scholarly journals A New Transmission Route for the Propagation of the SARS-CoV-2 Coronavirus

Biology ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 10
Author(s):  
Antoine Danchin ◽  
Tuen Wai Ng ◽  
Gabriel Turinici
Keyword(s):  
Compartmental Model ◽  
Transmission Route ◽  
Future Trends ◽  
Prevention Measures ◽  
Public Records ◽  
Specific Strategy ◽  
Virus Tropism ◽  
The World ◽  
Novel Coronavirus ◽  
Existing Data

Background: Starting late 2019, a novel coronavirus spread from the capital of the Hubei province in China to the rest of the country, then to most of the world. To anticipate future trends in the development of the pandemic, we explore here, based on public records of infected persons, how variation in the virus tropism could end up in different patterns, warranting a specific strategy to handle the epidemic. Methods: We use a compartmental model to describe the evolution of an individual through several possible states: susceptible, infected, alternative infection, detected, and removed. We fit the parameters of the model to the existing data, taking into account significant quarantine changes where necessary. Results: The model indicates that Wuhan quarantine measures were effective, but that alternative virus forms and a second propagation route are compatible with available data. For the Hong Kong, Singapore, and Shenzhen regions, the secondary route does not seem to be active. Conclusions: Hypotheses of an alternative infection tropism (the gut tropism) and a secondary propagation route are discussed using a model fitted by the available data. Corresponding prevention measures that take into account both routes should be implemented to the benefit of epidemic control.

scholarly journals A new transmission route for the propagation of the SARS-CoV-2 coronavirus

2020 ◽  
Author(s):  
Antoine Danchin ◽  
Tuen Wai Ng ◽  
Gabriel Turinici
Keyword(s):  
Compartmental Model ◽  
Transmission Route ◽  
Future Trends ◽  
Prevention Measures ◽  
Public Records ◽  
Epidemic Size ◽  
Virus Tropism ◽  
The World ◽  
Novel Coronavirus ◽  
Existing Data

Abstract Background: A novel coronavirus spread starting late 2019 from the capital of the Hubei province in China to the rest of the country, then to most of the world. To anticipate future trends in the development of the epidemic, we explore here, based on public records of infected persons how variation in the virus tropism could end up in different patterns, warranting specific way to handle the epidemic. Methods: We use a compartmental model to describe the evolution of an individual through several possible states: susceptible, infected, alternative infection, detected and removed. We t the parameters of the model to the existing data taking into account significant quarantine changes where necessary. Results: The model indicates that Wuhan quarantine measures were effective but that alternative virus forms and a second propagation route are compatible with available data. For Hong Kong, Singapore and Shenzhen region the secondary route does not seem to be active yet and the epidemic size limited. Conclusions: The alternative infection tropism (the gut tropism) and a secondary propagation route hypotheses are validated using a model fitted by the available data. Corresponding prevention measures that take into account both routes should be implemented to the benefit of epidemic control.

scholarly journals A new transmission route for the propagation of the SARS-CoV-2 coronavirus

2020 ◽  
Author(s):  
Antoine Danchin ◽  
Patrick Tuen Wai Ng ◽  
Gabriel Turinici
Keyword(s):  
Compartmental Model ◽  
Transmission Route ◽  
Future Trends ◽  
Prevention Measures ◽  
Public Records ◽  
Epidemic Size ◽  
Virus Tropism ◽  
The World ◽  
Novel Coronavirus ◽  
Existing Data

AbstractBackgroundA novel coronavirus (SARS-CoV-2) spread from the capital of the Hubei province in China to the rest of the country, then to most of the world. To anticipate future trends in the development of the epidemic, we explore here, based on public records of infected persons how variation in the virus tropism could end up in different patterns, warranting specific way to handle the epidemic.MethodsWe use a compartmental model to describe the evolution of an individual through several possible states: susceptible, infected, alternative infection, detected and removed. We fit the parameters of the model to the existing data taking into account significant quarantine changes where necessary.ResultsThe model indicates that Wuhan quarantine measures were effective but that alternative virus forms and a second propagation route are compatible with available data. For Singapore and Shenzhen region the secondary route does not seem to be active yet and the epidemic size limited.ConclusionsThe alternative infection tropism (the gut tropism) and a secondary propagation route are validated hypotheses using a model fitted by the available data. Corresponding prevention measures that take into account both routes should be implemented to the benefit of epidemic control.

scholarly journals Detecting Twitter's Impact on COVID-19 Pandemic in India

2020 ◽  
Vol 9 (8) ◽  
pp. 815-819
Keyword(s):  
Social Media ◽  
Large Population ◽  
Signs And Symptoms ◽  
Public Health Emergency ◽  
Prevention Measures ◽  
The World ◽  
National Unit ◽  
System 2 ◽  
Novel Coronavirus ◽  
Global Solidarity

India has etched a higher place in the economy as a fast growing country with a large population. India is one of the leading Twitter usage countries, with 13.15 million users as ofApril2020[1].A novel coronavirus(COVID-19), which is a pand emic, has been threatening nearly everywhere. This terrible disea se started at the end of 2019 from WUHAN in China and is sprea ding very quickly virtually all over the world. This disease's whist leblower Dr. Li Wenliang also died from coronavirus on Feb 7, 2 020.According to the WHO, on 30 January 2020, the outbreak w as declared a public health emergency. In response to COVID19 he called for National Unit and Global Solidarity. All the countries in the world are linked with each other due to globalization, the proportion of labor finances migrating economically. In this paper, Twitter reflects the reality of the world. The main issue like signs and symptoms, prevention measures, and medicines which are related to this disease are discussed. Twitter is used for detecting this disease by analyzing data on social media. Nowadays social media sites are very fast and less costly for communication and exchange of information, ideas, and thoughts. This disease is being monitored by Twitter. If there is any delay it will result in a big damage to not only society but also the country. There are two methods: 1. Monitoring system 2. Awareness and alertness

scholarly journals COVID-19 MOST AFFECTED AGE GROUPS AND LETHALITY IN EUROPE

2020 ◽  
Vol 2 (SP1) ◽  
pp. 179-184
Keyword(s):  
Age Groups ◽  
Case Fatality ◽  
Prevention Measures ◽  
Global Epidemic ◽  
Number Of Patients ◽  
The World ◽  
The Mean ◽  
Novel Coronavirus ◽  
Very High ◽  
Age Of Death

Introduction: The outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) was the beginning of one of the largest and most critical COVID-19 clusters in the world since late December 2019. Despite intensive prevention measures, the epidemic tends to propagate and the number of patients infected is growing. The case-fatality incidence was very high and is driven by very elderly people. Methods: in this study, we collected data from the (Covidgraph.com) database as the number of infection cases in the world reached 2736188 infections and the number of recovery cases reached 751805 and the number of deaths reached 191423.Results: it turns out that the virus infects older people and the older a person is, the higher the chance of infection with the virus. Results from this analysis the mean age of death is 78 years. Data from 106,399 cases and 12,550 deaths in Italy, to 2 April. In Spain, they are based on 7 April, 88,144 cases, and 3,479 deaths. There were less than 80 deaths in patients younger than 50 years of age. Conclusion: Coronavirus is a global epidemic, and it's hard to control, and it's not enough to prevent people from spreading the virus. The age groups most vulnerable to lethality are shown in this paper, in Italy, the virus destroys people over 75 years of age, In Spain, however, the virus destroys people aged over 85 Taking into account numerous comorbidities, including psychiatric, cerebrovascular, endocrine, metabolic, and respiratory disorders.

scholarly journals Deep phylogenetic analysis of Orthocoronavirinae genomes traces the origin, evolution and transmission route of 2019 novel coronavirus

2020 ◽  
Author(s):  
Amresh Kumar Sharma ◽  
Anup Som
Keyword(s):  
Phylogenetic Analysis ◽  
Large Scale ◽  
Adaptive Mutation ◽  
Transmission Route ◽  
Gene Trees ◽  
Mode Iii ◽  
Health Crisis ◽  
Evolutionary Pattern ◽  
The World ◽  
Novel Coronavirus

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan city, China in December 2019 and thereafter its spillover across the world has created a global pandemic and public health crisis. Today, it appears as a threat to human civilization. Scientists and medical practitioners across the world are involved to trace out the origin and evolution of SARS-CoV-2 (also called 2019 novel coronavirus and referred as 2019-nCoV), its transmission route, cause of pathogenicity, and possible remedial action. In this work, we aim to find out the origin, evolutionary pattern that led to its pathogenicity and possible transmission pathway of 2019-nCoV. To achieve the aims we conducted a large-scale deep phylogenetic analysis on the 162 complete Orthocoronavirinae genomes consisting of four genera namely Alphacoronavirus, Betacoronavirus, Deltacoronavirus and Gammacoronavirus, their gene trees analysis and subsequently genome and gene recombination analyses. Our analyses revealed that i) bat, pangolin and anteater are the natural hosts of 2019-nCoV, ii) outbreak of 2019-nCoV took place via inter-intra species transmission mode, iii) host-specific adaptive mutation made 2019-nCoV more virulent, and iv) the presence of widespread recombination events led to the evolution of new 2019-nCoV strain and/or could be determinant of its pathogenicity.

scholarly journals COVID-19 MOST AFFECTED AGE GROUPS AND LETHALITY IN EUROPE Authors

2020 ◽  
pp. 179-184
Keyword(s):  
Age Groups ◽  
Case Fatality ◽  
Prevention Measures ◽  
Global Epidemic ◽  
Number Of Patients ◽  
The World ◽  
The Mean ◽  
Novel Coronavirus ◽  
Very High ◽  
Age Of Death

Introduction: The outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) was the beginning of one of the largest and most critical COVID-19 clusters in the world since late December 2019. Despite intensive prevention measures, the epidemic tends to propagate and the number of patients infected is growing. The case-fatality incidence was very high and is driven by very elderly people. Methods: in this study, we collected data from the (Covidgraph.com) database as the number of infection cases in the world reached 2736188 infections and the number of recovery cases reached 751805 and the number of deaths reached 191423.Results: it turns out that the virus infects older people and the older a person is, the higher the chance of infection with the virus. Results from this analysis the mean age of death is 78 years. Data from 106,399 cases and 12,550 deaths in Italy, to 2 April. In Spain, they are based on 7 April, 88,144 cases, and 3,479 deaths. There were less than 80 deaths in patients younger than 50 years of age. Conclusion: Coronavirus is a global epidemic, and it's hard to control, and it's not enough to prevent people from spreading the virus. The age groups most vulnerable to lethality are shown in this paper, in Italy, the virus destroys people over 75 years of age, In Spain, however, the virus destroys people aged over 85 Taking into account numerous comorbidities, including psychiatric, cerebrovascular, endocrine, metabolic, and respiratory disorders.

ADDRESSING THE ISSUE OF СOVID-19, SARS-COV-2 VIRUS AND THE DISEASE

2020 ◽  
Vol 99 (6) ◽  
pp. 15-31
Author(s):  
A.A. Korenkova ◽  
◽  
E.M. Mayorova ◽  
V.V. Bahmetjev ◽  
M.V. Tretyak ◽  
...  
Keyword(s):  
Public Health ◽  
Immune Responses ◽  
Molecular Mechanisms ◽  
Herd Immunity ◽  
Significant Problem ◽  
Prevention Measures ◽  
Optimal Therapy ◽  
The World ◽  
Public Health Challenge ◽  
Coronavirus Infection

The new coronavirus infection has posed a major public health challenge around the world, but new data on the disease raises more questions than answers. The lack of optimal therapy is a significant problem. The article examines the molecular mechanisms of SARS-CoV-2 infection and the pathogenesis of COVID-19, special attention is paid to features of pathological processes and immune responses in children. COVID-19 leads to a wide diversity of negative outcomes, many of which can persist for at least months. Many of the consequences have yet to be identified. SARS-CoV-2 may provoke autoimmune reactions. Reinfection, herd immunity, vaccines and other prevention measures are also discussed in this review.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Current updates on COVID-19 - A review

2020 ◽  
Vol 10 (1) ◽  
pp. 1-8
Author(s):  
Ghotekar D S ◽  
Vishal N Kushare ◽  
Sagar V Ghotekar
Keyword(s):  
World Health Organization ◽  
Common Cold ◽  
Respiratory Diseases ◽  
Gastrointestinal Diseases ◽  
Hubei Province ◽  
World Health ◽  
The World ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

Coronaviruses are a family of viruses that cause illness such as respiratory diseases or gastrointestinal diseases. Respiratory diseases can range from the common cold to more severe diseases. A novel coronavirus outbreak was first documented in Wuhan, Hubei Province, China in December 2019. The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) a pandemic. A global coordinated effort is needed to stop the further spread of the virus. A novel coronavirus (nCoV) is a new strain that has not been identified in humans previously. Once scientists determine exactly what coronavirus it is, they give it a name (as in the case of COVID-19, the virus causing it is SARS-CoV-2).

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