scholarly journals Method for Horizontal Calibration of Laser-Projection Transnasal Fiberoptic High-Speed Videoendoscopy

2021 ◽  
Vol 11 (2) ◽  
pp. 822
Author(s):  
Hamzeh Ghasemzadeh ◽  
Dimitar D. Deliyski ◽  
Robert E. Hillman ◽  
Daryush D. Mehta
Keyword(s):  
Personalized Medicine ◽  
High Speed ◽  
Evidence Based Practice ◽  
Target Object ◽  
Evidence Based ◽  
Endoscopic Procedures ◽  
Fiberoptic Laryngoscope ◽  
Working Distance ◽  
And Personalized Medicine

Objective: Calibrated horizontal measurements (e.g., mm) from endoscopic procedures could be utilized for advancement of evidence-based practice and personalized medicine. However, the size of an object in endoscopic images is not readily calibrated and depends on multiple factors, including the distance between the endoscope and the target surface. Additionally, acquired images may have significant non-linear distortion that would further complicate calibrated measurements. This study used a recently developed in vivo laser-projection fiberoptic laryngoscope and proposes a method for calibrated spatial measurements. Method: A set of circular grids was recorded at multiple working distances. A statistical model was trained that would map from pixel length of the object, the working distance, and the spatial location of the target object into its mm length. Result: A detailed analysis of the performance of the proposed method is presented. The analyses have shown that the accuracy of the proposed method does not depend on the working distance and length of the target object. The estimated average magnitude of error was 0.27 mm, which is three times lower than the existing alternative. Conclusion: The presented method can achieve sub-millimeter accuracy in horizontal measurement. Significance: Evidence-based practice and personalized medicine could significantly benefit from the proposed method. Implications of the findings for other endoscopic procedures are also discussed.

scholarly journals Ultra-high-speed multi-parametric photoacoustic microscopy

2021 ◽  
Author(s):  
Song Hu ◽  
Fenghe Zhong
Keyword(s):  
High Speed ◽  
Laser Scanning ◽  
Ultrasonic Transducer ◽  
Hemoglobin Concentration ◽  
Blood Oxygenation ◽  
Flow Quantification ◽  
Photoacoustic Microscopy ◽  
Ultra High Speed ◽  
Working Distance

Multi-parametric photoacoustic microscopy (PAM) is uniquely capable of simultaneous, high-resolution mapping of blood hemoglobin concentration, oxygenation, and flow in vivo. However, its speed has been limited by the dense sampling required for blood flow quantification. To overcome this limitation, we have developed an ultra-high-speed multi-parametric PAM system, which enables simultaneous acquisition of ~500 densely sampled B-scans by superposing the rapid laser scanning across the line-shaped focus of a cylindrically focused ultrasonic transducer over the conventional mechanical scan of the optical-acoustic dual foci. A novel optical-acoustic combiner is designed and implemented to accommodate the short working distance of the transducer, enabling convenient confocal alignment of the dual foci in the reflection mode. This new system enables continuous monitoring of microvascular hemoglobin concentration, blood oxygenation, and flow over a 4.5 x 3 mm2 area in the awake mouse brain with high spatial and temporal resolution (6.9 μm and 0.3 Hz, respectively).

Proteomics in Personalized Medicine

2018 ◽  
pp. 80-98
Author(s):  
Srijan Goswami
Keyword(s):  
Personalized Medicine ◽  
Holistic Approach ◽  
Modern Medicine ◽  
Historical Background ◽  
Evidence Based ◽  
Future Prospects ◽  
Clinical Safety ◽  
Medical Concepts ◽  
And Personalized Medicine

The idea of personalized medicine system is an evolution of holistic approach of treatment and in more evidence based manner. The chapter begins with an introduction of how body system works naturally and impact of modern medicine on overall health, followed by a historical background and brief review of literature providing the description that the concept of personalized medicine is not new but a very old ideology which stayed neglected until the development in the field of medical genetics, followed by the role of omics in modern medicine, the comparison of modern medicine and personalized medicine, medical concepts relevant to proteomics in personalized medicine, impact of proteomics in drug development and clinical safety and finally closing the chapter with future prospects and challenges of proteomics in personalized medicine.

scholarly journals Evidence-Based and Personalized Medicine. It’s [AND] not [OR]

2017 ◽  
Vol 103 (1) ◽  
pp. 351-360 ◽  
Author(s):  
Sahar Mokhles ◽  
Johanna JM Takkenberg ◽  
Tom Treasure
Keyword(s):  
Personalized Medicine ◽  
Evidence Based ◽  
And Personalized Medicine

Let’s talk about adaptation! How individuals discuss adaptation during evidence-based practice implementation

2019 ◽  
Vol 14 (4) ◽  
pp. 266-277
Author(s):  
Rebecca Lengnick-Hall ◽  
Karissa Fenwick ◽  
Michael S. Hurlburt ◽  
Amy Green ◽  
Rachel A. Askew ◽  
...  
Keyword(s):  
Child Welfare ◽  
Evidence Based Practice ◽  
Evidence Based ◽  
Cross Sectional ◽  
Frontline Staff ◽  
Content Type ◽  
Group Settings ◽  
Ebp Implementation ◽  
Practice Implementation

Purpose Researchers suggest that adaptation should be a planned process, with practitioners actively consulting with program developers or academic partners, but few studies have examined how adaptation unfolds during evidence-based practice (EBP) implementation. The purpose of this paper is to describe real-world adaptation discussions and the conditions under which they occurred during the implementation of a new practice across multiple county child welfare systems. Design/methodology/approach This study qualitatively examines 127 meeting notes to understand how implementers and researchers talk about adaptation during the implementation of SafeCare, an EBP aimed at reducing child maltreatment and neglect. Findings Several types of adaptation discussions emerged. First, because it appeared difficult to get staff to talk about adaptation in group settings, meeting participants discussed factors that hindered adaptation conversations. Next, they discussed types of adaptations that they made or would like to make. Finally, they discussed adaptation as a normal part of SafeCare implementation. Research limitations/implications Limitations include data collection by a single research team member and focus on a particular EBP. However, this study provides new insight into how stakeholders naturally discuss adaptation needs, ideas and concerns. Practical implications Understanding adaptation discussions can help managers engage frontline staff who are using newly implemented EBPs, identify adaptation needs and solutions, and proactively support individuals who are balancing adaptation and fidelity during implementation. Originality/value This study’s unique data captured in vivo interactions that occurred at various time points during the implementation of an EBP rather than drawing upon data collected from more scripted and cross-sectional formats. Multiple child welfare and implementation stakeholders and types of interactions were examined.

scholarly journals Biobanking in oncology and radiology

2018 ◽  
Vol 11 (4) ◽  
pp. 170-177 ◽  
Author(s):  
Pavel O. Roumiantsev ◽  
Ali M. Mudunov
Keyword(s):  
Personalized Medicine ◽  
Biological Samples ◽  
Evidence Based ◽  
Thyroid Tumors ◽  
International Evidence ◽  
Information Logistics ◽  
Wide Range ◽  
The World ◽  
Methodological Guidelines

The first biobank in Russia was created in 1998 to investigate post-Chernobyl thyroid tumors. The number of biobanks in the world is growing. Infrastructure and collaboration are improving. Ethical, legal and methodological guidelines for biobanking have been developed and are regularly reviewed. Biobanking objects are now not only biological samples of patients but also their dynamic biomedical characteristics. Comparison of genetics, proteome and tumour metabolism and in vivo radiological visualization is necessary to improve personalized diagnostics, treatment and its effectiveness. The article focuses on international evidence-based experience of sample preparation and cryopreservation of biological samples, information logistics, and integration solutions in biobanking. Guiding principles and the model of a modern biobank, integrating up-to-date technologies of digital personalized medicine and telemedicine in oncology and radiology are reported. The article may be of interest to a wide range of experts in biomedicine, especially oncologists, radiologists, pathologists, geneticists, and IT specialists.

The Impact of Coaching on Teacher-Delivered Behavior-Specific Praise in Pre-K–12 Settings: A Systematic Review

2019 ◽  
Vol 45 (3) ◽  
pp. 148-166
Author(s):  
Robin Parks Ennis ◽  
David James Royer ◽  
Kathleen Lynne Lane ◽  
Kristin Diane Dunlap
Keyword(s):  
Professional Development ◽  
Performance Feedback ◽  
Evidence Based Practice ◽  
Teacher Behavior ◽  
Evidence Based ◽  
Behavior Specific Praise ◽  
K 12 ◽  
The Impact ◽  
Specific Praise

In this systematic literature review, we examined the effects of coaching (e.g., written, emailed, visual, video, and self-monitored performance feedback; in vivo bug-in-ear prompting; combinations) teachers and other educators to increase their use of behavior-specific praise, a low-intensity teacher-delivered strategy previously determined to be a potentially evidence-based practice based on Council for Exceptional Children’s (CEC) Standards for Evidence-Based Practices in Special Education. Research has shown that traditional lecture-style short-duration professional development does not typically lead to lasting change in teacher behavior, but follow-up observations with continued support (e.g., school-wide professional development for all, small group support for some, individualized support for a few) are much more likely to produce desired outcomes. As such, we examined the evidence base for coaching educators to increase behavior-specific praise by applying CEC quality indicators and standards, and concluded that coaching educators to increase behavior-specific praise meets CEC guidelines to be considered an evidence-based practice. Educational implications, limitations, and future directions are presented.

What Does Evidence-Based Practice Mean to You? A Follow-Up Study Examining School-Based Speech-Language Pathologists' Perspectives on Evidence-Based Practice

2020 ◽  
Vol 29 (2) ◽  
pp. 688-704
Author(s):  
Katrina Fulcher-Rood ◽  
Anny Castilla-Earls ◽  
Jeff Higginbotham
Keyword(s):  
Clinical Practice ◽  
Research Evidence ◽  
Evidence Based Practice ◽  
Evidence Based ◽  
Clinical Expertise ◽  
Speech Language Pathologists ◽  
School Based ◽  
Research Findings ◽  
Ebp Implementation

Purpose The current investigation is a follow-up from a previous study examining child language diagnostic decision making in school-based speech-language pathologists (SLPs). The purpose of this study was to examine the SLPs' perspectives regarding the use of evidence-based practice (EBP) in their clinical work. Method Semistructured phone interviews were conducted with 25 school-based SLPs who previously participated in an earlier study by Fulcher-Rood et al. 2018). SLPs were asked questions regarding their definition of EBP, the value of research evidence, contexts in which they implement scientific literature in clinical practice, and the barriers to implementing EBP. Results SLPs' definitions of EBP differed from current definitions, in that SLPs only included the use of research findings. SLPs seem to discuss EBP as it relates to treatment and not assessment. Reported barriers to EBP implementation were insufficient time, limited funding, and restrictions from their employment setting. SLPs found it difficult to translate research findings to clinical practice. SLPs implemented external research evidence when they did not have enough clinical expertise regarding a specific client or when they needed scientific evidence to support a strategy they used. Conclusions SLPs appear to use EBP for specific reasons and not for every clinical decision they make. In addition, SLPs rely on EBP for treatment decisions and not for assessment decisions. Educational systems potentially present other challenges that need to be considered for EBP implementation. Considerations for implementation science and the research-to-practice gap are discussed.

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