scholarly journals Photobiomodulation for Parkinson’s Disease in Animal Models: A Systematic Review

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 610 ◽  
Author(s):  
Farzad Salehpour ◽  
Michael R Hamblin
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Near Infrared ◽  
Infrared Light ◽  
Body Parts ◽  
Power Densities ◽  
The Brain ◽  
Deep Brain

Photobiomodulation (PBM) might be an effective treatment for Parkinson’s disease (PD) in human patients. PBM of the brain uses red or near infrared light delivered from a laser or an LED at relatively low power densities, onto the head (or other body parts) to stimulate the brain and prevent degeneration of neurons. PD is a progressive neurodegenerative disease involving the loss of dopamine-producing neurons in the substantia nigra deep within the brain. PD is a movement disorder that also shows various other symptoms affecting the brain and other organs. Treatment involves dopamine replacement therapy or electrical deep brain stimulation. The present systematic review covers reports describing the use of PBM to treat laboratory animal models of PD, in an attempt to draw conclusions about the best choice of parameters and irradiation techniques. There have already been clinical trials of PBM reported in patients, and more are expected in the coming years. PBM is particularly attractive as it is a non-pharmacological treatment, without any major adverse effects (and very few minor ones).

Directional Recording of Subthalamic Spectral Power Densities in Parkinson's Disease and the Effect of Steering Deep Brain Stimulation

2015 ◽  
Vol 8 (4) ◽  
pp. 730-741 ◽  
Author(s):  
L.J. Bour ◽  
M.A.J. Lourens ◽  
R. Verhagen ◽  
R.M.A. de Bie ◽  
P. van den Munckhof ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Spectral Power ◽  
Power Densities ◽  
Deep Brain

scholarly journals Deep brain stimulation. How it controls movements in Parkinson’s disease?

2019 ◽  
Vol 21 (3) ◽  
pp. 93-99
Author(s):  
Z. A. Zalyalova
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Treatment Rate ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Pain Syndromes ◽  
The Brain ◽  
Deep Brain

Deep brain stimulation (DBS) involves implantation of electrodes in the basal ganglia of the brain. Dysregulation of neuronal activity in these structures is the cause of motor disorders. DBS is used in many motor (Parkinson’s disease, essential tremor, dystonia, ticks, tardive dyskinesia and others), psychological, behavioral and affective (depression, obsessive-compulsive disorder, epilepsy and others) disorders, as well as in severe pain syndromes resistant to drug therapy. However, the mechanisms of action of DBS are not fully understood. Currently, different theories and hypotheses are considered which explain its mechanism of treatment: rate model, “jamming” theory, hypotheses about the effect on neurogenesis, astrocyte activity, increased brain circulation, electrotaxis, etc.

scholarly journals Comparison of General and Local Anesthesia for Deep Brain Stimulator Insertion: A Systematic Review

2017 ◽  
Vol 44 (6) ◽  
pp. 697-704 ◽  
Author(s):  
Veena Sheshadri ◽  
Nathan C. Rowland ◽  
Jigesh Mehta ◽  
Marina Englesakis ◽  
Pirjo Manninen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Outcome ◽  
Rating Scale ◽  
Quality Data ◽  
Cochrane Library ◽  
Disease Rating ◽  
Stn Dbs ◽  
Deep Brain

AbstractBackground: Subthalamic nucleus deep brain stimulation (STN–DBS) has become a standard treatment for many patients with Parkinson’s disease (PD). The reported clinical outcome measures for procedures done under general anesthesia (GA) compared to traditional local anesthetic (LA) technique are quite heterogeneous and difficult to compare. The aim of this systematic review and metaanalysis was to determine whether the clinical outcome after STN–DBS insertion under GA is comparable to that under LA in patients with Parkinson’s disease. Methods: The databases of Medline Embase, Cochrane library and Pubmed were searched for eligible studies (human trials, English language, published between 1946 and January of 2016). The primary outcome of this study was to assess the postoperative improvement in the symptoms, evaluated using either Unified Parkinson’s Disease Rating Scale (UPDRS) scores or levodopa equivalent dosage (LEDD) requirement. Results: The literature searches yielded 395 citations and six retrospective cohort studies with a sample size of 455 (194 in GA and 261 in LA) were included in the analysis. Regarding the clinical outcomes, there were no significant differences in the postoperative Unified Parkinson’s disease rating scale and levodopa equivalent drug dosage between the GA and the LA groups. Similarly, the adverse events and target accuracy were also comparable between the groups. Conclusions: This systematic review and meta-analysis shows that currently there is no good quality data to suggest equivalence of GA to LA during STN-DBS insertion in patients with PD, with some factors trending towards LA. There is a need for a prospective randomized control trial to validate our results.

scholarly journals Prediction of Deep Brain Stimulation Outcome in Parkinson’s Disease With Connectome Based on Hemispheric Asymmetry

2021 ◽  
Vol 15 ◽  
Author(s):  
Jingqi Wang ◽  
Ruihong Shang ◽  
Le He ◽  
Rongsong Zhou ◽  
Zhensen Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Motor Function ◽  
Brain Stimulation ◽  
Precentral Gyrus ◽  
True Value ◽  
The Brain ◽  
Stn Dbs ◽  
Deep Brain

Parkinson’s disease (PD) is a neurodegenerative disease that is associated with motor and non-motor symptoms and caused by lack of dopamine in the substantia nigra of the brain. Subthalamic nucleus deep brain stimulation (STN-DBS) is a widely accepted therapy of PD that mainly inserts electrodes into both sides of the brain. The effect of STN-DBS was mainly for motor function, so this study focused on the recovery of motor function for PD after DBS. Hemispherical asymmetry in the brain network is considered to be a potential indicator for diagnosing PD patients. This study investigated the value of hemispheric brain connection asymmetry in predicting the DBS surgery outcome in PD patients. Four types of brain connections, including left intra-hemispheric (LH) connection, right intra-hemispheric (RH) connection, inter-hemispheric homotopic (Ho) connection, and inter-hemispheric heterotopic (He) connection, were constructed based on the resting state functional magnetic resonance imaging (rs-fMRI) performed before the DBS surgery. We used random forest for selecting features and the Ridge model for predicting surgical outcome (i.e., improvement rate of motor function). The functional connectivity analysis showed that the brain has a right laterality: the RH networks has the best correlation (r = 0.37, p = 5.68E-03) between the predicted value and the true value among the above four connections. Moreover, the region-of-interest (ROI) analysis indicated that the medioventral occipital cortex (MVOcC)–superior temporal gyrus (STG) and thalamus (Tha)–precentral gyrus (PrG) contributed most to the outcome prediction model for DBS without medication. This result provides more support for PD patients to evaluate DBS before surgery.

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