scholarly journals Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice

2020 ◽  
Vol 10 (23) ◽  
pp. 8465
Author(s):  
João Rocha ◽  
Raquel Leandro ◽  
Rosa Direito ◽  
Margarida Gonçalves ◽  
Maria Paula Duarte ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Chronic Inflammatory Disease ◽  
Colonic Injury ◽  
Satureja Hortensis ◽  
Beneficial Effects ◽  
Experimental Inflammatory Bowel Disease ◽  
Phenolic Extract ◽  
Inflammatory Bowel

Summer Savory (Satureja hortensis L.) is a plant traditionally used as a food spice in the Mediterranean region. Surprisingly, not much is known about the health beneficial effects of its phenolic-rich extracts. The majority of publications have always focused on the properties of their essential oil. One of the main phenolic compounds of Summer Savory is rosmarinic acid, which has demonstrated anti-inflammatory outcomes in several animal models of inflammatory-mediated diseases. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease, in addition to Ulcerative Colitis and Crohn’s Disease, frequently related with increased morbidity and even mortality due to the complications associated, including colorectal cancer. Our work has shown, to our knowledge, for the first time, that administration of a phenolic extract of Summer Savory in a mouse model of Ulcerative Colitis led to the reduction of several markers for intestinal injury, including reduction of inducible nitric oxide synthase (iNOS) and Cyclooxygenase-2 (COX-2 or prostaglandin-endoperoxide synthase) expression, two well-known mediators of tissue inflammation and progression to cancer and led also to a reduction of the mortality. Given the chemical constitution found in the extract and the preclinical evidence of a beneficial effect of polyphenols in inflammatory processes, an opportunity arises for pharmacological modulation of pathways relevant for IBD and progression to cancer with phenolic-rich extracts.

scholarly journals Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Qingdong Guan ◽  
Jiguo Zhang
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Inflammatory Cytokines ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Beneficial Effects ◽  
Recent Advances ◽  
Inflammatory Bowel ◽  
Inflammation Targeting ◽  
Anti Inflammatory

Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD. In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.

scholarly journals Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Francesca Algieri ◽  
Alba Rodriguez-Nogales ◽  
M. Elena Rodriguez-Cabezas ◽  
Severiano Risco ◽  
M. Angeles Ocete ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Bowel Disease ◽  
Life Quality ◽  
Beneficial Effects ◽  
New Strategy ◽  
Inflammatory Bowel ◽  
Surgical Treatments

Crohn’s disease and ulcerative colitis are the two most common categories of inflammatory bowel disease (IBD), which are characterized by chronic inflammation of the intestine that comprises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their aetiology is not completely understood, nonfully efficient drugs have been developed and those that show effectiveness are not devoid of quite important adverse effects that impair their long-term use. Therefore, many patients try with some botanical drugs, which are safe and efficient after many years of use. However, it is necessary to properly evaluate these therapies to consider a new strategy for human IBD. In this report we have reviewed the main botanical drugs that have been assessed in clinical trials in human IBD and the mechanisms and the active compounds proposed for their beneficial effects.

FSGHF3 and peptides, prepared from fish skin gelatin, exert a protective effect on DSS-induced colitis via the Nrf2 pathway

2020 ◽  
Vol 11 (1) ◽  
pp. 414-423 ◽  
Author(s):  
Zhao Deng ◽  
Chenbin Cui ◽  
Yanan Wang ◽  
Jiangjin Ni ◽  
Liufeng Zheng ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Protective Effect ◽  
Inflammatory Disease ◽  
Bowel Disease ◽  
Chronic Inflammatory Disease ◽  
Fish Skin ◽  
Nrf2 Pathway ◽  
Fish Skin Gelatin ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide.

Anti-inflammatory effect of yoghurt in an experimental inflammatory bowel disease in mouse

2008 ◽  
Vol 75 (4) ◽  
pp. 497-504 ◽  
Author(s):  
Nadia Gobbato ◽  
Mirta Rachid ◽  
Gabriela Perdigón
Keyword(s):  
Inflammatory Bowel Disease ◽  
Experimental Model ◽  
Large Intestine ◽  
Bowel Disease ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Beneficial Effects ◽  
Pathogenic Factors ◽  
Experimental Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD; Crohn′s disease and ulcerative colitis) is the clinical outcome of three interactive pathogenic factors: genetic susceptibility, environmental triggers and immune dis-regulation. At present, only the immune response is targeted by most therapeutic or preventive strategies. The beneficial effect of yoghurt on health as well as its immunomodulator effect on the gut immune system is well documented. The aim of this work was to study the possible beneficial effects of yoghurt consumption on an experimental model of IBD in mice. Balb/c mice were fed with yoghurt for 10 consecutive days. At the end of the feeding period the mice received three inoculations of 2, 4, 6-trinitrobenzene sulphonic acid (TNBS) solutions once a week for 3 consecutive weeks. After TNBS instillation the mice received yoghurt again for 10 consecutive days. IBD control received only TNBS. After treatments we analysed the number of IgA–secreting cells, CD4+, CD8+ T cells population and the number of apoptotic cells in the large intestine. The number of erythrocytes and leucocytes in peripheral blood mononuclear cells (PBMCs) was also determined. We demonstrated the antinflammatory effect of yoghurt in an experimental model of IBD induced by TNBS. The effect was mediated by an increase in the number of the IgA+cells, a decrease in CD8+ population and by the induction of apoptosis of the infiltrative cells in the large intestine.

Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enabling enhanced intestinal barrier function

2015 ◽  
Vol 6 (8) ◽  
pp. 2568-2577 ◽  
Author(s):  
Yuan Yue ◽  
Shuangchan Wu ◽  
Zhike Li ◽  
Jian Li ◽  
Xiaofei Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Beneficial Effects ◽  
Experimental Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Dietary polysaccharides provide various beneficial effects for our health.

Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer

2021 ◽  
pp. 67-95
Author(s):  
Syed Nasar Rahaman ◽  
Prathiba Sivaprakasam ◽  
Ashok Kumar Pandurangan ◽  
Suresh Kumar Anandasadagopan
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Health Problem ◽  
Bowel Disease ◽  
The Other ◽  
Diallyl Trisulfide ◽  
Beneficial Effects ◽  
Natural Agents ◽  
The World ◽  
Inflammatory Bowel

Ulcerative colitis (UC) is a serious health problem around the world. Inflammatory bowel disease (IBD) is comprised of both Crohn's disease (CD) and UC. IBD is a clinical condition referred as inflammation in the colon. So far there is no proper medication available to treat IBD. On the other hand, untreated UC can be developed as colitis associated cancer. Natural agents are diverse molecules possess many beneficial effects. Many researchers have proven that natural agents can be better option to treat UC. Natural agents such as chrysin, chelidonic acid, euphol, fish oil, diallyl trisulfide, embelin, isatin, and rutin were already reported to have anti-colitic activity. In this chapter, the authors documented the natural agents that were used as treatment for UC.

Inflammatory Bowel Disease

2014 ◽  
pp. 734-747 ◽  
Author(s):  
Sonia Friedman
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Inflammatory Disease ◽  
Bowel Disease ◽  
Chronic Inflammatory Disease ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that can affect any site from the mouth to the anus. The two major types of IBD are Crohn's disease (CD) and ulcerative colitis (UC).

Sign in / Sign up

Export Citation Format

Share Document