivity ◽  
Highly Sensitive

The carbon dots/tyrosinase hybrid as a low-cost fluorescent probe for the detection of dopamine exhibits high sensitivity, stability, and precision.

A highly sensitive glucose sensor based on a gold nanoparticles/polyaniline/multi-walled carbon nanotubes composite modified glassy carbon electrode

2018 ◽  
Vol 42 (14) ◽  
pp. 11944-11953 ◽  
Author(s):  
Xinping Zeng ◽  
Yazhou Zhang ◽  
Xiling Du ◽  
Yanfei Li ◽  
Wenwei Tang
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Glucose Sensor ◽  
High Sensitivity ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Highly Sensitive ◽  
Multi Walled Carbon Nanotubes ◽  
Application Potential ◽  
Walled Carbon Nanotubes

The PTFE/GOx/AuNPs/PANI/MWCNTs/GCE glucose sensor possesses wide linear range, low detection limit, high sensitivity, which can measure the glucose in human serum and holds application potential.

Amplification-Free DNA Detection Using a Microtip-Sensor Decorated With LNA Probes for Rapid TB Screening

2011 ◽  
Author(s):  
Shinnosuke Inoue ◽  
Woon-Hong Yeo ◽  
Jong-Hoon Kim ◽  
Jae-Hyun Chung ◽  
Kyong-Hoon Lee ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Staphylococcus Epidermidis ◽  
Genomic Dna ◽  
Bacterial Culture ◽  
Low Cost ◽  
Surrogate Marker ◽  
High Sensitivity ◽  
Diagnostic Methods ◽  
Nucleic Acid Amplification ◽  
Highly Sensitive

Tuberculosis (TB) is an epidemic affecting one-third of the world’s population, mostly in developing and low-resource settings. People having active pulmonary TB are considered highly infectious; therefore, it is critical to identify and treat these patients rapidly before spreading to others. However, the most reliable TB diagnostic methods of bacterial culture or nucleic acid amplification are time-consuming and expensive. The challenge of TB diagnosis lies in highly sensitive and specific screening with low cost. Here, we present an LNA-modified microtip-sensor, which is capable of selectively detecting low-abundance DNA from bacteria. When genomic DNA of Bacillus Calmette-Gue´rin (BCG, a surrogate marker of Mycobacterium bovis), and genomic DNA of Staphylococcus epidermidis (S. epi) are used, the microtip-sensor yields the detection limit of 1,000 copies/mL within 20 minutes. The high sensitivity and specificity approaching nucleic acid amplification methods can potentially overcome the current challenges for rapid TB screening.

Highly Sensitive Determination of Dopamine Using Osmium/Nafion Modified Disposable Integrated Biosensor

2009 ◽  
Vol 60-61 ◽  
pp. 311-314 ◽  
Author(s):  
Chun Xiu Liu ◽  
Hong Min Liu ◽  
Qing De Yang ◽  
Nan Sen Lin ◽  
Yi Lin Song ◽  
...  
Keyword(s):  
Detection Limit ◽  
Correlation Coefficient ◽  
Gold Electrode ◽  
High Sensitivity ◽  
Differential Pulse ◽  
Redox Polymer ◽  
Highly Sensitive ◽  
Sensitive Determination ◽  
Excellent Reproducibility

A biosensor based on gold electrode modified by Pt nanaoparticles/Osmium redox polymer/Nafion trilayer film was fabricated and used for selective and sensitive determination of dopamine. The biosensor is explored for DA sensing using the cyclic voltammetry (CV), amperometric and differential pulse voltammetric (DPV) methods. The CV anodic peak currents showed a linear range with a correlation coefficient of 0.996, localized in the concentration range 0~192 μM. The differential pulse voltammetric (DPV) peak currents were linear with DA concentration during 2~425 μM with correlation coefficient of 0.99. The biosensor showed high sensitivity of 0.5 nA /nM cm2 and excellent reproducibility with the detection limit of ~10 nM (S/N=3) for the determination of DA. The easy fabrication, low detection limit and high sensitivity of the integrated biosensor making it particularly suitable for the analytical purposes.

scholarly journals Sequence-Independent DNA Adsorption on Few-Layered Oxygen-Functionalized Graphene Electrodes: An Electrochemical Study for Biosensing Application

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 273
Author(s):  
Narges Asefifeyzabadi ◽  
Torrey E. Holland ◽  
Poopalasingam Sivakumar ◽  
Saikat Talapatra ◽  
Ishani M. Senanayake ◽  
...  
Keyword(s):  
Divalent Cations ◽  
Low Cost ◽  
Differential Pulse ◽  
Current Response ◽  
Functionalized Graphene ◽  
Label Free ◽  
Dna Adsorption ◽  
Redox Probe ◽  
Highly Sensitive ◽  
Electrochemical Charge Transfer

DNA is strongly adsorbed on oxidized graphene surfaces in the presence of divalent cations. Here, we studied the effect of DNA adsorption on electrochemical charge transfer at few-layered, oxygen-functionalized graphene (GOx) electrodes. DNA adsorption on the inkjet-printed GOx electrodes caused amplified current response from ferro/ferricyanide redox probe at concentration range 1 aM–10 nM in differential pulse voltammetry. We studied a number of variables that may affect the current response of the interface: sequence type, conformation, concentration, length, and ionic strength. Later, we showed a proof-of-concept DNA biosensing application, which is free from chemical immobilization of the probe and sensitive at attomolar concentration regime. We propose that GOx electrodes promise a low-cost solution to fabricate a highly sensitive platform for label-free and chemisorption-free DNA biosensing.

Preparation of Ni(OH)2 nanosheets on Ni foam via a direct precipitation method for a highly sensitive non-enzymatic glucose sensor

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53665-53670 ◽  
Author(s):  
Yudong Zhao ◽  
Gaochen Gu ◽  
Shengquan You ◽  
Renhua Ji ◽  
Hui Suo ◽  
...  
Keyword(s):  
Glucose Concentration ◽  
Glucose Sensor ◽  
High Sensitivity ◽  
Precipitation Method ◽  
Ni Foam ◽  
Direct Precipitation ◽  
Highly Sensitive ◽  
Direct Precipitation Method

Ni(OH)2 nanosheets on Ni foam was prepared by the direct precipitation method. This electrode shows high sensitivity with 1130 μA mM−1 cm−2 at the glucose concentration range of 2 μM to 40 μM and 1097 μA mM−1 cm−2 at the range of 0.1 mM to 2.5 mM.

Low-cost and high sensitivity glucose sandwich detection using a plasmonic nanodisk metasurface

Nanoscale ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 10809-10815 ◽  
Author(s):  
Zhongwen Long ◽  
Yuzhang Liang ◽  
Lei Feng ◽  
Hui Zhang ◽  
Mingze Liu ◽  
...  
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
High Sensitivity ◽  
Glucose Detection ◽  
Sensing Platform ◽  
Highly Sensitive

A low-cost, large scale plasmonic metasurface sensing platform shows enormous potential for highly sensitive and selective SERS-based glucose detection.

A PNA-Mediated Clamping PCR for Routine Detection of KRAS Mutations in Colorectal Carcinoma

2014 ◽  
Vol 29 (1) ◽  
pp. e55-e61 ◽  
Author(s):  
Francesca Messa ◽  
Federica Tonissi ◽  
Enrico Millo ◽  
Enrico Bracco ◽  
Silvana Ungari ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Low Cost ◽  
Screening Method ◽  
High Sensitivity ◽  
Kras Mutations ◽  
Laboratory Equipment ◽  
Highly Sensitive ◽  
Appropriate Therapy ◽  
Definition Of ◽  
Very High

The detection of somatic mutations in a tumor represents a valuable tool for tumor characterization and provides the clinicians with information for setting up the most appropriate therapy. KRAS mutations in codons 12 and 13 are important biomarkers routinely analyzed in the clinic for the management of anti-EGFR treatment in colorectal carcinoma (CRC). Here we report a sensitive and inexpensive assay for KRAS mutations based on a PNA-mediated PCR clamping. The assay displays very high sensitivity (0.7%) and specificity (96.7%) when compared to traditional sequencing (SS) and pyrosequencing (PS), two of the most commonly and routinely used methods employed today by diagnostic laboratories. Furthermore, the PNA assay requires only basic and low-cost laboratory equipment, in contrast with all the most recent PCR-based technologies, which are highly sensitive but also much more expensive. Finally, despite the PNA assay does not allow for the definition of specific mutations, it is the cheapest and easiest screening method to firstly stratify wild-type and mutated patients, information that is strictly necessary to clinicians for the management of CRC and anti-EGFR treatment.

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