scholarly journals Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients

2021 ◽  
Vol 11 (19) ◽  
pp. 9356
Author(s):  
Ramona Gabriela Ursu ◽  
Ionut Luchian ◽  
Nicolae Ghetu ◽  
Victor Vlad Costan ◽  
Ovidiu Stamatin ◽  
...  
Keyword(s):  
Natural History ◽  
Head And Neck ◽  
Multiplex Pcr ◽  
Virus Detection ◽  
Squamous Cell Carcinomas ◽  
Herpes Viruses ◽  
Oncogenic Viruses ◽  
Skin Cancers ◽  
History Of ◽  
Pcr Genotyping

(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV and HPVs are recognized to be related to HNSCCs and skin cancers. There are no data from Romania regarding the involvement of herpes viruses and polyomaviruses in these types of cancer. We aim to evaluate the association of oncogenic viruses from Papillomaviridae, Herpesviridae, and Polyomaviridae families in HNSCCs and skin cancers. (2) Methods: A total of 26 fresh tumors (6/26 women) were tested for 67 viral agents using a multiplex PCR genotyping assay. (3) Results: A total of 23/26 (88.5%) samples were positive for one or more viruses. All the tested tumors were negative for any HPV (alpha or beta types). In total, we detected as positive samples: 16 (61.63%) EBV1, 12 (46.15%) HHV7, 8 (30.76%) MCV, 6 (23.07%) CMV and HHV6, 2 (7.69%) HHV8, 1 (3.8%) HPyV6 and EBV2. (4) Conclusions: We detected HPV-negative cases that are HPyV and HHV positive. In these fractions of HPV-negative HNSCCs cases, other oncogenic viruses may be involved, such as EBV1, MCV or CMV. Additional research is required for clarifying the natural history of these viruses in HNSCCs, as virus detection would have a decisive impact on diagnostic and decisional algorithms.

The natural history of untreated squamous cell carcinoma of the head and neck: how we do it

2011 ◽  
Vol 36 (4) ◽  
pp. 384-388 ◽  
Author(s):  
J.-P. Jeannon ◽  
E. Ofu ◽  
A. Balfour ◽  
J. Bowman ◽  
R. Simo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
History Of

The Majority of Cutaneous Squamous Cell Carcinomas Arise in Actinic Keratoses

2002 ◽  
Vol 6 (3) ◽  
pp. 207-209 ◽  
Author(s):  
D. Czarnecki ◽  
C. J. Meehan ◽  
F. Bruce ◽  
G. Culjak
Keyword(s):  
Family History ◽  
Squamous Cell ◽  
Retrospective Studies ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
Histological Features ◽  
Actinic Keratoses ◽  
Skin Cancers ◽  
History Of ◽  
A Prospective Study

Background: Retrospective studies have given conflicting results with respect to how many cutaneous squamous cell carcinomas (SCCs) arise in actinic keratoses (AK). Objective: This study was conducted to determine what percentage of SCCs arise in AKs and to obtain more information about two histological features of SCCs, namely, thickness and ulceration. Methods: A prospective study was done of all SCCs treated by the authors during one calendar year. Results: Two hundred eight patients with SCC were entered into the study. An AK was contiguous with an SCC in 72% of the cases. This was taken as evidence that the SCC arose in the AK. Men presented with thicker and more ulcerated SCCs than women, but these were not statistically significant: p = 0.06 for thickness and p = 0.07 for ulceration. Ulcerated SCCs were more likely to arise on the head and neck (p = 0.02), on patients who had multiple skin cancers ( p = 0.005), and on patients who had a family history of skin cancer ( p = 0.03). Conclusion: Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

The Natural History of Soft Tissue Hypertrophy, Bony Hypertrophy, and Nodule Formation in Patients With Untreated Head and Neck Capillary Malformations

2015 ◽  
Vol 41 (11) ◽  
pp. 1241-1245 ◽  
Author(s):  
Jeong Woo Lee ◽  
Ho Yun Chung ◽  
Eric W. Cerrati ◽  
Teresa M. O ◽  
Milton Waner
Keyword(s):  
Soft Tissue ◽  
Natural History ◽  
Head And Neck ◽  
Nodule Formation ◽  
History Of

scholarly journals The Evolution of Staging of Cutaneous Squamous Cell Carcinomas: A Structured Review

2017 ◽  
Vol 8 (2) ◽  
pp. 57-63 ◽  
Author(s):  
Mina N Le ◽  
Erica Lee ◽  
Bhuvanesh Singh
Keyword(s):  
Squamous Cell ◽  
Cancer Staging ◽  
Squamous Cell Carcinomas ◽  
Future Directions ◽  
Skin Cancers ◽  
Staging Systems ◽  
History Of ◽  
The Common ◽  
Ajcc Staging ◽  
Melanoma Skin

ABSTRACT Among non-melanoma skin cancers, cutaneous squamous cell carcinoma entails the highest morbidity and mortality, and yet there is little guidance on how to identify the subset of cutaneous squamous cell carcinomas that behave aggressively. The staging of non-melanoma skin cancers is meant to provide this guidance, by dividing patients into groups for which survival differs between groups, is similar within each group, and consistently decreases with each increasing stage group. In the present review, we explore the history of how the staging of non-melanoma skin cancers, focusing on cutaneous squamous cell carcinomas, has evolved over time. We describe the common criticisms leveled at the American Joint Committee on Cancer (AJCC) staging rubric. We discuss alternative staging systems that have recently been proposed, and how they have stood up to validation. Finally, we preview the AJCC staging changes that will go into effect next year and lay out some future directions for the improvement of skin cancer staging. How to cite this article Le MN, Lee E, Singh B. The Evolution of Staging of Cutaneous Squamous Cell Carcinomas: A Structured Review. Int J Head Neck Surg 2017;8(2):57-63.

Complications in head and neck surgery and how to avoid trouble

1989 ◽  
Vol 103 (10) ◽  
pp. 926-929 ◽  
Author(s):  
P. H. Rhys Evans
Keyword(s):  
Natural History ◽  
Head And Neck ◽  
Surgical Outcome ◽  
Neck Surgery ◽  
Pathological Process ◽  
Head And Neck Surgery ◽  
Realistic Expectation ◽  
Complex Anatomy ◽  
History Of ◽  
Potential Risks

AbstractIncreasing litigation in recent years has made it more and more necessary for the surgeon to be aware of the problems, pitfalls and complications which may arise as a result of surgery. The risks are compounded in the head and neck not only because of its complex anatomy but also because of additional difficulties relating to surgery of the upper aero-digestive tract.Some problems are unavoidable. The potential risks of surgery and its complications should be carefully weighed against the natural history of the pathological process and a realistic expectation of the surgical outcome compared with alternative treatments. Other problems may result from genuine mistakes, but a number of complications are caused through actions or omissions which are avoidable and which in certain circumstances may be construed as professional negligence. Some of the more common pitfalls and complications in head and neck surgery are discussed with particular reference to their causation and possible avoidance.

Natural history of untreated squamous cell carcinoma of the head and neck

2018 ◽  
Vol 44 (2) ◽  
pp. 200-203 ◽  
Author(s):  
Fei Liu ◽  
Shuai Yuan ◽  
Qigen Fang ◽  
Qiang Sun
Keyword(s):  
Squamous Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
History Of

Synovial Sarcomas of the Head and Neck

1992 ◽  
Vol 101 (4) ◽  
pp. 367-370 ◽  
Author(s):  
Rosario Carrillo ◽  
Jose Luis Rodriguez-Peralto ◽  
John G. Batsakis
Keyword(s):  
Natural History ◽  
Head And Neck ◽  
Synovial Sarcoma ◽  
High Grade ◽  
Appreciable Difference ◽  
Biologic Activity ◽  
History Of ◽  
Synovial Sarcomas ◽  
Synovial Tissues

Springing from mesenchyme rather than mature synovial tissues, synovial sarcomas are high-grade neoplasms that express epithelial as well as supporting tissue features. Accordingly, their histologic phenotypes can be epithelial, stromal, or mixed. Between 3% and 10% of all synovial sarcomas originate in the head and neck, particularly from parapharyngeal sites. These is no appreciable difference in biologic activity between synovial sarcomas of the head and neck and those arising from other anatomic sites. Five-year survivals are misleadingly optimistic and do not adequately reflect the natural history of the sarcoma. Synovial sarcoma is known to metastasize late, and few patients survive that event.

Mo1033 Natural History of Superficial Head and Neck Squamous Cell Carcinoma Under Follow-Up Endoscopic Observation With Narrow Band Imaging

2016 ◽  
Vol 83 (5) ◽  
pp. AB436
Author(s):  
Hiroshi Nakamura ◽  
Tomonori Yano ◽  
Satoshi Fujii ◽  
Tomohiro Kadota ◽  
Toshifumi Tomioka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Endoscopic Observation ◽  
History Of

Intramuscular haemangioma of head and neck region

1998 ◽  
Vol 112 (12) ◽  
pp. 1199-1201 ◽  
Author(s):  
Neena Chaudhary ◽  
Anurag Jain ◽  
Sanjay Gudwani ◽  
Rajeev Kapoor ◽  
Gul Motwani
Keyword(s):  
Skeletal Muscle ◽  
Natural History ◽  
Head And Neck ◽  
Neck Region ◽  
Sternocleidomastoid Muscle ◽  
Treatment Modalities ◽  
Head And Neck Region ◽  
History Of ◽  
Intramuscular Haemangioma

AbstractIntramuscular haemangiomas are rare benign haemangiomas occurring within the skeletal muscle. These are uncommon tumours in the head and neck region and occur most frequently on the trunk and extremities. Fewer than 80 cases of intra-muscular haemangioma in the head and neck region have been reported in the literature.A case of intramuscular haemangioma of the sternocleidomastoid muscle is presented. The review of occurrence and natural history of such tumours is described and clinical and radiological presentation, histological classifications and treatment modalities are discussed.

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