Peptide Multimerization as Leads for Therapeutic Development

Multimerization of peptide structures has been a logical evolution in their development as potential therapeutic molecules. The multivalent properties of these assemblies have attracted much attention from researchers in the past and the development of more complex branching dendrimeric structures, with a wide array of biocompatible building blocks is revealing previously unseen properties and activities. These branching multimer and dendrimer structures can induce greater effect on cellular targets than monomeric forms and act as potent antimicrobials, potential vaccine alternatives and promising candidates in biomedical imaging and drug delivery applications. This review aims to outline the chemical synthetic innovations for the development of these highly complex structures and highlight the extensive capabilities of these molecules to rival those of natural biomolecules.

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Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications

Protein and Peptide Letters ◽

10.2174/0929866528666211126160432 ◽

2021 ◽

Vol 28 ◽

Author(s):

Sara Yazdani ◽

Seyed Mohammad Ghoreishi ◽

Neda Habibi

Keyword(s):

Drug Delivery ◽

Building Blocks ◽

Amino Acid Sequences ◽

Molecular Structures ◽

Flufenamic Acid ◽

Mixture Ratio ◽

Drug Molecules ◽

Release Capacity ◽

Essential Properties ◽

Drug Delivery Applications

Background: Due to their solid-like porous structure, molecular organogel and microcrystal structures have the capabilities of loading drug molecules, encapsulation, and extended release, all considered as essential properties in drug delivery applications. Phases of these structures, however, depend on the solvent used during the gelation process. Objective: Understanding the phase transition between organogel and microcrystal structures through adjusting the mixture ratio of different co-solvents. Method: Short peptide Diphenylalanine as the gelation building block was used due to its amino acid sequences that can be exactly selected at its molecular levels. Ethanol as a polar solvent was used in combination with four other co-solvents with different polarity levels, namely Xylene, Toluene, Acetone, and Dimethyl Sulfoxide. The morphology of molecular structures of each co-solvent combination at each ratio level was examined as well as the loading and release properties for a non-polar Flufenamic Acid drug. Results: The resultant structure wasaffected by the polarity of the co-solvents; in particular, in the sample containing 25 μg/ml of the drug, 94% of the drug amount was loaded inside the organogel. By increasing the drug concentration to 50, 75, and 100 μg/ml, the loading capability decreased to 76%, 47%, and 33%, respectively. Conclusion: Molecular organogels have excellent capabilities of loading drug molecules, while microcrystal structures have higher release capacity. The findings of this study reveal how to best design a gelation method to obtain maximum loading or release properties for a particular peptide-based drug delivery application.

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Surfactant-free polymeric nanoparticles composed of PEG, cholic acid and a sucrose moiety

Journal of Materials Chemistry B ◽

10.1039/c3tb21632b ◽

2014 ◽

Vol 2 (25) ◽

pp. 3946-3955 ◽

Cited By ~ 8

Author(s):

Carina I. C. Crucho ◽

M. Teresa Barros

Keyword(s):

Drug Delivery ◽

Cholic Acid ◽

Self Assembly ◽

Polymeric Nanoparticles ◽

Building Blocks ◽

Amphiphilic Polymers ◽

Potential Candidate ◽

Nanoprecipitation Method ◽

Drug Delivery Applications

New amphiphilic polymers synthesized from a sucrose-containing conjugate exhibited interesting self-assembly properties in water. Owing to their amphiphilic characteristics polymeric nanoparticles were prepared by a nanoprecipitation method without any surfactants. These nanoparticles formulated with biocompatible building blocks can be considered a potential candidate for drug delivery applications.

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Tetraethyl Orthosilicate-Based Hydrogels for Drug Delivery—Effects of Their Nanoparticulate Structure on Release Properties

Gels ◽

10.3390/gels6040038 ◽

2020 ◽

Vol 6 (4) ◽

pp. 38

Author(s):

Bogdan A. Serban ◽

Emma Barrett-Catton ◽

Monica A. Serban

Keyword(s):

Drug Delivery ◽

Shear Stress ◽

Stress Response ◽

Drug Release ◽

Building Blocks ◽

Tetraethyl Orthosilicate ◽

Mechanism Of Formation ◽

Colloidal Aggregation ◽

Drug Delivery Applications ◽

Shear Stress Response

Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications.

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Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug

Journal of Materials Chemistry B ◽

10.1039/c5tb00625b ◽

2015 ◽

Vol 3 (29) ◽

pp. 5978-5990 ◽

Cited By ~ 5

Author(s):

Linsha Vazhayal ◽

Nishanth Kumar Sasidharan ◽

Sindhoor Talasila ◽

Dileep B. S. Kumar ◽

Ananthakumar Solaiappan

Keyword(s):

Drug Delivery ◽

Building Blocks ◽

Antifungal Drug ◽

Drug Delivery Applications ◽

Self Assembled

A fascinating 2D architecture of an alumino-siloxane gel self-assembled into a well-defined 3D porous aquagel cage. It is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications.

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Silica-Based Nanoparticles for Biomedical Imaging and Drug Delivery Applications

Frontiers in Nanobiomedical Research - Handbook of Nanobiomedical Research ◽

10.1142/9789814520652_0011 ◽

2014 ◽

pp. 403-437 ◽

Cited By ~ 1

Author(s):

Stephanie A. Kramer ◽

Wenbin Lin

Keyword(s):

Drug Delivery ◽

Biomedical Imaging ◽

Drug Delivery Applications

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A Review on Fast Dissolving Tablet

International Journal of Current Pharmaceutical Review and Research ◽

10.25258/ijcprr.v8i03.9218 ◽

2017 ◽

Vol 8 (03) ◽

Author(s):

Sagar T. Malsane ◽

Smita S. Aher ◽

R. B. Saudagar

Keyword(s):

Drug Delivery ◽

Patient Compliance ◽

Research Area ◽

Oral Route ◽

Dosage Forms ◽

The Novel ◽

The Past ◽

Orally Disintegrating Tablets ◽

Novel Drug ◽

Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

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